Federal State Institution Medical Radiological Research Center

Obninsk, Russia

Federal State Institution Medical Radiological Research Center

Obninsk, Russia

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Ivanov V.K.,Federal State Institution Medical Radiological Research Center | Kashcheev V.V.,Federal State Institution Medical Radiological Research Center | Chekin S.Yu.,Federal State Institution Medical Radiological Research Center | Menyaylo A.N.,Federal State Institution Medical Radiological Research Center | And 3 more authors.
Journal of Radiological Protection | Year: 2014

Multiple CT scans are often done on the same patient resulting in an increased risk of cancer. Prior publications have estimated risks on a population basis and often using an effective dose. Simply adding up the risks from single scans does not correctly account for the survival function. A methodology for estimating personal radiation risks attributed to multiple CT imaging using organ doses is presented in this article. The estimated magnitude of the attributable risk fraction for the possible development of radiation-induced cancer indicates the necessity for strong clinical justification when ordering multiple CT scans. © 2014 IOP Publishing Ltd.


Ivanov V.K.,Federal State Institution Medical Radiological Research Center | Tsyb A.F.,Federal State Institution Medical Radiological Research Center | Mettler F.A.,New Mexico VA Health Care Services | Menyaylo A.N.,Federal State Institution Medical Radiological Research Center | Kashcheev V.V.,Federal State Institution Medical Radiological Research Center
Health Physics | Year: 2012

Because of fast growing medical radiation use, estimating possible late health effects of radiation, including potential cancer risk, is an issue of substantial interest. Since physicians make the decision to order or perform a radiological procedure, it is very important to provide them with objective information about possible radiation-associated risks. Methodology for estimating cancer risks based on recommendations of ICRP Publication 103 is presented in the paper. Organ doses, age, and gender are used as basic parameters. An example of the evaluation of radiation-associated risks from computed tomography examination is presented. © 2012 Health Physics Society.


Fetisova E.K.,Moscow State University | Antoschina M.M.,Federal State Institution Medical Radiological Research Center | Cherepanynets V.D.,Moscow State University | Izumov D.S.,Moscow State University | And 6 more authors.
Cell and Tissue Biology | Year: 2015

It is shown that mitochondria-targeted antioxidant SkQR1 protects erythroleukemia K562 cells from radiation injury. Pretreatment with SkQR1 before irradiation decreased generation of DNA double-strand breaks, diminished the number of chromosomal aberrations, and suppressed delayed ROS production. Prevention of oxidative stress and normalization of mitochondrial function by mitochondria-targeted antioxidants may be a potential therapeutic strategy not only against the immediate consequences of radiation, but also against its late consequences, such as genomic instability. SkQR1 did not protect against radiation-induced damage of K562 cells with a high level of multidrug resistance (MDR) due to SkQR1 extrusion with a Pgp170 MDR pump. We suggest that mitochondria-targeted antioxidants can be used for selective protection of normal cells against radiation-induced damage without interference with radiotherapy of MDR-positive tumors. © 2015, Pleiades Publishing, Ltd.


Fetisova E.K.,Moscow State University | Antoschina M.M.,Federal State Institution Medical Radiological Research Center | Cherepanynets V.D.,Moscow State University | Izumov D.S.,Moscow State University | And 6 more authors.
Radiation Research | Year: 2015

We show here that mitochondria-targeted antioxidant composed of plastoquinone conjugated through hydrocarbon linker with cationic rhodamine 19 (SkQR1) protected against nuclear DNA damage induced by gamma radiation in K562 erythroleukemia cells. We also demonstrate that SkQR1 prevented the early (1 h postirradiation) accumulation of phosphorylated histone H2AX (γ-H2AX) an indicator of DNA double-strand break formation, as well as the radiation-induced increase in chromosomal aberrations. These data suggested that nuclear DNA damage induced by gamma radiation may be mediated by mitochondrial reactive oxygen species (ROS) production. We show that SkQR1 suppressed delayed accumulation of ROS 32 h after irradiation probably by inhibiting mitochondrial ROS-induced ROS release mechanisms. This suggests that mitochondria-targeted antioxidants may protect cells from the late consequences of radiation exposure related to delayed oxidative stress. We have previously reported that SkQRl is the substrate of multidrug resistance pump P-glycoproten (Pgp 170) and selectively protects Pgp 170-negative cells against oxidative stress. In line with this finding, we demonstrate here that SkQR1 did not protect Pgp170-positive K562 subline against DNA damage induced by gamma radiation. The selective radioprotection of normal Pgp 170-negative cells by mitochondria-targeted antioxidants could be a promising strategy to increase the efficiency of radiotherapy for multidrug-resistant tumors. © 2015 by Radiation Research Society.


Ivanov V.K.,Federal State Institution Medical Radiological Research Center | Kashcheev V.V.,Federal State Institution Medical Radiological Research Center | Zamulaeva I.A.,Federal State Institution Medical Radiological Research Center | Saenko A.S.,Federal State Institution Medical Radiological Research Center | And 5 more authors.
Radiation Protection Dosimetry | Year: 2012

The paper discusses technology for establishing potential cancer risk groups, based on methods of molecular and radiation epidemiology. Assay of gene mutations at the T-cell receptor (TCR) locus as the method of molecular epidemiology was used for measuring the frequency of TCR-mutations in 320 nuclear workers of the Institute of Physics and Power Engineering (IPPE). The method of radiation epidemiology was applied to the estimation of attributable risk fraction (ARF) for solid cancers in these groups. The main estimates of radiation risk after the Chernobyl accident are in close agreement with the International Commission on Radiological Protection (ICRP) Publication, 103 models published in 2007. In nuclear workers of the IPPE with ARF ≥ 10%, the increased level of TCR-mutations occurs more often (risk ratio=9.7; 95% CI: 2.9; 32.1). © World Health Organization 2012. All rights reserved.


Ivanov V.K.,Federal State Institution Medical Radiological Research Center
Health Physics | Year: 2014

The current study has two aims: the first is to quantify the difference between radiation risks estimated with the use of organ or effective doses, particularly when planning pediatric and adult computed tomography (CT) examinations. The second aim is to determine the method of calculating organ doses and cancer risk using dose-length product (DLP) for typical routine CT examinations. In both cases, the radiation-induced cancer risks from medical CT examinations were evaluated as a function of gender and age. Lifetime attributable risk values from CT scanning were estimated with the use of ICRP (Publication 103) risk models and Russian national medical statistics data. For populations under the age of 50 y, the risk estimates based on organ doses usually are 30% higher than estimates based on effective doses. In older populations, the difference can be up to a factor of 2.5. The typical distributions of organ doses were defined for Chest Routine, Abdominal Routine, and Head Routine examinations. The distributions of organ doses were dependent on the anatomical region of scanning. The most exposed organs/tissues were thyroid, breast, esophagus, and lungs in cases of Chest Routine examination; liver, stomach, colon, ovaries, and bladder in cases of Abdominal Routine examination; and brain for Head Routine examinations. The conversion factors for calculation of typical organ doses or tissues at risk using DLP were determined. Lifetime attributable risk of cancer estimated with organ doses calculated from DLP was compared with the risk estimated on the basis of organ doses measured with the use of silicon photodiode dosimeters. The estimated difference in LAR is less than 29%. Copyright © 2014 Health Physics Society.

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