Xiao H.-j.,Fengxian District Center Hospital |
Xue F.,Fengxian District Center Hospital |
He Z.-m.,Fengxian District Center Hospital |
Jin F.-q.,Fengxian District Center Hospital |
Shen Y.-c.,Fengxian District Center Hospital
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011
BACKGROUND: Bone adhesives have more or few shortcomings themselves at present. OBJECTIVE: To develop a new kind of bioactive bone cement that can be used as fracture adhesion. METHODS: Nano-hydroxyapatite/carboxymethychitosan-sodium alginate bone cement composite material as solid phase was prepared through a co-precipitation method, and citric acid derivant as liquid phase was prepared for solution. By optimized experimentation in situ setting, the appropriate prescription of the cement was screened out according to the test of setting time, compressive strength, tensile strength, anti-washout ability, and microstructure and crystal construction of the cement were characterized by using Fourier transform infrared spectroscopy and scanning electron microscope. RESULTS AND CONCLUSION: When the mass ratio of nano-hydroxyapatite/carboxymethychitosan-sodium alginate was 65/35 (among carboxymethychitosan/sodium alginate 4:1) and liquid/solid was 1.0: 0.5 (g: mL), the prepared cement was paste-like with good plasticity and anti-washout ability; the setting time was 12 to 18 minutes; the compressive strength was (4.5±2.1) MPa;the tensile strength of the femoral head of pigs had no difference at 25 °C nd 37 °C in vitro (P > 0.05); the tensile strength at 2 hours was 94% similar as that at 24 hours after the setting; the range of the porous structure was 100-300 μm;Nano-hydroxyapatite was well-distributed in the porous structure. The nano-hydroxyapatite/carboxymethychitosan-sodium alginate bone cement has good biological activity, appropriate compressive strength, and preferable adhesive strength.