Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen China

Shenzhen, China

Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen China

Shenzhen, China

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Chen X.,Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen China | Liang P.-Y.,Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen China | Li G.-G.,Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen China | Diao L.-H.,Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen China | And 5 more authors.
Tissue Antigens | Year: 2015

Immunogenetic studies have suggested that autoantibody production is commonly associated with particular human leukocyte antigens (HLA) class II genotypes in certain autoimmune diseases. The objective of this study was to investigate whether the production of anti-β2-glycoprotein I antibody (aβ2GPI) was associated with particular HLA-DQ alleles in patients with recurrent miscarriage (RM). The HLA-DQ genotypes in 126 patients with RM were determined using the polymerase chain reaction-sequence-specific primer method. Both the IgG and IgM isotypes of aβ2GPI were measured via enzyme-linked immunosorbent assay. Positive results for either IgG or IgM on two occasions within an interval of 12 weeks were defined as antiphospholipid antibody-positive. The frequencies of the HLA-DQA1*01:02 [odds ratio (OR) 3.4, 95% confidence interval (CI) 1.6-7.0, Pc = 0.018] and HLA-DQB1*02:01 alleles (OR 4.6, 95% CI 2.1-10.2, Pc = 9.18 × 10-4) were significantly increased in aβ2GPI-positive RM patients compared with aβ2GPI-negative RM patients. © 2015 John Wiley & Sons A/S.

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