Belo Horizonte, Brazil
Belo Horizonte, Brazil

Universidade Federal de Minas Gerais is a federal university located in Belo Horizonte, state of Minas Gerais, Brazil. UFMG is one of Brazil's five largest universities, being the largest federal university. It offers 75 undergraduate degrees, including a Medicine degree, Law and Economics, plus Engineering and Science and Art degrees. It offers 57 PhD programs, 66 MSc programs, 79 Post-Baccalaureate programs and 38 medical internship programs. UFMG has a population of 49,254 students.The undergratuate students are admitted through the national biannual exams called Unified Selection System . Its undergraduate courses were ranked in 1st place in the 2007 results for the National Student's Performance Exam and 4th place in the 2008 results. Its Computer Science course was considered the best in the country, as well the Social science course, from FAFICH by the latest edition of ENADE.The rector of UFMG is Clelio Campolina Diniz. Past students include former Brazilian presidents Juscelino Kubitschek and Tancredo Neves; writer, medical doctor and diplomat João Guimarães Rosa, writers Fernando Sabino, Pedro Nava and Cyro dos Anjos; plastic surgeon Ivo Pitanguy, poet Carlos Drummond de Andrade and musicians Fernando Brant, Samuel Rosa of Skank and Fernanda Takai of Pato Fu.UFMG is the tenth in the rankings of best universities in Latin America, according QS World University Rankings . As reported by the Academic Ranking of World Universities , UFMG is one of the five best universities in Brazil in 2013, and in the World Rank is in the range of 301-400 best universities. Wikipedia.


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Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP-SICA | Phase: SSH.2012.2.1-2 | Award Amount: 1.33M | Year: 2013

DESAFIO means challenge in both Portuguese and Spanish. The guiding concept of our proposal is to make a contribution towards tackling what is arguably one of the major challenges facing Brazil and Latin American countries in the 21st century: eradicating structural social inequality in the access to essential water and sanitation services. The overarching objective of our proposal is assessing existing experiences and developing new strategies that bring about sustainable, appropriate, and innovative socio-technical solutions to foster economic and social development through social transformation in vulnerable communities, particularly with reference to access to safe water supply and sanitation in urban, peri-urban, and rural areas of South America, with a particular emphasis on Brazil. These strategies will be developed through research and networking that actively engages beneficiary communities, practitioners, local authorities, and other relevant actors in their planning, design, assessment, implementation, monitoring, validation, and diffusion. Our transdisciplinary approach is predicated on a close interaction with non-academic actors in the production and validation of knowledge, among other things to underpin policy and behavioural transformations. We have selected a number of case studies that will cover a range of situations and characteristics, from informal settlements in the urban periphery of world megacities (Rio de Janeiro, Brazil) and in peri-urban areas of provincial capitals (Cali, Colombia), favelas located in the heart of booming mid-range urban centres (Recife, Brazil), to small rural villages (Mondomo, Colombia) and communities in semi-arid areas (Cear and Minas Gerais, Brazil and Santa Fe, Argentina). We will endeavour to draw lessons and develop recommendations that are applicable to other socio-cultural and economic contexts across the developing world.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC1-PM-22-2016 | Award Amount: 15.59M | Year: 2016

ZIKAlliance is a multidisciplinary project with a global One Health approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status.


Ferrari T.C.A.,Federal University of Minas Gerais | Moreira P.R.R.,Federal University of Minas Gerais
The Lancet Neurology | Year: 2011

Neuroschistosomiasis, referring to schistosomal involvement of the CNS, when symptomatic, is a severe disorder in which prognosis depends largely on early diagnosis and treatment. It is an underdiagnosed disorder, but has been increasingly reported in populations in endemic areas and in tourists. CNS involvement can occur at any time during schistosomal infection. Both the brain and the spinal cord can be affected. Schistosoma mansoni and Schistosoma haematobium usually cause myelopathy, whereas Schistosoma japonicum usually causes encephalic disease. There are substantial differences in the pathogenesis, clinical presentation, and outcome of the neurological disorder, depending on the phase and clinical form of schistosomiasis in which it occurs. © 2011 Elsevier Ltd.


Ribeiro A.L.,Federal University of Minas Gerais
Journal of the American Heart Association | Year: 2014

Electrocardiography has been considered an important tool in the management of Chagas disease (ChD) patients, although its value in elderly infected patients is unknown. This study was designed to investigate the prevalence and prognostic value of electrocardiographic abnormalities in Trypanosoma cruzi infected and noninfected older adults. We studied 1462 participants in Bambuí City, Brazil, with electrocardiogram (ECG) records classified by the Minnesota Code. Follow-up time was 10 years; the endpoint was mortality. Adjustment for potential confounding variables included age, gender, conventional risk factors, and B-type natriuretic peptide (BNP). The mean age was 69 years (60.9% women). The prevalence of ChD was 38.1% (n=557). ECG abnormalities were more frequent in ChD patients (87.6% versus 77.7%, P<0.001). Right bundle branch block (RBBB) with left anterior hemiblock (LAH) was strongly related to ChD (OR: 11.99 [5.60 to 25.69]). During the mean follow-up time of 8.7 years, 556 participants died (253 with ChD), and only 89 were lost to follow-up. ECG variables of independent prognostic value for death in ChD included absence of sinus rhythm, frequent ventricular and supraventricular premature beats, atrial fibrillation, RBBB, old and possible old myocardial infarction, and left ventricular hypertrophy. The presence of any major ECG abnormalities doubled the risk of death in ChD patients (HR: 2.18 [1.35 to 3.53]), but it also increased the risk in non-ChD subjects (HR: 1.50 [1.07 to 2.10]); the risk of death increased with the number of major abnormalities in the same patient. ECG abnormalities are more common among elderly Chagas disease patients and strongly predict adverse outcomes.


Di Lorenzo A.,Federal University of Minas Gerais
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2012

A weak measurement consists of coupling a system to a probe in such a way that constructive interference generates a large output. So far, only the average output of the probe and its variance were studied. Here, the characteristic function for the moments of the output is provided. The outputs considered are not limited to the eigenstates of the pointer or of its conjugate variable, so the results apply to any observable o of the probe. Furthermore, a family of well-behaved complex quantities, the normal weak values, is introduced, in terms of which the statistics of the weak measurement can be described. It is shown that, within a good approximation, the whole statistics of weak measurement is described by a complex parameter, the weak value, and a real one. © 2012 American Physical Society.


Weber G.,Federal University of Minas Gerais
Nucleic Acids Research | Year: 2013

Information about molecular interactions in DNA can be obtained from experimental melting temperature data by using mesoscopic statistical physics models. Here, we extend the technique to RNA and show that the new parameters correctly reproduce known properties such as the stronger hydrogen bonds of AU base pairs. We also were able to calculate a complete set of elastic constants for all 10 irreducible combinations of nearest neighbours (NNs). We believe that this is particularly useful as experimentally derived information about RNA elasticity is relatively scarce. The melting temperature prediction using the present model improves over those from traditional NN model, providing thus an alternative way to calculate these temperatures for RNA. Additionally, we calculated the site-dependent base pair oscillation to explain why RNA shows larger oscillation amplitudes despite having stronger AU hydrogen bonds. © 2012 The Author(s). Published by Oxford University Press.


Patent
Federal University of Minas Gerais and Ama Solucoes Tecnologicas Amatech | Date: 2015-01-05

The present invention describes the process of preparing ceramics for the absorption of ACIDIC gases, which worsen the greenhouse effect, that are released in combustion systems, or that are present in closed environments. In relation to carbon dioxide, principal target of the present invention, the process of absorption, transport, processing and transformation of the gas into other products is described. The process uses ceramic materials prepared through the solid mixture of one or more metallic oxides, with one or more binding agents and an expanding agent. The product generated can be processed and the absorbent system regenerated. The carbon dioxide obtained in the processing can be used as analytic or commercial carbonic gas, various carbamates and ammonium carbonate.


Patent
Federal University of Minas Gerais | Date: 2015-07-29

The present invention relates to a synthetic peptide of 19 amino acids, called PnTx(19), constituted from the sequence of the native toxin PnTx2-6 of the Phoneutria nigriventer spider. It also relates to pharmaceutical compositions containing such a peptide and to the use thereof in the treatment of erectile dysfunction and/or in potentiating the erectile function.


Patent
Federal University of Minas Gerais and Instituto Evandro Chagas | Date: 2015-03-25

The present invention describes the obtaining process of the dichloromethane fraction and subfractions from Eleutherine plicata, popularly known as marupazinho, marupar, palmeirinha, coquinho, marupa, marupa, marup-piranga, and lrio-folha-de-palmeira. This invention comprises the obtaining process of pharmaceutical compositions that contain the dichloromethane fraction and/or naphthoquinone, as well as its use for malaria treatment. Extract and fractions were assayed and presented antiplasmodial activity, particularly against chloroquine-resistant Plasmodium falciparum (clone W2).


Patent
Federal University of Minas Gerais | Date: 2015-12-23

The present invention relates to the peptide (arg0) n-angiotensin-(1-7) [(arg0) n-Ang-(1-7)], where n is 1 to 10 (Xaa-Asp-Arg-Val-Tyr-Ile-His-Pro; SEQ ID NO:1 where Xaa represents 1 to 10 L-Arg residues), which is produced by inserting at least one arginine amino acid at the amino terminal position of Ang-(1-7), as well as pharmaceutical compositions containing this peptide and the use thereof for the treatment or prevention of diseases or disorders that are due or associated with reduced nitric oxide production. Non-limiting examples of these diseases or disorders are cardiopulmonary and liver diseases, vascular disorders, metabolic disorders, neural disorders, genito-urinary tract disorders, skeletal muscle disorders, kidney disorders, skin disorders, alopecia or tumors. The peptide is able to cause, for example, dilation of aortic and mesenteric vessels, reduction of mean arterial blood pressure, decrease of body weight gain, blockade of the development of visceral adiposity, reduced serum and liver cholesterol levels, the normalization of glucose intolerance and insulin resistance, and an anti-proliferative effect. The peptides of the invention, such as (arg0) n-Ang-(1-7), optionally can be associated with a carrier system or controlled drug release system.

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