Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.91M | Year: 2015
The interaction of matter with light is one of the most fundamental processes occurring in nature with countless scientific and technological applications. In recent years, the continuing development of intense, ultrashort, coherent light sources from the mid-infrared (mid-IR) to the extreme ultraviolet (XUV) spectral range has opened new possibilities for the investigation of this interaction in new and complementary domains. In both the IR and XUV regimes, molecules and clusters of atoms interacting with light exhibit (correlated) multi-electron dynamics evolving on the few femtosecond (1 fs=10-15 s) to attosecond (1 as=10-18 s) timescale. Several experimental and theoretical investigations suggest that ultrafast multielectronic processes might be fundamental in determining the behaviour of molecules and clusters, and that understanding these phenomena might offer new perspectives on processes occurring on slower timescales, such as bond-breaking in complex molecules and Coulomb explosion in charged clusters. In this context, the main objectives of the MEDEA network are: 1) to advance attosecond and femtosecond XUV spectroscopy in molecules and clusters 2) to demonstrate the feasibility of nonlinear attosecond XUV spectroscopy, 3) to obtain benchmarks for the validation of attosecond tools and femtosecond XUV pulses for the time-resolved imaging of electron and nuclear dynamics in molecules, 4) to contribute to the development of new technological solutions that will increase the competiveness of the industrial partners 5) to train a group of early stage researchers (ESRs) and contribute to their career prospects, and 6) to increase the interest of young students in the networks core research field (Photonics) by introducing a dedicated experimental kit in several European secondary schools.
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 3.60M | Year: 2009
Worldwide there is great excitement about two new ultrafast XUV/x-ray sources that are presently coming available. Attosecond XUV pulses by high-harmonic generation (HHG) will now allow for the first time to make movies of ultrafast electron motion, and thereby to investigate photo-chemical processes beyond the Born-Oppenheimer limit. At the same time, XUV/x-ray Free Electron Lasers (FELs) based on self-amplification of spontaneous emission (SASE) of relativistic electrons moving through an undulator structure will allow for the first time to track structural changes in (bio-)molecules using femtosecond time-resolved x-ray diffraction. In this context, the objectives of ATTOFEL are six-fold: 1) by establishing a framework for collaborative research on attosecond science, the potential is created for major breakthroughs in our understanding of the role of ultrafast electron dynamics in atomic physics, molecular physics and materials science. 2) by bringing together groups who recently have combined research in attosecond science with research efforts at the FLASH-FEL in Hamburg, an effective channel is created for knowledge transfer between the HHG/attosecond laser community and the FEL-community, which have historically been separate. 3) a generation of young scientists is trained that can shape the future of attosecond and FEL science, or that can embark on successful careers in industry. 4) the competitive advantage that European attosecond science and European XUV/x-ray FEL facilities currently have is significantly aided. 5) the competitive position of European industrial partners in the very demanding high-end ultrafast lasers market is strengthened. 6) the structuring of the international research community in this field will be consolidated, strengthened and expanded.
Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-2012-1 | Award Amount: 1.41M | Year: 2012
FLAME will leverage a current revolution in ultrafast laser science and lead to the commercial availability of amplified laser systems with significantly higher pulse repetition rates, higher average powers and shorter pulse durations than has been possible up to now. In addition, the project will develop sophisticated ion and electron imaging detectors tailored to the experimental research carried out with the novel laser systems. Work to be performed by the RTD teams will be carried out in three directions: Development of a high power and high speed extremely short pulse (<10fs) laser source and a tunable visible high power and high speed ultrafast laser source. Development of dedicated detection instrumentation that maximizes the benefits that can be obtained from working with these laser sources The technology that will be developed in the project offers One-two orders of magnitude higher repetition rates, one order of magnitude shorter pulse durations and higher average powers than commercially available laser amplifiers, existing fiber lasers or few-cycle oscillators A multi-dimensional detection apparatus tailored to ultrafast laser pulse characterisation with an improvement in signal quality by an order of magnitude The FLAME consortium consists of 4 SME participants and two leading research centers as RTD participants. The SME participants are today already present in the ultrafast market, or as providers of characterization/detection equipment. They are in an excellent position to offer new products shortly after the completion of the project. The path for exploitation of foreground in the FLAME project will follow the model generally leading to wide industrial acceptance of new laser technologies: Develop a solid technology base from the research carried out in the project Leverage this technology base for a rapid access to fast growing scientific markets Build on the relationship with scientific customers to develop new industrial markets Short term scientific applications include attosecond research and time-resolved spectroscopy, while mid-term industrial applications include materials science and semiconductor metrology.
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.3.5 | Award Amount: 13.40M | Year: 2012
Biophotonics offers low-cost, non-invasive, accurate, rapid alternatives to conventional diagnostic methods and has the potential to address medical needs with early detection and to reduce the cost of healthcare. FAMOS will develop a new generation of light sources with step-changes in performance beyond the state-of-the-art to radically transform biophotonic technologies for point-of-care diagnosis and functional imaging. This will enable optical diagnostics with superior sensi-tivity, specificity, reliability and clinical utility at reduced cost, heralding an imaging renaissance in Europe.FAMOS addresses optical imaging from molecular over (sub)cellular to individual organs, with no gap in the arsenal of diagnostic tools for medical end-users. The world-class multidisciplinary FA-MOS team of 7 leading academic institutions and 10 top SMEs has unique complementary knowledge of optical coherence tomography, adaptive optics, photoacoustic tomography, coherent anti-stokes Raman scattering, multiphoton tomography as well as swept-source, diode-pumped ultrafast and tuneable nanosecond pulse lasers. Combinations of some techniques will offer multi-modal solutions to diagnostic needs that will exploit and enhance the benefits of each modality. FAMOS technologies have wide applicability, but our specific focus is on diagnosis in ophthalmol-ogy and oncology. Partnerships with leading innovative clinical users will enable preclinical evalua-tion.The objectives of FAMOS are:\tDevelop new light sources with a step-change in performance (2-3 times more compact and up to 3-4 times cheaper diode pumped Ti:sapphire, 4-10 times faster swept sources and tuneable nanosecond pulse sources)\tIntegrate these with optical imaging for a step-change in diagnosis (2-5 times better resolution cellular retinal imaging with more than 10 times larger field of view, up to 10 times enhanced penetration single source subcellular morphologic imaging, increased selectivity of intrinsic mo-lecular sensing as well as several frames per second deep tissue functional tomography\tPerform preclinical studies to demonstrate novel or improved ophthalmic and skin cancer diag-nosis establishing novel biomarkers (melanocyte shape, NADPH, melanin concentration, Hb/HbO2 as well as lipid, water and DNA/RNA concentration)\tEnable exceptional commercial opportunities for SMEs\tProvide state-of-the-art academic training
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: PEOPLE-2007-1-1-ITN | Award Amount: 5.04M | Year: 2008
The objective of this project is to set up an Initial Training Network on advanced techniques for ultrafast manipulation of atoms and molecules by strong femtosecond laser pulses. The project comprises a diverse range of applications of strong-field coherent control to ultrafast spectroscopy and microscopy; nuclear and electron wavepacket dynamics; alignment of molecules with applications to collisions, high harmonic generation and adsorption; characterization and control of dissipation; stabilization of cold atoms and molecules; quantum state and process tomography; and ultrafast information processing. The use of strong shaped femtosecond laser pulses opens a novel avenue to control of quantum dynamics via hitherto inaccessible physical mechanisms. The new control scenarios require the development of novel versatile femtosecond sources in the UV and VUV range of high shaping capabilities, to which a part of the research will be dedicated, with anticipated spin-offs of great multidisciplinary interest, e.g. in chemistry and biology. The combined expertise of the network - a joint effort of 10 universities and 3 industrial companies - represents the cutting edge of research and training in femtosecond light-matter interactions in Europe. The network will train 18 doctoral students and about 11 young postdoctoral researchers. The training activities will combine several dedicated instruments of network-wide training, capitalizing on their synergy with a backbone of specialized training inside the groups. The training program will be adapted to the ESRs, with elementary, advanced and expert phases initiated at the network schools and workshops. Prominent scientists from Europe and overseas, and industry leaders from the companies in the network and from outside, will contribute to the schools and workshops. Special attention will be focused on developing important complementary skills, such as communication, presentation, project planning and management.
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.90M | Year: 2016
FBI fosters education of ESRs on an emerging, multimodal imaging platform and its translation into clinical and biological applications. In FBI, 15 ESRs are trained at world-leading European academic institutions and companies, thus forming strong interdisciplinary relations between industry, technical sciences and clinical end-users. Optical imaging has huge potential to address unmet clinical needs by combining non-invasive and real-time capture of biomedical information; thus enabling earlier onset of treatment, reduced therapy costs, reduced recurrence rates, and improved clinical outcomes. Up to now, optical modalities were applied as standalone techniques each targeting one biomarker. Recently it has been shown that diagnosis is significantly improved by combining different contrast mechanisms simultaneously in a multimodal approach, i.e., staging and grading of lesions is feasible. FBI proposes to combine a selection of modalities depending on the targeted disease. Suspicious lesions are analysed with optical coherence tomography, optoacoustic tomography, multi-photon tomography, and Raman spectroscopy to provide morphological, label-free microangiography, and intrinsic biochemical information, respectively. An important issue is the need for endoscopy: combining said modalities into endoscopes is challenging due to the integration of different imaging concepts, scanning and detection methods, and laser sources. Accordingly, there is a huge need for effectively translating these technical solutions to industry and clinics, which traditionally is restricted by lack of understanding of applications or limited knowledge of new technology. All these barriers are addressed by FBI through research and development of novel photonic components and systems, through educating ESRs in understanding clinical, biological and commercial challenges, and through developing tailored technical solutions and efficient translation of technology within a strong network.
Koke S.,Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy |
Grebing C.,Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy |
Frei H.,Femtolasers Produktions GmbH |
Anderson A.,Femtolasers Produktions GmbH |
And 2 more authors.
Nature Photonics | Year: 2010
Carrier-envelope phase stabilization has opened an avenue towards achieving frequency metrology with unprecedented precision and optical pulse generation on the previously inaccessible attosecond timescale. Recently, sub-100-as pulse generation has been demonstrated, approaching the timescale of the fastest transients in atomic physics. However, further progress in attophysics appears to be limited by the performance of the traditional feedback approach used for carrier-envelope phase stabilization. Here, we demonstrate a conceptually different self-referenced feed-forward approach to phase stabilization. This approach requires no complicated locking electronics, does not compromise laser performance, and is demonstrated with 12-as residual timing jitter, which is below the atomic unit of time. This surpasses the precision of previous methods by more than a factor of five and has potential for resolving even the fastest transients in atomic or molecular physics. Such shot-noise-limited comb synthesis may also simplify progress in current research in frequency metrology. © 2010 Macmillan Publishers Limited. All rights reserved.
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-1.2-1;HEALTH-2007-1.2-2 | Award Amount: 7.09M | Year: 2008
The aim of FUN OCT is to expand the non-invasive optical biopsy capability of optical coherence tomography (OCT) and combination of OCT with multiphoton tomography (MT) to develop novel functional capabilities hereby enabling morphofunctional performance, i.e., the fusion of anatomic and functional imaging at the cellular resolution level. These methodologies will enable unprecedented non-invasive detection of depth resolved physiological, metabolic as well as molecular specific tissue information, i.e., forming a novel, powerful medical imaging platform. This novel platform fills an important gap left by todays medical imaging technology. The hypothesis is that the combination of cellular resolution, real time imaging of morphology and depth resolved tissue function could enable a major step forward in early cancer diagnosis and in the early detection of retinal pathologies that are world wide leading causes of blindness. This is accomplished due to a synergistic effect from joining complementary international expertise in the fields of laser sources, OCT, MT and beam delivery system technology. The consortium comprises 6 research groups and 2 SMEs. The consortium will make use of its existing relations to clinical collaborators in order to achieve proof-of-principle validation of the imaging modalities. The outcome contributes directly to improving and to maintaining the quality of life and living conditions of the European aging population through early diagnosis of cancer and of retinal pathologies as well as more efficient therapy monitoring. Moreover, the envisaged imaging modality may in the long term act as a screening device to investigate the prevalence of cancer as a function of geographic (regional) or gender related parameters. Finally, the diagnosis of other age-related diseases in a variety of medical fields, such as cardiology, neurology, gynaecology, and gastroenterology, benefit from this novel diagnostic platform provided by FUN OCT.
Femtolasers Produktions GmbH | Date: 2013-01-15
Method and device for optical inspection of a sample using spectral interferometry, wherein a beam (2) emitted by a radiation source (1) is directed onto the sample (5) and a reference beam (2) is directed onto a reference sample (4), and the spectral interference of both beams after being reflected on the samples or after passing the samples is recorded by means of a spectrograph (6); the interferogram I() thus obtained is numerically derived with respect to the angular frequency . For the function I() thus obtained the zeros _(i )are calculated numerically as solutions to the equation I()=0 and the frequency-dependent group delay () is then calculated from the zeros _(i )according to the equation (_(n))=/(_(i+1)_(i)), wherein i=1, 2 . . . and _(n)=(_(i+1)+_(i))2.
Femtolasers Produktions GmbH | Date: 2012-11-15
A multifunctional laser device configured to be applicable as such in each of: multiple photon processes, nano structuring processes, optical coherence tomography, Terahertz (THZ) spectroscopy, THz imaging; or a combination of such processes; and comprising a mode-locked linear (X or Z-folded) fs laser resonator having a repetition rate of at least 300 MHz and 600 MHz at most and, thus, a corresponding short resonator length, said fs laser resonator further being a dispersive mirrors cavity having an average negative GDD (Group Delay Dispersion) in the spectral range of the laser operation, and being arranged to generate laser pulses with a pulse width of less than 30 fs, and comprising a pump laser operating at an optical output pump power of less than 2 W.