The Universidade Federal de Goiás is a publicly funded university located in the Brazilian state of Goiás, headed in Goiânia and with campuses in the municipalities of Catalão, City of Goiás, and Jataí.Founded on December 14, 1960, after the merger of previously existing colleges, UFG is the only federally funded institution of higher education in the state, the richest and most populous in the Central-West Region of Brazil. The activities of the university involves 28,899 students in 150 undergraduate courses.According to the National Institute of Studies and Research on Education, linked to the Ministry of Education, UFG is the second best university in the Central-West Region, behind only University of Brasília. Wikipedia.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-22-2016 | Award Amount: 15.59M | Year: 2016
ZIKAlliance is a multidisciplinary project with a global One Health approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status.
Braga R.C.,Federal University of Goais |
Andrade C.H.,Federal University of Goais
Current Topics in Medicinal Chemistry | Year: 2013
Pharmacophore approaches have evolved to be one of the most successful tools in drug discovery, especially since the past two decades. 3D pharmacophore methods are now commonly used as part of more complex workflows in drug discovery campaigns, and have been successfully and extensively applied in virtual screening (VS) approaches. This review provides a perspective of how to assess the performance of 3D pharmacophore models to be used in VS. Since 3D VS protocols are in general assessed by their ability to discriminate between active and inactive compounds, we summarize the impact of the composition and preparation of modeling and external sets on the outcome of evaluations. Moreover, we highlight the significance of both classic enrichment parameters and advanced descriptors for the performance of 3D pharmacophore-based virtual screening methods. © 2013 Bentham Science Publishers.
Braghin F.L.,Federal University of Goais
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2016
Higher order quark effective interactions are found for SU(2) flavor by departing from a non-local quark–quark interaction. By integrating out a component of the quark field, the determinant is expanded in chirally symmetric and symmetry breaking effective interactions up to the fifth order in the quark bilinears. The resulting coupling constants are resolved in the leading order of the longwavelength limit and exact numerical ratios between several of these coupling constants are obtained in the large quark mass limit. In this level, chiral invariant interactions only show up in even powers of the quark bilinears, i.e. O(ψ¯ψ)2n (n=1,2,3,.), whereas (explicit) chiral symmetry breaking terms emerge as O(ψ¯ψ)n being always proportional to some power of the Lagrangian quark mass. © 2016 The Author(s)
Agency: European Commission | Branch: FP7 | Program: CP-SICA | Phase: HEALTH-2007-2.3.4-1 | Award Amount: 3.75M | Year: 2009
The focus of this multidisciplinary proposal is to elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. The project will unite skills in genotyping, genomics, genetics and pathogenesis in Europe with considerable compatible skills in South America, and with key research in endemic areas that have distinct characteristics. The proposal is intended to be high impact in terms of both research progress and fostering of collaborative networks. Aim: Elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. Technology development: 1. Develop further and apply MLST; PCR-RFLP and MLMT to the analysis of genetic populations of T. cruzi, 2. Sequence the unresolved genome of T. cruzi I, 3. Develop lineage specific diagnosis, 4. Develop an oligochromatography PCR-dipstick procedure for detection of T. cruzi. Molecular epidemiology: 5. Pilot studies of association between genetic lineage, clinical outcome, and prevalence of congenital infection, 6. Map the silvatic vector, silvatic mammal, human and ecological associations of the T. cruzi genotypes IId,e,b,a. 7. Compare lineage specific pathogenesis and transmissibility of congenital infection in a mouse model, and compare lineage susceptibility to drugs in vitro. Population genetics and phylogenetics: 8. Re-evaluate the population genetics and evolution of T. cruzi lineages. International cryobank and database: 9. Establish in South America an accessible, expanded, international cryobank for T. cruzi, 10. Establish a website and database for outputs of the project. The project encompasses the desirable characteristics prescribed by the call, in that they include: genomics/proteomics; effective, innovative relevance to disease, pathogenesis, drugs, interventions; an integrated multidisciplinarity, and capacity building, networking and training in endemic regions.
Soares R.M.,Federal University of Goais
Journal of Sound and Vibration | Year: 2014
An analysis of the linear and nonlinear vibration response and stability of a pre-stretched hyperelastic rectangular membrane under harmonic lateral pressure and finite initial deformations is presented in this paper. Geometric nonlinearity due to finite deformations and material nonlinearity associated with the hyperelastic constitutive law are taken into account. The membrane is assumed to be made of an isotropic, homogeneous, and incompressible Mooney-Rivlin material. The results for a neo-Hookean material are obtained as a particular case and a comparison of these two constitutive models is carried out. First, the exact solution of the membrane under a biaxial stretch is obtained, being this initial stress state responsible for the membrane stiffness. The equations of motion of the pre-stretched membrane are then derived. From the linearized equations, the natural frequencies and mode shapes of the membrane are analytically obtained for both materials. The natural modes are then used to approximate the nonlinear deformation field using the Galerkin method. A detailed parametric analysis shows the strong influence of the stretching ratios and material parameters on the linear and nonlinear oscillations of the membrane. Frequency-amplitude relations, resonance curves, and bifurcation diagrams, are used to illustrate the nonlinear dynamics of the membrane. The present results are compared favorably with the results evaluated for the same membrane using a nonlinear finite element formulation. © 2014 Elsevier Ltd.
Ponde R.A.A.,Federal University of Goais
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2013
During hepatitis B virus (HBV) infection, at least four antigen-antibody systems are observed: HBsAg and anti-HBs; preS antigen and anti-preS antibody; HBcAg and anti-HBc; and HBeAg and anti-HBe. Through the examination of these antigen-antibody systems, hepatitis B infection is diagnosed and the course of the disorder may be observed. Although the serologic findings that allow both the diagnosis of HBV infection as well as assessing of its clinical course are already well established, the dynamics of viral proteins expression and of the antibodies production may vary during the infection natural course. This causes the HBV infection to be occasionally associated with the presence of uncommon serological profiles, which could lead to doubts in the interpretation of results or suspicion of a serological result being incorrect. This paper is dedicated to the discussion of some of these profiles and their significance. © 2012 Springer-Verlag Berlin Heidelberg.
Franco Jr. A.,Federal University of Goais |
E Silva F.C.,Federal University of Goais
Applied Physics Letters | Year: 2010
Cobalt ferrite materials have a wide variety of technological applications that requires temperatures higher than room temperature. Thus the magnetic properties such as saturation magnetization, Ms remanent magnetization, Mr, coercivitty, Hc, and Curie temperature, Tc, of nanoparticles of CoFe2 O4 were studied in a broad range of temperature varying from room temperature to 870 K. It was observed that, for temperatures 100 K above room temperature, these magnetic properties are still the same as at room temperature. The results were discussed in terms of interparticle interactions induced by the thermal fluctuations, cation distribution, and other imperfections that exert fields on Co2+ ions could increase with temperature. © 2010 American Institute of Physics.
Brito D.,Federal University of Goais
Basic and Applied Ecology | Year: 2010
Knowledge of biodiversity is woefully inadequate. Only a fraction of the planet's species has been described by science (the " Linnean shortfall" ). Even for described species, scientists often have only fragmentary information about their distributions (the " Wallacean" shortfall). These shortfalls in biodiversity knowledge place serious limitations on the ability to conserve biodiversity in the face of the ongoing extinction crisis. Here, I test the hypothesis that data deficiency may be used to guide surveys and inventories to regions that would increase the probability of discovering new species. I compiled global distribution maps for all Data Deficient amphibian species (species described up to 2004) and constructed a Data Deficiency (DD) surface (the DD surface was based on distribution information obtained from the IUCN Red List). Then, I compared the type-locality sites of new amphibian species descriptions (species described between 2005 and 2009) with the DD surface in order to check if new species discoveries were significantly more abundant within the DD surface or not. Even though the amphibian DD species surface covers only 8% of Earth's land area, 79% of the amphibian species discovered between 2005 and 2009 were within the DD surface. The results suggest that directing surveys towards areas of known data deficiency will likely result in the discovery of species new to science, helping to address the Linnean shortfall. Incorporating DD information from the IUCN Red List may provide an efficient methodology for strategically targeting surveys and inventories, maximizing the chances of obtaining high conservation benefits from them, and helping minimize the costs associated with such endeavours. © 2010.
Vendruscolo F.,Federal University of Goais
International Journal of Energy Research | Year: 2015
Hydrogen is a clean energy carrier with great potential to be an alternative fuel. Anaerobic hydrogen fermentation seems to be more favorable, since hydrogen is yielded at high rates and various organic waste and wastewater enriched with carbohydrates as substrate result in low cost for hydrogen production. Abundant biomass from various industries could be a source for biohydrogen production where combination of waste treatment and energy production would be an advantage. Carbohydrate-rich nitrogen-deficient solid wastes such as starch residues can be used for hydrogen production by using suitable bioprocess technologies. Alternatively, converting biomass into gaseous fuels, such as biohydrogen, is possibly the most efficient way to use these agroindustrial residues. This review summarizes the potential of starch agroindustrial residues as a substrate for biohydrogen production. Types of potential starch agroindustrial residues, recent developments and bio-processing conditions for biohydrogen production will be discussed. © 2014 John Wiley & Sons, Ltd.
Lima-Ribeiro M.S.,Federal University of Goais |
Diniz-Filho J.A.F.,Federal University of Goais
Earth-Science Reviews | Year: 2014
Although Late Quaternary extinctions have long been widely debated, narrative reviews have often been the basis of these debates. Probabilistic interpretations of human-megafauna coexistence based on systematic reviews are scarce. As a result, contradictory perspectives have emerged on the role of human and climate-driven impacts as the causes of these extinctions on many islands and continents. In this study, we show how a formal meta-analytical approach dealing with reliable dated records incorporating spatial variation may solve the contradictory views about human-megafauna contemporaneity on Tasmania. Although many authors argue for human-megafauna coexistence using narrative reviews, the negative and statistically significant summary effect size from our formal meta-analysis undoubtedly indicates that most megafauna (of a total of 7 species) had been extinct at least 1000. yrs before humans reached Tasmania from mainland Australia via a land bridge approximately 43-37. ka BP. Thus, based on our current knowledge, our findings do not probabilistically support human-driven extinctions on Tasmania through the Late Quaternary. Moreover, by considering the overall characteristics of the systematic reviews, we believe that this meta-analytical approach can improve the quality of further debates and help researchers find better solutions to the puzzle of Late Quaternary extinctions. © 2014 Elsevier B.V.