Federal University of Sergipe

Aracaju, Brazil

The Federal University of Sergipe is a Brazilian public institution based in Sergipe, with campi sprawling through the cities of São Cristóvão , Aracaju, Itabaiana, Laranjeiras and Lagarto. Founded in 1967 by the junction of the State's existing colleges, it became its second university and its first, and so far only, public one. As traditionally seen in Brazilian educational system, in which state-banked universities tend to offer better quality of education, it became the State's most reputable and disputed higher education institution, ranking among the country's 40 best universities and Latin America's top 200. Wikipedia.

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Freire R.O.,Federal University of Sergipe | Simas A.M.,Federal University of Pernambuco
Journal of Chemical Theory and Computation | Year: 2010

PM6 is the first semiempirical method to be released already parametrized for the elements of the periodic table, from hydrogen to bismuth (Z ) 83), with the exception of the lanthanides from cerium (Z ) 58) to ytterbium (Z ) 70). In order to fill this gap, we present in this article a generalization of our Sparkle Model for the quantum chemical semiempirical calculation of lanthanide complexes to PM6. Accordingly, we present Sparkle/PM6 parameters for all lanthanide trications from La(III) to Lu(III). The validation procedure again considered only high-quality crystallographic structures and included 633 complexes. Sparkle/PM6 unsigned mean errors UME(Ln-L)s, corresponding to all the interatomic distances between the lanthanide ion and the atoms directly coordinated to it, range from 0.066 to 0.086 Å for Gd(III) and Ce(III), respectively. These minimum and maximum UME(Ln-L)s across the lanthanide series are comparable to the Sparkle/AM1 values of 0.054 and 0.085 Å for Ho(III) and Pr(III), respectively, as well as to the values for Sparkle/PM3 of 0.064 and 0.093 Å for Gd(III) and Pr(III), respectively. Moreover, for all 15 lanthanide ions, these interatomic distance deviations follow a γ distribution within a 95% level of confidence, indicating that these errors appear to be random around a mean, freeing the model of systematic errors, at least within the validation set. Sparkle/PM6 presented here, therefore, broadens the range of applicability of PM6 to the coordination compounds of the rare earth metals. © 2010 American Chemical Society.

Guimaraes A.G.,Federal University of Sergipe | Serafini M.R.,Federal University of Sergipe | Quintans-Junior L.J.,Federal University of Sergipe
Expert Opinion on Therapeutic Patents | Year: 2014

Introduction: Terpenes are natural compounds found in several organisms belonging to the animal and plant kingdoms. They constitute the largest class of natural products with > 55,000 known compounds structurally diversified. Several studies have attributed to this big family of compounds a range of pharmacological properties, such as anticancer, antimicrobial, antifungal, antiviral, antihyperglycemic, analgesic, anti-inflammatory and antiparasitic. Areas covered: In this review, the authors summarize therapeutic patent applications concerning the employment of terpenes for pain relief, focusing on the perspective for these compounds to become candidates for new drugs intended to control painful syndromes. Expert opinion: Over years of tremendous academic and industrial investment in the characterization of the analgesic action of terpenes, there was the development of a successful product that has been well-accepted clinically. Furthermore, there is still hope that new therapeutic options for the control of painful syndromes will be developed from terpenes, which have been shown to be great candidates for this purpose because of the range of pharmacological mechanisms in important target sites. © Informa UK, Ltd.

Guimaraes A.G.,Federal University of Sergipe | Quintans J.S.S.,Federal University of Sergipe | Quintans-Junior L.J.,Federal University of Sergipe
Phytotherapy Research | Year: 2013

There is still the need for efficacious therapies for pain. In the search for new therapeutic options, plants are a major source of novel biomolecules. Monoterpenes constitute 90% of essential oils, and there is a growing interest in understanding the mechanisms underlying their pharmacological activity. This systematic review reports what is so far known about the analgesic activity of monoterpenes and also provides an overview of their mechanisms of action. The search terms analgesia, anti-inflammatory, anaesthetic and antioxidant were used to retrieve English language articles in SCOPUS, PUBMED and EMBASE published between 1990 and 2012. Forty-five papers were found concerning the potential analgesic activity of 27 monoterpenes. The data reviewed here suggest these compounds are possible candidates for the treatment of painful conditions. Copyright © 2012 John Wiley & Sons, Ltd.

Morais A.L.,Federal University of Sergipe | Barreto-Souza W.,University of Sao Paulo
Computational Statistics and Data Analysis | Year: 2011

In this paper we introduce the Weibull power series (WPS) class of distributions which is obtained by compounding Weibull and power series distributions, where the compounding procedure follows same way that was previously carried out by Adamidis and Loukas (1998). This new class of distributions has as a particular case the two-parameter exponential power series (EPS) class of distributions (Chahkandi and Ganjali, 2009), which contains several lifetime models such as: exponential geometric (Adamidis and Loukas, 1998), exponential Poisson (Kus, 2007) and exponential logarithmic (Tahmasbi and Rezaei, 2008) distributions. The hazard function of our class can be increasing, decreasing and upside down bathtub shaped, among others, while the hazard function of an EPS distribution is only decreasing. We obtain several properties of the WPS distributions such as moments, order statistics, estimation by maximum likelihood and inference for a large sample. Furthermore, the EM algorithm is also used to determine the maximum likelihood estimates of the parameters and we discuss maximum entropy characterizations under suitable constraints. Special distributions are studied in some detail. Applications to two real data sets are given to show the flexibility and potentiality of the new class of distributions. © 2010 Elsevier B.V. All rights reserved.

DeSantana J.M.,Federal University of Sergipe | da Cruz K.M.L.,Federal University of Sergipe | Sluka K.A.,University of Iowa
Arthritis Research and Therapy | Year: 2013

Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predictive of effective treatments. Fibromyalgia is characterized by chronic widespread pain with associated co-morbid symptoms that include fatigue, depression, anxiety and sleep dysfunction. In this review, we present different animal models that mimic the signs and symptoms of fibromyalgia. These models are induced by a wide variety of methods that include repeated muscle insults, depletion of biogenic amines, and stress. All potential models produce widespread and long-lasting hyperalgesia without overt peripheral tissue damage and thus mimic the clinical presentation of fibromyalgia. We describe the methods for induction of the model, pathophysiological mechanisms for each model, and treatment profiles. © 2013 BioMed Central Ltd.

Lima A.F.,Federal University of Sergipe
Journal of Physics and Chemistry of Solids | Year: 2014

First principles calculations based on density functional theory have been employed to study the electronic, magnetic and optical properties of Co 3O4 in a cubic normal spinel structure. Exchange and correlation effects between electrons were treated by a B3PW91 hybrid functional, which produced better results than others scheme, such as GGA+U or PBE0 hybrid functionals or mBJ semilocal potential. The work focuses on clarifying the nature of the optical absorption bands, which have motivated various theoretical and experimental works in the literature. The calculated optical absorption spectrum was compared with available experimental data. On the basis of this calculated electronic and magnetic structure, the optical absorption peaks (theoretical and experimental) could be satisfactorily explained in terms of d3d charge transfer transitions between both CO2 +→CO2+ and CO3+→CO3+ions. The calculations also predicted that the crystal field splittings at both octahedral and tetrahedral sites in the Co3O4 compound are of the same magnitude. © 2013 Elsevier Ltd. All rights reserved.

De Sousa D.P.,Federal University of Sergipe
Molecules | Year: 2011

Research on neuroactive drugs is a pharmaceutical sector of high interest and growth. The discovery of efficient drugs that can relieve pain is a subject of research in the pharmaceutical industry and academic field because pain is a symptom of many diseases. This review will summarize results on the discovery of essential oil constituents with analgesic-like activity from the chemical and pharmacological perspectives. Overall, 43 bioactive compounds were selected in nociception models. Among them, 62.8% were monoterpenes, 18.6% sesquiterpenes and other constituents represented 18.6%. The data show the potential of this group of natural product chemicals as analgesic drugs that may be useful for therapeutic purposes. © 2011.

AIMS: To evaluate the antinociceptive effects of citronellal (CTL) on formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice and to investigate whether such effects might involve a change in neural excitability. METHODS: Male mice were pretreated with CTL (50, 100, and 200 mg/kg, ip), morphine (5 mg/kg, ip), or vehicle (distilled water plus one drop of Tween 80 0.2%) before formalin (20 microL, 2%), capsaicin (20 microL, 2.5 microg) or glutamate (40 microL, 25 microM) injection into the right vibrissa. Sciatic nerve recordings were made using the single sucrose gap technique in rats. The data obtained were analyzed by ANOVA followed by Dunnett's test for the behavioral analyses and by the Student t test for CAP evaluation. RESULTS: Pretreatment with CTL was effective in reducing nociceptive face-rubbing behavior in both phases of the formalin test, which was also naloxone-sensitive. CTL produced significantly antinociceptive effect at all doses in the capsaicin- and glutamate- tests. Rota-rod testing indicated that such results were unlikely to be provoked by motor abnormality. Recordings using the single sucrose gap technique revealed that CTL (10 mM) could reduce the excitability of the isolated sciatic nerve through a diminution of the compound action potential amplitude by about 42.4% from control recordings. CONCLUSION: These results suggest that CTL might represent an important tool for management and/or treatment of orofacial pain.

Lobo J.V.,Federal University of Sergipe
Jornal brasileiro de nefrologia : orgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia | Year: 2010

Peritonitis remains a major complication of peritoneal dialysis (PD). Evaluate peritonitis incidence, etiology and outcome in cronic PD patients. A retrospective cohort study was carried out on 330 patients (mean age of 53 ± 19 years) who had been treated by PD in a dialysis center in Aracaju/SE, Brazil between January 1st, 2003 and December 31th, 2007. Data of patients with and without peritonitis were compared using Student's t-test, chi-squared statistic and multiple logistic regression. There were 213 peritonitis among 141 patients (1.51 episode/patient) resulting in a rate of 28.44 patient/episode/ month (0.42 patient/episode/year). Staphylococcus aureus was the most frequent micro-organism isolated (27.8%), followed by Escherichia coli (13.4%) and 32.5% were culture-negative peritonitis. A greater risk of peritonitis was identified at the patients with hypoalbuminemia [relative risk (RR) = 2.0; 95% confidence interval (CI) = 1.21 - 3.43; p < 0,01], < 4 school years (RR = 2.15; CI = 1.09 - 4.24; p = 0.03) and catheter's exit site infection (RR = 2.63; IC = 1.57 - 4.41; p < 0.01). There were no significant difference among gender, age, family income, diabetes mellitus, type of dialysis treatment, type of catheter and its surgical implant. Hypoalbuminemia, low schooling and catheter's exit site infection were associated with greater risk to peritonitis. Although peritonitis rate follow international pattern, prophylactic strategies are recommended.

Viana A.,Federal University of Sergipe
Computers and Mathematics with Applications | Year: 2015

This paper is devoted to study local existence, uniqueness, and continuous dependence upon the initial data of mild solutions for a diffusive non-autonomous Lotka-Volterra system. Initial data are taken in the Besov space Bp,q,Nσ. © 2015 Elsevier Ltd. All rights reserved.

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