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Mexico City, Mexico

Vilchis-Ordonez A.,Federico Gomez | Vilchis-Ordonez A.,Mexican Institute for Social Security | Vilchis-Ordonez A.,National Autonomous University of Mexico | Contreras-Quiroz A.,Mexican Institute for Social Security | And 10 more authors.
BioMed Research International

B-cell acute lymphoblastic leukemia (B-ALL) is a serious public health problem in the pediatric population worldwide, contributing to 85% of deaths from childhood cancers. Understanding the biology of the disease is crucial for its clinical management and the development of therapeutic strategies. In line with that observed in other malignancies, chronic inflammation may contribute to a tumor microenvironment resulting in the damage of normal processes, concomitant to development and maintenance of neoplastic cells. We report here that hematopoietic cells from bone marrow B-ALL have the ability to produce proinflammatory and growth factors, including TNFα, IL-1β, IL-12, and GM-CSF that stimulate proliferation and differentiation of normal stem and progenitor cells. Our findings suggest an apparently distinct CD13+CD33+ population of leukemic cells contributing to a proinflammatory microenvironment that may be detrimental to long-term normal hematopoiesis within B-ALL bone marrow. © 2015 Armando Vilchis-Ordoñez et al. Source

Cantu G.,Panamerican University of Mexico | Rodriguez G.,National Autonomous University of Mexico | Luque-Coqui M.,Federico Gomez | Romero B.,Federico Gomez | And 4 more authors.
Boletin Medico del Hospital Infantil de Mexico

Background. Chronic renal disease (CRD) is a disease with a strong impact on the childhood Mexican population with short-range limiting and serious consequences. Poverty and a social environment devoid of social justice hinder timely medical attention and long-range rehabilitation. The aim of this study was to determine the differences regarding sociodemographic features in patients under treatment at Hospital Infantil de México Federico Gómez, with a 6-year difference: patients diagnosed in 2003 as compared to those diagnosed in 2009. Methods. A retrospective comparative study was carried out with end-stage chronic renal disease (ESRD) patients with information obtained from the clinical files. Data were obtained on age, gender, renal insufficiency etiology, socioeconomic level, type of financing, place of origin, and whether patient entered a rehabilitation program (dialysis or transplant). Results. In 2003, 69 patients with ESRD were received, whereas 50 patients were received in 2009. There were no differences in age or gender between dates. Etiology of uremia was determined in 40% of the children in 2003 and 50% in 2009. Most patients in the assessed years belong to the lowest socioeconomic levels, coming from the State of Mexico and metropolitan Mexico City. There was a decreasing trend in the number of patients coming from other states of the country: 30% in 2003 and 16% in 2009. Twenty-three patients (33%) entered the rehabilitation program in 2003 and 29 patients (58%) in 2009 (p = 0.007). Conclusions. There was a 28% decrease between 2003 and 2009 in the number of cases being managed. Attention has been focused on the State of Mexico and metropolitan Mexico City area. In spite of socioeconomic level being apparently similar in the studied years, there was a significant increase in the proportion of children entering a long-range rehabilitation program (from 33% in 2003 to 58% in 2009). Source

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