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Efimova I.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Efimova N.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Lishmanov Y.,Tomsk Polytechnic University
Journal of Clinical Hypertension | Year: 2014

The aim of the study was to estimate regional cerebral blood flow (rCBF) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single-photon emission computed tomography with technetium-99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6-month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six-month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients. © 2014 Wiley Periodicals, Inc. Source


Afanasiev S.A.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Pavliukova E.N.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Kuzmichkina M.A.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Rebrova T.Y.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | And 3 more authors.
Annals of Noninvasive Electrocardiology | Year: 2016

Background: Control of sympathetic hyperactivity is pivotal for treatment of heart failure (HF) in patients with coronary artery disease (CAD). Our earlier studies demonstrated that the auricular pulsed electrical stimulation of the vagus nerve (VNS) beneficially affected condition of CAD patients with HF. The aim of our study was to evaluate changes in heart rate (HR) and the levels of heat shock proteins in peripheral blood lymphocytes in patients with CAD in the course of VNS. Methods: The study comprised 70 individuals aged 50-68 years with chronic coronary insufficiency, severe left ventricular dysfunction, and NYHA functional class (FC) III-IV HF. Main group included 63 patients who received VNS course (group 1). Control patients (n = 7) received sham therapy (group 2). Results: According to the results of 6-minute walk test and 24-hour ECG monitoring, administration of VNS improved clinical condition of 58 of 63 patients, decreased HF FC, and attenuated HR. Clinical condition in sham therapy group did not change. Immunoenzyme method demonstrated that hsp70 and hsp60 contents in peripheral blood lymphocyte lysate increased by 58% and 48% (P < 0.05), respectively, in patients who initially had HR < 80 bpm. The hsp70 level significantly increased and hsp60 level remained unchanged in patients with initial HR > 80 bpm. Conclusions: Correction of autonomous nervous status by VNS attenuated HR and improved functional state of the heart in CAD patients. Cardiotropic effect of VNS was the most pronounced in patients with preserved endogenous stress-limiting systems associated with hsp60 and/or hsp70. © 2016 Wiley Periodicals, Inc. Source


Suslova T.E.,Tomsk State University | Sitozhevskii A.V.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Ogurkova O.N.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Kravchenko E.S.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | And 3 more authors.
Frontiers in Physiology | Year: 2015

Patients with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) have high risk of microcirculation complications and microangiopathies. An increase in thrombogenic risk is associated with platelet hyperaggregation, hypercoagulation, and hyperfibrinolysis. Factors leading to platelet activation in MetS and T2DM comprise insulin resistance, hyperglycemia, non-enzymatic glycosylation, oxidative stress, and inflammation. This review discusses the role of nitric oxide (NO) in the regulation of platelet adhesion and aggregation processes. NO is synthesized both in endotheliocytes, smooth muscle cells, macrophages, and platelets. Modification of platelet NO-synthase (NOS) activity in MetS patients can play a central role in the manifestation of platelet hyperactivation. Metabolic changes, accompanying T2DM, can lead to an abnormal NOS expression and activity in platelets. Hyperhomocysteinemia, often accompanying T2DM, is a risk factor for cardiovascular accidents. Homocysteine can reduce NO production by platelets. This review provides data on the insulin effects in platelets. Decrease in a number and sensitivity of the insulin receptors on platelets in T2DM can cause platelet hyperactivation. Various intracellular mechanisms of anti-aggregating insulin effects are discussed. Anti-aggregating effects of insulin are mediated by a NO-induced elevation of cGMP and upregulation of cAMP- and cGMP-dependent pathways. The review presents data suggesting an ability of platelets to synthesize humoral factors stimulating thrombogenesis and inflammation. Proinflammatory cytokines are considered as markers of T2DM and cardiovascular complications and are involved in the development of dyslipidemia and insulin resistance. The article provides an evaluation of NO-mediated signaling pathway in the effects of cytokines on platelet aggregation. The effects of the proinflammatory cytokines on functional activity of platelets are demonstrated. © 2015 Suslova, Sitozhevskii, Ogurkova, Kravchenko, Kologrivova, Anfinogenova and Karpov. Source


Ripp T.M.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Mordovin V.F.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Pekarskiy S.E.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Ryabova T.R.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | And 4 more authors.
Current Hypertension Reports | Year: 2015

The aims of the study were to evaluate the effects of renal sympathetic denervation (RSD) on the heart and to identify the predictors of RSD efficacy in patients with resistant arterial hypertension. The study comprised 60 RSD patients (54.6 ± 9.5 years) who received full-dose antihypertensive therapy (4.1 drugs) including diuretics. Initially, 58.6 % of patients had abnormal left ventricular (LV) diastolic function. All patients received echocardiography before and 24 weeks after RSD. Renal sympathetic denervation was achieved through the endovascular radiofrequency ablation (RFA) of the renal arteries. Drug therapy continued for the entire period of observation. After RSD, all patients were retrospectively assigned to two groups: group 1 comprised patients (n = 22; 36.7 %) in whom the myocardial mass (MM) of the left ventricle decreased by more than 10 g after RSD; group 2 comprised patients (n = 38; 63.3 %) in whom LV MM increased or decreased by less than 10 g. Anthropometry, arterial blood pressure, heart rate, therapy, and LV end-diastolic dimensions (EDD) were comparable in these groups. After RSD, the values of office blood pressure significantly decreased and MM regressed by more than 10 g in 36.7 % of patients; LV diastolic function normalized in 31 % of patients, and diastolic dysfunction improved in 14 % of patients. The study found the associations between the initial LV wall dimensions and LV MM changes. Unlike LV EDD, arterial blood pressure, or heart rate, the initial values of LV wall thickness predicted LV MM regress. Trial registration: #NCT01499810 https://clinicaltrials.gov/ct2/show/NCT01499810. © 2015, Springer Science+Business Media New York. Source


Rebrova T.Y.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Afanasiev S.A.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Putrova O.D.,Federal State Budgetary Scientific Institution Research Institute for Cardiology | Repin A.N.,Federal State Budgetary Scientific Institution Research Institute for Cardiology
Advances in Gerontology | Year: 2015

Microviscosity coefficients were studied in the area of integrated and annular lipids of erythrocyte membranes in the peripheral blood of patients aged 35–50 and 60–75 with chronic coronary heart disease (CHD), as well as healthy donors of corresponding age. It was found in healthy donors that the microviscosity coefficients in the area of integrated and of annular lipids are significantly higher in the senior age group (60–75 years). In CHD, both an increase and a decrease in the microviscosity parameters in the area of lipid–lipid interactions can be characteristic for erythrocyte membranes, regardless of the patient age. In the protein–lipid contacts, an increase in microviscosity parameters is characteristic for patients aged 35–50 and, in contrast, a decrease in the microviscosity coefficient was observed in 60- to 75-year-old patients. It was concluded that the indicators of erythrocyte membrane microviscosity in patients of different age groups reflect both the implementation of general mechanisms of adaptive changes in cell membranes and the individual characteristics determined by their lipid and protein composition during the development of chronic CHD. © 2015, Pleiades Publishing, Ltd. Source

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