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Afonso C.L.,University of Sao Paulo | Raza A.S.,Columbia University | Kreuz A.C.,University of Sao Paulo | Hokazono K.,University of Sao Paulo | And 3 more authors.
Investigative Ophthalmology and Visual Science | Year: 2015

Purpose. We evaluated the ability of transient pattern electroretinogram (PERG) parameters to differentiate between eyes with visual field (VF) loss and resolved papilledema from pseudotumor cerebri syndrome (PTC) and controls, to compare PERG and optical coherence tomography (OCT) with regard to discrimination ability, and to assess the correlation between PERG, frequency domain OCT (FD-OCT), and VF measurements. Methods. The VFs and full-field stimulation PERGs based on 48 and 14-min checks were obtained from patients with PTC (n = 24, 38 eyes) and controls (n = 26, 34 eyes). In addition, FD-OCT peripapillary retinal nerve fiber layer (RNFL) and segmented macular layer measurements were obtained and correlation coefficients were determined. Results. Compared to controls, PERG N95 and P50+N95 amplitude measurements with 48-minute checks were significantly reduced in eyes with resolved papilledema from PTC. Both PERG N95 amplitude and OCT parameters were able to discriminate papilledema eyes from controls with a similar performance. Significant correlations, ranging from 0.25 (P < 0.05) to 0.43 (P < 0.01) were found between PERG amplitude values and OCT-measured macular ganglion cell layer thickness, RNFL thickness, and total retinal thickness. The PERG amplitude also was significantly associated with VF sensitivity loss with correlation coefficients ranging from 0.24 (P < 0.05) and 0.35 (P < 0.01). Conclusions. The PERG measurements were able to detect neural loss in PTC eyes with resolved papilledema and were reasonably well correlated with OCT measurements and VF parameters. Thus, PERG may be a useful tool in the monitoring of retinal neural loss in eyes with active papilledema from PTC. © 2015 The Association for Research in Vision and Ophthalmology, Inc.

Neiva F.W.,Federal University Of Juiz Of Foraminas Gerais | David J.M.N.,Federal University Of Juiz Of Foraminas Gerais | Braga R.,Federal University Of Juiz Of Foraminas Gerais | Campos F.,Federal University Of Juiz Of Foraminas Gerais
Information and Software Technology | Year: 2016

Context: Many researchers have argued that providing interoperability support only considering the format and meaning (i.e. syntax and semantic) of data exchange is not enough to achieve complete, effective and meaningful collaboration. Pragmatic interoperability has been highlighted as a key requirement to enhance collaboration. However, fulfilling this requirement is not a trivial task and there is a lack of works discussing solutions to achieve this level of interoperability. Objectives: The aim of this study is to present a systematic review and mapping of the literature in order to identify, analyse and classify the published solutions to achieve pragmatic interoperability. Method: To conduct a systematic review and mapping in accordance with the guidelines proposed in the evidence-based software engineering literature. Results: Our study identified 13 papers reporting pragmatic interoperability computational solutions. The first paper in our set of selected papers was published in 2004; the main strategies used to address pragmatic interoperability issues were service discovery, composition and/or selection and ontologies. The application domain of the identified solutions was mainly e-business. In addition, most of the identified solutions were software architectures. Conclusion: Mature proposals addressing pragmatic interoperability are still rare in the literature. Although many works have discussed the importance of pragmatic interoperability, it is necessary that researchers report solutions that implement and evaluate pragmatic interoperability in order to make progress in this area. © 2016 Elsevier B.V. All rights reserved.

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