The Federal University of Bahia is a public university located mainly in the city of Salvador. It is the largest university of the state of Bahia.Students can study there without paying tuition fees, as it is a public university. To join the university they must pass an annual examination, known as the "vestibular". Wikipedia.
Marques C.R.,Federal University of Bahia
European Journal of Human Genetics | Year: 2017
Several genome-wide association studies have been conducted to investigate the influence of genetic polymorphisms in the development of allergic diseases, but few of them have included the X chromosome. The aim of present study was to perform an X chromosome-wide association study (X-WAS) for asthma symptoms. The study included 1307 children of which 294 were asthma cases. DNA was genotyped using 2.5 HumanOmni Beadchip from Illumina. Statistical analyses were performed in PLINK 1.9, MACH 1.0 and Minimac2. The variant rs12007907 (g.29483892C>A) in IL1RAPL gene was suggestively associated with asthma symptoms in discovery set (odds ratio (OR)=0.49, 95% confidence interval (CI): 0.37–0.67; P=3.33 × 10- 6). This result was replicated in the ProAr cohort in men only (OR=0.45, 95% CI: 0.21–0.95; P=0.038). Furthermore, investigating the functional role of the rs12007907 on the production a Th2-type cytokine, IL-13, we found a negative association between the minor allele A with IL-13 production in the discovery set (P=0.044). Gene-based analysis revealed that NUDT10 was the most consistently associated with asthma symptoms in discovery sample. In conclusion, the rs12007907 variant in IL1RAPL gene was negatively associated with asthma and IL-13 production in our study and a sex-specific association was observed in one of the validation samples. It suggests an effect on asthma susceptibility and may explain differences in severe asthma frequency between women and men.European Journal of Human Genetics advance online publication, 25 January 2017; doi:10.1038/ejhg.2016.197. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Chan F.K.-M.,University of Massachusetts Medical School |
Luz N.F.,University of Massachusetts Medical School |
Luz N.F.,Federal University of Bahia |
Moriwaki K.,University of Massachusetts Medical School
Annual Review of Immunology | Year: 2015
Cell proliferation and cell death are integral elements in maintaining homeostatic balance in metazoans. Disease pathologies ensue when these processes are disturbed. A plethora of evidence indicates that malfunction of cell death can lead to inflammation, autoimmunity, or immunodeficiency. Programmed necrosis or necroptosis is a form of nonapoptotic cell death driven by the receptor interacting protein kinase 3 (RIPK3) and its substrate, mixed lineage kinase domain-like (MLKL). RIPK3 partners with its upstream adaptors RIPK1, TRIF, or DAI to signal for necroptosis in response to death receptor or Toll-like receptor stimulation, pathogen infection, or sterile cell injury. Necroptosis promotes inflammation through leakage of cellular contents from damaged plasma membranes. Intriguingly, many of the signal adaptors of necroptosis have dual functions in innate immune signaling. This unique signature illustrates the cooperative nature of necroptosis and innate inflammatory signaling pathways in managing cell and organismal stresses from pathogen infection and sterile tissue injury. © 2015 by Annual Reviews. All rights reserved.
Agency: European Commission | Branch: H2020 | Program: ERC-ADG | Phase: ERC-ADG-2014 | Award Amount: 2.35M | Year: 2016
Fifteen years ago it was widely believed that asthma was an allergic/atopic disease caused by allergen exposure in infancy; this produced atopic sensitization and continued exposure resulted in eosinophilic airways inflammation, bronchial hyper-responsiveness and reversible airflow obstruction. It is now clear that this model is at best incomplete. Less than one-half of asthma cases involve allergic (atopic) mechanisms, and most asthma in low-and-middle income countries is non-atopic. Westernization may be contributing to the global increases in asthma prevalence, but this process appears to involve changes in asthma susceptibility rather than increased exposure to established asthma risk factors. Understanding why these changes are occurring is essential in order to halt the growing global asthma epidemic.This will require a combination of epidemiological, clinical and basic science studies in a variety of environments. A key task is to reclassify asthma phenotypes. These are important to: (i) better understand the aetiological mechanisms of asthma; (ii) identify new causes; and (iii) identify new therapeutic measures. There are major opportunities to address these issues using new techniques for sample collection from the airways (sputum induction, nasal lavage), new methods of analysis (microbiome, epigenetics), and new bioinformatics methods for integrating data from multiple sources and levels. There is an unprecedented potential to go beyond the old atopic/non-atopic categorization of phenotypes. I will therefore conduct analyses to re-examine and reclassify asthma phenotypes. The key features are the inclusion of: (i) both high and low prevalence centres from both high income countries and low-and-middle income countries; (ii) much more detailed biomarker information than has been used for previous studies of asthma phenotypes; and (iii) new bioinformatics methods for integrating data from multiple sources and levels.
Perelo L.W.,Federal University of Bahia
Journal of Hazardous Materials | Year: 2010
Organic pollutants in sediments are a worldwide problem because sediments act as sinks for hydrophobic, recalcitrant and hazardous compounds. Depending on biogeochemical processes these hydrocarbons are involved in adsorption, desorption and transformation processes and can be made available to benthic organisms as well as organisms in the water column through the sediment-water interface. Most of these recalcitrant hydrocarbons are toxic and carcinogenic, they may enter the food-chain and accumulate in biological tissue. Several approaches are being investigated or have been already used to remove organic hydrocarbons from sediments. This paper provides a review on types and sources of organic pollutants as well as their behavior in sediments. It presents the advantages and disadvantages of traditional sediment remediation techniques in use, such as dredging, capping and monitored natural attenuation. Furthermore, it describes new approaches with emphasis on bioremediation, like biostimulation, bioaugmentation and phytoremediation applied to sediments. These new techniques promise to be of lower impact and more cost efficient than traditional management strategies. © 2009.
Houndjo M.J.S.,Federal University of Bahia
International Journal of Modern Physics D | Year: 2012
We investigate the cosmological reconstruction in modified f(R, T) gravity, where R is the Ricci scalar and T the trace of the stressenergy tensor. Special attention is attached to the case in which the function f is given by f(R, T) = f 1(R) + f 2(T). The use of auxiliary scalar field is considered with two known examples for the scale factor corresponding to an expanding universe. In the first example, where ordinary matter is usually neglected for obtaining the unification of matter dominated and accelerated phases with f(R) gravity, it is shown in this paper that this unification can be obtained without neglecting ordinary matter. In the second example, as in f(R) gravity, model of f(R, T) gravity with transition of matter dominated phase to the acceleration phase is obtained. In both cases, linear function of the trace is assumed for f 2(T) and it is obtained that f 1(R) is proportional to a power of R with exponents depending on the input parameters. © World Scientific Publishing Company.
Paim J.S.,Federal University of Bahia
Cadernos de Saude Publica | Year: 2013
This article, celebrating the 25th anniversary of Brazil's 1988 Constitution, aims to review the country's social policy development, discuss political projects, and analyze challenges for the sustainability of the Unified National Health System (SUS). Based on public policymaking studies, the article revisits the origins of liberal social policy, focused on social assistance, and analyzes the hegemony of U.S. policies targeting poverty and their repercussions for universal policies. After identifying the formulation of political projects in Brazil's democratic transition, it discusses their implications during the various Administrations since 1988, along with the difficulties faced by the National Health System. The article concludes that the political forces occupying government in the last two decades have failed to present a project for the country on the same level as those who drafted the Citizen Constitution.
Oliveira B.G.D.,Federal University of Bahia
Physical Chemistry Chemical Physics | Year: 2013
In this paper, the intermolecular structural study asserted by the vibrational analysis in the stretch frequencies of hydrogen bonds (π⋯H) and dihydrogen bonds (H-δ⋯H +δ) have definitively been revisited by means of calculations carried out by Density Functional Theory (DFT) and topological parameters derived from the classic treatise of the Quantum Theory of Atoms in Molecules (QTAIM). As a matter of fact the π⋯H hydrogen bond is formed between the hydrofluoric acid and the CC bond of the acetylene, but the QTAIM calculations revealed a distortion in this interaction due to the formation of the ternary complex C2H2⋯2(HF). Although the π bonds of ethylene (C2H4), propylene (C2H 3(CH3)), and t-butylene (C2H 2(CH3)2) are considered proton acceptors, two hydrogen-bond types - π⋯H and C⋯H - can be observed. Over and above the analysis of the π hydrogen bonds, theoretical arguments also were used to discuss the red-shifts in the stretch frequencies of the binary dihydrogen complexes formed by BeH2⋯HX with X = F, Cl, CN, and CCH. Although a vibrational blue-shift in the stretch frequency of the H-C bond of HCF3 due to the formation of the BeH2⋯HCF 3 dihydrogen complex was obtained, unmistakable red-shifts were detected in LiH⋯HCF3, MgH2⋯HCF3, and NaH⋯HCF3. Moreover, the alkali-halogen bonds were identified in relation to the formation of the trimolecular systems NaH⋯2(HCF3) and NaH⋯2(HCCl3). At last, theoretical calculations and QTAIM molecular integrations were used to study a novel class of dihydrogen-bonded complexes (mC2H5 + ⋯nMgH2 with m = 1 or 2 and n = 1 or 2) based in the insight that MgH2 can bind with the non-localized hydrogen H +δ of the ethyl cation (C2H5 +). In an overview, QTAIM calculations were applied to evaluate the molecular topography, charge density, as well as to interpret the shifted frequencies either to red or blue caused by the formation of the hydrogen bonds and dihydrogen bonds. © the Owner Societies 2013.
Amorim L.D.A.F.,Federal University of Bahia |
Cai J.,University of North Carolina at Chapel Hill
International Journal of Epidemiology | Year: 2015
In many biomedical studies, the event of interest can occur more than once in a participant. These events are termed recurrent events. However, the majority of analyses focus only on time to the first event, ignoring the subsequent events. Several statistical models have been proposed for analysing multiple events. In this paper we explore and illustrate several modelling techniques for analysis of recurrent time-to-event data, including conditional models for multivariate survival data (AG, PWP-TT and PWP-GT), marginal means/ rates models, frailty and multi-state models. We also provide a tutorial for analysing such type of data, with three widely used statistical software programmes. Different approaches and software are illustrated using data from a bladder cancer project and from a study on lower respiratory tract infection in children in Brazil. Finally, we make recommendations for modelling strategy selection for analysis of recurrent event data. © The Author 2014.
Oliveira B.G.,Federal University of Bahia
Structural Chemistry | Year: 2014
An innovative theoretical study of intermolecular properties of standard hydrogen-bonded complexes of H2O···HCF 3, NH3···HCF3, H 2O···HF, and NH 3···HF is presented in this work. Several computational strategies were used, so initially the MP2/6-311++G(d,p) level of theory was applied to determine the optimized geometries by which the structural parameters, electronic properties, and the stretch vibration modes of these systems were examined. By taking into account the infrared spectrum analysis, the frequency shifted either to the red- or blue-region is the principal interpretation upon formation of intermolecular complexes. Due to this, the analysis of the interaction strengths corroborates with these vibration behaviors, and besides, the Natural Bond Orbital calculations revealed systematic changes in the percentage of the s and p orbitals, by which the stretch deformations on the proton donors (HF and HCF3) could be understood. In advance, it was quoted the appearing of intermolecular covalence in these complexes, and this event could be theoretically discovered through the topological computations based on the Bader's Quantum Theory of Atoms in Molecules. © 2013 Springer Science+Business Media New York.
Varandas P.,Federal University of Bahia
Journal of Statistical Physics | Year: 2012
We establish bounds for the measure of deviation sets associated to continuous observables with respect to not necessarily invariant weak Gibbs measures. Under some mild assumptions, we obtain upper and lower bounds for the measure of deviation sets of some non-uniformly expanding maps, including quadratic maps and robust multidimensional non-uniformly expanding local diffeomorphisms. For that purpose, a measure theoretical weak form of specification is introduced and proved to hold for the robust classes of multidimensional non-uniformly expanding local diffeomorphisms and Viana maps. © 2011 Springer Science+Business Media, LLC.