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Rio de Janeiro, Brazil

The Federal University of Rio de Janeiro or University of Brazil is a public university in the state of Rio de Janeiro, Brazil. UFRJ is the largest federal university in the country and is one of the Brazilian centers of excellence in teaching and research. In terms of scientific, artistic and cultural productions it is recognized nationally and internationally due to the great teachers, researchers, reviews and assessments made by international agencies. In 2014 QS World University Rankings ranked UFRJ as the best Brazilian federal university, as well as the third best university in the country occupying the fourth position among institutions of Latin America. In 2013 the Ranking Universitário Folha ranked UFRJ as the 2nd best university in Brazil and the best Federal University of the country.Brazil's first official higher education institution, it has worked uninterruptedly since 1792, when the "Real Academia de Artilharia, Fortificação e Desenho" was founded, and served as basis for the country's college system since its officialization in 1920. Besides its 157 undergraduate and 580 postgraduate courses, the UFRJ is responsible for seven museums, most notably the National Museum, nine hospitals, hundreds of laboratories and research facilities and forty-three libraries. Its history and identity are closely tied to the Brazilian ambitions of forging a modern, competitive and just society.The university is located mainly in Rio de Janeiro, with ramifications spreading to other ten cities. Its main campuses are the historical campus of "Praia Vermelha" and the newer "Cidade Universitária" , which houses the "Parque Tecnológico do Rio" - a science, technology and innovation development cluster. There are also several off-campus units scattered in Rio de Janeiro: the School of Music, the College of Law Studies, the Institute of Philosophy and Social science and the Institute of History, in downtown Rio; the National Museum and the Valongo Observatory in São Cristóvão; and the high-school unit "Colégio de Aplicação" in Lagoa. To the city of Macaé, located in the State's northern region, was dedicated a research and learning center focused on environmental issues and oil-related matters, and the city of Duque de Caxias, in partnership with the National Institute of Metrics, Normalization and Industrial Quality , saw the implementation of "Pólo Avançado de Xerém" , aimed at boosting research in the fields of biotechnology and nanotechnology.UFRJ is one of the main culprits in the formation of the Brazilian intellectual elite, contributing significantly to build not only the history of Rio de Janeiro but also of Brazil. Some of its former students include renowned economists Carlos Lessa and Mario Henrique Simonsen; Minister Marco Aurélio Mello; the architect Oscar Niemeyer; the educator Anísio Teixeira; the engineer Benjamin Constant Botelho; writers Clarice Lispector, Jorge Amado and Vinicius de Moraes; politicians Francisco Pereira Passos, Osvaldo Aranha and Pedro Calmon, besides the great physicians Carlos Chagas, Oswaldo Cruz and Vital Brazil. Wikipedia.


The present invention provides N-phenylpiperazine derivatives for use as multiple binders and/or antagonists of 1A adrenoceptors, 1D adrenoceptors and 5-HT1A serotonin receptors. These substances are candidates to prototypes for the treatment of benign prostate hyperplasia and lower urinary tract symptoms, and are useful in pharmaceutical compositions.


Andrade-Moraes C.H.,Federal University of Rio de Janeiro
Brain : a journal of neurology | Year: 2013

Alzheimer's disease is the commonest cause of dementia in the elderly, but its pathological determinants are still debated. Amyloid-β plaques and neurofibrillary tangles have been implicated either directly as disruptors of neural function, or indirectly by precipitating neuronal death and thus causing a reduction in neuronal number. Alternatively, the initial cognitive decline has been attributed to subtle intracellular events caused by amyloid-β oligomers, resulting in dementia after massive synaptic dysfunction followed by neuronal degeneration and death. To investigate whether Alzheimer's disease is associated with changes in the absolute cell numbers of ageing brains, we used the isotropic fractionator, a novel technique designed to determine the absolute cellular composition of brain regions. We investigated whether plaques and tangles are associated with neuronal loss, or whether it is dementia that relates to changes of absolute cell composition, by comparing cell numbers in brains of patients severely demented with those of asymptomatic individuals-both groups histopathologically diagnosed as Alzheimer's-and normal subjects with no pathological signs of the disease. We found a great reduction of neuronal numbers in the hippocampus and cerebral cortex of demented patients with Alzheimer's disease, but not in asymptomatic subjects with Alzheimer's disease. We concluded that neuronal loss is associated with dementia and not the presence of plaques and tangles, which may explain why subjects with histopathological features of Alzheimer's disease can be asymptomatic; and exclude amyloid-β deposits as causes for the reduction of neuronal numbers in the brain. We found an increase of non-neuronal cell numbers in the cerebral cortex and subcortical white matter of demented patients with Alzheimer's disease when compared with asymptomatic subjects with Alzheimer's disease and control subjects, suggesting a reactive glial cell response in the former that may be related to the symptoms they present. Source


Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF- levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.


Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF- levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.


Patent
Federal University of Rio de Janeiro | Date: 2012-11-21

The present invention refers to the construction of cloning vectors containing the max gene. Especially, the present invention refers to the introduction of cloning vectors containing the max gene in cells using transport vectors. In addition, the presence of cloning vectors containing the max gene in cells allows the differential expression of the max gene in the same cells. In addition, the present invention refers to a method of gene therapy in which the differential expression of the max gene has cytoprotective activity, especially neuroprotective activity, and is capable of application to medical and veterinary therapeutics of neurodegenerative conditions.

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