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Curitiba, Brazil

The Federal University of Paraná is a public university headquartered in Curitiba, Paraná, Brazil.Nowadays, its facilities are scattered over the capital Curitiba and other cities of the State of Paraná. It offers 124 undergraduate degree courses, 44 doctorate, 66 masters and 5 professional masters programs, apart from a number of lato sensu programs - see Higher-ed degrees in Brazil. Since 2004, the University has been adopting in its vestibular a program in which twenty percent of the spots offered are destined to students coming from public schools and another twenty percent are reserved for Afro-Brazilians.UFPR ranks among the 651-700 best universities in the world and 37th best in Latin-America, according to QS World University Rankings. It is placed as the 9th best in the country in the latest "Ranking Universitário Folha ", published by the nation's largest newspaper.Since 2009 internal elections the University is run by Rector Zaki Akel Sobrinho, D.Sc. in Administration from Universidade de São Paulo, and Vice-Rector Rogerio Andrade Mulinari, D.Sc. in Medicine from Universidade Federal de São Paulo, and with a Post-Doc from Boston University. Wikipedia.


Da Rocha R.,Federal University of ABC | Piloyan A.,Institute For Theoretische Physik | Piloyan A.,Yerevan State University | Kuerten A.M.,Federal University of ABC | Coimbra-Araujo C.H.,Federal University of Parana
Classical and Quantum Gravity | Year: 2013

This paper aims to evince the corrections on the black string warped horizon in the braneworld paradigm, and their drastic physical consequences, as well as to provide subsequent applications in astrophysics. Our analysis concerning black holes on the brane departs from the Schwarzschild case, where the black string is unstable to large-scale perturbation. The cognizable measurability of the black string horizon corrections due to braneworld effects is investigated, as well as their applications in the variation of quasars luminosity. We delve into the case wherein two solutions of Einstein's equations proposed by Casadio, Fabbri and Mazzacurati, regarding black hole metrics presented a post-Newtonian parameter measured on the brane. In this scenario, it is possible to analyze purely the braneworld corrected variation in quasars luminosity, by an appropriate choice of the post-Newtonian parameter that precludes Hawking radiation on the brane: the variation in quasars luminosity is uniquely provided by pure braneworld effects, as the Hawking radiation on the brane is suppressed. © 2013 IOP Publishing Ltd.


Abib F.C.,Federal University of Parana | Holzchuh R.,University of Sao Paulo | Schaefer A.,University of Sao Paulo | Schaefer T.,University of Sao Paulo
Cornea | Year: 2012

Purpose:: To evaluate endothelial cell sample size and statistical error in corneal specular microscopy (CSM) examinations. Methods:: One hundred twenty examinations were conducted with 4 types of corneal specular microscopes: 30 with each BioOptics, CSO, Konan, and Topcon corneal specular microscopes. All endothelial image data were analyzed by respective instrument software and also by the Cells Analyzer software with a method developed in our labUS Patent. A reliability degree (RD) of 95% and a relative error (RE) of 0.05 were used as cut-off values to analyze images of the counted endothelial cells called samples. The sample size mean was the number of cells evaluated on the images obtained with each device. Only examinations with RE < 0.05 were considered statistically correct and suitable for comparisons with future examinations. The Cells Analyzer software was used to calculate the RE and customized sample size for all examinations. Results:: Bio-Optics: sample size, 97 ± 22 cells; RE, 6.52 ± 0.86; only 10% of the examinations had sufficient endothelial cell quantity (RE < 0.05); customized sample size, 162 ± 34 cells. CSO: sample size, 110 ± 20 cells; RE, 5.98 ± 0.98; only 16.6% of the examinations had sufficient endothelial cell quantity (RE < 0.05); customized sample size, 157 ± 45 cells. Konan: sample size, 80 ± 27 cells; RE, 10.6 ± 3.67; none of the examinations had sufficient endothelial cell quantity (RE > 0.05); customized sample size, 336 ± 131 cells. Topcon: sample size, 87 ± 17 cells; RE, 10.1 ± 2.52; none of the examinations had sufficient endothelial cell quantity (RE > 0.05); customized sample size, 382 ± 159 cells. Conclusions:: A very high number of CSM examinations had sample errors based on Cells Analyzer software. The endothelial sample size (examinations) needs to include more cells to be reliable and reproducible. The Cells Analyzer tutorial routine will be useful for CSM examination reliability and reproducibility. © 2012 by Lippincott Williams & Wilkins.


Armani F.,Federal University of Sao Paulo | Andersen M.L.,Federal University of Sao Paulo | Andreatini R.,Federal University of Parana | Frussa-Filho R.,Federal University of Sao Paulo | And 2 more authors.
CNS Neuroscience and Therapeutics | Year: 2012

Background: Previous studies have suggested that manic states and sleep deprivation could contribute to the pathophysiology of bipolar disorder (BD) through protein kinase C (PKC) signaling abnormalities. Moreover, adjunctive therapy has become a standard strategy in the management of BD patients who respond poorly to current pharmacological treatments. Aim: Thus, the aim of this study was to investigate the possible involvement of PKC inhibition by tamoxifen both separately or in combination with lithium, in paradoxical sleep deprivation (PSD)-induced hyperactivity, one facet of mania-like behavior. Materials & Methods: Adult male C57BL/6J mice were randomly distributed (n = 7/group) in 24-h PSD or control groups and injected intraperitoneally (i.p.) with vehicle, lithium (50, 100, or 150 mg/kg) or tamoxifen (0.5, 1.0, or 2.0 mg/kg - experiment 1). In a second experiment, mice were injected i.p. with vehicle or a combination of subeffective doses of lithium and tamoxifen. Animals were subjected to a protocol based on repetitive PSD conditions, followed by assessment of locomotion activity in the open-field task. Results: PSD significantly increased locomotor activity in both experiments. These behavioral changes were prevented by a treatment with lithium or tamoxifen, or a combined treatment with both lithium and tamoxifen. Discussion: Therefore, our findings suggest that lithium and tamoxifen exert reversal effects against PSD-induced hyperactivity in mice. Conclusion: Furthermore, tamoxifen as an adjunct to lithium therapy provides support for an alternative treatment of individuals who either do not respond adequately or cannot tolerate the adverse effects associated with therapeutic doses of lithium. © 2011 Blackwell Publishing Ltd.


Labiak P.H.,Federal University of Parana | Rouhan G.,French Natural History Museum | Sundue M.,New York Botanical Garden
Taxon | Year: 2010

A new genus of grammitid ferns, Leucotrichum, is described. Segregated from Lellingeria on the basis of molecular analyses and morphological characters, it comprises five species distributed in the Antilles, Central America, and Southeastern Brazil. We present a phylogeny based on two cpDNA genes, atpB and rbcL, showing the relationships between Leucotrichum and other genera of grammitid ferns. Both Bayesian and Maximum Parsimony analyses support the monophyly of Leucotrichum, with bootstrap value of 100% and posterior probability value of 1.0, and its sister-group relationship to the Terpsichore lanigera group. Leucotrichum is characterized by seven morphological characters: arching fronds, clathrate rhizome scales, blackish rhizome scale cell walls, laterally marginate petioles, laminar apices subconform to the lateral pinnae, pinna costae without blackish sclerenchyma, and hairs bearing acicular branch cells. We also provide a key, descriptions, complete synonymy, discussions, specimens examined, and illustrations for all the species.


A descriptive mode, named Five Bar Model, is presented in this work to explicate thermal stress generation in welding. Taking as base the widely known Three Bar Model, it is claimed that the proposed model is also capable of explaining stress generation at the HAZ. This stress would be progressively smaller than in the FZ, turning null at the material point in which the thermal stress do not reach the material yielding stress. In addition, the model also showed to be able to explain that the highest stress will be generated in the FZ and that the resultant stress will be defined by the yielding stress of the bead material and by the capability of the material in consuming these stresses through plastic deformation. However, the stresses in the HAZ might be as high as in the BM, once the coarse grain region of the HAZ sustains a higher yielding stress than in the FZ, defining the final intensity of the generated stress. The One bar Model, in turn, based on the same approach, allows to demonstrate that the generated thermal stresses happen when the piece is free of angular bending or at limited plastic deformation and they are always tensile stresses. Analogy, the resultant stresses on the component are defined by the yielding stress of the weld bead material and by the capacity of the whole material in accommodate the stress through plastic deformation. © 2014, Universidade Federal de Uberlandia. All rights reserved.


Piucco R.O.,Whirlpool Corp. | Hermes C.J.L.,Federal University of Parana | Melo C.,Federal University of Santa Catarina
Applied Thermal Engineering | Year: 2011

This paper evaluates a theoretical criterion to predict whether frost will form on the inner liners of refrigerated compartments. In-situ experiments were carried out using a 'Combi' top-mount refrigerator tested within a climatized chamber with rigid control of the temperature and humidity. Two experimental tests were performed, one keeping the doors closed and another using an automatic door-opening device. During the tests, both the liner surface temperature and supercooling degree were monitored at different locations within the refrigerated cabinet. After the test period, the cabinet was opened and photographed to identify the sites of frost nucleation. In addition, samples of different liner materials were extracted from the refrigerated cabinet in order to measure the contact angle. For each surface, the maximum supercooling degree observed experimentally was plotted as a function of the contact angle and thus compared to the nucleation limits provided by a theoretical model introduced in a previous study [1]. © 2011 Elsevier Ltd. All rights reserved.


Da Silva D.L.,Federal University of Santa Catarina | Hermes C.J.L.,Federal University of Parana | Melo C.,Federal University of Santa Catarina
Applied Thermal Engineering | Year: 2011

Compact tube-fin evaporators have been extensively used in refrigeration cassettes for light commercial applications. Such refrigeration systems are space constrained and, therefore, the heat exchangers (condenser and evaporator) must have a large area-to-volume ratio. In addition, such applications require a subfreezing evaporating temperature that induces the growth of a frost layer on the finned surface, which may block the evaporator if a proper defrost strategy is not used. Before completely blocking the evaporator, the frost layer depletes the heat exchanger performance by adding an extra thermal resistance and also by reducing the fan-supplied air flow rate. Understanding the way the frost forms on these compact heat exchangers and also the way the fan is affected by frost clogging is mandatory for the design of robust refrigeration systems and also to devise more efficient defrost strategies. In this study an experimental investigation on the frost accretion of tube-fin evaporators considering the fan characteristics is carried out. To this end, a specially designed, constructed and calibrated closed-loop wind-tunnel facility was used. Experimental tests were carried out with four different (three wavy-fin and one louvered-fin) evaporator coils under different conditions. It was found that the frost formation rate increases with the air flow rate, supercooling degree and the density of fins. A strict relation between accumulated mass of frost, air-side pressure drop and cooling capacity was also observed. It was also noted that the fan characteristics play an important role on the evaporator thermal performance, indicating that under frosting conditions the fan-evaporator pair must be designed as a coupled system. Furthermore, for the same operating conditions, the louvered-fin evaporator showed to be more sensitive to the frost formation effects than the wavy-fin coils. © 2010 Elsevier Ltd. All rights reserved.


Martins L.E.A.M.,Federal University of Parana | dos Reis V.M.S.,University of Sao Paulo
Anais Brasileiros de Dermatologia | Year: 2011

Allergic contact dermatitis is the consequence of an immune reaction mediated by T cells against low molecular weight chemicals known as haptens. It is a common condition that occurs in all races and age groups and affects the quality of life of those who present it. The immunological mechanism of this disease has been reviewed in recent decades with significant advance in its understanding. The metabolism and pathway of the haptens as well as the activation and mechanism of action of the cells responsible for both the immune reaction and its completion are discussed in this article. © 2011 by Anais Brasileiros de Dermatologia.


Van Ofwegen L.P.,Netherlands Center for Biodiversity Naturalis | Haddad M.A.,Federal University of Parana
Zootaxa | Year: 2011

Stragulum bicolor n. gen. & n. sp. (Octocorallia: Clavulariidae) is described from Brazil. It was found in shallow waters of the States of Ceará, Rio de Janeiro, São Paulo, Paraná and Santa Catarina, and is probably invasive. The genus forms encrusting sheets on solid objects, such as seaweed basal stems, barnacle shells and artificial substrates. The new taxon has spindles, crosses and radiates in the outer layer of the coenenchyme, fused sclerites in the interior and the polyps are unarmed. The new genus is compared with other taxa that have fused sclerites. Copyright © 2011 Magnolia Press.


Queiroz-Telles F.,Federal University of Parana | de C L Santos D.W.,Federal University of Sao Paulo | de C L Santos D.W.,University of Sao Paulo
Mycopathologia | Year: 2013

Chromoblastomycosis (CBM) is an implantation mycosis mainly occurring in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long-term therapy with systemic antifungals flanked by various physical treatment regimens. As in other neglected endemic mycoses, comparative clinical trials have not been performed for this disease; nowadays, therapy is mainly based on a few open trials and on expert opinions. Itraconazole, either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been employed successfully in combination with antifungals in patients presenting with CBM. In the present paper, the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome. © 2013 Springer Science+Business Media Dordrecht.


The neotropical otter Lontra longicaudis (Olfers, 1818) is a semi-aquatic mammal that inhabits rivers, lakes and coastline. Although it has been recorded in artificial lentic environments, little is known about the impacts of reservoir creation on their populations. This paper aims to compare the habitat use and population estimates of the neotropical otter in the area of the reservoir Salto Caxias Hydroelectric Power Plant, before and after damming. The study area includes the portion of the Iguaçu River and its tributaries from Salto Caxias dam until Chopim River, upstream, totaling about 80 km. We performed four field surveys before the impoundment (pre-damming) and four field surveys 17 months after it (post-damming). During the surveys the Iguaçu River and its tributaries were covered in a motor-boat, near to the bank, to record and characterize defecation sites and dens. Data collected in the field were tabulated according to the occurrence in 112 squares (2 km x 2 km). The number of resident females (y) was estimated from the number of dens (x), pre and post-damming, through the regression equation: y = 0.331x + 0.238. Most of the quantitative parameters for evaluating the presence and activity of otters declined in the post-damming. The distribution of defecation sites was aggregated and the main aggregation factors are dens and mouths of major tributaries. Dens were found in cavities under the roots of riparian vegetation during pre-damming, turning to cavities between rocks in the post-damming. Four resident females were estimated in the pre-damming (y = 4.21) and two in the post-damming (y = 2.22). © 2012 by Unisinos.


To characterize the registered nurse's management activities in an emergency department. Qualitative research, implemented from February to April 2009 by a semi-structured interview with eight nurses from an emergency department at a university hospital in Curitiba, PR. Brazil. The data was submitted to content analyses. Two categories emerged: Management focused on meeting the institutional demands that emphasizes the Registered Nurses' bureaucratic activities required by the hospital; and Management focused on meeting the nursing care demands that prioritizes the care as the main management activity. The study reached its objective and joined the literature findings that the division between care and management does not match with the registered nurse's performance at an emergency department.


Bonato F.T.,Federal University of Parana
Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery | Year: 2012

Insulinoma is a pancreatic neuroendocrine tumor originated from pancreatic islet beta cells. Although rare, is the most common pancreatic endocrine tumor, with about four cases per million people. The preferential treatment of insulinoma is surgical. To analyze the epidemiological, pathological, clinical and surgical patients treated in the last decade in two surgical services. Were retrospectively reviewed the medical records of patients undergoing surgical treatment of insulinoma in the period of 1999 to 2011. Demographic data, type and duration of symptoms, associated or not with endocrine syndrome and diagnostic tests were obtained from medical records. Were analyzed the method of surgery, intraoperative findings and immediate and late complications. Sixteen patients with insulinoma underwent surgical treatment, 68,7% were women. The age ranged from 20 to 60 years, with a mean age of 39 years. Only one case was associated with multiple endocrine neoplasia type 1. Neuropsychiatric manifestations, mainly syncope, were the most prevalent. The average duration of clinical manifestations until the diagnosis was one year and a half. Imaging tests were used in all patients with 68.7% of preoperative tumor localization. All operations were performed in a conventional (open) manner, without use of laparoscopy. The lesions were identified in all portions of the pancreas with the majority in the pancreatic head. Relief of symptoms was not obtained only in one patient. There were no deaths among the patients. The diagnosis of insulinoma is often established after several months of the onset of clinical manifestations and surgical treatment is curative in almost all patients.


Martins C.C.,Federal University of Parana | Seyffert B.H.,Grande Rio University | Braun J.A.F.,Grande Rio University | Fillmann G.,Grande Rio University
Journal of the Brazilian Chemical Society | Year: 2011

The Paranaguá Estuarine System is one of the most important environments of the South American coast. Fishing, urban and tourist activities, industries, sewage and the main shipping port for the export of grains in Brazil are sources of environmental impacts. The sources of sedimentary organic matter were evaluated by sterol concentrations which were obtained by gas chromatography with a mass spectrometer (GC-MS). The coprostanol levels were comparatively low, except at sites close to Paranaguá City, where high concentrations have shown sewage contamination. The principal component analysis showed the distinction between sterols form marine (cholesterol, cholestanol, stigmasterol and campesterol), fecal (coprostanol and epicoprostanol) and terrigenous inputs (β-sitosterol). The sterol composition of the sediments indicated that the estuary system is an embayment dominated by inputs of marine organic matter associated with phytoplankton. Terrestrial inputs were detected only at sites close to mangroves, uncontaminated rivers and semi-closed inlets. Fecal input is restricted around Paranaguá City. © 2011 Sociedade Brasileira de Química.


This paper describes a glacially grooved surface developed on Late Carboniferous sandstones that crop out in the Vila Velha State Park, southeastern border of the Paraná Basin, southern Brazil. The sandstones that host the glacial surface comprise two main lithofacies: 1. Crossbedded coarse grained sandstones and 2. normally graded conglomerates with oversized clasts and cut and fill features. The grooved surface exhibit linear and parallel striations, grooves and ridges up to 20 cm wide and with a maximum relief of about 10 cm. Pebbles take place embedded on the surface, which allow determining its emplacement and consequently ice flow from southwest to northeast. By comparisons with recent case studies from the Pleistocene glacial record the facies association can be interpreted as a subaqueous proglacial fan system developed in front of a retreating temperate marine glacier. The erosive features were generated by ice motion on a non-lithified sandy substratum. The absence of glaciotectonic deformation and the subaqueous nature of the facies association strongly suggest scouring by icebergs as the main process. Similar origin is considered for other occurrences of intraformational glacial surfaces present in Paraná State, since diagnostic features and orientation patterns are in conformity with Quaternary iceberg scours reported in the literature.


Vidotti M.,Federal University of Parana | Carvalhal R.F.,University of Campinas | Mendes R.K.,University of Campinas | Ferreira D.C.M.,University of Campinas | Kubota L.T.,University of Campinas
Journal of the Brazilian Chemical Society | Year: 2011

The present review discusses the latest advances in biosensor technology achieved by the assembly of biomolecules associated with gold nanoparticles in analytical devices. This review is divided in sections according to the biomolecule employed in the biosensor development: (i) immunocompounds; (ii) DNA/RNA and functional DNA/RNA; and (iii) enzymes and Heme proteins. In order to facilitate the comprehension each section was subdivided according to the transduction mode. Gold nanoparticles based immunosensors have a wide range of applications in food, environmental, pharmaceutical, chemistry and clinical diagnostics. The nanoparticles were employed to improve whether the analytical signal or the immunocompounds immobilization. In another section, biosensors based on DNA/RNA biomolecules employing gold nanostructures as labels and label-free funtional DNA/RNA biosensors associated to gold nanostructures as tranducers were systematically reported for rapid identification of pathogens, species of environmental interest and clinical diagnostics, respectively. The inclusion of gold nanoparticles in modified electrodes itself enhances the electron transfer between the transducer and biomolecules leading to improved bioanalytical devices when redox enzymes and heme proteins are used. Biosensors for the detection and quantification of glucose and hydrogen peroxide are discussed as well. © 2011 Sociedade Brasileira de Química.


Kalempa D.,Federal University of Santa Maria | Sharipov F.,Federal University of Parana
International Journal of Heat and Fluid Flow | Year: 2012

Acoustic waves propagating through a rarefied gas between two plates induced by both oscillation and unsteady heating of one of them are considered on the basis of a model of the linearized Boltzmann equation. The gas flow is considered as fully established so that the dependence of all quantities on time is harmonical. The problem is solved for several values of two main parameters determining its solution, namely, the gas rarefaction defined as the ratio of the distance between the plates to the equivalent free path of gaseous molecules, and the oscillation parameter given as the ratio of the intermolecular collision frequency to the wave frequency. The reciprocal relation for such flows is obtained and verified numerically. An influence of the gas-surface accommodation coefficients on the wave characteristics is analyzed by employing the Cercignani-Lampis scattering kernel to the boundary conditions. © 2012 Elsevier Inc.


Lima H.C.,Federal University of Parana | Kimball A.B.,Harvard University
Indian Journal of Dermatology | Year: 2010

Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis. Studies with anti-IL-12/23 therapeutic agents, which act in different steps of the psoriatic inflammatory cascade, have also shown demonstrable efficacy. Here, we discuss this approach and its potential within the armamentarium for the treatment of psoriasis. Evidences that the selective blocking of IL-23 may be effective and safe therapy are also addressed.


De Araujo Duarte C.,Federal University of Parana
Vacuum | Year: 2011

The construction of a thermocouple vacuum gauge for the range of pressures from 200 to 800 mbar is reported. The gauge differs from similar ones that cover the medium vacuum region. The main difference is that the thermocouple is not fixed to the filament, as usual, but is placed at some distance from the filament. © 2010 Published by Elsevier Ltd.


Kallupi M.,Scripps Research Institute | Kallupi M.,University of Camerino | Varodayan F.P.,Scripps Research Institute | Oleata C.S.,Scripps Research Institute | And 4 more authors.
Neuropsychopharmacology | Year: 2014

The central nucleus of the amygdala (CeA) mediates several addiction-related processes and nociceptin/orphanin FQ (nociceptin) regulates ethanol intake and anxiety-like behaviors. Glutamatergic synapses, in the CeA and throughout the brain, are very sensitive to ethanol and contribute to alcohol reinforcement, tolerance, and dependence. Previously, we reported that in the rat CeA, acute and chronic ethanol exposures significantly decrease glutamate transmission by both pre-and postsynaptic actions. In this study, using electrophysiological techniques in an in vitro CeA slice preparation, we investigated the effects of nociceptin on glutamatergic transmission and its interaction with acute ethanol in naive and ethanol-dependent rats. We found that nociceptin (100-1000 nM) diminished basal-evoked compound glutamatergic receptor-mediated excitatory postsynaptic potentials (EPSPs) and spontaneous and miniature EPSCs (s/mEPSCs) by mainly decreasing glutamate release in the CeA of naive rats. Notably, nociceptin blocked the inhibition induced by acute ethanol (44 mM) and ethanol blocked the nociceptin-induced inhibition of evoked EPSPs in CeA neurons of naive rats. In neurons from chronic ethanol-treated (ethanol-dependent) rats, the nociceptin-induced inhibition of evoked EPSP amplitude was not significantly different from that in naive rats. Application of Nphe1 Nociceptin(1-13)NH2, a nociceptin receptor (NOP) antagonist, revealed tonic inhibitory activity of NOP on evoked CeA glutamatergic transmission only in ethanol-dependent rats. The antagonist also blocked nociceptin-induced decreases in glutamatergic responses, but did not affect ethanol-induced decreases in evoked EPSP amplitude. Taken together, these studies implicate a potential role for the nociceptin system in regulating glutamatergic transmission and a complex interaction with ethanol at CeA glutamatergic synapses. © 2014 American College of Neuropsychopharmacology.


Kratz D.,Federal University of Parana | Wendling I.,Embrapa Florestas
Floresta | Year: 2013

The pressing need to increase the number of seedlings planted annually and variability of raw materials for traditional composition of substrates have led to the need to develop studies aimed at evaluating these materials, technically and economically feasible. Based on this, the present study aimed to evaluate the technical feasibility of using fine vermiculite (VF) and component-based renewable coconut fiber (FC), rice hulls (CAC) in different grain sizes and two commercial substrates composed by pine bark semidecomposta (SC) in the composition of substrates for the production of seedlings of Eucalyptus dunnii, and assess the correlation between the physical and chemical properties of the substrates with the quality of the seedlings. 14 treatments were formulated, and the sowing in tubes of 55 cm3. Based on these results, the substrate that provided greater seedling growth of Eucalyptus dunniiCAC was combined with VF, followed by the SC, while those based CAC in different particle sizes, combined or not with CF, gave low growth. Regarding the properties of the substrates, it was identifiedthat the bulk density, total porosity, macroporosity, pH and cation exchange capacity correlated with seedling growth.


Irkhin P.,Lehigh University | Ryasnyanskiy A.,Lehigh University | Koehler M.,Federal University of Parana | Biaggio I.,Lehigh University
Physical Review B - Condensed Matter and Materials Physics | Year: 2012

We report the intrinsic absorption and photoluminescence spectra of rubrene single crystals, deriving them from a series of experiments performed at different excitation wavelengths and in different experimental geometries. We describe the absorption spectra for all three light polarizations in the crystal, and discuss how anisotropic wavelength-dependent absorption and emission affect the characteristics of observed photoluminescence spectra. We identify vibronic progressions both in absorption and emission and discuss their parameters and the main vibrational modes that are responsible for them. We propose that the most commonly measured absorption and emission in rubrene, the one with light polarization perpendicular to the c axis of the crystal, is caused by vibronic-induced depolarization of the c-polarized electronic transition between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO). © 2012 American Physical Society.


The avifauna of a 70-ha forest fragment located in the North of the state of Rio Grande do Sul, southern Brazil was analyzed. The trophic structure, preferential habitats, relative abundance, and frequency of occurrence of the species were studied, with the aim of analyzing the conservation status of the sampled area. Pre-existing trails in the fragment were used as linear transects and they were monthly coursed between October 2012 and September 2013. Hundred-twenty species of birds were recorded; November and December 2012 had the highest bird abundance and species richness. Forty-two species were registered in 25% of the samples and 39 species in 25.1% - 50% of the samples. The trophic categories with highest diversity were insectivorous, omnivorous and frugivorous. The obtained data indicated that the sampling area plays an important role in the conservation of the local avifauna, housing many species with dependence of environments showing low levels of human disturbance. © 2015, Universidade do Vale do Rio dos Sinos. All rights reserved.


Doghman M.,French National Center for Scientific Research | Doghman M.,University of Nice Sophia Antipolis | Figueiredo B.C.,French National Center for Scientific Research | Figueiredo B.C.,Federal University of Parana | And 5 more authors.
Nucleic Acids Research | Year: 2013

Steroidogenic Factor-1 (SF-1) is a nuclear receptor that has a pivotal role in the development of adrenal glands and gonads and in the control of steroid hormone production, being also implicated in the pathogenesis of adrenocortical tumors. We have analyzed the mechanisms how SF-1 controls gene expression in adrenocortical cells and showed that it regulates different categories of genes according to its dosage. Significant correlations exist between the localization of SF-1-binding sites in chromatin under different dosage conditions and dosage-dependent regulation of gene expression. Our study revealed unexpected functional interactions between SF-1 and Neuron-Restrictive Silencer Factor/RE1-Silencing Transcription Factor (NRSF/REST), which was first characterized as a repressor of neuronal gene expression in non-neuronal tissues, in the regulation of gene expression in steroidogenic cells. When overexpressed, SF-1 reshapes the repertoire of NRSF/REST - regulated genes, relieving repression of key steroidogenic genes. These data show that NRSF/REST has a novel function in regulating gene expression in steroidogenic cells and suggest that it may have a broad role in regulating tissue-specific gene expression programs. © 2013 The Author(s) 2013.


Mejdalani G.,Federal University of Rio de Janeiro | Cavichioli R.R.,Federal University of Parana
Zoologia | Year: 2013

The Neotropical sharpshooter Parasubrasaca felixi, gen. nov., sp. nov., is described and illustrated from the Atlantic Rainforest of Southeastern Brazil (state of Espírito Santo). The new genus can be distinguished from other members of the Cicadellini by several morphological features, including a unique modification of the basal portion of the aedeagus, which bears a conspicuous, ventrally directed projection that articulates with the connective. The projection bears a pair of strong spines directed posteriorly. In addition to the external morphology, color pattern, and male genitalia, the female genitalia of the new taxon are also described in detail. A discussion comparing the new genus with similar Neotropical taxa (Subrasaca Young, 1977, Soosiulus Young, 1977, Ramosulus Young, 1977, Geitogonalia Young, 1977, Ladoffa Young, 1977, and Scopogonalia Young, 1977) is provided. © 2013 Sociedade Brasileira de Zoologia All rights reserved.


Cardoso F.C.G.,Laboratorio Of Ecologia Vegetal | Marques R.,Federal University of Parana | Botosso P.C.,EMBRAPA - Empresa Brasileira de Pesquisa Agropecuaria | Marques M.C.M.,Laboratorio Of Ecologia Vegetal
Plant and Soil | Year: 2012

Background and aims: Phenological variations in tropical forests are usually explained by climate. Nevertheless, considering that soil water availability and nutrient content also influence plant water status and metabolism, soil conditions may also be important in the regulation of plant reproductive and vegetative activities over time. We investigated whether phenological patterns and stem growth differ in trees growing in two types of soil that display contrasting water and nutrient availability, namely, Gleysol (moist and nutrient-poor) and Cambisol (drier and nutrient-rich). Methods: Phenological observations (flushing, leaf fall, flowering and fruiting) and stem diameter growth were recorded for 120 trees fitted with fixed dendrometer bands, at 15 days intervals, for 1 year. Two species of contrasting deciduousness were investigated: Senna multijuga (semi-deciduous) and Citharexylum myrianthum (deciduous). Results: Both species were seasonal in all phenophases, regardless of soil type. However, frequency, mean date and intensity of phenophases varied according to soil type. Girth increment of C. myrianthum was four times greater in Cambisol than in Gleysol, whereas the type of soil had no significant effect on that of S. multijuga. Conclusions: These results show that soil characteristics also play an important role in determining phenological patterns and growth and must be considered when analysing phenological patterns in tropical forests. © 2011 Springer Science+Business Media B.V.


Bonato K.O.,Federal University of Parana | Delariva R.L.,West Parana State University | da Silva J.C.,West Parana State University
Zoologia | Year: 2012

In the present study, we describe the diets of the fish assemblages in two streams in the Maringá region of Paraná that are under the influence of different anthropic impacts. We also evaluate how the origin and use of food resources varies temporally and spatially and how the trophic organization of the fish assemblages differs between the two streams. Fish were collected every two months from October 2006 to October 2007 using sieves, seining and closing nets along two 50 m stretches of each stream. We used the volumetric method to analyze the stomach contents of 599 fish belonging to 15 species. We then employed ANOSIM, SIMPER, NMDS and cluster analyses (using the Bray-Curtis index) to examine how different factors (species, stream, sampling site and season) influenced the diets of the assemblages. The dietary analysis revealed a total of 21 types of items consumed, with the most common being detritus and immature Diptera. Spatial factors resulted in differences in diets between the two streams, with detritus representing the material consumed most often in the Morangueiro stream and immature Diptera being the most consumed item in the Queçaba stream. SIMPER analysis indicated a 76.33% dissimilarity between species' diets during the dry and rainy seasons, with detritus, immature Diptera and testate amoebae making the greatest contributions to this differentiation. In the Morangueiro stream, three trophic guilds were found: detritivorous, detritivorous/aquatic insectivorous, and aquatic insectivorous. In Queçaba stream, six trophic guilds were present: detritivorous, benthophagous, aquatic insectivorous, terrestrial insectivorous, herbivorous and carnivorous. Autochthonous items were generally the items most consumed by species, in particularly in the Queçaba stream. In the Morangueiro stream, food items of indeterminate origin were more relevant. The differences in the diets of fish species between the two streams support the conclusion that urbanization causes the disruption of aquatic environments and trophic organization. © 2012 Sociedade Brasileira de Zoologia. All rights reserved.


Chin S.Y.,Federal University of Parana
International Journal of Manufacturing Research | Year: 2013

The main goal of this research work is to present a performance comparison of different lot sizing splitting strategies applied to virtual cells in a robust distributed layout. This paper considers basically three strategies related to lot sizing splitting, analysing firstly the performance of the production system without any lot sizing splitting. Next, considers an equally balanced of lot sizing to K virtual cells. And finally, unbalanced splitting is considered, where in this last case, it is proposed a makespan based procedure for determining different part quantities to each virtual cells. For the computational simulation, the sequences in which different parts are submitted for manufacturing (parts input orderings) are also considered. The results show that separating parts to virtual cells reduces significantly, in general, the makespan. The performance of the proposed method increases when the total number of machines and part input orderings are embedded in the analysis. Copyright © 2013 Inderscience Enterprises Ltd.


Furini M.A.,Federal University of Parana | Pereira A.L.S.,Federal University of Goais | Araujo P.B.,Sao Paulo State University
International Journal of Electrical Power and Energy Systems | Year: 2011

This work presents the application of the Decentralized Modal Control method for pole placement in multimachine power systems utilizing FACTS (Flexible AC Transmission Systems), STATCOM (Static Synchronous Compensator) and UPFC (Unified Power Flow Controller) devices. For this, these devices are equipped with supplementary damping controllers, denominated POD (Power Oscillation Damping), achieving a coordinated project with local controllers (Power System Stabilizers - PSS). Comparative analysis on the function of damping of the FACTS, STATCOM and UPFC is performed using the New England System that has 10 generators, 39 buses and 46 transmission lines. © 2010 Elsevier Ltd. All rights reserved.


The great biological diversity and the high endemism of species nominate Brazil as a mega-diverse country, containing about one tenth of the world's biota. This richness is distributed in the country in six continental Biomes: Amazon, Caatinga, Atlantic Forest, Cerrado, Pantanal and Pampa, which are characterized by the uniformity of the environment, according to climate, vegetation type, soil and altitude. In one of the major insect orders, Diptera, the taxonomic and ecological knowledge is focused on species of economic or medical importance, for example, in Culicidae. There are approximately 470 species of Culicidae distributed in Brazil, with species considered wild and others anthropogenic, with greater adaptability to human-modified systems. One factor that determines the occurrence of these species is the structural heterogeneity of the Biome, being that the greatest diversification of resources in the habitat allows the coexistence. However, the trend of the habitats becoming smaller and more isolated has been causing biodiversity loss, that in Brazil, the most conservative estimates indicate that 30% of the natural territory is changed by human use. The Culicidae adaptability to the anthropic environment is the reason why this family has a great evolutionary success, allowing these insects to live in the middle of anthropized environments. It is possible that the diseases spreadby these insects will make continuous adjustments, so it is important to highlight the distribution of Culicidae in Brazil and relate it to changes in natural environments and to epidemiology of some diseases. We should, then, assume epidemiological and entomological surveillance policies, also relating wild Culicidae, in favor of a lucid picture of the Culicidae fauna, as a whole, in local and global scale.


Goncalves R.H.,Federal University of Sao Carlos | Schreiner W.H.,Federal University of Parana | Leite E.R.,Federal University of Sao Carlos
Langmuir | Year: 2010

This article describes a different approach to the colloidal synthesis of TiO2 nanocrystals using a polymer melt as a solvent. This approach allowed us to obtain a colloidal dispersion with a high degree of stability in a polymeric solvent, resulting in a transparent colloid. Using this method, it was possible to obtain the TiO2 nanocrystal with Brønsted acid sites and polymer chains chemically anchored on the nanocrystal surface. The acid surface of those nanocrystals has the chemical property to react in the presence of amine organic compounds and to maintain the colloidal stability. In this way, TiO2 nanocrystals were combined with a molecular probe containing amine functional groups such as polyaniline. Through the combination of the molecular probe and inorganic nanocrystals, we obtained a hybrid material with interesting chemical, optical, and electronic behavior, making it a promising material for photovoltaic, photochromic, and sensor devices.© 2010 American Chemical Society.


Kremer G.M.,Federal University of Parana
AIP Conference Proceedings | Year: 2012

Relativistic field equations for a gas in special and general relativity are determined from the Boltzmann equation. The constitutive equations are obtained from the Chapman-Enskog methodology applied to a relativistic model equation proposed by Anderson and Witting. Two applications in general relativity are considered: one refers to a gas in a homogeneous and isotropic Universe where irreversible processes are present during its evolution; in the other it is analyzed a gas under the influence of a spherically symmetrical non-rotating and uncharged source of the gravitational field. © 2012 American Institute of Physics.


Silveira J.L.M.,Federal University of Parana | Bresolin T.M.B.,Vale do Itajai University
Quimica Nova | Year: 2011

The pharmaceutical use of galactomannans from different sources, commercial and noncommercial, has been extensively studied over the past decade. Galactomannans show potential in the global trend towards the use of more plant-based products for ecological motives, and their production and application do not cause pollution or disturb the ecosystem. There is a variety of galactomannan sources and various pharmaceutical forms of application, such as tablets or capsules, hydrogels and films. Besides the simple use as inert excipient this polysaccharides play role in the modification of drug release, especially in colonic environmental, as a matrix or coating material.


Nobre F.S.,Federal University of Parana
Journal of Manufacturing Technology Management | Year: 2011

Purpose - The contributions proposed in this paper are motivated by principles of incompatibility, and non-equilibrium states, existing between the continuous growth in the level of environmental complexity and the insufficient cognitive capacity of the organization. From such a view, the purpose of this paper is to ask: What are the core competencies of the new industrial organization in the twenty-first century? Design/methodology/approach - First, the paper examines the characteristics and limitations of past and current industrial organizations; second, it contributes by extending their frontiers and by proposing technological, managerial and organizational core competencies of the new enterprise. Findings - From such analyses, this paper introduces the features of customer-centric systems (CCS) which represent new industrial organizations in the pursuit of high degrees of organizational cognition, intelligence and autonomy, and consequently, high degrees of agility and flexibility, in order to manage high levels of environmental complexity and uncertainty, to operate through intensive mass customization, and to provide customers with immersiveness. Research limitations/implications - For further research, this paper suggests the investigation of practical implementation of the features of the new enterprise of CCS. In such a direction, it recommends additional reading on the concept and design of computational organizational management networks. Practical implications - This paper emphasizes that CCS are firm types which strategically organize their resources and competencies around customers' values and needs, in order to involve customers into their business. By involving customers into their task environments and business, CCS-based firms have the chance to understand their clients' real needs and to produce the appropriate goods and services. Originality/value - The uniqueness of this paper lies in its attempt to master, analyze and integrate technological, managerial andorganizational perspectives of past and currentmanufacturing organizations, which contribute to illuminate features and to identify core competencies of future industrial firms, which are in the pursuit of innovation and sustainable competitive advantage in the twenty-first century. © Emerald Group Publishing Limited.


Grimm A.M.,Federal University of Parana | Reason C.J.C.,University of Cape Town
Journal of Climate | Year: 2011

Teleconnections between the South American monsoon and southern African rainfall are investigated for years with Benguela Niño or Niña events in the South Atlantic. During these events, it is found that substantial rainfall anomalies also occur over South America in addition to those previously known for southern Africa. The appearance of large rainfall anomalies in the South American monsoon region prior to the onset of the Benguela Niño proper suggests that anomalous convection over South America may influence the evolution of both the SST anomalies and the African rainfall anomalies associated with Benguela Niño events. This teleconnection between South America and southern African rainfall may occur directly, via atmospheric circulation anomalies induced by convection over South America, or indirectly, via the effect of induced circulation anomalies on regional SST. To investigate these teleconnections, a vorticity equation model, which is linearized about a realistic basic state and which includes the divergence in this state and the advection of vorticity by the divergent wind, is applied to the events. The model is forced with anomalous divergence patterns observed during the events, and the steady-state solutions show that anomalies of convection during the South American monsoon produce the main circulation anomalies observed during the Benguela Niño events and hence influence rainfall and circulation patterns over Angola and other southern African countries. An influence function analysis confirms this result, indicating that South America is the most efficient source region to produce the observed anomalies, and also shows that there is no influence of convection over Africa on the South American monsoon. Based on these linear model and observational results, it is concluded that the South American monsoon can influence the evolution of Benguela Niños and associated rainfall anomalies in southern Africa. © 2011 American Meteorological Society.


Moran R.C.,New York Botanical Garden | Labiak P.H.,Federal University of Parana | Sundue M.,New York Botanical Garden
International Journal of Plant Sciences | Year: 2010

We performed a phylogenetic analysis of the traditionally recognized genera of bolbitidoid ferns (i.e., Arthrobotrya, Bolbitis, Elaphoglossum, Lomagramma, and Teratophyllum) using two noncoding chloroplast spacers: trnL-trnF and rps4-trnS. The sampling included 57 species, of which 55 had not been sequenced previously. The results supported the monophyly of bolbitidoid ferns and of Arthrobotrya, Elaphoglossum, Lomagramma, and Teratophyllum; however, Bolbitis was resolved as polyphyletic. A clade of eight Neotropical species currently placed in Bolbitis is sister to Elaphoglossum, not the other species of Bolbitis. We refer to this group of species as the Bolbitis nicotianifolia clade. Lomagramma (or Bolbitis) guianensis, whose generic placement has been uncertain, was found to belong to the B. nicotianifolia clade. Bolbitis s.s. was resolved sister to the rest of the bolbitidoid ferns, which are in turn divided into two clades, one consisting of Elaphoglossum and the B. nicotianifolia clade and the other of Lomagramma, Teratophyllum, and Arthrobotrya. We optimized 34 morphological characters on the resulting phylogenetic tree. The characters found to be synapomorphic for bolbitidoid ferns were ventral root insertion, elongated ventral meristeles, sterile-fertile leaf dimorphism, acrostichoid sori, and the absence of hairs on the leaves. Other characters, such as articulate pinnae, venation patterns, laminar buds, paraphyses, and growth habit, are discussed in relation to the clades they support at different nodes on the tree. The bolbitidoid ferns show a transition series from terrestrial (Bolbitis) to hemiepiphytic (the B. nicotianifolia clade, Arthrobotrya, Lomagramma, and Teratophyllum) to epiphytic (Elaphoglossum). A sister-species relationship between the Neotropical Bolbitis serratifolia and the African Bolbitis acrostichoides was recovered, supporting their relationship as previously postulated on the basis of morphology. © 2010 by The University of Chicago. All rights reserved.


Moran R.C.,New York Botanical Garden | Labiak P.H.,Federal University of Parana | Sundue M.,New York Botanical Garden
Brittonia | Year: 2010

Our recent molecular phylogenetic study revealed a previously unrecognized clade of six species that is sister to Elaphoglossum. Within this clade, four species are currently classified in Bolbitis, one in Lomagramma, and one in Acrostichum. For this clade, we propose the name Mickelia, with M. nicotianifolia as the type species. We also make new combinations for the species in our phylogenetic study shown to belong to Mickelia (M. bernoullii, M. guianensis, M. hemiotis, M. nicotianifolia, M. oligarchica, and M. scandens) and two other species believed to belong to the clade based on morphology (M. lindigii, M. pergamentacea). A new hybrid and two new species are also described (M. ×atrans, M. furcata, and M. pradoi). In total, Mickelia consists of ten species and one hybrid. It is entirely neotropical. We provide a key to the genera of bolbitidoid ferns and a synopsis of Mickelia that gives for each species a complete synonymy, geographical distribution, comparative discussion, and illustration. © 2010 The New York Botanical Garden.


Simberloff D.,University of Tennessee at Knoxville | Vitule J.R.S.,Federal University of Parana
Oikos | Year: 2014

Calls for the end of invasion biology are misguided. There is no evidence that modern invasion biology has progressed slowly in its short life. Although some aspects of biological invasions fit comfortably in the framework of ecological succession, many others do not. Some native species, particularly in the wake of various anthropogenic impacts, behave like invasive non-native species, but the probability and degree of harmful impact are greater for non-native than for native species. Neither native nor non-native species suffer lack of attention and research by virtue of the fact that invasion biology focuses on the latter. Basing management solely on current observed impact is highly risky because impacts may be subtle but nonetheless important, and impacts often change, as they are contingent on the physical or biotic environment. The known harmful impacts of many non-native species suggest that recent introductions warrant attention even if impacts are not evident. Neither is the focus of modern invasion biology on non-native species motivated by xenophobia. Rather, it reflects the recognition of their likelihood of harmful impact. A related call for the end of traditional restoration ecology shares many features with calls to terminate invasion biology, not least because management of invasive non-native species is a key component of restoration ecology. Such species are a dominant element in generating the 'novel ecosystems' that are said to render traditional restoration ecology obsolete. The argument that both invasion management and traditional restoration are largely futile endeavors is contradicted by substantial and growing successes in both fields. © 2013 The Authors.


Rotta I.,Pharmaceutical science Postgraduate Program | Ziegelmann P.K.,Federal University of Rio Grande do Sul | Otuki M.F.,Pharmaceutical science Postgraduate Program | Riveros B.S.,Pharmaceutical science Postgraduate Program | And 2 more authors.
JAMA Dermatology | Year: 2013

Importance: Considering that most randomized controlled trials compare antifungals with placebo instead of other antifungals, conventional meta-analysis is insufficient to define superiority between the evaluated strategies. To our knowledge, this is the first mixed-treatment comparison meta-analysis on antifungal treatments in the literature and shows all the evidence available at the time of the study. Objective: To evaluate and compare the efficacy of topical antifungals used in dermatophytosis treatment, using mixed-treatment comparisons. Evidence Acquisition: We performed a comprehensive search (up to July 31, 2012) for all entries in MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, Literatura Latino Americana e do Caribe em Ciências da Saúde, and International Pharmaceutical Abstracts. Randomized controlled trials that compared topical antifungals with one another or with placebo in dermatophytosis treatment were selected for analysis. Methodologic quality of the trials was assessed using the Jadad scale. We excluded studies that scored less than 3 points. The outcomes evaluated were mycologic cure at the end of treatment and sustained cure. A random-effects Bayesian mixedtreatment comparisons model was applied to combine placebo-controlled and direct topical antifungals comparison trials. Results: Pooled data of the 65 trials identified did not show any statistically significant differences among the antifungals concerning the outcome of mycologic cure at the end of treatment. Regarding the sustained cure outcome, butenafine hydrochloride and terbinafine hydrochloride were significantly more efficacious than were clotrimazole, oxiconazole nitrate, and sertaconazole nitrate. Terbinafine also demonstrated statistical superiority when compared with ciclopirox (ciclopiroxolamine), and naftifine hydrochloride showed better response compared with oxiconazole. No inconsistency was detected in the network of evidence for both outcomes, sustaining the validity of the mixedtreatment comparisons results. Conclusions and Relevance: With the outcome mycologic cure at the end of treatment, there was no significant difference among the antifungals. Butenafine, naftifine, and terbinafine might be the best strategies for maintaining cured status. Because of the different costs of the antifungals, pharmacoeconomic analysis is required to identify the most efficient strategy for dermatophytosis management. © 2013 American Medical Association. Copyright © 2013 American Medical Association.


Three new species of the genus Incadorcus are described from Junín, Peru, and Coroico and Carrasco, Bolivia. The new species are compared with related species and illustrated. Dorsal habitus, head, pronotum, elytra and male genitalia of all species are figured and a distribution map is included. Incadorcus cuzcoensis Arnaud, Noguchi & Bomans is elevated to species status and Incadorcus kirchneri Schenk is synonymized with Incadorcus michellae Arnaud & Bomans. The species Metadorcus rufolineatus Nagel and Aegognathus nigrosuturalis Weinreich are transferred to the genus Onorelucanus. Copyright © 2011 Magnolia Press.


Brand M.A.,University Estadual de Santa Catarina. Av. Luiz de Camoes | Bolzon de Muniz G.I.,Federal University of Parana | Quirino W.F.,U.S. Department of Agriculture | Brito J.O.,University of Sao Paulo
Biomass and Bioenergy | Year: 2011

This work analysed the influence of storage in the quality of forest biomass for energy generation in the region of Lages, Brazil. Logs of Pinus taeda L. and Eucalyptus dunnii Maiden were harvested and piled during the four different seasons: spring, summer, fall and winter. The analyses were performed immediately after harvesting (without being stored), after two, four and six months of storage. The evaluated properties were: moisture content, gross and net calorific value, ash content and solubility in cold water, hot water and sodium hydroxide. The species composition, storage span, harvesting season and storage season influenced the forest biomass characteristics. In general, eucalyptus presented better results than pine, losing moisture faster, having less alteration in the chemical composition and producing greater energetic gain over storage time. For both species, the ideal storage time was four months. Furthermore, spring and summer were the best harvesting seasons. Thus, if the forest biomass is harvested at the end of winter or beginning of spring with subsequent storage during the summer, this biomass will have the best performance for energy production. © 2011 Elsevier Ltd.


Speranca L.D.,Federal University of Parana
International Journal of Modern Physics D | Year: 2014

In this paper, we provide a new derivation of the Dirac equation which promptly generalizes to higher spins. We apply this idea to spin-half Elko dark matter. © 2014 World Scientific Publishing Company.


Metzeltin D.,Am Stegskreuz 3b | Tremarin P.I.,Federal University of Parana
Iheringia - Serie Botanica | Year: 2011

The study of periphytic material sampling in the Atlantic Rainforest of Southeast Brazil revealed the occurrence of a new species, Eunotia fuhrmannii sp. nov., found in humid rocks associated to Sphagnum L. The taxon has strongly dorsiventral valve with a median ridge, rounded to cuneate-obtuse apex, prominent polar nodules, spaced striae in the middle, and shortened at the junction of valve face with the mantle. E. fuhrmannii distinguished from similar species, as E. prolongata var. simplex Hustedt e E. brinkmannii Metzeltin & Lange-Bertalot, mainly by the shape of valve ends, density of striae, position of polar nodules and shape of terminal raphe fissures.


Bourguignon C.,Pantheon Sorbonne University | Bourguignon C.,Federal University of Parana
Land Use Policy | Year: 2013

It has been nearly 10 years since the federal government of Brazil decided to make land tenure regularization a true priority. In theory, millions of families who informally occupy the federal domain should receive freeholds, emphyteutic leases, concessions of real or special rights, or occupancy authorizations. However, this paper questions the capacity of the Federal Land Agency to issue and manage these leases, concessions, and authorizations. It also argues that the future and sustainability of this land regularization policy are challenged by a controversial federal land tax and inaccessible land registration services. © 2012 Elsevier Ltd.


Muller D.,Federal University of Santa Catarina | Rambo C.R.,Federal University of Santa Catarina | Porto L.M.,Federal University of Santa Catarina | Schreiner W.H.,Federal University of Parana | Barra G.M.O.,Federal University of Santa Catarina
Carbohydrate Polymers | Year: 2013

An electrically conducting composite based on bacterial cellulose (BC) and polypyrrole (PPy) was prepared through in situ oxidative polymerization of pyrrole (Py) in the presence of BC membrane using ammonium persulfate (APS), as an oxidant. The electrical conductivity, morphology, mechanical properties and thermal stability of the composites obtained using APS (BC/PPy·APS) were evaluated and compared with BC/PPy composites prepared using as oxidant agent Iron III chloride hexahydrate (FeCl3·6H2O). The morphology of the BC/PPy·APS composites is characterized by spherical conducting nanoparticles uniformly distributed on the BC nanofiber surface, while the composites produced with FeCl3·6H2O (BC/PPy·FeCl3) is composed of a continuous conducting polymer layer coating the BC-nanofibers. The electrical conductivity of BC/PPy·FeCl3 was 100-fold higher than that found for BC/PPy·APS composites. In order to understand the site-specific interaction between PPy and BC functional groups, both composites were characterized by Fourier transform infrared (attenuated total reflectance mode) spectroscopy attenuation reflectance (FTIR-ATR) and X-ray photoelectron spectrometry (XPS). The affinity between functional groups of PPy·FeCl3 and BC is higher than that found for BC/PPy·APS composite. In addition, the tensile properties were also influenced by the chemical affinity of both components in the polymer composites. © 2013 Elsevier Ltd. All rights reserved.


Canavese D.,Federal University of Parana | Ortega N.R.S.,University of Sao Paulo
Ecological Indicators | Year: 2013

A challenging activity in the promotion of sustainable development is to synthesise indicators that can support decision-making. In developing countries such as Brazil, the use of information in support of the health and health-related environment of humans needs improvement. This paper presents a proposal for a system that can evaluate human health and urban environment sanitation in an integrated manner. The indicators selected for human health were child mortality rate, mortality rate due to acute diarrhoea for all ages and 1-4-year-old mortality rate due to acute respiratory tract infections. Environmental sanitation has been represented by indicators of sanitation coverage, such as sewerage. The paper describes the design of a fuzzy linguistic model that synthesises these indicators. The designed fuzzy rule-based system has proved to be a useful tool to integrate information and assist in the public planning of interrelated areas. © 2013 Elsevier Ltd. All rights reserved.


Castro M.A.A.,Federal University of Parana
Nature Genetics | Year: 2015

Genetic risk for breast cancer is conferred by a combination of multiple variants of small effect. To better understand how risk loci might combine, we examined whether risk-associated genes share regulatory mechanisms. We created a breast cancer gene regulatory network comprising transcription factors and groups of putative target genes (regulons) and asked whether specific regulons are enriched for genes associated with risk loci via expression quantitative trait loci (eQTLs). We identified 36 overlapping regulons that were enriched for risk loci and formed a distinct cluster within the network, suggesting shared biology. The risk transcription factors driving these regulons are frequently mutated in cancer and lie in two opposing subgroups, which relate to estrogen receptor (ER)+ luminal A or luminal B and ER- basal-like cancers and to different luminal epithelial cell populations in the adult mammary gland. Our network approach provides a foundation for determining the regulatory circuits governing breast cancer, to identify targets for intervention, and is transferable to other disease settings. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.


Buch A.C.,Federal University of Parana | Brown G.G.,Embrapa Forestry | Niva C.C.,Embrapa Forestry | Sautter K.D.,Positivo University | Sousa J.P.,University of Coimbra
Applied Soil Ecology | Year: 2013

The indiscriminate and excessive use of pesticides poses serious risks to humans and the environment, including soil biota. Ecotoxicological tests are useful to indicate the extent to which these chemicals are harmful and how and where their effects occur. Some of these tests were standardized by ISO (International Organization for Standartization) using the earthworm species Eisenia fetida and Eisenia andrei, both native to temperate climates. However, these species may be of lower relevance for soil ecotoxicological studies since they live in the litter and feed on fresh organic matter. The species Pontoscolex corethrurus, native to tropical regions, may be an alternative for more relevant ecotoxicological tests as it is an endogeic geophagous species. However, little is known of its sensitivity to pesticides. Therefore, avoidance and mortality tests were performed using E. andrei and P. corethrurus and three pesticides commonly used in Brazilian agriculture: carbendazim, carbofuran and glyphosate. The tests were conducted in tropical artificial soil (TAS). For carbendazim, the median avoidance concentration (AC50) was 76.1 and 65.8mga.i.kg-1 and the median lethal concentration (LC50) 19.7 and 15.3mga.i.kg-1 for E. andrei and P. corethrurus, respectively. For carbofuran, the AC50 was 9.7 and 7.3mga.i.kg-1 and LC50 13.5 and 9.3mga.i.kg-1 for E. andrei and P. corethrurus, respectively. Concentrations applied in the field of these two pesticides have toxic effects on both species. Glyphosate showed no toxic effects for either species even at the highest concentration tested (47mga.i.kg-1), although they displayed avoidance behavior at this concentration. The sensitivity of P. corethrurus appears to be similar to the standard species for the pesticides evaluated reinforcing the notion that E. andrei is a good test species. Nevertheless, further studies should be undertaken using other contaminants to confirm the similar sensitivity of both species and the relevance of E. andrei in ecotoxicological tests. © 2012 Elsevier B.V.


Sakakibara A.M.,Federal University of Parana
Revista Brasileira de Entomologia | Year: 2013

The genus Lycoderides Sakakibara, stat. nov., its composition and descriptions of new species (Hemiptera, Membracidae, Stegaspidinae).The subgenus Lycoderes (Lycoderides) Sakakibara, 1972 is raised to the genus category - Lycoderides stat. nov. - and it now includes: Lycoderides amazonicus (Sakakibara, 1991), comb. nov., Lycoderides brevilobus (Sakakibara, 1972), comb. nov., Lycoderides burmeisteri (Fairmaire, 1846), comb. nov., Lycoderides cultratus (Sakakibara, 1991), comb. nov., Lycoderides fernandezi (Strümpel, 1988), comb. nov., Lycoderides fuscus (Amyot & Serville, 1843), comb. nov., Lycoderides gradatus (Sakakibara, 1972), comb. nov., Lycoderides hippocampus (Fabricius, 1803), comb. nov., Lycoderides luteus (Funkhouser, 1940), comb. nov., Lycoderides marginalis (Walker, 1851), comb. nov., Lycoderides nathanieli (Cryan, 1999), comb. nov., Lycoderides obtusus (Sakakibara, 1991), comb. nov., Lycoderides pennyi (Sakakibara, 1991), comb. nov., Lycoderides phasianus (Fowler, 1896), comb. nov. (= Enchenopa minamen Buckton, 1901, syn. nov.), Lycoderides protensus (Sakakibara, 1991), comb. nov., Lycoderides serraticornis (Fowler, 1896), comb. nov., and Lycoderides strumpeli (Sakakibara, 1991), comb. nov. The following new species are described: Lycoderides abditus, sp. nov., Lycoderides brulei, sp. nov. (both from French Guiana), Lycoderides capixaba, sp. nov. (from Brazil, Espírito Santo), Lycoderides cavichiolii, sp. nov. (from Brazil, Rio de Janeiro), Lycoderides meloi, sp. nov. (from Brazil, Bahia), and Lycoderides oliviae, sp. nov. (from Brazil, Minas Gerais). Other nomenclatural change: Stegaspis bracteata (Fabricius, 1787) = Lycoderes capitata Buckton, 1903, syn. nov. New records of geographical distribution and a key to the species are provided.


Melo G.A.R.,Federal University of Parana
Revista Brasileira de Entomologia | Year: 2013

On the identity of Melipona torrida Friese (Hymenoptera, Apidae). Melipona marginata var. torrida Friese, 1916, described from three workers putatively collected in Costa Rica, never had its identity properly recognized. Since its original description, no additional specimens have ever been collected in Costa Rica. It is argued here that Melipona torrida was based on mislabeled specimens and corresponds to Melipona marginata obscurior Moure, 1971, a form known only from southern Brazil, Argentina and Paraguay. A lectotype is designated for Melipona torrida and notes on the type material of Melipona marginata obscurior are provided. Other known examples of species described from mislabeled specimens in Friese's Zur Bienenfauna von Costa Rica are discussed. It is pointed out that additional names proposed in this work, based on material from Costa Rica, might turn out to correspond to South American taxa. Also, the date of publication of this Friese's paper is discussed.


Garcete-Barrett B.R.,Federal University of Parana | Hermes M.G.,Federal University of Lavras
ZooKeys | Year: 2013

An identification table and descriptions are given to recognize the two species of Hypodynerus (Hymenoptera: Vespidae: Eumeninae) recorded from Brazil: H. arechavaletae (Bréthes) and H. duckei (Bertoni) comb. n. Telectotype is designated and the male is described for Hypodynerus duckei, its presence being recorded from Brazil for the first time. © B.R. Garcete-Barrett, M.G. Hermes.


Goldenberg R.,Federal University of Parana | Caddah M.K.,University of Campinas
Phytotaxa | Year: 2013

We propose nine synonyms and five lectotypifications for South American Miconia (Melastomataceae). Miconia acreana is synonymized under M. erioclada; Miconia depauperata and M. doriana under M. paniculata; Miconia inconspicua var. glabrata under M. petropolitana; Miconia japuraensis under M. juruensis; Miconia martiusiana under M. cinnamomifolia; Miconia maximiliana under M. ibaguensis, Miconia pileata under M. ciliata and Miconia pseudonervosa under M. nervosa. We propose lectotypes for M. acreana, M. doriana, M. juruensis, M. longicuspis and M. pileata. © 2013 Magnolia Press.


Cnemidophorus vacariensis (Teiidae) is endemic to southern Brazil, occurring in the states of Rio Grande do Sul, Santa Catarina and Paraná. In the state of Paraná, this species has only been recorded in the municipality of Candói, central-south region of the state. Herein, a new record of one individual of C. vacariensis is reported for the municipality of Tibagi, located in the central-eastern region of Paraná. This record represents the northern limit of distribution of the species. © 2013 Check List and Authors.


Da Silva D.L.,Federal University of Santa Catarina | Hermes C.J.L.,Federal University of Parana | Melo C.,Federal University of Santa Catarina
Applied Thermal Engineering | Year: 2011

The present paper investigates the frost formation on air-supplied tube-fin evaporator coils under typical operating conditions of light commercial refrigerating appliances. To this end, a first-principles simulation model based on air-side mass, energy and momentum balances was put forward to predict the evaporator frosting over time. Experiments were also carried out to gather key data for the model validation exercise. The numerical results were compared with the experimental air-side pressure drop, air-flow rate, cooling capacity, and accumulated frost mass, with all predictions falling within the experimental uncertainty range. The model was then used to investigate the evaporator thermal-hydraulic performance under frosting conditions accounting for the non-linear effect induced by the combination of the frosted evaporator and the fan-supplied air-flow rate. The effects of progressive frost clogging and low conductivity frost layer on the overall thermal resistance were also assessed. It was found that the former is the main cause of cooling capacity reduction under frosting conditions. © 2011 Elsevier Ltd. All rights reserved.


Azevedo V.F.,Federal University of Parana
Revista brasileira de reumatologia | Year: 2012

Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of various cellular types involved in immune response through expression of several other cytokines, it is possible that the use of its inhibitors may cause cytopenia. We report two cases of bicytopenia induced by etanercept. Both cases recovered after drug withdrawal. We discuss the need of introduction of routine laboratorial tests in patients using anti-TNF therapy, in order to identify possible hematological changes.


Background: Developmental Coordination Disorder (DCD) is characterized by impaired development of motor coordination, with impact on daily life activities and academic performance. The Motor Coordination and Dexterity Assessment (MCDA) was created to offer Brazilian rehabilitation professionals a valid and reliable instrument for detecting DCD. Objective: To examine the MCDA criterion validity. Methods: One hundred and eighty one children aged 7 and 8 years from the metropolitan region of Belo Horizonte, MG, Brazil, pre-selected using the Developmental Coordination Disorder Questionnaire (DCDQ-Brazil), were evaluated with the MCDA and the Movement Assessment Battery for Children (MABC-II). Concurrent validity was assessed using Spearman correlation index and the predictive validity was calculated using sensitivity, specificity, positive and negative predictive values. ROC curves were constructed to determine the optimal cutoff point of MCDA. Results: Spearman correlation between the total scores of MCDA and MABC-II at 7 and 8 years were 0.596 (p=0.000) and 0.730 (p=0.000), respectively. The cutoff points defined by the ROC curves approached the 40th percentile, corresponding to a sensitivity of 0.91 and 0.74 and specificity of 0.74 and 0.90 for children 7 and 8 years old, respectively. Conclusion: The results indicate moderate values of concurrent and predictive validity of the MCDA. Future studies should reexamine the cutoff points of the MCDA in other random samples, representative of Brazilian children 4 to 8 years of age. The predictive validity of the full instrument for DCD should be re-examined in well defined clinical samples. © Revista Brasileira de Fisioterapia.


Tognon G.B.,Federal University of Parana | Petry C.,University Of Passo Fundo
Revista Brasileira de Plantas Medicinais | Year: 2012

Ipomoea cairica (L.) Sweet is an herbaceous climbing plant widely used in Brazilian folk medicine and there is no information regarding its vegetative propagation. In view of this, the aim of this study was to evaluate the presence of leaves on stem cuttings and the most adequate substrate and level of plant growth regulators for propagation by stem cuttings of this morning glory. Two experiments were conducted, in the first, two types of stem cuttings (with and without leaves) and four substrates (sand; carbonized rice hull; Haplortox + organic matter - 1:1; Haplortox + organic matter + sand - 1:1:2) were evaluated, and in the second experiment five different concentrations of IBA (0, 250, 500, 750 and 1000 mg L-1) were tested. After 20 days, we obtained 86.2% of cuttings rooted in sand substrate and in the second experiment IBA did not affect the rooting percentage (94% on average). We can conclude that the presence of leaves improved the quality of rooting, the substrates indicated for propagation are sand and carbonized rice hull due to greater rooting, easy availability and low cost, and the use of IBA at 250 mg L-1 is more appropriate to propagation by stem cuttings of I. cairica.


The aim of this study was to evaluate the allelopathic effects of extracts from Coleus barbatus on germination and seedling growth of lettuce. The experiments were conducted in the laboratory using different concentrations (0, 7.5, 15, 22.5, 30%) of aqueous extracts from "falso-boldo" leaves harvested in all four seasons; extracts were obtained by grinding, maceration, infusion and decoction. Seeds were distributed on Petri dishes moistened with 10 mL solution. Results showed that the leaf extracts affected the germination of lettuce seeds only at the concentration of 30% extract prepared by decoction of leaves harvested in the winter. Germination speed index showed significant reduction for ground extracts prepared in the fall and winter, as well as for macerated leaves harvested in the summer and fall and for extracts prepared through decoction in the winter. The extracts stimulated the growth of shoots of lettuce seedlings, whereas root length was affected by the extracts, which either stimulated or inhibited its growth. Extracts of "falso-boldo" leaves harvested in all four seasons had allelopathic effect on germination and development of lettuce, and the latter varied depending on the harvest season, the form of preparing the extracts and the tested concentrations.


Cuphea carthagenensis (Jacq.) J.F. Macbr. is an herb, which occurs preferably in wet places. Amongst other species of the genus, C. carthagenensis is distinguished for its great chemical potential and frequent use in popular medicine. In this study the morphological and anatomical structures were identified, as well as the histochemical characterization was done. Samples of root, stem and leaves were collected from adult plants. This material was processed for anatomical and histochemical analysis in light microscopy and for morphological analysis, in scanning electron microscopy. Important morphological and anatomical considerations were added for C. carthagenensis, such as: the occurrence of aerenchymatous phellem with suberized layers; the types of trichomes present in the vegetative organs, the characterization of secretory trichomes, as well as the secreted substances. The groups of secondary metabolites presents in the root, stem and leaf of C. carthagenensis with more intense histochemical reaction were: proanthocyanidins, phenolic compounds, acids polysaccharides (mucilage especially) and lipids.


Carducci C.E.,Federal University of Lavras | de Oliveira G.C.,Brazilian National Council for Scientific and Technological Development | da Costa Severiano E.,Instituto Federal Of Educacao | Zeviani W.M.,Federal University of Parana
Revista Brasileira de Ciencia do Solo | Year: 2011

The clay fraction mineralogy and the granular structure of Oxisols in the Cerrado (Brazilian savanna) are the reason for the great volume of large pores as well as of extremely small pores, but no significant medium pore volume, resulting in low available water for plants. This study aimed to characterize and model the behavior of water retention in Oxisols with different texture classes of the Cerrado region. Samples were collected from the Bw horizon of 10 Oxisols under native vegetation. Water retention was measured at matric potentials of 1, 2, 4, 6, 8, 10 kPa using a Richards plate, and the water retained in potentials of 1.500 and 300.000 kPa determined by a thermocouple psychrometer model WP4-T Dewpoint Potentia Meter. The double van Genuchten model was proposed to fit the experimental water retention data by non-linear fitting using software R 2.10.1. The relationship between the estimated model parameters and the inflection point with soil texture properties was evaluated also by the Pearson correlation test. Results indicated good fitting of the model and great prediction power and correlation between the soil clay content and equation parameters (Usat, Upmp, Ures), as well as with the slope of the second inflection point (Itex). Oxisol texture influenced the behavior of water retention curves. The water retention curves of Oxisols were bimodal in the studied range of water potential.


Qualitative descriptive, exploratory research developed in 2009, in the emergency service of a general hospital in Curitiba, Paraná, Brazil. It aims to investigate how nurses take care of patients with clinical and psychiatric comorbidity. Six nurses, seven nursing technicians and 14 nursing assistants participated. We obtained data through semi-structured interviews and submitted to analysis of thematic content. The categories that emerged from the data were: Care is technical and without specificity; Safety and protection of patient; and Physical and chemical restraint as protective measures. The study revealed that nursing care of patients with clinical and psychiatric comorbidity does not have any specificity, with emphasis on basic care, physical and chemical restraint. We concluded that it is necessary to establish local training in mental health and make nurses aware of the care needs of this clientele.


Scotti A.,Federal University of Parana | Ponomarev V.,Federal University of Uberlandia | Lucas W.,Independent Consultant
Journal of Materials Processing Technology | Year: 2014

Metal transfer modes in arc welding processes have previously been classified as Natural or Controlled Metal Transfer. Modern laboratory techniques have helped to establish a new transfer classification mode in GMAW of carbon steels, which has been termed Interchangeable Metal Transfer. In order to characterize the new mode, a series of specimens was welded at different combinations of welding current (wire feed speed), arc voltage and gas composition. Laser backlighting techniques and high speed filming were employed to study metal transfer. The video was synchronized with the welding current and arc voltage signals to aid the understanding of the transfer behaviour. The results showed that this new interchangeable metal transfer class is distinguished from the Natural or Controlled Metal Transfer class because of its unique characteristic of periodical changes in the transfer mode induced by changes in welding parameters (a self-sustained behaviour). The characteristic feature of the interchangeable metal transfer class was shown to comprise of two or more natural transfer modes occurring in a regular repetitive sequence. The metal transfer sequence occurs without interference from the operator or the adaptive control system of the power source. Phenomenological explanations based on arc physics are given to justify the main governing factors for the particular metal transfer characteristics. © 2014 Published by Elsevier B.V.


The objective of this essay is to reflect on the possibility of searching for individual and family's autonomy in public health services through health professionals, mainly nurses in the development of home care. Some aspects related to the organization and health professionals' education must be considered in order to perform home care in health systems, mainly in the public service scope. Effective home care must watch individuals and their families in their context, visualizing and considering their social environment, their insertions, their homes, their habits and relationships, and anything or any situation that are part of their existence in the world. Autonomy - for individuals as well as their families to be able to carry out home care during an illness - is the possibility to deliver care supported by the health system, with professionals teaching, guiding and giving follow up, mainly a sensitive and technically-scientifically competent nurse to set up caring goals attending health reality - lived disease.


Teixeira I.N.D.O.,Federal University of Parana | Guariento M.E.,University of Campinas
Ciencia e Saude Coletiva | Year: 2010

The article reviews the major biological theories of aging, and discusses the most relevant mechanisms to explain the aging process. It begins with the evolutionary theories, explores the molecular-cellular mechanisms, and presents the perspective of the systemic theories. The complex etiology of aging is a challenge to the researchers. The knowledge on that phenomenon develops towards an integrative approach.


Schurt L.C.,Federal University of Santa Catarina | Hermes C.J.L.,Federal University of Santa Catarina | Hermes C.J.L.,Federal University of Parana | Trofino Neto A.,Federal University of Santa Catarina
Applied Thermal Engineering | Year: 2010

This paper explores the controlling characteristics of a first-principles model-based controller specially developed for vapor compression refrigeration systems. Mathematical sub-models were put forward for each of the system components: heat exchangers (condenser and evaporator), variable-speed compressor and variable-orifice electric expansion device. The dynamic simulation model was then used to design a multivariable controller based on the linear-quadratic-Gaussian technique using a Kalman filter for the estimator design. A purpose-built testing apparatus comprised of a variable-speed compressor and a pulse-width modulated expansion valve was used to collect data for the system identification, and model and controller validation exercises. It was found that the model reproduces the experimental trends of the working pressures and power consumption in conditions far from the nominal point of operation (±30%) with a maximum deviation of ±5%. Additional experiments were also performed to verify the ability of the controller of tracking reference changes and rejecting thermal load disturbances. It was found that the controller is able to keep the refrigeration system running properly when the thermal load was changed from 340 to 580 W (460 W nominal), and the evaporator superheating degree was varied from 9.5 °C to 22 °C (16.6 °C nominal). © 2010 Elsevier Ltd. All rights reserved.


Unsihuay-Vila C.,Federal University of Parana | Marangon-Lima J.W.,Federal University of Itajuba | Zambroni De Souza A.C.,Federal University of Itajuba | Perez-Arriaga I.J.,Comillas Pontifical University
International Journal of Electrical Power and Energy Systems | Year: 2011

A novel multiobjective, multiarea and multistage model to long-term expansion planning of integrated generation and transmission corridors incorporating sustainable energy developing is presented in this paper. The proposed MESEDES model is a "bottom-up" energy model which considers the electricity generation/transmission value-chain, i.e., power generation alternatives including renewables, nuclear and traditional thermal generation along with transmission corridors. The model decides the optimal location and timing of the electricity generation/transmission abroad the multistage planning horizon. The proposed model considers three objectives belonging to sustainable energy development criteria such as: (a) the minimization of investments and operation costs of power generation, transmission corridors, energy efficiency (demand side management (DSM) programs) considering CO2 capture technologies; (b) minimization of Life-Cycle Greenhouse Gas Emissions (GHG); and (c) maximization of the diversification of electricity generation mix. The proposed model consider aspects of the carbon abatement policy under the CDM - Clean Development Mechanism or European Union Greenhouse Gas Emission Trading Scheme. A case study is used to illustrate the proposed framework. © 2010 Elsevier Inc. All rights reserved.


Bergamini M.F.,Federal University of Parana | Santos D.P.,Sao Paulo State University | Zanoni M.V.B.,Sao Paulo State University
Journal of Electroanalytical Chemistry | Year: 2013

Pyrazinamide (Pyrazinecarboxamide-PZA) is a drug that is used to treatment tuberculosis. In the present work, the voltammetric behavior of PZA was studied using a screen-printed modified electrode (SPCE). The modified electrode was constructed using poly-histidine films, and it showed an electrocatalytic effect, thus promoting a decrease in PZA reduction potential and improving the voltammetric response. Cyclic voltammetry and electrochemical impedance spectroscopy techniques have been employed in order to elucidate of the electrodic reaction. The results allowed the proposal that in the PZA reduction, a further chemical reaction occurs that corresponds to a second-order process which is subsequent to the electrode reaction. In addition, a sensitive voltammetric method was developed, and it was successfully applied for PZA determination in human urine samples. The best response was found using SPCE modified with poly-histidine prepared by histidine monomer electropolymerization (SPCE/EPH). The electroanalytical performance of the SPCE/EPH was investigated by linear sweep (LSV), differential pulse (DPV), and square wave voltammetry (SWV). A linear relationship between peak current and PZA concentrations was obtained from 9.0 × 10-7 to 1.0 × 10-4 mol L-1 by using DPV. The limit of detection at 5.7 × 10 -7 mol L-1 was estimated, and a relative standard deviation of the 5.0 × 10-6 mol L-1 of PZA of 10 measurement was 3.7%. © 2012 Elsevier B.V. All rights reserved.


Using a co-precipitation process, we intercalated zinc layered hydroxide salts (zinc LHS) with anionic orange azo dyes (methyl orange-MO or orange II-OII), co-intercalated with chloride anions; for comparison purposes, we also intercalated zinc LHS with chloride anions only, which furnished ZHC. After XRD characterization, we filled high-density polyethylene (HDPE) with the intercalated materials and submitted them to melt compounding and injection molding. We also obtained control batches of HDPE filled with ZHC, the MO sodium salt, or the OII sodium salt. XRD, thermal (simultaneous TGA/DTA), DSC, SEM, and UV-radiation photostability analyses confirmed that homogeneous composites were obtained. HDPE filled with zinc LHS intercalated with MO (a probable more hydrophobic anionic azo dye) displayed improved mechanical properties, good interface bonding, and stability to UV photodegradation; the other fillers afforded materials with poorer mechanical properties. © 2013 Springer Science+Business Media.


Lalli E.,French National Center for Scientific Research | Lalli E.,University of Nice Sophia Antipolis | Figueiredo B.C.,French National Center for Scientific Research | Figueiredo B.C.,Federal University of Parana | Figueiredo B.C.,Institute Pesquisa Pele Pequeno Principe
Frontiers in Endocrinology | Year: 2015

Adrenocortical tumors (ACT) in children are very rare and are most frequently diagnosed in the context of the Li-Fraumeni syndrome, a multiple cancer syndrome linked to germline mutations of the tumor suppressor gene TP53 with loss of heterozygosity in the tumors. A peak of children ACT incidence is present in the states of southern Brazil, where they are linked to the high prevalence in the population of a specific TP53 mutation (R337H). Children ACT have specific features distinguishing them from adult tumors in their pathogenetic mechanisms, genomic profiles, and prognosis. Epidemiological and molecular evidence suggests that in most cases they are derived from the fetal adrenal. © 2015 Lalli and Figueiredo.


Pereira E.F.,Santa Catarina State University | Moreno C.,University of Sao Paulo | Louzada F.M.,Federal University of Parana
Chronobiology International | Year: 2014

Active travel to school has been referred to as one way of increasing the level of daily physical exercise, but the actual impacts on student's general health are not clear. Recently, a possible association between active travel to school and the duration of sleep was suggested. Thus, the aim was of this study to investigate the associations between the type of transportation and travel time to school, the time in bed and sleepiness in the classroom of high school students. Information on sleeping habits and travel to school of 1126 high school students were analyzed, where 55.1% were girls with an average age of 16.24 (1.39) years old, in Santa Maria Municipality, Rio Grande do Sul, Brazil. Multiple linear regression and adjusted prevalence rates analyses were carried out. The frequency of active travel found was 61.8%. Associations between time in bed, sleepiness in the classroom and the type of transportation (active or passive) were not identified. Nevertheless, the time in bed was inversely associated with the travel time (p = 0.036) and with a phase delay. In the adjusted analysis, active travel was more incident for the students of schools in the suburbs (PR: 1.68; CI: 1.40-2.01) in comparison with the students of schools in the center. Therefore, longer trips were associated with a reduction of sleep duration of morning and night groups. Interventions concerning active travel to school must be carried out cautiously in order not to cause a reduction of the sleeping time. © Informa Healthcare USA, Inc.


Guedes I.C.M.,Federal University of Sergipe | Bertoli S.R.,University of Campinas | Zannin P.H.T.,Federal University of Parana
Science of the Total Environment | Year: 2011

This paper discusses the results of a study about the influence of urban shapes on environmental noise in the city of Aracaju (Brazil). The study, which involved in situ measurements and acoustic simulations using SoundPLAN software, began with an analysis of the current acoustic scenario, followed by the creation and simulation of hypothetical scenarios in as yet unoccupied sectors of the region under study. The acoustic modeling and simulations were based on measurements of equivalent-continuous sound pressure level, LAeq, and vehicle flow data, and on the region's geometrics. The results reveal that the physical characteristics of the urban shape, such as construction density, the existence of open spaces, and the shape and physical position of buildings exert a significant influence on environmental noise. © 2011 Elsevier B.V.


Spinillo C.G.,Federal University of Parana
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

Animation has been proved to facilitate content learning. However, in Brazil the electronic Patient Information Leaflets (e-PILs) do not employ animation, but static images, to show medicine usage to patients. By considering animation a beneficial communication resource to PILs, a study was conducted with 80 participants on comprehension and simulated tasks of using the medicines: vaginal cream, insulin syringe, inhaler and nasal spray. The results ratified the assumption, however, suggest that (a) participants’ perception of their understanding and task performance are related to their satisfaction with the animation, and (b) there is a gap between users’ understanding of medicine animation and their task performance when using a medicine. Recommendations are proposed based upon the literature and the outcomes of the study. © Springer International Publishing Switzerland 2016.


Valencia-Tello D.C.,Federal University of Parana
ACM International Conference Proceeding Series | Year: 2016

The greatest challenges of the 21st century demand greater coordination and cooperation between public entities, private sector and communities, which should seize the new opportunities that technological innovations can bring for sustainable development. In Colombia the public policy, "Plan Vive Digital" allowed the reduction of digital divide through connection of remote areas of the country by broadband, using a collaborative governance approach. This enabled the increase of coverage of education, but at the same time it showed new challenges for the quality of education. © 2016 ACM.


Goldenberg R.,Federal University of Parana | Chagas E.C.D.O.,Instituto Do Meio Ambiente Do Estado Of Alagoas
Systematic Botany | Year: 2014

Miconia nordestina has been collected 80 times in four Brazilian states (Ceará , Pernambuco, Alagoas, and Bahia) since 1939, but remained undescribed. It shares its glabrescent leaves, lax inflorescences, and small flowers with white stamens with several species of Miconia that are difficult to distinguish from one another. It can be recognized by the decorticant branches covered with sessile-stellate trichomes, opposite leaves with basal nerves, entire margins, and glabrous or glabrescent abaxial surface, panicles without additional lateral branches and without accessory branches at the nodes, 5-merous flowers with regular, well-defined calyx lobes, the calyx tube glabrous inside, rounded to emarginate petals, weakly dimorphic stamens with appendaged connectives, and large and ventral inclined anther pores that are equal to or broader than the anther thecae, glabrous ovary and style. It always occurs in montane habitats between 250 and 1,100 m where it usually grows in riparian forests associated with rocky outcrops and on sandy or clay soil. This new species is described, illustrated, and compared with similar species occurring in Brazil and neighboring countries. © Copyright 2014 by the American Society of Plant Taxonomists.


Han X.Y.,University of Texas M. D. Anderson Cancer Center | Aung F.M.,University of Texas M. D. Anderson Cancer Center | Choon S.E.,Hospital Sultanah Aminah | Werner B.,Federal University of Parana
American Journal of Clinical Pathology | Year: 2014

Objectives: To differentiate the leprosy agents Mycobacterium leprae and Mycobacterium lepromatosis and correlate them with geographic distribution and clinicopathologic features. Methods: Species-specific polymerase chain reactions were used to detect each bacillus in archived skin biopsy specimens from patients with leprosy from Brazil (n = 52), Malaysia (n = 31), Myanmar (n = 9), and Uganda (n = 4). Findings were correlated with clinical and pathologic data. Results: Etiologic species was detected in 46 of the 52 Brazilian patients, including 36 patients with M leprae, seven with M lepromatosis, and three with both bacilli. The seven patients with sole M lepromatosis all had tuberculoid leprosy, whereas only nine of the 36 patients infected with M leprae exhibited this type, and the rest were lepromatous (P < .001). All patients with dual infections had lepromatous leprosy. Of the nine patients from Myanmar, six were test positive: four with M leprae and two with M lepromatosis. Of the Malaysian and Ugandan patients, only M leprae was detected in 27 of the 31 Malaysians and two of the four Ugandans. Conclusions: The leprosy agents vary in geographic distribution. Finding M lepromatosis in Brazil and Myanmar suggests wide existence of this newly discovered species. The leprosy manifestations likely vary with the etiologic agents. © American Society for Clinical Pathology.


Stefanello M.E.A.,Federal University of Parana | Pascoal A.C.R.F.,University of Campinas | Salvador M.J.,University of Campinas
Chemistry and Biodiversity | Year: 2011

Myrtaceae family (121 genera, 3800-5800 spp.) is one of the most important families in tropical forests. They are aromatic trees or shrubs, which frequently produce edible fruits. In the neotropics, ca. 1000 species were found. Several members of this family are used in folk medicine, mainly as an antidiarrheal, antimicrobial, antioxidant, cleanser, antirheumatic, and anti-inflammatory agent and to decrease the blood cholesterol. In addition, some fruits are eaten fresh or used to make juices, liqueurs, and sweets very much appreciated by people. The flavor composition of some fruits belonging to the Myrtaceae family has been extensively studied due to their pleasant and intense aromas. Most of the essential oils of neotropical Myrtaceae analyzed so far are characterized by predominance of sesquiterpenes, some with important biological properties. In the present work, chemical and pharmacological studies carried out on neotropical Myrtaceae species are reviewed, based on original articles published since 1980. The uses in folk medicine and chemotaxonomic importance of secondary metabolites are also briefly discussed. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.


Saglio G.,University of Turin | Kim D.-W.,Catholic University of Korea | Issaragrisil S.,Mahidol University | Le Coutre P.,Charite - Medical University of Berlin | And 12 more authors.
New England Journal of Medicine | Year: 2010

BACKGROUND: Nilotinib has been shown to be a more potent inhibitor of BCR-ABL than imatinib. We evaluated the efficacy and safety of nilotinib, as compared with imatinib, in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (CML) in the chronic phase. METHODS: In this phase 3, randomized, open-label, multicenter study, we assigned 846 patients with chronic-phase Philadelphia chromosome-positive CML in a 1:1:1 ratio to receive nilotinib (at a dose of either 300 mg or 400 mg twice daily) or imatinib (at a dose of 400 mg once daily). The primary end point was the rate of major molecular response at 12 months. RESULTS: At 12 months, the rates of major molecular response for nilotinib (44% for the 300-mg dose and 43% for the 400-mg dose) were nearly twice that for imatinib (22%) (P<0.001 for both comparisons). The rates of complete cytogenetic response by 12 months were significantly higher for nilotinib (80% for the 300-mg dose and 78% for the 400-mg dose) than for imatinib (65%) (P<0.001 for both comparisons). Patients receiving either the 300-mg dose or the 400-mg dose of nilotinib twice daily had a significant improvement in the time to progression to the accelerated phase or blast crisis, as compared with those receiving imatinib (P=0.01 and P=0.004, respectively). No patient with progression to the accelerated phase or blast crisis had a major molecular response. Gastrointestinal and fluid-retention events were more frequent among patients receiving imatinib, whereas dermatologic events and headache were more frequent in those receiving nilotinib. Discontinuations due to aminotransferase and bilirubin elevations were low in all three study groups. CONCLUSIONS: Nilotinib at a dose of either 300 mg or 400 mg twice daily was superior to imatinib in patients with newly diagnosed chronic-phase Philadelphia chromosome-positive CML. (ClinicalTrials.gov number, NCT00471497.) Copyright © 2010 Massachusetts Medical Society.


Fujimoto M.M.,Federal University of Parana | Tennyson J.,University College London | Michelin S.E.,Federal University of Santa Catarina
European Physical Journal D | Year: 2014

A theoretical study on elastic electron collisions with two conformers of amino acid alanine (CH3CH(NH2)COOH) is reported. Differential and integral cross sections are computed for collision energies in the 1-10 eV range. The UK molecular R-matrix codes are used to compute scattering amplitudes within the static exchange plus polarization (SEP) approximation. Both alanine conformers have large permanent dipole moment so to calculate cross sections the Born closure procedure is included to take into account long-range interactions. Comparisons of calculated differential cross sections with available data for glycine are made and display certain similarities. Two shape resonances are detected for each conformer: a narrow one located at 2.7 eV and 3.5 eV which is probably associated with the unoccupied π ∗ orbital of the carboxyl group, and a broader resonance at 8.6 eV and 9.8 eV. © 2014 The Author(s).


Busnardo V.L.,University Catolica do Parana | Biondo-Simoes M.L.P.,Federal University of Parana
Revista Brasileira de Fisioterapia | Year: 2010

Objective: To evaluate the effects of low-level helium-neon (HeNe) laser on cutaneous wound healing in rats. Methods: Sixty Wistar rats were divided into control group and experimental group. A sutured longitudinal, dorsal-medial incision was made, with simple separate stitches. The experimental group was irradiated daily in three areas of the wound with HeNe laser (5mW maximum continuous power, 632.8 nm wavelength, 4 J/cm2 energy density and 0.015 cm2 laser beam area) for 36 seconds. The areas were evaluated on the third, seventh and fourteenth days postoperative. Histological sections were stained with hematoxylin-eosin to determine the type of inflammatory reaction according to the protocol by Vizzotto et al. (2003)* and with Picrosirius to identify types I and III collagen and the collagen maturation index (CMI). Immunohistochemical detection was employed with anti-CD45-LCA to recognize the inflammatory cells. Results: Both groups had the same inflammatory pattern. The experimental group had fewer inflammatory cells at the three evaluation times (p<0.001) with faster reduction in the number of leukocytes. The experimental group had greater total collagen density on the third day (p=0.001), with more type III collagen (p=0.001) and more type I collagen (p=0.001). There was no significant difference in the CMI. Conclusion: Low-level laser irradiation does not change the quality of the inflammatory response, but it does reduce its intensity; it increases collagen deposition in the early stages of the healing process and does not interfere with collagen maturation. © Revista Brasileira de Fisioterapia.


Ramadas N.V.,Indian National Institute for Interdisciplinary Science and Technology | Soccol C.R.,Federal University of Parana | Pandey A.,Indian National Institute for Interdisciplinary Science and Technology
Applied Biochemistry and Biotechnology | Year: 2010

The aim of this work was to statistically optimize the cultural and nutritional parameters for the production of polyhydroxybutyrate (PHB) under submerged fermentation using jackfruit seed hydrolysate as the sole carbon source. On the basis of results obtained from "one variable at a time" experiment, inoculum age, jackfruit seed hydrolysate concentration, and pH were selected for response surface methodology studies. A central composite design (CCD) was employed to get the optimum level of these three factors to maximize the PHB production. The CCD results predicted that jackfruit seed hydrolysates containing 2.5% reducing sugar, inoculum age of 18 h, and initial medium pH 6 could enhance the production of PHB to reach 49% of the biomass (biomass 4.5 g/l and PHB concentration 2.2 g/l). Analysis of variance exhibited a high coefficient of determination (R 2) value of 0.910 and 0.928 for biomass and PHB concentration, respectively, and ensured that the quadratic model with the experimental data was a satisfactory one. This is the first report on PHB production by Bacillus sphaericus using statistical experimental design and RSM in submerged fermentation with jackfruit seed hydrolysate as the sole source of carbon. © 2009 Humana Press.


Bonfleur E.J.,Federal University of Parana | Kookana R.S.,CSIRO | Tornisielo V.L.,University of Sao Paulo | Regitano J.B.,University of Sao Paulo
Journal of Agricultural and Food Chemistry | Year: 2016

We evaluated the effects of the soil organic matter (SOM) composition, distribution between soil aggregates size, and their interactions with the mineral phase on herbicide sorption (alachlor, bentazon, and imazethapyr) in tropical and subtropical Oxisols under no-till systems (NT). Using soil physical fractionation approach, sorption experiments were performed on whole soils and their aggregates. SOM chemistry was assessed by CP/MAS 13C NMR. The lower sorption observed in tropical soils was attributed to the greater blockage of SOM sorption sites than in subtropical soils. When these sites were exposed upon physical fractionation, sorption of the three herbicides in tropical soils increased, especially for imazethapyr. High amounts of poorly crystallized sesquioxides in these soils may have contributed to masking of sorption sites, indicating that organomineral interactions may lead to blockage of sorption sites on SOM in tropical soils. © 2015 American Chemical Society.


Slomp Junior H.,Federal University of Parana | Feuerwerker L.C.M.,University of Sao Paulo | Land M.G.P.,Federal University of Rio de Janeiro
Ciencia e Saude Coletiva | Year: 2015

The general objective of this research was to assess the possible contribution of homeopathy to the development of caregiving therapeutic projects in multidisciplinary workshops of permanent education in health, in the context of primary health care. The chosen points of analysis were the series of inconveniences expressed by health workers with respect to their work processes and it was the emergence of the theme of health education in the first meetings with the teams that led to the production of this article. This study discusses the existential territory of “being a health professional” as understood from a concept of education as a significant benchmark, and of a certain interventionist mission as a transcendent value. A progressive waning of the importance of health education was observed during the workshops, sometimes even disappearing from the discussions, as the caregiving therapeutic projects took shape. The conclusion reached is that this waning involved a process of moving towards a pact with the health system user, eventually considered to be a valid interlocutor; and that health care transcends any strictly pedagogical dimension. © 2015, Associacao Brasileira de Pos - Graduacao em Saude Coletiva. All rights reserved.


Da Luz M.G.E.,Federal University of Parana | Anteneodo C.,RIO SYSTEMS
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2011

This introduction to the special issue, Nonlinear dynamics in meso and nano scales: fundamental aspects and applications, gives a short overview about different contexts and current challenges posed by the emergence of nonlinearities at meso and nano characteristic sizes. It also addresses different aspects related to classical and quantum chaos. Moreover, it comments on the articles in this thematic publication, briefly summarizing their relevance in helping to understand the uprise of chaos and complex behaviour at those small scales. © 2011 The Royal Society.


Workers of Lestrimelitta ehrhardti (Friese, 1931) were studied based on a great number of individuals collected in the municipality of Castro, Paraná State, Brazil. The specimens were described morphologically, measured and illustrated.


Dos Santos Nunes V.,Sao Paulo State University | El Dib R.,Sao Paulo State University | Boguszewski C.L.,Federal University of Parana | Nogueira C.R.,Sao Paulo State University
Pituitary | Year: 2011

Cabergoline and bromocriptine are the most used drugs in the treatment of hyperprolactinemia, they are able to normalize the prolactin levels, restore gonadal function and promote tumor reduction in the majority of patients. We undertake a systematic review and meta-analysis of randomized controlled trials to compare caberg-oline versus bromocriptine in the treatment of patients with idiopathic hyperprolactinemia and prolactinomas. The data sources were: Embase, Pubmed, Lilacs and Cochrane Central. The outcome measures were: normalization of prolactin secretion, restoration of gonadal function, reduction of tumoral volume, quality of life and adverse drug effects. Were identified 418 references and after screening by title and abstract, we obtained complete copies of 34 articles potentially eligible for inclusion in the review. From this total, 19 were selected to be included, but fifteen of them were excluded due to the following reasons: one randomized study compared cabergoline versus placebo and other randomized study compared different doses of cabergoline; five references were cases series; four were only controlled studies; three were retrospectives series and; one was a cohort study. Therefore, four publications were included in the review and in the final analysis. The meta-analysis of normalization of serum prolactin levels and menstruation with return of ovulatory cycle showed a significant difference in favor of cabergoline group (RR 0.67 [CI 95% 0.57, 0.80]) e (RR 0.74 [CI 95% 0.67, 0.83]), respectively. The number of adverse effects was significantly higher in the bromocriptine number than in cabergoline group (RR 1.43 [CI 95% 1.03, 1.98]). The meta-analysis showed new evidence favoring the use of cabergo-line in comparison with bromocriptine for the treatment of prolactinomas and idiopathic hyperprolactinemia. © Springer Science+Business Media, LLC 2011.


Pagnan N.A.B.,Federal University of Parana | Visinoni A.F.,Positivo University
American Journal of Medical Genetics, Part A | Year: 2014

Monogenic genetic disorders constitute a very large group of rare conditions, each of which is defined by a characteristic combination of phenotypic features. Their enormous clinical variability and their etiological heterogeneity may result in difficulties for the establishment of a syndromic diagnosis. In this context, classifications were proposed for different nosological groups, including ectodermal dysplasias. Freire-Maia proposed a clinical based classification, but nowadays the need of connecting clinical and molecular data on EDs demands a re-evaluation of the knowledge and the formulation of a new classification approach. The aim of this article is to provide an update of an article published in 2009 in this Journal. In order to check for newarticles and information on ectodermal dysplasias, we have consulted theOMIM, PUBMED, and Science Direct online databases. © 2014 Wiley Periodicals, Inc.


Aiming to contribute to the better understanding of this kind of Pantanal forest, the results from a floristic-structural survey performed in a 1ha plot commonly classified as “Acuri Forest”, located at RPPN SESC Pantanal (Municipality of Barão de Melgaço - MT, Brazil - 16º45’S; 56º15’W) are presented. The floristic data were obtained from systematic collection of botanical material on the studied area and surroundings. The structural data were obtained from a one ha plot, divided into 100 contiguous sub-plots (10m x 10m). Inside these sub-plots, all arboreal individuals with diameter at breast high equal or greater than 5.0 cm, including palms, were identified, measured and mapped, using a coordinate system. 1224 individual ha-1 were sampled, representing 44 species, 43genus and 27 families; diversity index H’= 1.613 (var. 0.003514). The highest diversity families were Fabaceae (9 spp.), Sapindaceae e Anacardiaceae (3 spp. each), Bignoniaceae, Malvaceae, Moraceae e Rubiaceae (2 spp. each). Among the sampled species, 39 % were evergreen; 32 % semideciduous and 29% deciduous. Considering the tree individuals total (n = 440), 51 % were decíduos; 23% semideciduous and 26% evergreen. Attalea phalerata was the species with the highest structural value (VI= 121.62), due to its high density (64% of the total sampled individuals), frequency (100%) e and very high basal area (74.10 m2 ha-1). On second level of importance were Anadenanthera colubrina, Triplaris americana and Phyllostylon rhamnoide (VI= 35.41; 28.51; 18.5 respectively). The studied area was identified as very peculiar comparatively with other Seasonal Forest areas, especially because the Attalea phalerata massive density and absence of Myrtaceae representatives. The high representation of pioneer species in association with high density of individuals within this successional category reinforces that Mata com Acuri represents an early successional stage or a transitional stage. Based on the great percentage of deciduous and semi-deciduous species recorded for the area of study, it was classified as being representative of Deciduous Forest. © 2016, Universidade Federal de Santa Maria. All Rights Reserved.


Duarte C.A.,Federal University of Parana
Computer Physics Communications | Year: 2010

Here we study the convergence of numeric solutions for the one-dimensional Schrödinger-Poisson problem for electrons confined into a semiconductor quantum well structure. One kind of algorithm that is largely used is based on a simple iterative procedure that is finished when the solution is achieved when particular parameter (for example, an energy) converges. There is also the possibility of the employ of a mixing parameter to control the variation of a particular parameter of the system, or to fix the number of iterations while a particular parameter of the system is gradually increased (for example, the electron density). We show that the two latter algorithms are capable of solving the problem for a wider class of situations if compared to the former iterative without mixing, without significant loss of precision. © 2010 Elsevier B.V.


Smadja D.,Bordeaux University Hospital Center | Smadja D.,Cleveland Clinic | Santhiago M.R.,Cleveland Clinic | Santhiago M.R.,Federal University of Rio de Janeiro | And 3 more authors.
Journal of Refractive Surgery | Year: 2013

PURPOSE: To compare the discriminating ability of corneal elevation generated by a dual Scheimpflug analyzer calculated with different reference surfaces for distinguishing normal corneas from those with keratoconus and subclinical keratoconus. METHODS: A total of 391 eyes of 208 patients were prospectively enrolled in the study and divided into three groups: 167 eyes of 113 patients with keratoconus, 47 contralateral topographically normal eyes of patients with clinically evident keratoconus in the fellow eye, and 177 eyes of 95 refractive surgery candidates with normal corneas. All eyes were measured with a dual Scheimpflug analyzer (GALILEI Analyzer; Ziemer Ophthalmic Systems AG, Port, Switzerland). Maximum elevation values were recorded within the central 5-mm diameter in both anterior and posterior elevation maps. Discriminating ability of corneal elevation measurements obtained by best-fit toric and aspheric (BFTA) and best-fit sphere (BFS) reference surfaces were compared by receiver operator characteristic (ROC) curves. RESULTS: ROC curve analysis showed that corneal elevation measured by BFTA had a significantly better ability than with BFS for distinguishing normal corneas from those with keratoconus and forme fruste keratoconus (P = .01). Posterior elevation measured by BFTA had a significantly higher predictive accuracy for forme fruste keratoconus than anterior elevation with an area under ROC curves of 0.88 and 0.80, respectively (P = .01). The sensitivity and specificity achieved with the maximum posterior elevation for detecting keratoconus and forme fruste keratoconus were 99% and 99% for keratoconus and 82% and 80% for forme fruste keratoconus with the cut-off value at 16 and 13 μm, respectively. CONCLUSIONS: The ability to discriminate between normal cornea and forme fruste keratoconus with elevation parameters was significantly improved by using BFTA instead of BFS reference surface. Copyright © SLACK Incorporated.


Van-Dal E.S.,Federal University of Parana | Bouallou C.,MINES ParisTech
Journal of Cleaner Production | Year: 2013

There has been a large increase in anthropogenic emissions of CO 2 over the past century. The use of captured CO2 can become a profitable business, in addition to controlling CO2 concentration in the atmosphere. A process for producing fuel grade methanol from captured CO2 is proposed in this paper. The process is designed and simulated with Aspen Plus. The CO2 is captured by chemical absorption from the flue gases of a thermal power plant. The hydrogen is produced by water electrolysis using carbon-free electricity. The methanol plant provides 36% of the thermal energy required for CO2 capture, reducing considerably the costs of the capture. The CO2 balance of the process showed that it is possible to abate 1.6 t of CO2 per tonne of methanol produced if oxygen by-product is sold, or 1.2 t if it is not.


Chor T.L.,Federal University of Parana
Water Resources Research | Year: 2014

The Boussinesq groundwater equation is widely used in hydrology to predict streamflow from an unconfined aquifer and derive the aquifer's saturated hydraulic conductivity and drainable porosity, and to predict water table height in drainage engineering. In this work, we solve this equation in an unconfined horizontal aquifer for nonhomogeneous boundary conditions for the water table height. The solution is found in the form of a Taylor series that has a finite radius of convergence, which is different for each initial condition. We also present an expression for the flux boundary condition at the origin as a function of the depth of the adjoining stream that automatically satisfies the boundary condition at infinity, and thus eliminates the need for a trial-and-error approach for the solution, which is accurate to 10-7. In order to obtain an approximation for the water table height in the region where the series solution diverges, first we computed a diagonal Padé approximation from the series coefficients, which converges in a larger interval than the series, and then we matched it with a new asymptotic approximation for large values of the independent variable. We found that the proposed matched solution is better suited to cases where the water head at the origin is close to the initial water head in the aquifer. © 2014. American Geophysical Union.


Depra M.,Federal University of Rio Grande do Sul | Poppe J.L.,Federal University of Rio Grande do Sul | Schmitz H.J.,Federal University of Parana | De Toni D.C.,Federal University of Santa Catarina | Valente V.L.S.,Federal University of Rio Grande do Sul
Journal of Pest Science | Year: 2014

This paper presents the first report of the occurrence of Drosophila suzukii (Diptera: Drosophilidae) in South America. Several samples were collected during various seasons in 2012 and 2013, and a significant number of individuals were obtained and identified. Based on the data recorded during each sampling campaign, including the locality, temperature, time of year, and number of individuals collected, several conclusions were drawn about the development of this invasion in southern Brazil. © 2014 Springer-Verlag Berlin Heidelberg.


De Araujo Duarte C.,Federal University of Parana
International Journal of Geometric Methods in Modern Physics | Year: 2015

Following the line of the history, if by one side the electromagnetic theory was consolidated on the 19th century, the emergence of the special and the general relativity theories on the 20th century opened possibilities of further developments, with the search for the unification of the gravitation and the electromagnetism on a single unified theory. Some attempts to the geometrization of the electromagnetism emerged in this context, where these first models resided strictly on a classical basis. Posteriorly, they were followed by more complete and embracing quantum field theories. The present work reconsiders the classical viewpoint, with the purpose of showing that at first-order of approximation the electromagnetism constitutes a geometric structure aside other phenomena as gravitation, and that magnetic monopoles do not exist at least up to this order of approximation. Even though being limited, the model is consistent and offers the possibility of an experimental test of validity. © 2015 World Scientific Publishing Company.


Monteiro S.N.,State University of Rio de Janeiro | Satyanarayana K.G.,Federal University of Parana | Lopes F.P.D.,State University of Rio de Janeiro
Materials Science Forum | Year: 2010

A statistical evaluation based on the Weibull method was performed to correlate the mechanical properties and the diameter of different lignocellulosic fibers. The sisal, rami and curaua fibers were found to have a hyperbolic correlation between their ultimate strength and diameter. This permitted to select thinner high strength fibers, with over 1000 MPa, as reinforcement for the strongest polymer composites ever fabricated with these fibers. A structural analysis was conducted by electron microscopy to identify the strengthening mechanism for both, the high performance fiber and their improved polymer composites. © (2010) Trans Tech Publications.


Kunne C.,Tytgat Institute for Liver and Intestinal Research | Acco A.,Tytgat Institute for Liver and Intestinal Research | Acco A.,Federal University of Parana | Hohenester S.,Tytgat Institute for Liver and Intestinal Research | And 4 more authors.
Hepatology | Year: 2013

The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient rehydroxylation of deoxycholic acid. The aim of this study was to characterize bile formation in a mouse model (Hrn mice) with hepatic disruption of the cytochrome p450 (CYP) oxidoreductase gene, encoding the single electron donor for all CYPs. Bile formation was studied after acute BS infusion or after feeding a BS-supplemented diet for 3 weeks. Fecal BS excretion in Hrn mice was severely reduced to 7.6% ± 1.8% of wild-type (WT), confirming strong reduction of (CYP-mediated) BS synthesis. Hrn bile contained 48% ± 18% dihydroxy BS, whereas WT bile contained only 5% ± 1% dihydroxy BS. Upon tauroursodeoxycholate infusion, biliary BS output was equal in WT versus Hrn, indicating that canalicular secretion capacity was normal. In contrast, taurodeoxycholic acid (TDC) infusion led to markedly impaired bile flow and BS output, suggesting onset of cholestasis. Feeding a cholate-supplemented diet (0.1%) resulted in a completely restored bile salt pool in Hrn mice, with 50% ± 9% TDC and 42% ± 10% taurocholic acid in bile, as opposed to 2% ± 1% and 80% ± 3% in WT mice, respectively. Under these conditions, biliary cholesterol secretion was strongly increased in Hrn mice, whereas serum alanine aminotransferase levels were decreased. Conclusion: Hrn mice have strongly impaired bile salt synthesis and (re)hydroxylation capacity and are more susceptible to acute TDC-induced cholestasis. In this mouse model, a more-human BS pool can be instilled by BS feeding, without hepatic damage, which makes Hrn mice an attractive model to study the effects of human BS. © 2012 American Association for the Study of Liver Diseases.


Teive H.A.G.,Federal University of Parana | Munhoz R.P.,University of Toronto
Arquivos de Neuro-Psiquiatria | Year: 2014

The authors present the original Charcot's description of postural instability in Parkinson's disease as well as the evolution of this sign after 120 years of Charcot's death.


Kustova E.V.,Saint Petersburg State University | Kremer G.M.,Federal University of Parana
Chemical Physics | Year: 2014

Viscous gas flows with vibrational relaxation and chemical reactions in the state-to-state approach are analyzed. A modified Chapman-Enskog method is used for the determination of chemical reaction and vibrational transition rates and non-equilibrium pressure. Constitutive equations depend on the thermodynamic forces: velocity divergence and chemical reaction/transition affinity. As an application, N2 flow with vibrational relaxation across a shock wave is investigated. Two distinct processes occur behind the shock: for small values of the distance the affinity is large and vibrational relaxation is in its initial stage; for large distances the affinity is small and the chemical reaction is in its final stage. The affinity contributes more to the transition rate than the velocity divergence and the effect of these two contributions are more important for small distances from the shock front. For the non-equilibrium pressure, the term associated with the bulk viscosity increases by a small amount the hydrostatic pressure. ©2014 Elsevier B.V. All rights reserved.


Dartora C.A.,Federal University of Parana | Nobrega K.Z.,Federal Institute of Technological Education of Maranhao IFMA | Cabrera G.G.,University of Campinas
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2011

We show that in the context of paraxial optics, which can be analyzed through a wave equation similar to the non-relativistic Schrödinger equation of quantum mechanics but replacing time t by spatial coordinate z, the existence of a vector potential A⊥ mimicking the magnetic vector potential in quantum mechanics is allowed by specific gauge symmetries of the optical field in a medium with anisotropic refractive index. In this way, we use Feynmans path integral to demonstrate an optical analogue of the quantum-mechanical Aharonov-Bohm effect, encouraging the search for another optical systems with analogies with more complex quantum field theories. © 2011 Elsevier B.V. All rights reserved.


Oliveira R.A.,Federal University of Technology of Parana | Neves Jr. P.T.,Federal University of Technology of Parana | Pereira J.T.,Federal University of Parana | Canning J.,University of Sydney | Pohl A.A.P.,Federal University of Technology of Parana
Optics Communications | Year: 2010

This work presents an analysis of the vibration modes of a silica horn-fiber Bragg grating device, which is used for different applications in photonics. The analysis, based on the finite elements method, shows the different acoustical regimes for the excitation of flexural and longitudinal waves in the fiber. Using one single device, experimental results support the analysis by showing the change of the FBG reflectivity, an effect that happens when flexural waves are present, and also by showing the modulation of the FBG, an effect that is caused by longitudinal waves. © 2009 Elsevier B.V. All rights reserved.


Ribeiro A.D.,Federal University of Parana
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2011

The semiclassical formula for the coherent-state propagator is written in terms of complex classical trajectories of an equivalent classical system. Depending on the parameters involved, more than one trajectory may contribute to the calculation. Eventually, however, two contributing trajectories coalesce, characterizing what is called phase space caustic. In this case, the usual semiclassical formula for the propagator diverges, so that a uniform approximation is required to avoid this singularity. In this Letter, we present a non-trivial numerical application illustrating this scenario, showing the accuracy of the uniform formula that we have previously derived. © 2010 Elsevier B.V. All rights reserved.


Tuon F.F.,Federal University of Parana | Tuon F.F.,Hospital Universitario Evangelico Of Curitiba | Rigatto M.H.,Grande Rio University | Lopes C.K.,Hospital Universitario Evangelico Of Curitiba | And 3 more authors.
International Journal of Antimicrobial Agents | Year: 2014

Polymyxin B (PMB) and colistin, administered as the prodrug colistin methanesulfonate sodium (CMS), are increasingly used to treat carbapenem-resistant Gram-negative bacteria. Nephrotoxicity is the major dose-limiting adverse effect of both polymyxins. A retrospective cohort study of 132 patients was conducted to evaluate risk factors for acute kidney injury (AKI), classified according to Acute Kidney Injury Network criteria, in patients treated with =48 h of intravenous PMB or CMS, with particular focus on potential differences between each polymyxin. The overall incidence of AKI was 25.8% (34/132) [20.8% (20/96) and 38.9% (14/36) in patients treated with PMB and CMS, respectively; P = 0.06]. In the Cox regression model, doses =2 million International Units (MIU) of PMB or >9 MIU of CMS were the only variable independently associated with AKI [adjusted hazard ratio (aHR) = 2.11, 95% confidence interval (CI) 1.01-4.41; P = 0.04]. Vancomycin co-administration was strongly associated with AKI, although this was not statistically significant (aHR = 2.22, 95% CI 0.98-5.04; P = 0.058). There was no statistically significant difference in the incidence of AKI between patients treated with PMB or CMS in the multivariate model (aHR = 1.74, 95% CI 0.82-3.69; P = 0.15). High dose was the main risk factor for AKI regardless of the polymyxin administered. Vancomycin co-administration likely increases the risk of AKI. Although there was a higher overall incidence of AKI in patients treated with CMS compared with PMB, CMS was not significantly associated with this outcome after adjusting for the above variables. © 2013 Elsevier B.V. and the International Society of Chemotherapy.


De Andrade L.F.,QIMR Berghofer Medical Research Institute | De Andrade L.F.,Federal University of Parana | Smyth M.J.,QIMR Berghofer Medical Research Institute | Smyth M.J.,University of Queensland | Martinet L.,QIMR Berghofer Medical Research Institute
Immunology and Cell Biology | Year: 2014

Natural killer (NK) cells represent key innate immune cells that restrain viral infection and malignant transformation and help mount an adaptive immune response. To perform such complicated tasks, NK cells express a wide set of inhibitory and activating receptors that alert them against cellular stress without damaging healthy cells. A new family of receptors that recognize nectin and nectin-like molecules has recently emerged as a critical regulator of NK cell functions. The most famous member of this family, DNAX accessory molecule (DNAM-1, CD226), is an adhesion molecule that control NK cell cytotoxicity and interferon-γ production against a wide range of cancer and infected cells. Its ligands CD112 and CD155 have been described in different pathological conditions, and recent evidence indicates that their expression is regulated by cellular stress. Additional receptors have been shown to bind DNAM-1 ligands and modulate NK cell functions bringing another level of complexity. These include CD96 (TACTILE) and TIGIT (WUCAM, VSTM3). Here, we review the role of DNAM-1, TIGIT and CD96 in NK cell biology summarizing the recent advances made on the role of these receptors in various pathologies, such as cancer, viral infections and autoimmunity. © 2014 Australasian Society for Immunology Inc.


The deaths and diseases of slaves in the São Paulo State sugarcane municipality of Capivari are addressed, associating the causes attributed to these deaths to the social and economic context and characteristics of the local slave communities. The impact of malaria, relating it to the age brackets, the environment created by work on the sugarcane plantations and the evolution of the occupation of the area, initially by expanding frontiers, is emphasized. The relationship between illness and work processes, as well as the postdisembarkation mortality of Africans and the possibility of mortality crises among the sugarcane captives is explored. The results lead to a discussion of the impact of habitat and Atlantic displacement and the difficulty in acclimatizing. © 2015 Taylor & Francis Group, London.


Boguszewski C.L.,Federal University of Parana | Paz-Filho G.,Australian National University | Velloso L.A.,University of Campinas
Endokrynologia Polska | Year: 2010

Human body weight is maintained at a fairly stable level regardless of changes in energy intake and energy expenditure. Compensatory mechanisms within the central nervous system (CNS), which regulate food intake and energy expenditure, are triggered by other central and peripheral signals. Peripherally, the main sources of those signals are the adipose tissue, gastrointestinal tract, and pancreas. The main signal originating from the adipose tissue is leptin, which promotes the activation of anorexigenic pathways in the CNS. Similarly, the central action of insulin also reduces food intake and stimulates catabolic pathways. The gastrointestinal tract contributes with several peptides that influence food intake, such as ghrelin, glucagon-like peptide 1 (GLP-1), peptide YY (PYY), oxyntomodulin (OXM), and cholecystokinin (CCK). Other substances secreted by the pancreas, such as pancreatic polypeptide (PP) and amylin, a hormone co-secreted with insulin, also affect energy balance. More recently, the endocannabinoid system has also been identified as a contributor in the maintenance of energy balance. Better understanding of these mechanistic systems involved in the regulation of energy metabolism will hopefully lead to the development of new therapeutic approaches against obesity, metabolic syndrome, and other nutritional disorders.


Scrok G.J.,University of Tuiuti do Parana | Varassin I.G.,Federal University of Parana
Acta Botanica Brasilica | Year: 2011

Reproductive biology, including phenology, f ower biology, pollination, and the reproductive system in the bromeliad Aechmea distichantha were studied in an Araucaria forest in the state of Paraná. Phenology and reproduction in terricolous plants were followed in October 2006 and May - October of 2007. Flowering peaked from June to September and fruiting was from June to October. Flower anthesis lasted one day. Flowers were pollinated the most by the hummingbird Stephanoxis lal-andi and the most common butterf y visitor was Lychnuchoides ozias ozias. Nectar concentration declined during anthesis, while nectar volume was constant. Aechmea distichantha is self-compatible with 30-45% fruit formation in self-pollination tests. Sunlight inf uences reproduction: when controlling for bromeliad and inf orescence size, plants in sunlight produced more seeds per fruit than plants in the shade. Reproduction was also associated with inf orescence size when controlling for bromeliad size. T at is, larger inf orescences in similar sized plants produced more f owers and more seeds per fruit.


Bernardino E.,Federal University of Parana
Revista brasileira de enfermagem | Year: 2010

This paper aims to identify the demand and potential activities of the Liaison Nurse position in the Hospital de Clínicas of the Universidade Federal do Paraná. It is a descriptive research, based on a case study, and it was carried out in two stages, within August 2007 to May 2008. In the first stage, and through the use of forms, it was made a follow-up of hospital discharges. Then, it was selected a hospital admission unit in which a Liaison Nurse treated discharged patients, and ten of them were interviewed through the use of a semi-structured questionnaire. Lastly, the interviews were categorized and the data obtained was submitted so as its content could be analyzed. The results demonstrated that the implementation of the Liaison Nurse position is an essential step in the integration of the HC/UFPR to the network and promote the medical care integrity.


Borges B.N.,Federal University of Santa Catarina | Hermes C.J.L.,Federal University of Parana | Goncalves J.M.,Federal University of Santa Catarina | Melo C.,Federal University of Santa Catarina
Applied Energy | Year: 2011

This paper outlines a simulation model for the cycling behavior of household refrigerators and, therefore, for predicting their energy consumption. The modeling methodology follows a quasi-steady approach, where the refrigeration system and also the refrigerated compartments are modeled following steady-state and transient approaches, respectively. The mass, energy and momentum conservation principles were used to put forward the equation set, whereas experimental data were collected and used to reduce the model closing parameters such as the thermal conductances and capacitances. The experiments were carried out using a controlled temperature and humidity environmental chamber. The model predictions were compared to experimental data, when it was found that the energy consumption is well predicted by the model with a maximum deviation of ±2%. A sensitivity analysis was also carried out to identify opportunities for energy savings. © 2010 Elsevier Ltd.


Negrao C.O.R.,Federal University of Technology of Parana | Hermes C.J.L.,Federal University of Parana
Applied Energy | Year: 2011

In this study a novel design methodology for household refrigeration systems focused on both energy savings and cost reduction is presented and evaluated. Mathematical models were put forward for each of the system components and used to simulate the energy performance of the entire refrigeration system. The system simulation model was validated against experimental data obtained for a single-door 300-l vertical freezer. It was found that the model predictions for the energy consumption, cooling capacity and runtime ratio deviated from the experimental data within an error band of ±10%. An optimization algorithm was built upon the simulation model to size the condenser and evaporator heat transfer areas, and also the cabinet insulation thickness aiming at minimizing the total cost of the refrigeration system for a target energy consumption. A trade-off relation between the minimum cost and the minimum energy consumption was achieved, bringing about a system configuration that consumes 14% less energy than the baseline system if the total cost remains unchanged. The effect of the compressor stroke volume and efficiency on the minimum cost was also taken into account. It was demonstrated that the refrigerator/freezer becomes less costly in cases where highly efficient compressors are used in low energy consumption refrigerating appliances. © 2011 Elsevier Ltd.


Wen H.,Florida State University | Ordonez J.C.,Florida State University | Vargas J.V.C.,Federal University of Parana
Journal of Power Sources | Year: 2011

In this paper a dynamic model of a single solid oxide fuel cell (SOFC) is developed using a volume element methodology. It consists of a set of algebraic and ordinary differential equations derived from physical laws (e.g., the first law of thermodynamics, Fick's law, and Fourier's law), which allow for the prediction of the temperature and pressure spatial distribution inside the single SOFC, as functions of geometric and operating parameters. The thermodynamic model is coupled with an electrochemical model that is capable of determining the voltage, current, and power output. Based on the simulation results, the internal configuration (structure of the positive electrode-electrolyte-negative electrode assembly) and the operating conditions (air stoichiometric ratio and fuel utilization factor), as well as their impact on the performance of the single SOFC are discussed. Optimal geometric and operating parameters are obtained so that electrical power of the single SOFC at the nominal operating point is maximized. The method used is general and the fundamental optimization results are sharp, showing up to a 357% single SOFC performance variation within the studied parameters' range, therefore these findings show the potential to use the model as a tool for future SOFC design, simulation and optimization. © 2010 Elsevier B.V. All rights reserved.


Wanzeller W.G.,Federal University of Parana
Journal of Physics: Conference Series | Year: 2014

We analyzed the short-time behavior of percolation observables at three dimensional O(3) spin models. Following the Metropolis time evolution we can compare the magnetic and percolation order parameters. The magnetic order parameter evolves with a power law M ∼ tθ, as expected. However the percolation order parameter follows a different law. We explored this particularity and raised some hypothesis. This paper is a preliminar analysis on this subject. © Published under licence by IOP Publishing Ltd.


Waltrich M.,Federal University of Santa Catarina | Hermes C.J.L.,Federal University of Parana | Melo C.,Federal University of Santa Catarina
Applied Energy | Year: 2011

A model-driven design and optimization methodology for sizing the components of refrigeration cassettes for light commercial applications (i.e., cooling capacities ranging from 0.5 to 1.5. kW) is presented. Mathematical models were devised for each of the system components and their numerical results were compared with experimental data taken with different cassettes. It was found that the model predictions for the working pressures, power consumption, cooling capacity and coefficient of performance (COP) showed maximum deviations of ±10%. A genetic optimization algorithm was used to design the condenser and evaporator and also to select the compressor model based on an objective function which considers both the COP and cost. The optimization led to two improved cassette designs, which were assembled and tested. One of the optimized cassettes showed a COP/cost ratio approximately 50% higher than that of the baseline system. © 2011 Elsevier Ltd.


Manfredi G.,CNRS Institute of Genetics and of Molecular and Cellular Biology | Hervieux P.-A.,CNRS Institute of Genetics and of Molecular and Cellular Biology | Haas F.,Federal University of Parana
Classical and Quantum Gravity | Year: 2013

Using a variational approach based on a Lagrangian formulation and Gaussian trial functions, we derive a simple dynamical system that captures the main features of the time-dependent Schrödinger-Newton equations. With little analytical or numerical effort, the model furnishes information on the ground-state density and energy eigenvalue, the linear frequencies, as well as the nonlinear long-time behaviour. Our results are in good agreement with those obtained through analytical estimates or numerical simulations of the full Schrödinger-Newton equations. © 2013 IOP Publishing Ltd.


Mattos I.,Federal University of Rio de Janeiro | Mermudes J.R.M.,Federal University of Rio de Janeiro | Moura M.O.,Federal University of Parana
Zoologia | Year: 2014

Males of sexually dimorphic anthribid species display structural modifications that suggest sexual selection. Polyphenism, which is expressed through morphological and behavioral novelties, is an important component of the evolutionary process of these beetles. In this study, we endeavored to ascertain the presence of variations in selected monomorphic traits, polyphenism in males, and variation in structures associated with sexual dimorphism and allometric patterns in two species: Systaltocerus platyrhynus Labram & Imhoff, 1840 and Hypselotropis prasinata (Fahraeus, 1839). To that end, we used Principal Components Analysis (PCA) and Canonical Variate analysis (CVA) to statistically analyze 26 measurements of 91 specimens. The PCA discriminated three groups (females, major, and minor males) for S. platyrhinus, but only two groups (males and females) for H. prasinata. The same groups discriminated by the PCA for Systaltocerus were confirmed by the CVA analysis, indicating a highly significant variation separating the three groups. We also analyzed positive allometry with respect to prothorax length - independent variable by Reduced Major Axis (RMA). The allometric pattern indicated by most of the linear measurements was strong and corroborates a possible relationship between male polyphenism and the reproductive behavior of major and minor males. We believe that these patterns, in species that show both sexual dimorphism and male polyphenism, are associated with the behavior of defending the female during oviposition, performed by major males.


Pereira-Netto A.B.,Federal University of Parana
Trees - Structure and Function | Year: 2012

The treatment of in vitro-grown shoots of the marubakaido apple rootstock with 0.5 μg stigmasterol, an end-pathway sterol of the bifurcated sterol biosynthetic pathway, in 5 μL acetone per shoot led to a significant (p ≤ 0.05) enhancement of the multiplication rate (MR) from 5.1 (shoots treated with 5 μL acetone only) to 10.3. This increase in the MR was due to a significant enhancement of the number of newly formed main shoots suitable for micropropagation purposes (measuring at least 15 mm in length) from 2.6 to 3.3 per explant, and of the number of newly formed primary lateral shoots from 2.2 to 5.0 per explant as well. Shoots treated with stigmasterol at 0.5 and 2.5 μg per shoot presented primary and secondary lateral shoots with significantly (p ≤ 0.05) longer length compared to shoots treated with acetone only. These results provide an insight into the morphological responses of the marubakaido rootstock shoots to the treatment with an end-pathway sterol. To the best of my knowledge, this is the first report on the successful use of stigmasterol for the improvement of a micropropagation system. These results also demonstrate that stigmasterol-induced shoot proliferation is a low-cost and effective way to enhance the in vitro MR for the apple rootstock. © 2011 Springer-Verlag.


Queiroz-Telles F.,Federal University of Parana
Revista do Instituto de Medicina Tropical de Sao Paulo | Year: 2015

Summary Chromoblastomycosis (CMB) is a chronic fungal infection of the skin and the subcutaneous tissue caused by a transcutaneous traumatic inoculation of a specific group of dematiaceous fungi occurring mainly in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long term therapy with systemic antifungals, sometimes associated with physical methods. Unlike other neglected endemic mycoses, comparative clinical trials have not been performed for this disease. Nowadays, therapy is based on a few open trials and on expert opinion. Itraconazole either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been successfully employed in combination with antifungals in patients presenting with CBM. In the present revision the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient’s outcome. © 2015, Instituto de Medicina Tropical de Sao Paulo. All rights reserved.


Badin A.A.,Federal University of Parana | Barbi I.,Federal University of Santa Catarina
IEEE Transactions on Power Electronics | Year: 2011

This paper proposes an isolated three-phase rectifier power-factor correction using two single-phase buck preregulators in continuous conduction mode. The use of the Scott transformer renders a simple and robust rectifier to operate with unity power factor. With only two active switches, the rectifier is able to generate symmetrical currents in the line and a regulated voltage output without any necessary synchronous switches. The proposed control technique with sinusoidal pulse width modulation uses a feedforward of the output inductor current and only one voltage control regulates the output. Complete simulation results under closed-loop operation are given and a 12-kW prototype has been implemented in the laboratory, which demonstrated to operate successfully with excellent performance, and thus can feasibly be implemented in higher power applications. © 2010 IEEE.


Wen H.,Florida State University | Ordonez J.C.,Florida State University | Vargas J.V.C.,Federal University of Parana
Applied Thermal Engineering | Year: 2013

This paper improves previously published models by the authors for a single solid oxide fuel cell (SOFC), and introduces a procedure to optimize its external configuration and operating conditions, so that the net power is maximized. The previous models are hereby improved to include: i) a constant offset overpotential in total potential drop; ii) heat generation associated with all the potential losses; iii) temperature-dependent thermo-physical properties of fuel and air, and iv) pumping power to maximize fuel cell performance. The thermodynamic model is derived from physical laws (e.g., the first law of thermodynamics, Fick's law, Fourier's law) to obtain the temperature and pressure spatial distribution in the SOFC. The electrochemical model is validated by direct comparison with experimental data from the Pacific Northwest National Laboratory (PNNL), and allows for the computation of the SOFC voltage, current, and power output. Based on the simulation results, the structural design, the active three phase boundaries regions at the electrodes and the fuel utilization factor, and their impact on the SOFC performance are discussed. Subjected to fixed total volume, the optimal geometric and operating parameters are pursued so that the net power of the SOFC is maximized through a 4-way-optimization procedure. The method used is general and the numerically obtained maxima are sharp, taking into account that up to a 631% single SOFC performance variation was observed within the studied parameters' range. The fixed volume constraint was then relaxed, and the effect of total volume variation on performance was investigated, delivering the general optimal parameters for the 4-way maximized SOFC net power output within the studied total dimensionless fuel cell volume range. These findings show the potential to use the model as a tool for future SOFC design, simulation and optimization. © 2012 Elsevier Ltd. All rights reserved.


Mitishita R.S.,Federal University of Technology of Parana | Barreira E.M.,Federal University of Technology of Parana | Negrao C.O.R.,Federal University of Technology of Parana | Hermes C.J.L.,Federal University of Parana
Applied Thermal Engineering | Year: 2013

An optimization methodology aiming at energy and cost savings in frost-free refrigerators is advanced. A steady-state simulation model was devised and its predictions for energy consumption were compared with experimental data obtained elsewhere, with differences not exceeding a +/- 9% error band. The model was used to find out the evaporator air flow rate, the number of evaporator and condenser fins, the compressor size and efficiency, and the insulation thicknesses of both fresh- and frozen-food compartments which yield the minimum energy consumption when the total cost is constrained. The optimization led to a refrigeration system with energy consumption 18% lower than that observed for the baseline system without any cost penalty. The system performance for four different compressors, including a high efficiency, a large capacity and a variable-speed one, was also analyzed. For the refrigerator under analysis, it was found that, to ensure an economically feasible design, the variable-speed compressor should not cost 26% more than a single-speed one with the same piston displacement. © 2012 Elsevier Ltd. All rights reserved.


Guzzi A.,Federal University of Piaui | Favretto M.A.,Federal University of Parana
Neotropical Biology and Conservation | Year: 2014

Forest fragmentation is the main process of destruction of the Atlantic Forest that creates heterogeneous environments that affect the structure and stability of ecological communities. The present study aimed to characterize the bird communityin a riparian forest remnant along the Chapecozinho river, in southern Brazil, between 2006 and 2009. The birds were analyzed for their predominant diet, preferential habitat, frequency of occurrence and relative abundance. One hundred and five species of birds were recorded. The seasons with highest species richness were spring 2007 and winter 2008. The more representative trophic categories were insectivorous (n=44), omnivorous (n=29) and frugivorous (n=10). Most species were classified as forest birds (n=48). The results showed that the forest remnant may be suffering fromanthropogenic pressures because: (1) seasonal patterns were not verified; (2) generalists and species from open areas were more dominant, such as Guira guia (RA=2,81%), Pyrrhura frontalis (RA=2,66%) and Theristicus caudatus (RA=2,51%). The significant number of omnivores in the area of study corroborates other studies in the region, suggesting that the area suffered environmental changes. © 2014 by Unisinos.


Almeida E.A.B.,University of Sao Paulo | Almeida E.A.B.,Cornell University | Pie M.R.,Federal University of Parana | Brady S.G.,Smithsonian Institution | Danforth B.N.,Cornell University
Journal of Biogeography | Year: 2012

Aim The evolutionary history of bees is presumed to extend back in time to the Early Cretaceous. Among all major clades of bees, Colletidae has been a prime example of an ancient group whose Gondwanan origin probably precedes the complete break-up of Africa, Antarctica, Australia and South America, because modern lineages of this family occur primarily in southern continents. In this paper, we aim to study the temporal and spatial diversification of colletid bees to better understand the processes that have resulted in the present southern disjunctions. Location Southern continents. Methods We assembled a dataset comprising four nuclear genes of a broad sample of Colletidae. We used Bayesian inference analyses to estimate the phylogenetic tree topology and divergence times. Biogeographical relationships were investigated using event-based analytical methods: a Bayesian approach to dispersal-vicariance analysis, a likelihood-based dispersal-extinction-cladogenesis model and a Bayesian model. We also used lineage through time analyses to explore the tempo of radiations of Colletidae and their context in the biogeographical history of these bees. Results Initial diversification of Colletidae took place at the Late Cretaceous (≥70Ma). Several (6-14) lineage exchanges between Australia and South America via Antarctica during the Late Cretaceous and Eocene epochs could explain the disjunctions observed between colletid lineages today. All biogeographical methods consistently indicated that there were multiple lineage exchanges between South America and Australia, and these approaches were valuable in exploring the degree of uncertainty inherent in the ancestral reconstructions. Biogeographical and dating results preclude an explanation of Scrapterinae in Africa as a result of vicariance, so one dispersal event is assumed to explain the disjunction in relation to Euryglossinae. The net diversification rate was found to be highest in the recent history of colletid evolution. Main conclusions The biogeography and macroevolutionary history of colletid bees can be explained by a combination of Cenozoic vicariance and palaeoclimatic changes during the Neogene. The austral connection and posterior break-up of South America, Antarctica and Australia resulted in a pattern of disjunct sister lineages. Increased biome aridification coupled with floristic diversification in the southern continents during the Neogene may have contributed to the high rates of cladogenesis in these bees in the last 25-30 million years. © 2011 Blackwell Publishing Ltd.


Hermes C.J.L.,Federal University of Parana | Melo C.,Federal University of Santa Catarina | Knabben F.T.,Federal University of Santa Catarina
Applied Thermal Engineering | Year: 2013

This paper outlines an alternative test method to evaluate the energy consumption of frost-free refrigerators and freezers for residential applications. While the standardized methods require the refrigerating appliance to be kept running according to its onboard control system, which usually drives the refrigerator through an on-off cycling pattern, the proposed approach assesses the refrigerator energy performance in the steady-state regime, being therefore much faster and more reliable. In this procedure, the cooling capacity is matched to the cooling loads by PID-controlled electrical heaters installed within the refrigerated compartments, so that the compartment temperatures are kept at the desired standardized levels. Comparisons between the experimental results obtained using the steady-state energy test and the standardized procedures showed that the former follows closely the trends observed for the latter. © 2012 Elsevier Ltd. All rights reserved.


Da Silveira Firmiano E.G.,Federal University of Sao Carlos | Rabelo A.C.,Federal University of Sao Carlos | Dalmaschio C.J.,Federal University of Sao Carlos | Pinheiro A.N.,Federal University of Sao Carlos | And 3 more authors.
Advanced Energy Materials | Year: 2014

Layered molybdenum disulfide (MoS2) is deposited by microwave heating on a reduced graphene oxide (RGO). Three concentrations of MoS 2 are loaded on RGO, and the structure and morphology are characterized. The first layers of MoS2 are detected as being directly bonded with the oxygen of the RGO by covalent chemical bonds (Mo-O-C). Electrochemical characterizations indicate that this electroactive material can be cycled reversibly between 0.25 and 0.8 V in 1 m HClO4 solution for hybrids with low concentrations of MoS2 layers (LCMoS 2/RGO) and between 0.25 and 0.65 V for medium (MCMoS2/RGO) and high concentrations (HCMoS2/RGO) of MoS2 layers on graphene. The specific capacitance measured values at 10 mV s-1 are 128, 265, and 148 Fg-1 for the MoS2/RGO with low, medium, and high concentrations of MoS2, respectively, and the calculated energy density is 63 W h kg-1 for the LCMoS2/RGO hybrid. This supercapacitor electrode also exhibits superior cyclic stability with 92% of the specific capacitance retained after 1000 cycles. Investigation of MoS2 synthesized on reduced graphene oxide (RGO) reveals that the first layers are directly bonded on to oxygen groups of the RGO surface, resulting in good supercapacitive properties. These results provide an important step toward application of this system as a supercapacitor, demonstrating that it is possible to improve supecapacitive properties by controlling the MoS 2 concentration. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Dos Santos T.H.,Federal University of Parana | Goedtel A.,Federal University of Technology | Da Silva S.A.O.,Federal University of Technology | Suetake M.,Federal University of Sao Carlos
Electric Power Systems Research | Year: 2014

The induction motor plays a key role in many industrial sectors, primarily due to its robustness and low cost. When the load coupled to the motor axis requires speed control, some of the drive and control strategies are based on the estimated axis speed of the motor. The direct measurement of this quantity reduces its robustness and increases the driver implementation cost. This paper proposes an alternative methodology for estimating the speed of a three phase induction motor driven by a voltage source inverter, using space vector modulation under the scalar control strategy and based on artificial neural networks. To validate the performance of the proposed method under motor load torque and speed reference set point variations, simulation and experimental results are presented. © 2013 Elsevier Ltd. All rights reserved.


Cortes J.E.,University of Texas M. D. Anderson Cancer Center | Kantarjian H.M.,University of Texas M. D. Anderson Cancer Center | Brummendorf T.H.,RWTH Aachen | Brummendorf T.H.,Universitats Klinikum Hamburg Eppendorf | And 12 more authors.
Blood | Year: 2011

Bosutinib, a dual Src/Abl kinase inhibitor, has shown potent activity against chronic myeloid leukemia (CML). In this phase 1/2 study we evaluated bosutinib in patients with chronic phase imatinib-resistant or imatinib-intolerant CML. Part 1 was a dose-escalation study to determine the recommended starting dose for part 2; part 2 evaluated the efficacy and safety of bosutinib 500 mg once-daily dosing. The study enrolled 288 patients with imatinib-resistant (n = 200) or imatinib-intolerant (n = 88) CML and no other previous kinase inhibitor exposure. At 24 weeks, 31% of patients achieved major cytogenetic response (primary end point). After a median follow-up of 24.2 months, 86% of patients achieved complete hematologic remission, 53% had a major cytogenetic response (41% had a complete cytogenetic response), and 64% of those achieving complete cytogenetic response had a major molecular response. At 2 years, progression-free survival was 79%; overall survival at 2 years was 92%. Responses were seen across Bcr-Abl mutants, except T315I. Bosutinib exhibited an acceptable safety profile; the most common treatment-emergent adverse event was mild/moderate, typically self-limiting diarrhea. Grade 3/4 nonhematologic adverse events (> 2% of patients) included diarrhea (9%), rash (9%), and vomiting (3%). These data suggest bosutinib is effective and tolerable in patients with chronic phase imatinib-resistant or imatinib-intolerant CML. This trial was registered at http://www.clinicaltrials. gov as NCT00261846. © 2011 by The American Society of Hematology.


Paiva E.S.,Federal University of Parana | Jones K.D.,Oregon Health And Science University
Best Practice and Research: Clinical Rheumatology | Year: 2010

Fibromyalgia (FM) is a challenging condition, but the management of patients with FM is becoming facilitated by new medications that act in what are thought to be some of most important pathophysiological features in this syndrome. However, it is of pivotal importance that an interdisciplinary approach is used to improve pain, fatigue, sleep and other domains to improve quality of life. Here, we present elements of management that the solo practitioner can tackle, focussing in the formally approved drugs for FM and other drugs commonly used in this condition. Further, the elements of an ideal multidisciplinary team are presented, and on how to incorporate their recommendations for the treatment of FM. © 2009 Elsevier Ltd. All rights reserved.


Barauce Bento P.C.,Federal University of Parana
Revista Brasileira de Cineantropometria e Desempenho Humano | Year: 2010

Falls are associated with morbidity and mortality in older adults. The aim of this systematic RE was to identify, describe and analyze the effects of physical exercise programs on the reduction of the risk of falls in adults above the age of 60. For this purpose, the Medline/ Pubmed, Lilacs, and SciELO databases available at the site of the Latin American Center of Information in Health Sciences (BIREME) were searched for articles comprising the period between 1999 and 2009 using the following keywords: accidental falls, elderly, exercise. A total of 385 publications were identified and 10 articles that met the criteria established in this study were selected. Strength and balance activities were the most frequent components of the exercise programs, in addition to coordination, flexibility and aerobic exercise. However, there was no clear information regarding the frequency, duration and intensity of the sessions. It was concluded that programs combining strength and balance components with other interventions, performed at least twice a week, and monitoring the participants for 3 to 6 months after intervention were the most effective in reducing and preventing falls in older adults. However, a more detailed presentation of some methodological aspects is necessary to permit the reproduction of these studies and the comparison of their results.


Salvador E.P.,University of Sao Paulo | Reis R.S.,Pontiff Catholic University of Parana | Reis R.S.,Federal University of Parana | Florindo A.A.,University of Sao Paulo
International Journal of Behavioral Nutrition and Physical Activity | Year: 2010

Background: The aim of this study was analyze associations between the practice of walking and environmental perception among elderly Brazilians in a region of low socioeconomic level.Methods: A cross-sectional study was conducted among 385 elderly people aged 60 years and over. To evaluate walking, the International Physical Activity Questionnaire (IPAQ), long version (leisure and transport modules) was used. The environment was evaluated by means of the Neighborhood Environmental Walkability Scale (NEWS) (adapted Brazilian version). For the statistical analysis, multiple logistic regression models were created separately for men and women. The practice of at least 150 minutes a week of walking was the dependent variable, and the variables of environmental perception were the independent variables. All the models were controlled for schooling level and age.Results: The proportion of elderly people active in walking was 56.9% for the men and 26.4% for the women. The perception of the presence of soccer fields (OR = 4.12) and their proximity, within ten minutes' walk from home (OR = 3.43), were associated with the practice of walking among the men. The perception of the presence of public squares (OR = 4.70) and the proximity of primary healthcare units, within ten minutes' walk from home (OR = 3.71), were associated with the practice of walking among the women. An association with adequate perception of vehicle traffic remained at the threshold of significance for the women.Conclusion: Accessibility of leisure structures such as football fields and public squares and of health services such as primary healthcare units were important environmental variables associated with the practice of walking among elderly people living in a region of low socioeconomic level in Brazil. These variables need to be taken into consideration when aiming to promote the practice of walking among elderly people living in similar regions. © 2010 Salvador et al; licensee BioMed Central Ltd.


McKerr M.,Queens University of Belfast | Kourakis I.,Queens University of Belfast | Haas F.,Federal University of Parana
Plasma Physics and Controlled Fusion | Year: 2014

The occurrence of rogue waves (freak waves) associated with electrostatic wavepacket propagation in a quantum electron-positron-ion plasma is investigated from first principles. Electrons and positrons follow a Fermi-Dirac distribution, while the ions are subject to a quantum (Fermi) pressure. A fluid model is proposed and analyzed via a multiscale technique. The evolution of the wave envelope is shown to be described by a nonlinear Schrödinger equation (NLSE). Criteria for modulational instability are obtained in terms of the intrinsic plasma parameters. Analytical solutions of the NLSE in the form of envelope solitons (of the bright or dark type) and localized breathers are reviewed. The characteristics of exact solutions in the form of the Peregrine soliton, the Akhmediev breather and the Kuznetsov-Ma breather are proposed as candidate functions for rogue waves (freak waves) within the model. The characteristics of the latter and their dependence on relevant parameters (positron concentration and temperature) are investigated. © 2014 IOP Publishing Ltd.


Rosario N.,Federal University of Parana | Bielory L.,Rutgers University
Current Opinion in Allergy and Clinical Immunology | Year: 2011

Purpose of Review: To describe currently available epidemiological data on the prevalence of allergic conjunctivitis. Allergic conjunctivitis is often underdiagnosed and consequently undertreated except when it is severe and the chief complaint of a consultation in a specialty clinic. Use of healthcare resources and reduced quality of life of affected individuals justify studies on the prevalence of allergic conjunctivitis. Recent Findings: The association of allergic nasal and ocular symptoms (rhinoconjunctivitis) is common. Most children with allergic conjunctivitis have allergic rhinitis. Older population studies estimate a prevalence of 15-20% of allergic conjunctivitis, but more recent studies implicate rates as high as 40%. Ocular symptoms are common and contribute to the burden of allergic rhinitis and lower quality of life. Ocular allergies rank a very close second and at times may overcome the primary complaints of nasal congestion in rhinoconjunctivitis patients. Summary: Little focus has been set on the impact of allergic conjunctivitis as comorbidity to asthma and rhinitis in atopic patients. Conjunctivitis symptoms are at least as severe as rhinitis symptoms in patients with 'hay fever' and some have even generated the term of conjunctivorhinitis stressing the ocular symptoms. Prevalence studies should be specifically addressed to ocular allergy symptoms. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.


Da Silva R.,Federal University of Santa Catarina | Rego L.G.C.,Federal University of Santa Catarina | Freire J.A.,Federal University of Parana | Rodriguez J.,Comision Nacional de la Energia Atomica | And 2 more authors.
Journal of Physical Chemistry C | Year: 2010

The structural, energetic, and electronic properties of the TiO 2-electrolyte interface in dye-sensitized solar cells is studied by molecular dynamics simulations and electronic structure calculations. The investigation enlightens the mechanisms responsible for the recombination of photoelectrons with redox species in the electrolyte (back-reaction effect), taking into account the important influence of surface defects, the underlying solvent dynamics, and the presence of pyridine additives at the interface. The free-energy barrier for the adsorption of redox species at the TiO2 surface is calculated. Electronic structure calculations of the TiO 2/redox/solvent system evidence the distinct recombination mechanisms for the different redox species. The study provides a deeper insight on the molecular processes taking place at the interface and should stimulate further theoretical and experimental investigations. © 2010 American Chemical Society.


Pinto-Zevallos D.M.,Mtt Agrifood Research Finland | Pinto-Zevallos D.M.,Federal University of Parana | Vanninen I.,Mtt Agrifood Research Finland
Crop Protection | Year: 2013

Yellow sticky traps (YSTs) are a key component of IPM programmes for several greenhouse pests. The development of YST-based decision-making tools, e.g. sampling protocols and economic thresholds (ETs), however, has been limited. This review assesses to what extent YST-counts comply with the four criteria of effective sampling (reliability, representativeness, relevance and practicality) as described by Binns et al. (2000) in an attempt to understand the feasibility of designing YST-based decision-making tools for managing whiteflies in greenhouse crops, particularly tomato (Lycopersicon esculentum Mill) and cucumber (Cucumis sativus L.). Many factors are known to affect whitefly flight behaviour and thus, trap catches. The possibility of manipulating such factors to improve YST efficiency and reliability or of interpreting whitefly catches in YSTs with automated tools is discussed. A few studies have shown the correlation between trap and direct visual pest counts from plants. These studies are discussed in the context of whiteflies and trap densities to enhance the representativeness of sampling with YSTs. Relevance implies that the results of sampling reflect crop loss to a sufficient degree. Only few YSTs-based action thresholds have been suggested in the literature, particularly for use with chemical control. There are a number of approaches and technological innovations that can improve the practicality of YSTs by decreasing the effort and time associated with counting insects, a method to facilitate the identification of species in mixed populations on the trap, and sampling methods such as sequential sampling for calculating appropriate sample size, which have been already put in practice to develop YSTs-based sampling protocols. Knowledge gaps are identified and discussed, and a route map for further research to advance YSTs as a decision-making tool is outlined, with geostatistical methods as the recommended approach for further increasing the usefulness of YSTs-based decision-making. © 2013 Elsevier Ltd.


Marques Jr. W.,Federal University of Parana | Mendez A.R.,Metropolitan Autonomous University
Physica A: Statistical Mechanics and its Applications | Year: 2013

Based on a Boltzmann-like traffic equation for aggressive drivers we construct in this paper a second-order continuum traffic model which is similar to the Navier-Stokes equations for viscous fluids by applying two well-known methods of gas-kinetic theory, namely the Chapman-Enskog method and the method of moments of Grad. The viscosity coefficient appearing in our macroscopic traffic model is not introduced in an ad hoc way-as in other second-order traffic flow models-but comes into play through the derivation of a first-order constitutive relation for the traffic pressure. Numerical simulation shows that our Navier-Stokes-like traffic model satisfies the anisotropy condition and produces numerical results which are consistent with our daily experiences in real traffic. © 2013 Elsevier B.V. All rights reserved.


Padilha J.E.,Federal University of Parana | Pontes R.B.,Federal University of Goais
Solid State Communications | Year: 2016

Ab initio electronic structure and transport calculations of 2D hexagonal germanium with four possible structural defects were performed. The considered defects were Stone-Wales (SW), single vacancy (5-9) and two divacancies (5-8-5 and 555-777). We showed that these defects present a local reconstruction that can be clearly identified by STM images. Among the investigated defects, we verified that the SW defect has the lowest formation energy. We showed that in the presence of structural defects the 2D hexagonal germanium maintains its Dirac cone feature only for the single vacancy. The divacancies and the SW defect destroy the linear dispersion relation of the electrons, near the Fermi level, in this system. Moreover, we verified that these defects create scattering centers, which can lead to diminishing of the current by roughly 42% for the Stone-Wales and single vacancy, 55% for the divacancy 5-8-5 and 68% for the 555-777 divacancy. © 2015 Elsevier B.V. All rights reserved.


Rios E.d.C.,Ceramica Centro Multidisciplinar para o Desenvolvimento | Viana Rosario A.,Ceramica Centro Multidisciplinar para o Desenvolvimento | Flavia Nogueira A.,University of Campinas | Micaroni L.,Federal University of Parana
Solar Energy Materials and Solar Cells | Year: 2010

In this paper, the electrochemical properties of poly(3-methylthiophene) (PMT), poly(3,4-ethylenedioxythiophene) (PEDOT) and niobium pentoxide (Nb 2O 5) films deposited on ITO are described. PMT films were made by galvanostatic electrodeposition. PEDOT and Nb 2O 5 were deposited by spin-coating from a suspension, in the case of PEDOT, and from a precursor solution obtained by the Pechini method, for Nb 2O 5. Three electrochromic devices were assembled from these films, with different arrangements of electrodes, using poly(epichlorohydrin-co-ethylene oxide) (P(EPI-EO))+LiClO 4 as the polymer electrolyte. The PMT films were employed as the working electrode (E 1) and PEDOT, Nb 2O 5 or ITO as counter-electrodes (E 2). The devices showed color changes from red to blue in response to the applied potential from -1.5 to +1.5 V (PMT vs. E 2), respectively. The transmittance variation was measured in the visible region (λ=650 nm) during the polarization. The systems were also characterized with respect to their coulombic efficiency (CE), electrochromic efficiency (η) and response time (τ). The three devices gave similar results, as follows: CE of 107%, η from 92 to 126 cm 2 C -1 and τ∼2 s. The cycle life and optical memory were also analyzed and the devices showed good durability for 1000 cycles and good optical memory, demonstrating the potential applicability of the electrochromic devices presented here. © 2010 Elsevier B.V. All rights reserved.


Dartora C.A.,Federal University of Parana | Cabrera G.G.,University of Campinas
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2010

The non-relativistic Pauli-Schrödinger theory has a richer gauge structure than usually expected, being invariant under the U (1) × SU (2) gauge group, which allows to define spin-current density vectors and obtains the relevant conserved quantities from Noether's theorem. The electromagnetic fields E and B play the role of the gauge potentials for the SU (2) sector of the gauge group and can possibly contribute with a corresponding invariant curvature self-energy term in the Lagrangian density. From the dynamics of the U (1) and SU (2) gauge fields we show that electric fields can be induced by spin-currents originated from the SU (2) gauge symmetry. © 2010 Elsevier B.V. All rights reserved.


Dartora C.A.,Federal University of Parana | Cabrera G.G.,University of Campinas
Annals of Physics | Year: 2010

The experiment by Collela et al. (1975) [1] evidenced in a striking manner how the gravitational field appears in quantum mechanics. Within the modern framework of gauge theories, one can ascribe such effect as due to gauge fields originated from fundamental symmetries of spacetime: local transformations of the Lorentz-Poincaré group. When this gauge principle is applied to the Dirac equation, we obtain kinematical correlations between the gravitational field and the spin of the particles. The phenomenon is similar to the spin Hall effect found in condensed matter systems, although much smaller in magnitude. Actual measurements may require highly precision interferometric techniques with spin-polarized neutrons. © 2010 Elsevier Inc.


Sharipov F.,Federal University of Parana | Graur I.A.,Aix - Marseille University
Vacuum | Year: 2012

A rarefied gas flow through a channel of zigzag shape is calculated over the wide range of the gas rarefaction and for several values of the aspect ratio applying the linearized kinetic equation. In the hydrodynamic flow regime, the kinetic solution is compared with that obtained from the Stokes equation. An approach to calculate a flow rate through a chain composed from an arbitrary number of zigzags is proposed. It was found that in some situations, the flow rate through a zigzag channel is higher than that trough a straight channel of the same length. © 2012 Elsevier Ltd. All rights reserved.


Hermes C.J.L.,Federal University of Parana
International Journal of Heat and Mass Transfer | Year: 2012

This paper advances an algebraic first-principles simulation model to predict the frost growth and densification on flat surfaces. The model was put forward based on macroscopic heat and mass balances in the frost layer, which were written according to a dimensionless formulation and solved analytically to obtain an algebraic expression for the time evolution of the frost thickness as a function of the Nusselt number, the supersaturation degree and the air-to-surface temperature difference. The model predictions for the frost thickness were compared with experimental data obtained elsewhere, when a very good agreement between calculated and measured counterparts was observed. The sensitivity of the frost growth rate to key heat and mass transfer parameters is also assessed and reported. © 2012 Elsevier Ltd. All rights reserved.


Ribas M.O.,Faculdades Integradas Espirita | Kremer G.M.,Federal University of Parana
Gravitation and Cosmology | Year: 2010

The accelerated-decelerated transition in a primordial Universe is investigated by using the dynamics of fermion fields within the context of the Einstein-Cartan theory, where, apart from the curvature, the space-time is also described by a torsion field. The model analyzed here has only a fermion field as a source of the gravitational field. The term associated with the spin of the fermion field plays the role of an inflaton which contributes to an accelerated regime whereas the one related to the fermion mass behaves as a matter field and is responsible for a decelerated regime. Hence, by taking into account the spin of a massive fermion field, it is possible to characterize the transition from an accelerated to a decelerated period of the primordial Universe. © 2010 Pleiades Publishing, Ltd.


Lacerda M.R.,Federal University of Parana
Revista brasileira de enfermagem | Year: 2011

Bibliographic research developed among the 24 fascicles from the "Revista Brasileira de Enfermagem" presented in the SciELO database, from 2005 to 2008. The objective was to identify emergent themes on qualitative researches published on a nursing periodic; correlate theses themes with the knowledge production in nursing and reflect about the social role of these qualitative researches analyzed. After analysis, 173 qualitative studies were identified, and three categories arose: nursing training, areas of practice, nursing care basis/ principles/ conceptions, and professional issues. In the relationship among the categories, the patterns of knowledge and the social role highlight the social-political knowledge, reflecting the profession maturation regarding intrinsic social issues, part of it social body; and extrinsic, the demands from society.


Zhang T.,Federal University of Parana | Tao Z.,Henan Polytechnic University
Computers and Mathematics with Applications | Year: 2015

In the paper we consider the penalty finite element method for the stationary incompressible magnetohydrodynamics (MHD) problem with a factor of penalty parameter. Stability and convergence of numerical solutions are established. Furthermore, two level penalty methods are also developed for the MHD problem. Our methods consist of solving a nonlinear MHD problem by the usual penalty method on a coarse mesh with mesh size. H, and then a linearized MHD problem based on the Stokes, Newton and Oseen iterations on a fine mesh is solved by the penalty method with mesh size. h(h≪H), respectively. Stability and error estimates of numerical solutions in two level penalty methods are presented. Finally, some numerical tests are provided to demonstrate the effectiveness of the developed algorithms. © 2015 Elsevier Ltd.


Rego L.G.C.,Federal University of Santa Catarina | Da Silva R.,Federal University of Santa Catarina | Freire J.A.,Federal University of Parana | Snoeberger R.C.,Yale University | Batista V.S.,Yale University
Journal of Physical Chemistry C | Year: 2010

We combine ab initio DFT molecular dynamics simulations and quantum dynamics propagation of transient electronic excitations to investigate visible light sensitization of TiO2-anatase surfaces by covalent attachment of derivatized aluminum tris-(8-hydroxyquinoline) (Alq3) complexes. Hydroxylated arylquinoline and benzoquinoline ligands are introduced as robust anchoring groups to form Alq3/TiO2 molecular assemblies. We show that photoexcitation of the resulting surface complexes with visible light triggers ultrafast interfacial electron injection into the TiO2 host substrate. Furthermore, we show that derivatization of the Alq3/TiO2 surface complexes with oligothiophenes should hinder electron-hole pair recombination after photoinduced interfacial electron transfer. These findings are particularly relevant to the development of molecular based photo-optic devices based on the general class of metaloquinolate complexes Mq3, with q = 8-hydroxyquinoline and M = Al, Zn, Ga, and In, which have already attracted significant interest in the development of new technologies. © 2010 American Chemical Society.


Galiceanu M.,Federal University of Parana
Journal of Physics A: Mathematical and Theoretical | Year: 2010

We focus on the generalized Husimi cacti, which are dual structures to the dendrimers but, distinct from the latter, contain loops. We determine their complete spectra by making use of the normal mode analysis. These spectra have been used in computing some physical quantities, such as the averaged monomer displacement and the mechanical relaxation moduli with its two components: the storage and the loss modulus. We also study the dynamics of Husimi cacti in solutions, introducing the hydrodynamic interactions in a preaveraged Oseen fashion, the so-called Zimm model. We observe that the relaxation quantities mentioned above do not scale, in the presence or in the absence of the hydrodynamic interactions. Our results show that all the relaxation forms depend on the number of monomers in the networks in the absence of the hydrodynamic interactions (Rouse model), while by taking into account the hydrodynamic interactions the results do not vary too much. © 2010 IOP Publishing Ltd.


Dal Pupo J.,Federal University of Santa Catarina | Gheller R.G.,Federal University of Santa Catarina | Dias J.A.,Federal University of Santa Catarina | Rodacki A.L.F.,Federal University of Parana | And 2 more authors.
Journal of Science and Medicine in Sport | Year: 2014

Objectives: To determine the test-retest reliability and concurrent validity of the 30-s continuous jump (CJ30) test using the Wingate test as a reference. Design: Descriptive validity study. Methods: Twenty-one male volleyball players (23.8±3.8 years; 82.5±9.1kg; 185±4.7cm) were tested in three separate sessions. The first and second sessions were used to assess the reliability of the CJ30 while in the third session the Wingate test was performed. In the continuous jump test, consisting of maximal continuous jumps performed for 30s, jump height was determined by video kinematic analysis. Blood samples were collected after each test to determine lactate concentration. Results: The CJ30 showed excellent test-retest reliability for the maximal jump height (ICC=0.94), mean vertical jump height (ICC=0.98) and fatigue index (ICC=0.87). Peak lactate showed moderate reliability (ICC=0.45). Large correlations were found between the mean height of the first four jumps of CJ30 and the peak power of the Wingate (r=0.57), between the mean vertical jump height of CJ30 and the mean power of the Wingate (r=0.70) and between the lactate peak of CJ30 and Wingate (r=0.51). A moderate correlation of fatigue index between CJ30 and the Wingate was found (r=0.43). Conclusions: The continuous jump is a reliable test and measures some of the same anaerobic properties as WAnT. The correlations observed in terms of anaerobic indices between the tests provide evidence that the CJ30 may adequately assess anaerobic performance level. © 2013 Sports Medicine Australia.


Luhm K.R.,University of Sao Paulo | Luhm K.R.,Federal University of Parana | Cardoso M.R.A.,University of Sao Paulo | Waldman E.A.,University of Sao Paulo
Revista de Saude Publica | Year: 2011

Objective: To evaluate the immunization program for 12 and 24-month-old children based on electronic immunization registry. Methods: A descriptive study of a random sample of 2,637 children born in 2002 living in the city of Curitiba, Southern Brazil was performed. Data was collected from local electronic immunization registers and the National Live Birth Information System, as well as from a household survey for cases with incomplete records. Coverage at 12 and 24 months was estimated and analyzed according to the socioeconomic characteristics of each administrative district and the child's enrollment status in the health care service. The coverage, completeness, and record duplication in the registry were analyzed. Results: Coverage of immunization was 95.3% at 12 months, with no disparities among administrative districts, and 90.3% at 24 months, with higher coverage in a district with lower socioeconomic conditions (p < 0.01). The proportion of vaccines, according to type, given before and after the recommended age reached 0.9% and 32.2%, respectively. In the surveyed sample, electronic immunization registry coverage was 98%, underreporting of vaccine doses was 11%, and record duplication was 20.6%. Groups with highest coverage included children with permanent records, children with three or more appointments through the National Unified Health Care System, and children seen within Primary Health Care Facilities fully adopting the Family Health Strategy. Conclusions: Vaccination coverage in Curitiba was high and homogeneous among districts, and health service enrollment status was an important factor in these results. The electronic immunization registry was a useful tool for monitoring vaccine coverage; however, it will be important to determine cost-effectiveness prior to wide-scale adoption by the National Immunization Program.


The Brazilian Unified Health Care System (SUS) offers treatment for patients with RA through federal funding (Ministry of Health) and state co-financing. The Clinical Protocol and Therapeutic Guidelines for the treatment of rheumatoid arthritis describe the therapeutic regimen for the disease, including the anticytokines adalimumab, etanercept or infliximab. The aim of this study was to evaluate the profile of registered users of those anticytokines, biologics registered in the Information System of the Pharmaceutical Assistance Specialized Division, managed by the Paraná State Drug Center. A cross-sectional study regarding data from March 2010 was conducted. Based on dispensation data, information regarding the following variables were collected: age; gender; regional health care centers; International Classification of Diseases (ICD); and drug dispensed. In addition, the monthly cost with anticytokines for the SUS was calculated. In the state of Paraná, 923 patients on anticytokines were identified, 40%, 44% and 16% of whom receiving adalimumab, etanercept and infliximab, respectively. This generated a monthly cost of R$3,403,195.59. Regarding the ICD, the distribution of patients was as follows: 55% had ICD M05.8; 27%, ICD M06.0; 9%, ICD M6.8; 8%, ICD M5.0; and 1% had other ICDs related to the disease. The regional health care centers of the state of Paraná with the largest number of patients on anticytokines were in the following municipalities: Ponta Grossa; Cornélio Procópio; Londrina; Cianorte; Maringá; Irati; and Campo Mourão. This study assessed the distribution and profile of users of anticytokines for the rheumatoid arthritis treatment covered by the SUS in the state of Paraná, in March 2010.


Kremer L.P.,Federal University of Santa Catarina | da Rocha R.M.,Federal University of Parana
Biological Invasions | Year: 2016

Predation may often influence native species dynamics and so may be important for the control of introduced species as well. Here, we examine how predation can regulate fouling communities on artificial substrates in the coast of Brazil. Specifically, we tested whether predators limit colonization and establishment of introduced species. A predation experiment using plastic plates as experimental replicates (predator excluded and not excluded) was carried out in Ceará, Bahia, São Paulo and Santa Catarina, between 3°S and 27°S. Ninety-eight species colonized the plates, 14 of which were introduced. While species richness was similar among the treatments (except in Santa Catarina), community structure varied by treatment and introduced species were less abundant in the predation treatment at all sites. Also, predation was selective and controlled introduced, poorly defended, species, specifically ascidians. Thus, biotic resistance driven by predation was not ubiquitous but apparently targets one group of major economic and environmental impact. As a consequence, introduced barnacles were released from competition with dominant ascidians and thus the ecosystem service (biotic resistance) performed by fish alone was unable to completely avoid or control the introduction of non-native species. Control measures must rely on various approaches, but if we want fish to contribute in this control, it is very important to conserve the local native assembly of predators in order to reap their benefits in this ecosystem service. © 2016 Springer International Publishing Switzerland


Tierney S.M.,Smithsonian Tropical Research Institute | Sanjur O.,Smithsonian Tropical Research Institute | Grajales G.G.,Smithsonian Tropical Research Institute | Santos L.M.,Federal University of Parana | And 2 more authors.
Proceedings of the Royal Society B: Biological Sciences | Year: 2012

Most bees rely on flowering plants and hence are diurnal foragers. From this ancestral state, dim-light foraging in bees requires significant adaptations to a new photic environment. We used DNA sequences to evaluate the phylogenetic history of the most diverse clade of Apoidea that is adapted to dim-light environments (Augochlorini: Megalopta, Megaloptidia and Megommation). The most speciose lineage, Megalopta, is distal to the remaining dim-light genera, and its closest diurnal relative (Xenochlora) is recovered as a lineage that has secondarily reverted to diurnal foraging. Tests for adaptive protein evolution indicate that long-wavelength opsin shows strong evidence of stabilizing selection, with no more than five codons (2%). under positive selection, depending on analytical procedure. In the branch leading to Megalopta, the amino acid of the single positively selected codon is conserved among ancestral Halictidae examined, and is homologous to codons known to influence molecular structure at the chromophorebinding pocket. Theoretically, such mutations can shift photopigment λ max sensitivity and enable visual transduction in alternate photic environments. Results are discussed in light of the available evidence on photopigment structure, morphological specialization and biogeographic distributions over geological time. © 2011 The Royal Society.


Antoniuk S.A.,Federal University of Parana
Revista de Neurologia | Year: 2013

Acute muscle weakness, a common disorder in pediatrics, can occur from impairment of any part of the motor unit, including the upper motor neuron, lower motor neuron, peripheral nerve, neuromuscular junction or muscle. It usually manifests itself as an acute or hyperacute motor disorder of progressive or rapidly progressive course. Acute muscle weakness is a neuromuscular emergency, especially if it affects the respiratory or oropharyngeal musculature. The location of the motor weakness and associated neurological signs and symptoms usually indicate the location of the lesion. The onset, speed and clinical evolution, as well as other data from the patient's history, suggest the pathophysiological differential diagnosis. Successful treatment depends on the immediate and correct differential diagnosis. This paper presents the main differential diagnosis of main neuromuscular diseases that cause acute muscle weakness in children. © 2013 Revista de Neurología.


Kotov A.,Federal University of Parana | Strobl T.,University Claude Bernard Lyon 1
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

We present a Yang-Mills-Higgs (YMH) gauge theory in which structure constants of the gauge group may depend on Higgs fields. The data of the theory are encoded in the bundle E→M, where the base M is the target space of Higgs fields and fibers carry information on the gauge group. M is equipped with a metric g and E carries a connection. If is flat, R=0, there is a local field redefinition which gives back the standard YMH gauge theory. If R≠0, one obtains a new class of gauge theories. In this case, contrary to the standard wisdom of the YMH theory, the space (M,g) may have no isometries. We build a simple example which illustrates this statement. © 2015 American Physical Society.


Motta F.A.,Federal University of Parana
Pediatric Infectious Disease Journal | Year: 2016

BACKGROUND:: Candida species are the primary cause of invasive fungal infection in hospitalized children. There are few data on risk factors for postoperative candidemia in pediatric patients with congenital heart defects. This study aimed to identify risk factors for candidemia in patients with congenital heart defects who underwent cardiac surgery. METHODS:: This was a case-control study conducted in patients admitted to a pediatric cardiology intensive care unit from January 2006 to December 2013. Candidemia cases were matched with control patients without candidemia. Multivariate analyses were conducted to determine predictive probabilities for the incidence of candidemia at a risk higher than 10%. RESULTS:: Thirty patients diagnosed with candidemia (incidence: 0.7 cases/1,000 patient days) were matched with 75 controls. Risk factors independently associated with candidemia included RACHS-1 (Risk Adjustment for Congenital Heart Surgery) category ≥3 (odds ratio [OR]=3.165, 95% confidence interval [CI]: 1.377-8.467), use of acid suppression therapy (AST) (OR=1.9, 95% CI: 0.949-3.979), and thrombocytopenia (OR=2.2, 95% CI: 1.2-4.2). Predictive probabilities ranged from 11% (only in RACHS-1 category ≥3) to 58% (combined RACHS-1 ≥3, thrombocytopenia, and AST use). The case fatality rate within 30 days after candidemia was 50%. CONCLUSION:: This is the first report using the RACHS-1 category as a risk factor for invasive candidiasis in patients with congenital heart defects in the pediatric intensive care unit (PICU). Further studies must be conducted to validate the risk factors for candidemia in this pediatric population. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


This is an intervention study conducted in a Unidade Básica de Saúde (Basic Health Unit) in Colombo, Parana, Brazil from March to November 2009, with 35 carriers of chronic diseases aged between 18 and 60 years, and enrolled in the Hypertension and Diabetes Program. The objectives were to identify their knowledge about arterial hypertension and act through educational group activities. Data were collected though semistructured interviews and four group meetings, and the following categories emerged from the analysis: "Understanding of the disease" and "Ways of caring". It was found that users knew the disease, its risk factors and possible complications, and that educational activities favored the sharing of experiences,provided reflection and the possibility of treatment management. This is a strategy that should be used and promoted by nurses.


Kremer G.M.,Federal University of Parana
International Journal of Geometric Methods in Modern Physics | Year: 2014

In this work, two systems are analyzed within the framework of the relativistic Boltzmann equation. One of them refers to a description of binary mixtures of electrons and protons and of electrons and photons subjected to external electromagnetic fields in special relativity. In this case the Fourier and Ohm laws are derived and the corresponding transport coefficients are obtained. In the other a relativistic gas under the influence of the Schwarzschild metric is studied. It is shown that the heat flux in Fourier's law in the presence of gravitational fields has three contributions, the usual dependence on the temperature gradient, and two relativistic contributions, one of them associated with an acceleration and another to a gravitational potential gradient. Furthermore, it is shown that the transport coefficient of thermal conductivity decreases in the presence of a gravitational field. The dependence of the temperature field in the presence of a gravitational potential is also discussed. © World Scientific Publishing Company.


Miyamoto S.,University of Sao Paulo | Martinez G.R.,Federal University of Parana | Medeiros M.H.G.,University of Sao Paulo | Di Mascio P.,University of Sao Paulo
Journal of Photochemistry and Photobiology B: Biology | Year: 2014

The chemistry behind the phenomenon of ultra-weak photon emission has been subject of considerable interest for decades. Great progress has been made on the understanding of the chemical generation of electronically excited states that are involved in these processes. Proposed mechanisms implicated the production of excited carbonyl species and singlet molecular oxygen in the mechanism of generation of chemiluminescence in biological system. In particular, attention has been focused on the potential generation of singlet molecular oxygen in the recombination reaction of peroxyl radicals by the Russell mechanism. In the last ten years, our group has demonstrated the generation of singlet molecular oxygen from reactions involving the decomposition of biologically relevant hydroperoxides, especially from lipid hydroperoxides in the presence of metal ions, peroxynitrite, HOCl and cytochrome c. In this review we will discuss details on the chemical aspects related to the mechanism of singlet molecular oxygen generation from different biological hydroperoxides. © 2014 Elsevier B.V. All rights reserved.


D'A.Sanchez S.,Federal University of Parana | Lima M.A.P.,University of Campinas | Varella M.T.D.N.,University of Sao Paulo | Varella M.T.D.N.,Federal University of ABC
Physical Review Letters | Year: 2011

The mechanisms for multimode vibrational couplings in resonant positron annihilation are not well understood. We show that these resonances can arise from positron-induced distortions of the potential energy surface (target response to the positron field). Though these distortions can transfer energy into single- and multiquantum vibrations, they have so far been disregarded as a pathway to resonant annihilation. We also compare the existing annihilation theories and show that the currently accepted model can be cast as a special case of the Feshbach annihilation theory. © 2011 American Physical Society.


Labiak P.H.,Federal University of Parana
Brittonia | Year: 2011

Stenogrammitis, a new genus of grammitid ferns, is segregated from Lellingeria based on morphological and molecular evidence. It differs from Lellingeria by linear leaves usually less than 5 mm wide, clathrate iridescent rhizome scales that are glabrous except for a single apical cilium, veins unbranched and only one per segment, fertile veins usually with the dark sclerenchyma visible beneath the sporangia, and x = 33. In contrast, Lellingeria has broader laminae, veins pinnate within the segments, and fertile veins not visible beneath the sporangia. Melpomene, which is sister to Stenogrammitis and Lellingeria, differs from those two genera by reddish setae on the leaves and rhizome scales papillate at the apex. Some species of Stenogrammitis are also distinctive by hemidimorphic laminae that have the fertile portion less dissected than the sterile. Stenogrammitis is pantropical and currently comprises 24 species, 12 of which occur in the Neotropics, six in Africa, four in Madagascar, and two on Pacific Islands. New combinations are made for Stenogrammitis aethiopica, S. anamorphosa, S. ascensionensis, S. boivinii, S. delitescens, S. jamesonii, S. hartii, S. hellwigii, S. hildebrandtii, S. limula, S. luetzelburgii, S. myosuroides, S. nutata, S. oosora, S. paucipinnata, S. prionodes, S. pumila, S. ruglessii, S. rupestris, S. saffordii, S. strangeana, S. tomensis, S. subcoriacea, and S. wittigiana. Lectotypifications are made for Grammitis muscosa, Polypodium itatiayense, P. oosorum var. micropecten, P. serrulatum forma major, P. serrulatum forma minor, S. luetzelburgii, S. myosuroides, and S. wittigiana. Illustrations are presented for the diagnostic characters of the genus, as well as a map with the geographical distribution. © 2010 The New York Botanical Garden.


Kulak J.,Yale University | Kulak J.,Federal University of Parana | Ferriani R.A.,University of Sao Paulo | Komm B.S.,Pfizer | Taylor H.S.,Yale University
Reproductive Sciences | Year: 2013

Selectiveestrogen receptor modulators (SERMs) have tissue-specific estrogen receptor (ER) modulating properties. Combining an SERM with one or more estrogens to form a tissue selective estrogen complex (TSEC) can provide an improved blend of tissue-specific ER agonist and antagonist effects. While both estrogens and SERMs affect the uterine endometrium, not all TSECs reverse the endometrial effects of estrogens preventing endometrial proliferation and hyperplasia. Their action in uterine cells is not completely understood. HOXA 10, leukemia inhibitory factor (LIF), progesterone receptor (PR), and EMX2 are genes known to regulate endometrial proliferation and differentiation. The expression of these genes was used to assess endometrial effects of SERMs and TSECs. We evaluated the effects of raloxifene (RAL), tamoxifen (TAM), lasofoxifene (LAS), bazedoxifene acetate (BZA), and progesterone (P) alone and in combination with estradiol (E2) in Ishikawa cells. Increased HOXA10, LIF, PR, and EMX2 messenger RNA (mRNA) expression was noted in E2-treated cells compared with vehicle-treated controls. All TSECs maintained E2-induced PR expression and all except TAM prevented estrogen-induced LIF expression. The TSEC containing BZA uniquely decreased HOXA10 expression and increased EMX2 expression. The TSECs alter endometrial cell proliferation by selective modulation of estrogen responsive genes, maintaining the antiproliferative effects mediated by PR and inhibiting LIF. The differential effect of TSECs on endometrial gene expression suggests a mechanism by which they manifest differential effects on endometrial safety against the risk of estrogen-induced endometrial hyperplasia. © 2013 The Author(s).


Garcete-Barrett B.R.,Federal University of Parana
Zootaxa | Year: 2011

Stenonartonia is a neotropical genus restricted to the forested regions of South America east of the Andes. The genus is revised here and numbers 14 species. Nine new species S. hasyva sp. nov., S. perdita sp. nov., S. cooperi sp. nov., S. guaraya sp. nov., S. rejectoides sp. nov., S. occipitalis sp. nov., S. tanykaju sp. nov., S. hermetica sp. nov., S. grossa sp. nov. are discribed and illustrated. New combination is proposed for S. mimica (Kohl), comb. nov. (from Paranortonia). Lectotype is designated for Nortonia polybioides von Schulthess. A key, along with full descriptions, illustrations of morphological features and distribution maps for all of the species are given. © 2011.


De Oliveira C.S.N.,Federal University of Parana | Silva F.L.D.,Federal University of Sao Carlos
Zootaxa | Year: 2011

Two new species of Larsia Fittkau, 1962 are described and figured as male, pupa and larva. Diagnosis to male of this genus is emended. An annotated checklist of the world's valid Larsia species is given and keys to pupae and larvae of known species in the Neotropical region are provided. Copyright © 2011 - Magnolia Press.


Parenti F.,Federal University of Parana
Quaternary Geochronology | Year: 2015

A recent paper on Vale da Pedra Furada (VPF, Lahaye et al., this journal), a final Pleistocene archaeological site of Northeastern Brazil (VPF), while comparing to some other sites in the region, fails to refere to the very close rock-shelter of Boqueirao da Pedra Furada (BPF), the main reference, and controversial, site of lowland South America. Because I studied exhaustively this last, I provide some explanations both on stratigraphic, taphonomic and palaeoclimatic grounds, pointing to a more careful intra-site analysis of such a critical archaeological area. Both VPF and BPF are two parts of the same site: in fact, VPF correlates with the youngest Pleistocene layer of BPF, Pedra Furada 3 (26-18 cal ky BP) but also seems to fill the gap between the last millennia of final Pleistocene and the onsent of Holocenic conditions. A tight ressemblance of archaological features is underlined as long as analogies and differences regarding taphonomic analysis of the artifacts between the two sectors. © 2015 Elsevier B.V.


Conceicao P.C.,Federal Technological University of Parana | Dieckow J.,Federal University of Parana | Bayer C.,Federal University of Rio Grande do Sul
Soil and Tillage Research | Year: 2013

Increases in carbon (C) input and stabilization are key processes to turn soils into sinks of atmospheric CO2-C and help mitigating global warming. We hypothesized (i) that C sequestration in no-tillage soil is further enhanced by high input cropping systems and (ii) that the sequestered C is stored mainly in the mineral associated fraction. The objective of this study was to assess, in 2003, the C sequestration and stabilization in a subtropical Acrisol (Eldorado do Sul, Brazil) subjected to 18-year conventional tillage [CT] and no-tillage [NT] combined with two cropping systems: black oat (Avena strigosa Schreb) as winter cover crop - maize (Zea mays L.) as summer grain crop [Ot/M]; and black oat plus vetch (Vicia villosa Roth) as winter cover crops - maize in summer intercropped with cowpea (Vigna unguiculata (L.) Walp) cover crop [Ot+V/M+C]. Soil C stock in the 0-20cm layer was higher in NT than in CT, either in Ot/M (31.1 vs. 27.8Mgha-1, P<0.05) or Ot+V/M+C (37.3 vs. 32.8Mgha-1, P<0.05). Annual C sequestration rate in NT relative to CT was 0.25Mgha-1 in Ot+V/M+C and 0.18Mgha-1 in Ot/M, in agreement to the higher biomass-C addition and legume cover crops inclusion in Ot+V/M+C (7.6 vs 4.0Mgha-1 year-1) and to our first hypothesis. Increase in the proportion of large macroaggregates (9.51-4.76mm) and of mean weight diameter occurred in NT soil up to 10cm depth, both in Ot/M and Ot+V/M+C. In NT, most of the C accumulation relative to CT occurred in the mineral-associated fraction, showing the importance of organo-mineral interaction in C stabilization and supporting our second hypothesis. However, the physical protection by aggregates played equally important role by stabilizing the occluded particulate organic matter (occluded-POM) before it was further stabilized by organo-mineral interaction. No-tillage is recommended as a sustainable soil management, but to increase soil C accumulation, the potential of cropping systems such those based on legume cover crops must be concurrently explored. © 2013 Elsevier B.V.


Hermes C.J.L.,Federal University of Parana
International Journal of Heat and Mass Transfer | Year: 2012

This paper conflates two heat exchanger design approaches - the ε-N tu (effectiveness-number of transfer units) and the EGM (entropy generation minimization) - focusing on heat exchangers with uniform wall temperature, i.e. condensers and evaporators. An algebraic formulation which expresses the dimensionless rate of entropy generation as a function of the heat exchanger geometry (number of transfer units), the thermal-hydraulic characteristics (friction factor and Colburn j-factor), and the operating conditions (heat transfer duty, core velocity, surface temperature, and fluid properties) is derived. It is shown that there does exist a particular number of transfer units which minimizes the dimensionless rate of entropy generation. An algebraic expression for the optimum heat exchanger effectiveness, based on the working conditions, heat exchanger geometry and fluid properties, is also presented. The theoretical analysis led to the conclusion that a high effectiveness heat exchanger design does not necessarily provide the best thermal-hydraulic performance. © 2012 Elsevier Ltd. All rights reserved.


Spinillo C.G.,Federal University of Parana
Work | Year: 2012

The use of pictograms is discussed considering their information content, graphic complexity and cultural dimension. The resemblance and the illusion theories are highlighted to define pictogram as a salience-based representation system, which communicational efficacy depends upon historical and cultural aspects in their interpretation. Thus, the competence in interpreting pictograms is considered relative to users' acquaintance with the pictorial system and with the referents. Pictogram as a general/neutral visual statement is questioned, pointing out the cultural and gender attributes added to pictures to represent people, professions and social events. As a result of this discussion, some critical points of the standardization of pictograms are presented. © 2012 - IOS Press and the authors. All rights reserved.


Hyeda A.,Instituto Superior Of Administracao E Economia Fundacao Getulio Vargas Isae Fgv | da Costa E.S.M.,Federal University of Parana
Value in Health Regional Issues | Year: 2015

Objective: Chemotherapy is essential for the cancer treatment. Usually, in the preparation process of the chemotherapy, part of the medication must be discarded to achieve the dose prescribed by the doctor. The dose of medication discarded results in toxic waste production. The objective is to analyze the chemotherapy waste in the preparation process of the drug. Methods: It has been conducted a cross-sectional observational study. The study data were obtained from chemotherapy's requests by oncologists linked to a health insurance plan. It has been calculated the dose of chemotherapy waste in each application, considering the dose prescribed by the doctor and the drug dosage form. Results: It were analyzed 1,289 prescriptions for intravenous chemotherapy of 106 users with cancer. There were a total of 63,824. mg of chemotherapy residue produced, with an average of 602. mg by user and 49. mg by application. The average percentage of chemotherapy waste was 11.96[%], between 0 to 50[%]. Conclusion: The number of applications and the dose used in the treatment protocol, the commercial dosage forms and the no use of dose rounding of medication to the nearest vial size were factors related to increased production of chemotherapy waste. © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR).


Lucini T.,Federal University of Parana | Panizzi A.R.,Laboratory of Entomology
Entomologia Experimentalis et Applicata | Year: 2016

Stink bugs (Hemiptera: Heteroptera: Pentatomidae) are in general robust and restless insects, which makes them difficult to wire for electropenetrograph (EPG) studies. In addition, cuticular lipids may reduce wire effectiveness, and their removal could improve success of wiring. We compared wiring effectiveness for three species of stink bugs, differing in walking behaviour and degree of cuticular waxiness, that is, Piezodorus guildinii (Westwood), Nezara viridula (L.), and Loxa deducta (Walker). Results indicated that removal of cuticular lipids by mechanical abrasion (via sanding) greatly improved attachment success with gold wire. Our hypothesis that heavier and bigger bugs would lose the wire attachment more quickly than lighter and smaller bugs was not confirmed, regardless of the sanding. In contrast, our hypothesis that greater movement of a bug would cause the wire to break more often was supported by extensive testing. Behaviour appears to be more relevant for successful wiring than body weight. We used the sanding and wiring technique to characterize and correlate direct current EPG waveforms for the large and restless stem-feeding stink bug Edessa meditabunda (Fabricius) on soybean plants. This marks the first published example of pentatomid EPG waveforms. Edessa meditabunda recordings on soybean stems generated eight types of waveforms in three phases and two families, named as follows: non-probing = Np and Z; pathway phase = Em1; X wave phase = X; ingestion phase, family I = Em2 and Em3; ingestion phase, family N = Em4 and Em5. These eight were described based on their frequencies, relative amplitudes, and level voltages. Histological studies of stylets within salivary sheaths correlated the Em1, Em2, and Em3 waveforms with specific penetration sites. The waveform with the longest duration when feeding was Em2, representing xylem sap ingestion; in addition, waveform Em3 (always preceded by an X wave) was correlated with phloem sap ingestion. © 2016 The Netherlands Entomological Society.


Waldman E.A.,University of Sao Paulo | Luhm K.R.,Federal University of Parana | Monteiro S.A.M.G.,Federal University of Mato Grosso | de Freitas F.R.M.,University of Sao Paulo
Revista de Saude Publica | Year: 2011

The aim of the review was to analyze conceptual and operational aspects of systems for surveillance of adverse events following immunization. Articles available in electronic format were included, published between 1985 and 2009, selected from the PubMed/Medline databases using the key words "adverse events following vaccine surveillance", "post-marketing surveillance", "safety vaccine" and "Phase IV clinical trials". Articles focusing on specific adverse events were excluded. The major aspects underlying the Public Health importance of adverse events following vaccination, the instruments aimed at ensuring vaccine safety, and the purpose, attributes, types, data interpretation issues, limitations, and further challenges in adverse events following immunization were describe, as well as strategies to improve sensitivity. The review was concluded by discussing the challenges to be faced in coming years with respect to ensuring the safety and reliability of vaccination programs.


Melostelis gen. nov., new species and complementary notes on Anthidiini (Hymenoptera, Apidae). Melostelis gen. nov. is proposed to a new cleptoparasitic Anthidiini. Two new species, Melostelis amazonensis sp. nov. from Manaus, Amazonas and Larocarathidium chacoense sp. nov. from Porto Murtinho, Mato Grosso do Sul, are described and illustrated. The males from Epanthidium bolivianum Urban, 1995 and Epanthidium araranguense Urban, 2006, are described. The occurrences from Ketianthidum zanolae Urban, 2000 and Epanthidium bolivianum, are registred by the first time in the Brazilian Chacoan subregion.


Rotta I.,Federal University of Parana
Arquivos de neuro-psiquiatria | Year: 2011

The central nervous system (CNS) and the immune system are considered major target organs for HIV infection. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV associated dementia, vacuolar myelopathy and involvement of the peripheral nervous system. Changes in diagnosis and clinical management have changed the aspect of HIV infection so that it is no longer a fatal disease, and has become a chronic disease requiring sustained medical management. After HAART the incidence of most opportunistic infections, including those affecting the CNS, has dropped markedly. Some studies suggest that neurological involvement of infected patient occur with different frequency, depending on HIV subtype involved in the infection. Subtype C may have reduced neuroinvasive capacity, possibly due to its different primary conformation of HIV transactivating regulatory protein (Tat), involved in monocyte chemotaxis. This review focus on physiopathologic aspects of HIV infection in CNS and its correlation with HIV clades.


Queiroz-Telles F.,Federal University of Parana | Nucci M.,Federal University of Rio de Janeiro | Tobon A.,Corporacion para Investigaciones Biologicas | Restrepo A.,Corporacion para Investigaciones Biologicas
Medical Mycology | Year: 2011

Implantation or subcutaneous mycoses are a frequent health problem in Latin American countries and other tropical and subtropical areas. Although such infections rarely cause disseminated or invasive disease, they have an important impact on public health, and timely diagnosis and appropriate treatment remain important. Although some implantation mycoses are found in immunocompromised persons, the immunocompetent population is the principal target in Latin America. Most etiologic agents are found in soil, vegetation, and decaying matter in tropical, subtropical, and humid environments and infection is commonly the result of penetrating injury. Infections primarily occur (1) among low socioeconomic groups, (2) among those living in rural areas or involved in farming, hunting, or other outdoor activities, and (3) particularly among adult men. This review focuses on the epidemiology of the most clinically significant implantation mycoses in Latin America, i.e., sporotrichosis, eumycetoma, chromoblastomycosis, subcutaneous phaeohyphomycosis, subcutaneous zygomycosis, and lacaziosis. Main epidemiologic findings, clinical manifestations, diagnosis, and treatment options are also discussed. © 2011 ISHAM.


Spinillo C.G.,Federal University of Parana
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2014

This Patient information leaflet - PIL provides support to medicine usage. However, there is a lack of empirical evidence on the usability of PILs since most research has focused on their readability and legibility, and legal regulations worldwide have neglected their usability aspects. Considering the importance of this matter, a proposal for assessing PILs' usability is presented here, consisting of three phases: (1) task analysis diagram flow, (2) interaction test, and (3) follow-up interview, and the outputs are analyzed in a qualitative manner. To validate the usability assessment proposed, a study was conducted in Brazil with 60 participants on using medicines differing in their pharmaceutical presentation, based upon the instructions in their PILs. The results showed a direct relation between task complexity-errors; and the decision points-actions/ steps. The usability assessment aids in identifying drawbacks in the PILs design and information flow, thus, providing support to improvements towards their effectiveness in medicine usage. © Springer International Publishing Switzerland 2014.


Dias N.L.,Federal University of Parana
Water Resources Research | Year: 2013

In this paper, several lines of investigation of atmospheric turbulence, by Wilfried Brutsaert, his students, and collaborators, are reviewed. Overall, we classify these lines as K-theory, surface roughness parameterization dealing with momentum and scalar fluxes, radiative effects on temperature fluctuations, stable conditions, scalar similarity, and atmospheric boundary-layer parameterization. Emphasis is placed on turbulence parameterization. Although these topics are presented more or less in chronological order, this order is broken whenever connections need to be established. Hopefully, these connections are the most interesting part of this review: it is there that Brutsaert's insights and long-range scientific questions may be found. His approach invariably included a careful formulation of the physical and mathematical basis of the problem at hand, and proceeded to focus on some essential issues that allowed analytical, numerical or statistical treatment. There is much to be learned from this approach; it is hoped that some of it can be glimpsed here. © 2013. American Geophysical Union. All Rights Reserved.


Sharipov F.,Federal University of Parana
Physica A: Statistical Mechanics and its Applications | Year: 2012

The reciprocal relations for open gaseous systems are obtained on the basis of main properties of the non-stationary Boltzmann equation and gassurface interaction law. It is shown that the main principles to derive the kinetic coefficients satisfying the reciprocal relations remain the same as those used for time-independent gaseous systems [F. Sharipov, OnsagerCasimir reciprocal relations based on the Boltzmann equation and gassurface interaction law single gas, Phys. Rev. 73 (2006) 026110]. First, the kinetic coefficients are obtained from the entropy production expression; then it is proved that the coefficient matrix calculated for time reversed source functions is symmetric. The proof is based on the reversibility of the gasgas and gassurface interactions. Three examples of applications of the present theory are given. None of these examples can be treated in the frame of the classical OnsagerCasimir reciprocal relations, which are valid only in a particular case, when the kinetic coefficients are odd or even with respect to the time reversion. The approach is generalized for gaseous mixtures. © 2011 Elsevier B.V. All rights reserved.


Krieger N.,Federal University of Parana
Advances in Experimental Medicine and Biology | Year: 2010

In recent years biosurfactants have attracted attention because of their low toxicity, biodegradability and ecological acceptability. However, their use is currently extremely limited due to their high cost in relation to that of chemical surfactants. Solid-state cultivation represents an alternative technology for biosurfactant production that can bring two important advantages: Firstly, it allows the use of inexpensive substrates and, secondly, it avoids the problem of foaming that complicates submerged cultivation processes for biosurfactant production. In this chapter we show that, despite its potential, to date relatively little attention has been given to solid-state cultivation for biosurfactant production. We also note that this cultivation technique brings its own challenges, such as the selection of a bioreactor type that will allow adequate heat removal, of substrates with appropriate physico-chemical properties and of methods for monitoring of the cultivation process and recovering the biosurfactants from the fermented solid. With suitable efforts in research, solid-state cultivation can be used for large-scale production of biosurfactants. © 2010 Landes Bioscience and Springer Science+Business Media.


Depieri R.A.,Federal University of Parana | Panizzi A.R.,Laboratory Of Bioecologia Of Percevejos | Panizzi A.R.,Laboratory Of Entomologia
Neotropical Entomology | Year: 2011

Laboratory studies were conducted to compare duration of feeding and superficial and in-depth damage to soybean (Glycine max) seeds by the Southern green stink bug, Nezara viridula (L.), the Neotropical brown stink bug, Euschistus heros (F.), the red-banded stink bug, Piezodorus guildinii (Westwood), and the green-belly stink bug, Dichelops melacanthus (Dallas). Results indicated that feeding time was significantly longer for N. viridula (≈ 133 min) compared to E. heros and D. melacanthus (≈ 70 min), but not different from P. guildinii (≈ 103 min). There was a positive correlation between feeding time and the resulting damage for E. heros, N. viridula and P. guildinii (R2>0.80, P<0.0001), but not for D. melacanthus (R2 = 0.1011, P = 0.1493). The deepest seed damage (2.0 mm) was made by P. guildinii and the shallowest (0.5 mm) by D. melacanthus. The depth of the seed damage by E. heros and N. viridula (0.8, 1.2 mm, respectively) was intermediate in comparison to the other species studied. Feeding damage to the seed endosperm caused variable cell disruption and protein body dissolution, particularly when P. guildinii fed on seeds, suggesting that the deleterious action of salivary enzymes was greater for this bug compared to the others. © 2011 Sociedade Entomológica do Brasil.


Graf H.,Federal University of Parana
European Journal of Endocrinology | Year: 2015

Multinodular goiter (MNG) is a very common thyroid disorder determined by diverse goitrogenic factors, the most important one being iodine deficiency. The clinical presentation of a patient with MNG varies from a completely asymptomatic goiter to a life-threatening disease due to upper airway compression. Patients can develop underlying subclinical or overt hyperthyroidism due to autonomously hyperfunctioning nodules. In the absence of clinical, ultrasonographic, or cytological findings suggestive of malignancy, the best therapeutic approach for a patient with MNG will depend on the size and location of the goiter, the presence and severity of compressive symptoms, and the presence or absence of thyrotoxicosis. There is still no consensus regarding the treatment of atoxic MNGs. Hence, its optimal management remains controversial; possible therapies include levothyroxine (LT4), surgery, and radioactive iodine (131I). Suppressive treatment with LT4 is discouraged due to the development of sub-clinical or overt hyperthyroidism and to its low efficacy when compared with surgery or 131I. Total thyroidectomy is effective; however, it is associated with the risk of surgical complications and is often refused by the patient. 131I therapy is an alternative to thyroid surgery to reduce the size of benign MNGs. Based on the ability of recombinant human TSH (rhTSH) to more than double thyroid 131I uptake, this compound has been evaluated as an adjuvant to 131I in the treatment of MNG. Very small doses of rhTSH have been used in patients with MNG and few safety concerns have been observed, but the ideal dose, both effective and safe, is yet to be defined. © 2015 European Society of Endocrinology Printed in Great Britain.


Nascimento D.C.O.,State University of Rio de Janeiro | Ferreira A.S.,State University of Rio de Janeiro | Monteiro S.N.,State University of Rio de Janeiro | Aquino R.C.M.P.,Federal Center for Technological Education | Kestur S.G.,Federal University of Parana
Composites Part A: Applied Science and Manufacturing | Year: 2012

This paper presents morphology, physical and strength properties of piassava fiber, a very rigid fiber having a potential to be used as composite reinforcement. Composites of continuous and aligned piassava fibers with and without alkali treatment dispersed in epoxy matrix were subjected to three point bend, tensile, and Izod impact tests. Composites with fibers above 20 vol.% showed an effective reinforcement behavior both in flexural and tensile tests, while the impact energy linearly increased for the amount of piassava fibers used in this study. Fractographic study revealed a relatively weaker fiber/matrix adhesion acting as preferential site for crack nucleation. Evidence was also found for crack arrest by the fiber above 20 vol.%. This, together with spiny surface protrusion in the piassava fibers, was found to be responsible for the reinforcement of the epoxy composites. © 2011 Elsevier Ltd. All rights reserved.


Scotti A.,Federal University of Parana
Welding International | Year: 2016

A descriptive mode, named the five-bar model, is presented in this work to explicate thermal stress generation in welding. Taking as the base the widely known three-bar model, it is claimed that the proposed model is also capable of explaining stress generation at the HAZ. This stress would be progressively smaller than in the FZ, turning null at the material point in which the thermal stress does not reach the material yielding stress. In addition, the model also showed itself to be able to explain that the highest stress will be generated in the FZ and that the resultant stress will be defined by the yielding stress of the bead material and by the capability of the material in consuming these stresses through plastic deformation. However, the stresses in the HAZ might be as high as in the BM, once the coarse grain region of the HAZ sustains a higher yielding stress than in the FZ, defining the final intensity of the generated stress. The one-bar model, in turn, based on the same approach, allows us to demonstrate that the generated thermal stresses happen when the piece is free of angular bending or at limited plastic deformation and they are always tensile stresses. By analogy, the resultant stresses on the component are defined by the yielding stress of the weld bead material and by the capacity of the whole material to accommodate the stress through plastic deformation. © 2016 Taylor & Francis.


Medeiros R.A.,Federal University of Parana | Lima M.G.,Brazilian Technological Institute of Aeronautics
Construction and Building Materials | Year: 2016

This paper aims to contribute with durability studies by monitoring the unsaturated concrete resistivity over 2 years. Four types of cements commercially used in Brazil were investigated. Some statistical tests (ANOVA and Turkey's test) were performed to analyze the data. It was found that w/b ratios have no significant influence on the electrical resistivity values of the concrete for a same type of cement. However, the types of cement have a significant effect on resistivity. Cements with blast furnace slag and pozzolan additions have a higher resistivity. Trend lines to estimate the changes in resistivity over time were discovered. © 2015 Elsevier Ltd. All rights reserved.


Soares S.A.,Federal University of Parana
Oecologia Australis | Year: 2013

Understanding the mechanisms that determine local patterns of diversity is among the primary goals of ecology. Among these mechanisms, competition is mentioned as the regulatory factor structuring biological communities, despite the fact that the concept is controversial in ecology. Myrmecologists, however, for the most part, view competition as one of the main factors structuring ant communities. Two hypotheses on the mechanisms underlining species coexistence have received support from empirical studies. The first predicts a balance between competition and colonization, which form a continuum along which species are distributed. Species at one extreme are good at competing and bad at colonizing, whereas species on the opposite end are bad competitors and good colonizers. The interactions among various species over time are in a state of constant flux along this continuum. The second hypothesis predicts spatial clustering. According to it, ecologically dominant species have an aggregated spatial distribution, which would increase competition among individuals and the species' coexistence with subordinate species. Beyond these two, there are the trade-off and the mosaic theories, which involve competition and promote coexistence, and also the null models, which are used to determine if competition is responsible for ant community structures. In the Myrmecology, the competition is par excellence as one of the main factors structuring ant communities. Some hypotheses have been supported in empirical studies of natural communities as mechanisms for species coexistence. The first is the balance competition/colonization, species were distributed along a continuum between good and bad contestants competing colonizing up bad and good colonizers, and their interactions over time would allow a state of constant flux along this continuum. The second hypothesis is the spatial clustering, in which ecologically dominant species have an aggregated spatial distribution, which would increase competition among individuals and species coexistence with subordinates. Besides these there are the trade-off theory and the mosaics, which involve competition and promote coexistence, and also the null models, which are used to determine if competition structures communities of ants. However, the objective is to demonstrate the main mechanisms that involve competition in structuring ant communities.


Chaiben C.L.,Federal University of Parana
Stomatologija / issued by public institution "Odontologijos studija" ... [et al.] | Year: 2013

Keratoacanthoma is a lesion typical crater, symmetrical, rounded, rapid growth with high potential for self-involution. The lesions may be multiple, disseminated and associated with some syndromes. The etiology of keratoacanthoma is not known, but it is often observed in patients chronically exposed to sun. Histopathological features of keratoacanthoma may resemble those of a well differentiated squamous cell carcinoma. The hallmark of the disease is spontaneous resolution after an intermediary stationary stage. The majority of the cases is treated by surgical excision. For this reason, very few cases have been documented until resolution, which constitutes the gold standard for this clinic diagnosis. The aim of this article is to report a case of keratoacanthoma in the inferior lip of an immunosuppressed patient.


Mitchell S.D.,University of Newcastle | Oliveira G.H.C.,Federal University of Parana
International Journal of Electrical Power and Energy Systems | Year: 2015

This article presents a novel approach to analysing a power transformer's internal response to system transients. In this approach a hybrid modelling methodology is adopted which leverages the distinct advantages offered by both Black and Grey Box modelling techniques. The Black Box model of the transformer is used within the EMTP system study environment in order to take advantage of its mathematical flexibility and modelling accuracy. Transients derived from network switching operations within the study can then be used for injection tests within the Grey Box modelling environment. The Grey Box model, which is based upon the physical structure of the transformer, will facilitate analysis of the transformer's internal voltage response to the external stimulus. A fundamental difference between the approach described in this paper and more traditional approaches is that it does not require prior knowledge of the internal geometry of the transformer. All of the modelling parameters are derived from external tests, nameplate details and an intrinsic understanding of common transformer design principles. This can be a distinct advantage since in most cases a transformer's design specifications are not readily available outside of the laboratory due to the manufacturer's intellectual property restrictions. A study of a gas insulated substation within a hydroelectric power plant in Brazil is used to demonstrate the proposed technique. © 2015 Elsevier Ltd. All rights reserved.


The reciprocal influences between biodiversity and ecosystem function comprise a central objective of ecology. By represent the relationship between the functions of the organisms and environmental processes, the functional perspectives might reveal aspects of the organization and dynamics of biological communities unsolved by traditional approaches. About these points, this study presents a literature research over the emergence and development of general ecological concepts related to biology of communities and functional ecology, including a discussion of the adopted consensus, aims of study and their association with the traditional parameters of research. It was noted that the synthesis and association of taxonomic and functional perspectives may comprise the most promising areas on realization of studies of biodiversity dynamics. However, is still necessary: a well established and concise theoretical support, accurate determinations of adopted parameters and the search for practices for uncover ecological patterns with purposes of generalization.


Peralta-Zamora P.,Federal University of Parana
Journal of the Brazilian Chemical Society | Year: 2010

In recent years, many studies have related the efficient degradation of relevant substrates by photoelectrochemical processes. Usually, it is accepted that the synergy observed between photo and electrochemical processes involves the improvement of the photocatalytic efficiency as a result of a favorable electrochemical support. In this work some experimental observations are discussed with the aim of demonstrating that in several situations, the synergic effect involves a divergent concept. That is, an efficient electrochemical- based process assisted by subsequent photochemical reactions. As far as we know, the high degradation capacity shown by DSA electrodes used in the presence of reactive electrolytes, such us sodium chloride, is due to electrochemical generation of powerful oxidant agents, as molecular chlorine, followed by photochemical generation of active radicals, such chlorine radical. This assumption becomes clearly visible in degradation studies involving humic acid, camphor and an anthraquinone dye (reactive blue 19). © 2010 Sociedade Brasileira de Química.


This article aims to organize a synthesis about the feeding preference and feeding strategies presented by the Coccinellidae. The family is heterogeneous with regard to eating behavior and it can be divided into three main groups: predators, phytophagous and mycophagous. The predators coccinellids are subdivided according to the taxonomic status of their preferred prey: mite feeders, aphidophagous and coccidophagous. The phytophagous are subdivided into: phyllophagous, which feed exclusively on leaves, stems or other plant parts and polenophagous. The frugivory in coccinellids appears to be rare, but has been documented for some species. Both larvae and adults of predators coccinellids can consume an enormous range of food and many species are considered polyphagous. The polyphagy is usually observed as an emergency strategy when the preferred food is scarce. The coccinellids exhibit a wide range of preferred food types, which cover different kingdoms and trophic levels. The knowledge of feeding habits, even of the most common species, is still restrict, making a difficult task to discuss the food specialties of each tribe. Due to the huge range of species with great potential to act as biological control agents, especially of pests of agricultural importance, it is necessary to intensify the studies related to biology, behavior and phylogeny.


Dias N.L.,Federal University of Parana
Water Resources Research | Year: 2013

Two formulations for the radiative dissipation of temperature fluctuations, in the spatial and the spectral domains, are reconciled. Both can be written in terms of a first-order decay of temperature variance. The decay constant was obtained originally by Brutsaert (1972) for stable conditions from considerations on the temperature autocovariance function (in the spatial domain). Here it is obtained directly from a spectral dissipation function, using the appropriate Monin-Obukhov dimensionless functions for a stable atmosphere. The general behavior of the constant with stability is the same for the two formulations, with Brutsaert's original formulation producing stronger dissipation than its spectral counterpart. Key Points a 1st-order decay constant is obtained from a spectral dissipation function the kaimal spectrum constant is reviewed to give an exact integral two approaches to the 1st-order decay are shown to have similar behaviors ©2013. American Geophysical Union. All Rights Reserved.


This study investigated the mechanisms by which β-hydroxy-β-methylbutyrate (HMB) administration in rats reduces Walker-256 tumor growth. Male Wistar rats were supplemented with HMB (76 mg/kg/day) (HW), or a placebo (W), during 8 wk by gavage. At the 6th wk, rats were inoculated with a suspension of Walker 256 tumor cells (3 × 10(7)/mL). Fifteen days after inoculation, the HW group showed higher glycemia (109.4 ± 5.53 vs. 89.87 ± 7.02 mg/dL, P < 0.05) and lower spleen (1.35 ± 0.05 vs. 1.65 ± 0.12 g, P < 0.05) and tumor weights (9.64 ± 1.07 vs. 13.55 ± 1.19 g, P < 0.05) compared to the W group. Tumor cells extracted from the HMB-treated rats displayed a 36.9% decrement in rates of proliferation ex vivo and a significant increase in the Bax/Bcl-2 protein expression ratio in comparison to those extracted from the placebo-treated rats (P < 0.05). Both phagocytic capacity and H(2)O(2) production rates were higher in polymorphnuclear cells that were obtained from the blood of the HW rats in comparison to those from the W rats (P < 0.05). Reduction of necrotic regions and an intense infiltration of leukocytes and activated granulocytes in HW were evident by transmission electron microscopy. Our findings suggest that HMB supplementation decreases tumor burden by modifying the inner environment of tumor cells and by interfering with blood leukocyte function.


Intensive surveys have been conducted to unravel spatial patterns of benthic infauna communities. Although it has been recognized that benthic organisms are spatially structured along the horizontal and vertical dimensions of the sediment, little is known on how these two dimensions interact with each other. In this study we investigated the interdependence between the vertical and horizontal dimensions in structuring marine nematodes assemblages. We tested whether the similarity in nematode species composition along the horizontal dimension was dependent on the vertical layer of the sediment. To test this hypothesis, three-cm interval sediment samples (15 cm depth) were taken independently from two bedforms in three estuaries. Results indicated that assemblages living in the top layers are more abundant, species rich and less variable, in terms of species presence/absence and relative abundances, than assemblages living in the deeper layers. Results showed that redox potential explained the greatest amount (12%) of variability in species composition, more than depth or particle size. The fauna inhabiting the more oxygenated layers were more homogeneous across the horizontal scales than those from the reduced layers. In contrast to previous studies, which suggested that reduced layers are characterized by a specific set of tolerant species, the present study showed that species assemblages in the deeper layers are more causal (characterized mainly by vagrant species). The proposed mechanism is that at the superficial oxygenated layers, species have higher chances of being resuspended and displaced over longer distances by passive transport, while at the deeper anoxic layers they are restricted to active dispersal from the above and nearby sediments. Such restriction in the dispersal potential together with the unfavorable environmental conditions leads to randomness in the presence of species resulting in the high variability between assemblages along the horizontal dimension.


This theoretical study aimed to analyze the attributes, antecedents, and consequences of the transpersonal caring concept through using the Concepts Analysis Model. For this purpose, books published based on Jean Watson's theory in Portuguese and English from 1979 to 2012 were listed. Fulfilled inclusion criteria, only six literary works remained. The time of care and intention to be in relationship were the most cited antecedents. The most present attributes were intersubjectivity and relationships among those ones involved in the process. With regard to consequences, the most present element was the fact that the transpersonal caring provides restoration/reconstitution (healing). The study allowed noting tiny changes in the concept definition over the years and publications of theory. Thus, analyzing the attributes, antecedents, and consequences of concept provided its better understanding and comprehension of its importance in the Human Caring Theory proposed by American theorist.


De Oliveira E.M.,University of Campinas | Varella M.T.D.N.,University of Sao Paulo | Bettega M.H.F.,Federal University of Parana | Lima M.A.P.,University of Campinas
European Physical Journal D | Year: 2014

We report elastic integral (ICS), differential (DCS) and momentum transfer cross sections (MTCS) for low-energy electron scattering by n-pentanol alcohol in the gas phase. The Schwinger multichannel method implemented with pseudopotentials was employed in the calculations. The DCSs were computed for energies from 1 to 50 eV and the ICS and MTCS from 1 to 100 eV. Due to the significant value of the electric dipole moment, the DCSs are dominated by strong forward scattering. Despite this fact, the DCS around 10 eV displays a behavior related to a f-wave scattering pattern at intermediate angles which may be associated with shape resonances. This result is consistent with the ICS and the MTCS since they show a pronounced peak near this energy. For energies below 1 eV, the MTCS obtained in the static-exchange plus polarization approximation does not increase, as expected for polar molecules, suggesting that a Ramsauer-Townsend minimum could be present. This finding motivated us to revisit the previously studied methanol, ethanol, n-propanol and n-butanol molecules and to perform new calculations for impact energies below 1 eV (not addressed before). With the inclusion of polarization effects, the MTCS for the five alcohols suggest a Ramsauer-Townsend minimum coming from the negative to the positive scattering energies. To the best of our knowledge, there are neither experimental nor calculated cross sections for comparison with the present results. © 2014 EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg.


Torres-Acosta J.F.J.,Autonomous University of Yucatan | Molento M.,Federal University of Parana | Mendoza de Gives P.,National Research Center Disciplinaria en Parasitologia Veterinaria
Veterinary Parasitology | Year: 2012

The widespread presence of anthelmintic resistant gastrointestinal parasitic nematodes in outdoor ruminant production systems has driven the need to identify and develop novel approaches for the control of helminths with the intention to reduce the dependence on commercial anthelmintic drugs. This paper identifies what has been done in Latin America (LA) in terms of estimating the prevalence of anthelmintic resistance (AR) in ruminant production systems and the application of different novel approaches for the control of helminths in those systems, including research and extension activities. Firstly, the paucity of knowledge of AR is discussed in the context of different countries, as well as, the available economic resources for research, the technical infrastructure available and the practical difficulties of the production systems. It is then proposed that the search for novel approaches is not only driven by AR but also by the need for techniques that are feasible for application by resource-poor farmers in non-commercial subsistence farming systems. However, the commercial benefits of these approaches are often limited and so are funding inputs in most countries. The workers participating in the research into different novel approaches are identified as well as the different methods being studied in the different areas of LA according to their published results. In addition, the difficulties experienced during extension efforts to reach farmers and help them to adopt novel approaches for the control of parasitic nematodes in LA are discussed. The role of regulatory authorities in these countries is discussed as some methods of control might need an official confirmation of their efficacy as well as authorization prior to application as they may affect animal products (i.e. residues) and/or impose a hazard for animal welfare. The role of the pharmaceutical companies is also discussed. © 2011 .


Vandenberghe L.,Pontifical Catholic University of Goias | Da Silveira J.M.,Federal University of Parana
Journal of Contemporary Psychotherapy | Year: 2013

This article discusses how the way the therapist relates to his or her personal responses to client material during the session contributes to making the relationship with the client an effective tool for treatment. Ideas from third wave behavior therapy are used to describe aspects of therapist involvement in the relationship and modes of therapist awareness of inner responses. In two vignettes, negative client reactions to an intervention bring problematic therapist material to the fore. Both cases highlight how the stories the therapists spun about themselves as professionals and persons could easily have limited their effectiveness in responding to the material. The vignettes also illustrate how clinicians can overcome personal meanings and judgments to access a more productive mode of interacting with the feelings a critical incident in the relationship evokes in them. It is argued that observing their own content from a psychological distance makes it possible for clinicians to use their feelings without getting caught up in them. These same feelings may then help the therapist perceive how the incident relates to the client's daily life problems. The therapist's engagement in a sense of self-as-context is described as a therapeutic stance that provides the psychological distance needed to help overcome alliance ruptures and other potential gridlocks and which may transform the therapist's inner response to client content into a tool for addressing important client issues. © 2013 Springer Science+Business Media New York.


Azevedo V.F.,Federal University of Parana
Revista brasileira de reumatologia | Year: 2010

Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the axial skeletal system, causing pain and functional incapacity. To measure the impact of AS on patient's life, questionnaires are used to assess disease activity (BASDAI); functional incapacity (BASFI); and quality of life (ASQoL). Fibromyalgia (FM) is one of the most common causes of generalized pain and can coexist with other diseases; it can be assessed by the Fibromyalgia Impact Questionnaire (FIQ). Few studies have demonstrated correlations between FM and AS. The present study obtained data regarding the epidemiologic profile of patients with AS and FM and evaluated the prevalence of FM in patients with AS. The FM influence on BASDAI, BASFI and ASQoL test scores was assessed. A total of 71 patients with AS, diagnosed according to the modified New York criteria, were studied. Clinical and functional assessment was performed and BASDAI, BASFI and ASQoL tests were applied. Patients with a diagnosis of FM were evaluated through the FIQ. Eleven patients met the criteria for FM; thus a FM prevalence of 15% was observed among the patients with AS. FM was more prevalent among women (3.8:1). Age at disease onset (AS) was 27.5 years. The HLA-B27 antigen was positive in most of them (80.4%). When comparing BASDAI, BASFI and ASQoL test means, it was observed that values are significantly higher (P < 0.01) among patients with FM. We concluded that the coexistence of FM can worsen AS activity aspects, as well as functional incapacity and quality of life.


Szortyka M.M.,Federal University of Santa Catarina | Fiore C.E.,Federal University of Parana | Henriques V.B.,University of Sao Paulo | Barbosa M.C.,Federal University of Rio Grande do Sul
Journal of Chemical Physics | Year: 2010

In this paper we investigate the dynamic properties of the minimal Bell-Lavis (BL) water model and their relation to the thermodynamic anomalies. The BL model is defined on a triangular lattice in which water molecules are represented by particles with three symmetric bonding arms interacting through van der Waals and hydrogen bonds. We have studied the model diffusivity in different regions of the phase diagram through Monte Carlo simulations. Our results show that the model displays a region of anomalous diffusion which lies inside the region of anomalous density, englobed by the line of temperatures of maximum density. Further, we have found that the diffusivity undergoes a dynamic transition which may be classified as fragile-to-strong transition at the critical line only at low pressures. At higher densities, no dynamic transition is seen on crossing the critical line. Thus evidence from this study is that relation of dynamic transitions to criticality may be discarded. © 2010 American Institute of Physics.


Knabben F.T.,Federal University of Santa Catarina | Hermes C.J.L.,Federal University of Parana | Melo C.,Federal University of Santa Catarina
International Journal of Refrigeration | Year: 2011

The present paper advances an in-situ study of frosting and defrosting processes in tube-fin evaporators of household refrigerators and freezers. Frost growth experiments were carried out using a purpose-built test facility comprised of a refrigerated cabinet placed inside a climatized chamber, and a vapor compression refrigeration loop that controls both the evaporating temperature and the evaporator superheating. A first-principles two-dimensional simulation model was put forward to predict the evaporator blocking over time, and also the heat and mass transfer rates. The model validation exercise has shown that the model follows well the experimental trends of pressure drop, frost mass, cooling capacity and air flow rate, with all predictions falling inside ±10% error bounds. The model was then used to assess the impact of several design parameters on both the evaporator blockage and defrost efficiency. It was found that a nearly ideal defrost efficiency is achieved when the defrosting process is performed by two simultaneous heaters. © 2011 Elsevier Ltd and IIR. All rights reserved.


Perussello C.A.,Federal University of Parana | Kumar C.,Queensland University of Technology | De Castilhos F.,Federal University of Santa Maria | Karim M.A.,Queensland University of Technology
Applied Thermal Engineering | Year: 2014

Osmotic treatments are often applied prior to convective drying of foods to impart sensory appeal aspects. During this process a multicomponent mass flow, composed mainly of water and osmotic agent, takes place. In this work, a heat and mass transfer model for the osmo-convective drying of yacon was developed and solved by the Finite Element Method using COMSOL Multiphysics ®, considering a 2-D axisymmetric geometry and moisture dependent thermophysical properties. Yacon slices were osmotically dehydrated for 2 h in a solution of sucralose and then dried in a tray dryer for 3 h. The model was validated by experimental data of temperature, moisture content and sucralose uptake (R2 > 0.90).© 2013 Elsevier Ltd. All rights reserved.


The Guarani cuisine is marked by the record of food processing techniques and a diet that involves the selection and combination of nutrients which can be thought from its implications in the organization of their social world. This text provides an ethnography of the Guarani food produced among populations of the ethnic bias Mbya living in territories located in the far west of the state of Paraná, proposing a reinterpretation of the levi-straussian culinary triangle in light of ethnographic findings among the contemporary Guarani. The relation between food materials and culinary processing techniques inferred the construction and organization of the social forms of the Guarani world with their tensions between inside/outside and female/male resounding in oppositions between developed and non-developed on the one hand, and culture and nature on the other.


Real L.,Federal University of Parana | Retore C.,Labri University Of Bordeaux
Journal of Logic, Language and Information | Year: 2014

We propose a lexical account of event nouns, in particular of deverbal nominalisations, whose meaning is related to the event expressed by their base verb. The literature on nominalisations often assumes that the semantics of the base verb completely defines the structure of action nominals. We argue that the information in the base verb is not sufficient to completely determine the semantics of action nominals. We exhibit some data from different languages, especially from Romance language, which show that nominalisations focus on some aspects of the verb semantics. The selected aspects, however, seem to be idiosyncratic and do not automatically result from the internal structure of the verb nor from its interaction with the morphological suffix. We therefore propose a partially lexicalist approach view of deverbal nouns. It is made precise and computable by using the Montagovian generative lexicon, a type theoretical framework introduced by Bassac, Mery and Retoré in this journal in 2010. This extension of Montague semantics with a richer type system easily incorporates lexical phenomena like the semantics of action nominals in particular deverbals, including their polysemy and (in)felicitous copredications. © 2014 Springer Science+Business Media Dordrecht.


Emmerich D.,Martin Luther University of Halle Wittenberg | Vanchanagiri K.,Martin Luther University of Halle Wittenberg | Baratto L.C.,Federal University of Parana | Schmidt H.,Martin Luther University of Halle Wittenberg | Paschke R.,Martin Luther University of Halle Wittenberg
European Journal of Medicinal Chemistry | Year: 2014

Both betulinic acid 1 and cisplatin are promising antitumor agents, which induce apoptotic cell death of cancer cells. In the present investigation a new series of betulinic acid-cisplatin conjugates were synthesized and cytotoxicity and selectivity were assessed against five different tumor cell lines. The aim was to combine two structural units, both related with apoptosis induction. The derivatives exerted a dose-dependent antiproliferative action at micromolar concentrations and the effect of these structural variations on anticancer activity was studied and discussed. Several compounds revealed significant antitumor activity, as the most active substance 3-O-acetylbetulinic (2-(2-aminoethyl)aminoethyl)amide (IC50 = 1.30-2.24 μM). Interestingly, Betulinic acid-cisplatin conjugates were less cytotoxic than the precursors. © 2014 Elsevier Masson SAS. All rights reserved.


Sharipov F.,Federal University of Parana
Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films | Year: 2013

In vacuum technology, one deals with gaseous mixtures more frequently than with a single gas, but the information about transport phenomena in mixtures published in the open literature is very poor. Moreover, methods to model mixture flows are more complicated than those for single gas. The aim of this work is to review general approaches to modeling mass, heat, and momentum transfer through gaseous mixtures over the whole range of gas rarefaction. This review is written in an easy, accessible manner avoiding hard mathematical derivations, though an extensive list of references is provided for readers wishing to find more details about the field. Results for some classical problems such as velocity slip and temperature jump coefficients, Poiseuille flow, Couette flow, and heat transfer for gaseous mixtures are presented in graphical form. A comparison of these results with those corresponding to a single gas is presented, which shows the peculiarities of the transport phenomena in mixtures and gives us an idea how to model mixture flows in vacuum systems and microfluidics. © 2013 American Vacuum Society.


Kossoski F.,University of Sao Paulo | Bettega M.H.F.,Federal University of Parana
Journal of Chemical Physics | Year: 2013

We report elastic integral and differential cross sections for electron scattering from the aza-derivatives of pyrrole, furan, and thiophene, namely, pyrazole, imidazole, isoxazole, oxazole, isothia-zole, and thiazole. The calculations were performed within the Schwinger multichannel method with pseudopotentials, with inclusion of static, exchange, and polarization interactions, for energies up to 10 eV. We found two π* shape resonances and a high-lying σ* shape resonance in each system. A sharp low-energy σ* resonance was also identified in isothiazole and thiazole. Pyrazole and imida-zole presented yet a broad low-lying σ* resonance. The positions of the resonances agree very well with existing experimental results. We discuss the similarities and differences among the resonances of these compounds. © 2013 AIP Publishing LLC.


Colanzi T.E.,Federal University of Parana
Proceedings - International Conference on Software Engineering | Year: 2012

The Product-Line Architecture (PLA) is the main artifact of a Software Product Line (SPL). However, obtaining a modular, extensible and reusable PLA is a people-intensive and non-trivial task, related to different and possible conflicting factors. Hence, the PLA design is a hard problem and to find the best architecture can be formulated as an optimization problem with many factors. Similar Software Engineering problems have been efficiently solved by search-based algorithms in the field known as Search-based Software Engineering. The existing approaches used to optimize software architecture are not suitable since they do not encompass specific characteristics of SPL. To easy the SPL development and to automate the PLA design this work introduces a multi-objective optimization approach to the PLA design. The approach is now being implemented by using evolutionary algorithms. Empirical studies will be performed to validate the neighborhood operators, SPL measures and search algorithms chosen. Finally, we intend to compare the results of the proposed approach with PLAs designed by human architects. © 2012 IEEE.


May-De Mio L.L.,Federal University of Parana | Luo Y.,University of California Kearney Research and Extension Center | Michailides T.J.,University of California Kearney Research and Extension Center
Plant Disease | Year: 2011

The aim of this study was to investigate the sensitivity of Monilinia fructicola isolates to tebuconazole (demethylation inhibitor [DMI]), azoxystrobin (quinone outside inhibitor), and thiophanate-methyl (methyl benzimidazole carbamate) in 118 isolates collected from four states in Brazil from orchards with different histories of fungicide use. Sensitivity to fungicides was determined by inhibition of mycelial growth and spore germination on fungicide-amended media. Polymerase chain reaction was used to determine the frequencies of M. fructicola genotypes exhibiting high (HR) and low (LR) resistance to thiophanate-methyl among sampled populations. Resistance to tebuconazole was found in 15.8% of isolates collected from São Paulo State. The 50% effective concentration (EC 50) values varied from 0.01 to greater than 100 μg/ml. The EC 50 values for tebuconazole corresponded to its historic use frequency in the orchard; for instance, isolates from orchards with no DMI fungicide use had the lowest mean EC 50 value (0.04 μg/ml), while those collected from orchards where more than five DMI fungicide sprays were applied per season had a mean EC 50 value of 21.17 μg/ml. All isolates were sensitive to azoxystrobin but their EC 50, based on tests of inhibition of conidial germination, increased from 0.05 in 2002 to 0.44 μg/ml in 2008. The EC 50 values based on mycelial growth inhibition for thiophanate-methyl were >162 μg/ml, 1.99 to 12.5 μg/ml, and <1.0 μg/ml for HR, LR, and sensitive isolates, respectively. © 2011 The American Phytopathological Society.


Merchant S.S.,Massachusetts Institute of Technology | Zanoelo E.F.,Federal University of Parana | Speth R.L.,Massachusetts Institute of Technology | Harper M.R.,Massachusetts Institute of Technology | And 3 more authors.
Combustion and Flame | Year: 2013

The first reaction mechanism for iso-butanol (372 species and 8723 reversible elementary reactions) pyrolysis and combustion that includes pressure dependent kinetics and proposes reaction pathways to soot precursors has been automatically generated using the open-source software package RMG. High-pressure reaction rate coefficients for important hydrogen abstraction reactions from iso-butanol by hydrogen, methyl and HO2 were calculated using quantum chemistry at the CBS-QB3 level. The mechanism was validated with recently published iso-butanol combustion experiments as well as new pyrolysis speciation data under diluted and undiluted conditions from 900 to 1100K at 1.72atm representative of fuel rich combustion conditions. Sensitivity and rate of production analysis revealed that the overall good agreement for the pyrolysis species, and in particular for the soot precursors like benzene, toluene and 1,3-cyclopentadiene, depends strongly on pressure dependent reactions involving the resonantly stabilized iso-butenyl radical. Laminar flame speed, opposed flow diffusion flame speciation profiles, and autoignition are also well-captured by the model. The agreement with speciation profiles for the jet-stirred reactor could be improved, in particular for temperatures lower than 850K. Flux and sensitivity analysis for iso-butanol consumption revealed that this is primarily caused by uncertainty in iso-butanol+OH, iso-butanol+HO2 and the low temperature peroxy chemistry rates. Further theoretical and quantum chemical studies are needed in understanding these rates to completely predict the combustion behavior of iso-butanol using detailed chemistry. © 2013 The Combustion Institute.


Martin H.D.,Baylor University | Palmer I.J.,Baylor University | Hatem M.,Federal University of Parana
Arthroscopy - Journal of Arthroscopic and Related Surgery | Year: 2014

Purpose The purpose of this study was to evaluate the temperature at the sciatic nerve when using a monopolar radiofrequency (RF) probe to control bleeding in deep gluteal space endoscopy, as well as assess the fluid temperature profile. Methods Ten hips in 5 fresh-frozen human cadaveric specimens from the abdomen to the toes were used for this experiment. Temperatures were measured at the sciatic nerve after 2, 5, and 10 seconds of continuous RF probe activation over an adjacent vessel, a branch of the inferior gluteal artery. Fluid temperatures were then measured at different distances from the probe (3, 5, and 10 mm) after 2, 5, and 10 seconds of continuous probe activation. All tests were performed with irrigation fluid flow at 60 mm Hg allowing outflow. Results After 2, 5, or 10 seconds of activation over the crossing branch of the inferior gluteal artery, the mean temperature increased by less than 1 C on the surface and in the perineurium of the sciatic nerve. Considering the fluid temperature profile in the deep gluteal space, the distance and duration of activation influenced temperature (P <.05). Continuous delivery of RF energy for 10 seconds caused fluid temperature increases of 1.2 C, 2 C, and 3.1 C on average at 10 mm, 5 mm, and 3 mm of distance, respectively. Conclusions This study found the tested monopolar RF device to be safe during use in vessels around the sciatic nerve after 2, 5, and 10 seconds of continuous activation. The maximum fluid temperature (28 C) after 10 seconds of activation at 3 mm of distance is lower than the minimal reported temperature necessary to cause nerve changes (40 C to 45 C). Clinical Relevance Monopolar RF seems to be safe to the neural structures when used at more than 3 mm of distance and with less than 10 seconds of continuous activation in deep gluteal space endoscopy with fluid inflow and outflow. © 2014 by the Arthroscopy Association of North America.


Torii A.J.,Federal University of Parana | Lopez R.H.,INSA Rouen | Biondini F.,Polytechnic of Milan
Engineering Optimization | Year: 2012

This article deals with the reliability based geometry and topology optimization of truss structures. It presents an approach to optimize simultaneously the geometry and topology of statically undetermined trusses considering the acting forces and the yielding stress of the bars as random variables. Based on the assumptions of linear structural behaviour and independent and normally distributed random variables, the optimization problem is posed in such a way that its computational cost is similar to a standard deterministic optimization problem, which is the main contribution of this study. It is shown in the numerical analysis that when uncertainties are considered, the resulting optimum structure may not be a simply scaled version of the deterministic solution, but there may be a change in the structural geometry as well. © 2012 Copyright Taylor and Francis Group, LLC.


Bautitz I.R.,Sao Paulo State University | Bautitz I.R.,Federal University of Parana | Velosa A.C.,Sao Paulo State University | Velosa A.C.,Instituto Federal Of Educacao Ciencia E Tecnologia Do Sul Of Minas Gerais | Nogueira R.F.P.,Sao Paulo State University
Chemosphere | Year: 2012

Parameters that influence the zero valent iron mediated degradation of the pharmaceutical diazepam (DZP) were evaluated including the iron concentration and its pre-treatment, the effect of complexation with EDTA and oxic versus anoxic condition. It was observed that acid pre-treatment of iron particles is important for degradation efficiency and that H 2SO 4 is a better choice than HCl, resulting in higher degradation of DZP. Under oxic conditions, the degradation of DZP achieved 96% after 60min using Fe 0 (25gL -1) pre-treated with H 2SO 4 in the presence of EDTA (119mgL -1), while mineralization achieved around 60% after the same time. Under anoxic conditions, degradation occurred, however at lower extent, achieving 67% after 120min. The addition of EDTA improved the treatment efficiency in 20% leading to 99% DZP degradation after 120min. The first intermediates formed during DZP degradation were identified using LC/MS analysis and revealed the formation of mono- and di-hydroxylated products from DZP during Fe 0/EDTA/O 2 degradation, which evidences that OH was the main oxidizing species formed in this process. © 2012 Elsevier Ltd.


Weinert W.R.,Federal University of Parana | Lopes H.S.,Federal University of Technology of Parana
International Journal of Innovative Computing and Applications | Year: 2011

A parallel rule induction system based on gene expression programming (GEP) is reported in this paper. The system was developed for data classification. The parallel processing environment was implemented on a cluster using a message-passing interface. A master-slave GEP was implemented according to the Michigan approach for representing a solution for a classification problem. A multiple master-slave system (islands) was implemented in order to observe the co-evolution effect. Experiments were done with ten datasets, and algorithms were systematically compared with C4.5. Results were analysed from the point of view of a multi-objective problem, taking into account both predictive accuracy and comprehensibility of induced rules. Overall results indicate that the proposed system achieves better predictive accuracy with shorter rules, when compared with C4.5. © 2011 Inderscience Enterprises Ltd.


Linzmeier A.M.,Federal University of Grande Dourados | Ribeiro-Costa C.S.,Federal University of Parana
Biota Neotropica | Year: 2013

The aim of this paper was to describe the seasonal patterns of Chrysomelidae and of its most abundant species at eight sites in different geomorphological and floristic regions in the state of Paraná, southern Brazil. Samples with Malaise traps, from August 1986 to July 1988 were performed. The Chrysomelidae showed seasonal patterns with the highest abundance in the spring and/or summer at all sites, but with variations in the months of highest captures. Photoperiod was the variable that most influenced the seasonality of Chrysomelidae, and along with temperature and relative humidity, determined most of the seasonal patterns of the family at the different sites. Some dominant species of Chrysomelidae showed different seasonal pattern compared to the family level. A better knowledge of the seasonal distribution patterns of these species will only be possible when their life history, such as host plants and behavior, was better understood.


Caetano R.A.,Federal University of Parana | Caetano R.A.,Federal University of Alagoas
Physical Review B - Condensed Matter and Materials Physics | Year: 2014

Bloch oscillation and Zener tunneling are investigated in helicoidal molecules, with DNA as the representative example, in the presence of spin-orbit coupling induced by electrical charges accumulated along the structure of the molecule. We show that the presence of the spin-orbit coupling does not destroy the Bloch oscillations and, further, it induces the appearance of nontrivial Bloch oscillation frequencies associated with resonances among Wannier-Stark states. The Zener tunneling between the spin states is also studied here by looking at the time evolution of the polarization of the wave packet. The results show that the polarization also oscillates with nontrivial well-determined frequencies. © 2014 American Physical Society.


Brunatto S.F.,Federal University of Parana
Journal of the Brazilian Society of Mechanical Sciences and Engineering | Year: 2010

The acquirements and potentiality universe of cleaning, heating and/or sputtering effects caused by plasma species bombardment phenomenon on the surface characteristics and finishing of manufactured parts treated in DC abnormal glow discharge opens a new research and development field, called here of Plasma Assisted Parts' Manufacturing (PAP'M). The adequate control of the sputtering mechanism allows the production of different kinds of surface. Therefore, the design of rough or smooth surface, presenting a modified distribution of surface porosity and texturing could be idealized, in accordance with the desired surface characteristics, as the parts are simultaneously sinteredand treated. The first part (out of two) of this work performed in hollow cathode discharge (HCD) presents the results of the surface morphology's changes in the pressed iron samples and in the internal surfaces of the external cathodes as a function of the sintering time andtemperature. Potential applications include small diameters' cylindrical parts and components like axles, pins, pivots, and tubes and pipes presenting small internal diameters. Sputtering effects were quantified by means of mass loss and Ra and Rz roughness measurements and qualified by means of SEM. The overall work comprises the study of different parameters, including sintering time and temperature (Part I),and intercathode distance and pressure (Part II). Results indicate the sputtering mechanism in HCD sintering and surface texturing treatments could be adequately controlled as a function of the plasma parameters, comprising an important contribution to the development of green technologies for surface texturing, surface engineering, and part'smanufacturing. Copyright © 2010 by ABCM.


Carrer J.A.M.,Federal University of Parana | Mansur W.J.,Federal University of Rio de Janeiro
International Journal for Numerical Methods in Engineering | Year: 2010