The Federal University of Paraná is a public university headquartered in Curitiba, Paraná, Brazil.Nowadays, its facilities are scattered over the capital Curitiba and other cities of the State of Paraná. It offers 124 undergraduate degree courses, 44 doctorate, 66 masters and 5 professional masters programs, apart from a number of lato sensu programs - see Higher-ed degrees in Brazil. Since 2004, the University has been adopting in its vestibular a program in which twenty percent of the spots offered are destined to students coming from public schools and another twenty percent are reserved for Afro-Brazilians.UFPR ranks among the 651-700 best universities in the world and 37th best in Latin-America, according to QS World University Rankings. It is placed as the 9th best in the country in the latest "Ranking Universitário Folha ", published by the nation's largest newspaper.Since 2009 internal elections the University is run by Rector Zaki Akel Sobrinho, D.Sc. in Administration from Universidade de São Paulo, and Vice-Rector Rogerio Andrade Mulinari, D.Sc. in Medicine from Universidade Federal de São Paulo, and with a Post-Doc from Boston University. Wikipedia.
Castro M.A.A.,Federal University of Parana
Nature Genetics | Year: 2015
Genetic risk for breast cancer is conferred by a combination of multiple variants of small effect. To better understand how risk loci might combine, we examined whether risk-associated genes share regulatory mechanisms. We created a breast cancer gene regulatory network comprising transcription factors and groups of putative target genes (regulons) and asked whether specific regulons are enriched for genes associated with risk loci via expression quantitative trait loci (eQTLs). We identified 36 overlapping regulons that were enriched for risk loci and formed a distinct cluster within the network, suggesting shared biology. The risk transcription factors driving these regulons are frequently mutated in cancer and lie in two opposing subgroups, which relate to estrogen receptor (ER)+ luminal A or luminal B and ER- basal-like cancers and to different luminal epithelial cell populations in the adult mammary gland. Our network approach provides a foundation for determining the regulatory circuits governing breast cancer, to identify targets for intervention, and is transferable to other disease settings. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Hermes C.J.L.,Federal University of Parana
International Journal of Heat and Mass Transfer | Year: 2012
This paper advances an algebraic first-principles simulation model to predict the frost growth and densification on flat surfaces. The model was put forward based on macroscopic heat and mass balances in the frost layer, which were written according to a dimensionless formulation and solved analytically to obtain an algebraic expression for the time evolution of the frost thickness as a function of the Nusselt number, the supersaturation degree and the air-to-surface temperature difference. The model predictions for the frost thickness were compared with experimental data obtained elsewhere, when a very good agreement between calculated and measured counterparts was observed. The sensitivity of the frost growth rate to key heat and mass transfer parameters is also assessed and reported. © 2012 Elsevier Ltd. All rights reserved.
Teive H.A.G.,Federal University of Parana
Parkinsonism and Related Disorders | Year: 2012
Classically, essential tremor (ET) was defined by the Movement Disorder Society Consensus Statement on Tremor (1998) as "a bilateral, largely symmetric postural or kinetic tremor involving hands and forearms that is visible and persistent". Additional or isolated tremor of the head may occur but in the absence of abnormal posture. Duration is more than 5 years and the neurological examination is normal, with exception of the cogwheel phenomenon. In the last years ET has evolved into two different meanings. First of all, the classical ET, as a monosymptomatic disorder, and second, a heterogenous disorder, the Essential Tremors, or a family of diseases. Nowadays, ET can be classified with both motor and non-motor elements. Tremor may occur also in the legs, feet, trunk, jaw, chin, tongue, and voice. Although postural and kinetic tremors are the main features of ET, intentional tremor and tremor at rest may also occur in some patients. Other motor features described in patients with ET are gait ataxia, postural instability and eyemotion abnormalities. Non-motor features include cognitive (memory and executive problems and dementia), psychiatric (anxiety, depression and social phobia), and sensory abnormalities (olfactory deficits, hearing loss). © 2011 Elsevier Ltd.
Huergo L.F.,Federal University of Parana |
Chandra G.,John Innes Center |
Merrick M.,John Innes Center
FEMS Microbiology Reviews | Year: 2013
The PII proteins are one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite remarkably, PII proteins control the activities of a diverse range of enzymes, transcription factors and membrane transport proteins, and in recent years the extent of these interactions has been recognized to be much greater than heretofore described. Major advances have been made in structural studies of PII proteins, including the solution of the first structures of PII proteins complexed with their targets. We have also begun to gain insights into how the key effector molecules, 2-oxoglutarate and ATP/ADP, influence the activities of PII proteins. In this review, we have set out to summarize our current understanding of PII biology and to consider where future studies of these extraordinarily adaptable proteins might lead us. Copyright © 2013 © 2012 Federation of European Microbiological Societies Published by Blackwell Publishing Ltd. All rights reserved.
Grimm A.M.,Federal University of Parana
Stochastic Environmental Research and Risk Assessment | Year: 2011
Interannual variability is an important modulator of synoptic and intraseasonal variability in South America. This paper seeks to characterize the main modes of interannual variability of seasonal precipitation and some associated mechanisms. The impact of this variability on the frequency of extreme rainfall events and the possible effect of anthropogenic climate change on this variability are reviewed. The interannual oscillations of the annual total precipitation are mainly due to the variability in austral autumn and summer. While autumn is the dominant rainy season in the northern part of the continent, where the variability is highest (especially in the northeastern part), summer is the rainy season over most of the continent, thanks to a summer monsoon regime. In the monsoon season, the strongest variability occurs near the South Atlantic Convergence Zone (SACZ), which is one of the most important features of the South American monsoon system. In all seasons but summer, the most important source of variability is ENSO (El Niño Southern Oscillation), although ENSO shows a great contribution also in summer. The ENSO impact on the frequency of extreme precipitation events is also important in all seasons, being generally even more significant than the influence on seasonal rainfall totals. Climate change associated with increasing emission of greenhouse gases shows potential to impact seasonal amounts of precipitation in South America, but there is still great uncertainty associated with the projected changes, since there is not much agreement among the models' outputs for most regions in the continent, with the exception of southeastern South America and southern Andes. Climate change can also impact the natural variability modes of seasonal precipitation associated with ENSO. © 2010 Springer-Verlag.