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Budazhapov L.V.,Federal State Budgetary Scientific Institution
Biosciences Biotechnology Research Asia

This paper presents results of long-term model, greenhouse and microfield experiments on nitrogen transformation in soil-plant systems with application of stable nitrogen isotope (15N) as renewed efforts to make a biokinetic conception of nitrogen status in harsh climates of the northern part of Central Asia, namely in Transbaikalia. It uses a theory to investigate velocity characteristics of nitrogen pool change in cryogenic soil environments. The goal of theoretical background of nitrogen pool velocity transformation is to reveal modern approach to assessment of inherent nature cycle. In nitrogen cycle of soil-plant systems kinetic parameters were evaluated as the main processes of nitrogen 15N uptake and immobilization in terms of scaling with constant of growth velocity and microorganism performance being a key position in nitrogen transformation. The results show a new possibility to assess nitrogen cycle through calculated velocity constant and revealed dynamic pattern of the main processes. The ongoing assessment enables us to formulate a new original hypothesis for theoretical kinetical model. Source

Inzhevatkin E.V.,Russian Academy of Sciences | Savchenko A.A.,Federal State Budgetary Scientific Institution
Biology Bulletin

This work summarizes the authors’ recent investigations into metabolic changes in blood lymphocytes, cancer cells, and hepatocytes during tumor growth from mice with Ehrlich ascites carcinoma. These results were compared with the metabolic changes in hepatocytes from rats after hyperthermia and in lymphocytes from patients with different diseases. It was shown that the extreme conditions induced metabolic changes that were independent of the cell type or the nature of the extreme factor. These changes characterized the metabolic mechanisms of cell adaptation and disadaptation. The concept of the “nonspecific metabolic reaction” of cells to extreme exposures had been introduced. © 2016, Pleiades Publishing, Inc. Source

Efimova N.Y.,Tomsk Polytechnic University | Chernov V.I.,Tomsk Polytechnic University | Efimova I.Y.,Federal State Budgetary Scientific Institution | Lishmanov Y.B.,Tomsk Polytechnic University
Cardiovascular Therapeutics

Aims: To investigate the regional cerebral blood flow, cognitive function, and parameters of 24-h arterial blood pressure monitoring in patients with metabolic syndrome before and after combination antihypertensive therapy. Methods: The study involved 54 patients with metabolic syndrome (MetS) investigated by brain single-photon emission computed tomography, 24-h blood pressure monitoring (ABPM), and comprehensive neuropsychological testing before and after 24 weeks of combination antihypertensive therapy. Results: Patients with metabolic syndrome had significantly poorer regional cerebral blood flow compared with control group: by 7% (P = 0.003) in right anterior parietal cortex, by 6% (P = 0.028) in left anterior parietal cortex, by 8% (P = 0.007) in right superior frontal lobe, and by 10% (P = 0.00002) and 7% (P = 0.006) in right and left temporal brain regions, correspondingly. The results of neuropsychological testing showed 11% decrease in mentation (P = 0.002), and 19% (P = 0.011) and 20% (P = 0.009) decrease in immediate verbal and visual memory in patients with MetS as compared with control group. Relationships between the indices of ABPM, cerebral perfusion, and cognitive function were found. Data showed an improvement of regional cerebral blood flow, ABPM parameters, and indicators of cognitive functions after 6 months of antihypertensive therapy in patients with MetS. Conclusion: The study showed the presence of diffuse disturbances in cerebral perfusion is associated with cognitive disorders in patients with metabolic syndrome. Combination antihypertensive treatment exerts beneficial effects on the 24-h blood pressure profile, increases cerebral blood flow, and improves cognitive function in patients with MetS. © 2015 John Wiley & Sons Ltd. Source

Storozheva Z.I.,Federal State Budgetary Scientific Institution | Gruden M.A.,Federal State Budgetary Scientific Institution | Proshin A.T.,Federal State Budgetary Scientific Institution | Sewell R.D.E.,University of Cardiff
Journal of Psychopharmacology

Learning aptitude has never been a focus of visuospatial performance studies, particularly on memory consolidation and reconsolidation. The aim of this study was to determine the consequences of learning ability on memory consolidation/reconsolidation following inhibition of glucose synthase kinase-3 (GSK-3) by 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8). The anxiety-like nature of rats was characterized in the elevated plus maze. The rats were then trained for four days in the Morris water maze (MWM) and classified as 'superior', 'intermediate' or 'inferior' learners. There were no major differences between superior, intermediate or inferior learners with respect to anxiety which might have influenced learning. After training (day-5), TDZD-8 (2.0 mg/kg) was administered and half of the cohort were exposed to a MWM retrieval trial. Ten days later, animals were subjected to repeated MWM learning. TDZD-8 without a retrieval trial impaired subsequent reconsolidation in inferior learners, but enhanced it in superior learners. There was no modification of performance in intermediate learners. In TDZD-8-treated subjects exposed to retrieval, the pattern of outcomes was identical whereby impairment of reconsolidation occurred in inferior learners, enhancement occurred in superior learners but there was no modification of performance in intermediate learners. Thus, learning ability was a key determinant of the qualitative outcome from GSK-3 inhibition on visuospatial memory. © The Author(s) 2015. Source

Voskresenskaya E.,Federal State Budgetary Scientific Institution | Bardin M.,Russian Academy of Sciences | Kovalenko O.,Federal State Budgetary Scientific Institution
Quaternary International

The climatology of winter anticyclone frequency in the Mediterranean-Black Sea region is studied on the basis of NCEP/NCAR reanalyses for 1951-2012. Time series of average anticyclone frequency are calculated for different parts of the region. It is found that the anticyclone frequency is increased significantly over the Black sea and Western Mediterranean regions while decreased over the Eastern Mediterranean. Regional manifestation of global climate processes in variability of the anticyclone frequency is investigated. © 2016 Elsevier Ltd and INQUA. Source

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