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Lisovskaya T.V.,Institute for Child and Family Health | Malgina G.B.,Federal State Budgetary Institution FGBU | Perepletina T.A.,Federal State Budgetary Institution FGBU | Medvedeva V.V.,Institute for Child and Family Health | And 3 more authors.
Gynecological Endocrinology

Aim: The purpose of the study is to detect endometrial pathology in individuals with blood-borne infections (hepatitis C virus [HCV] and HIV) and to assess the impact of quality of the endometrium on the efficiency of assisted reproductive technologies (ART).Materials and methods of research: The study involved 56 women of reproductive age, 33 women with HCV, 22 with HIV infection (stages 3 and 4A) and 1 patient with co-infection of HCV and HIV, which was excluded from the further study. Ultrasound investigation of the small pelvic organs, hysteroscopy with biopsy of the mucosa of the uterine cavity, histological examination of the endometrium, determination of HCV RNA and HIV RNA in serum and endometrial tissue by PCR method were conducted.Results: Ultrasound and histological studies of the endometrium revealed a high incidence of development of hyperplastic and inflammatory processes of the endometrium in women with HCV (86% and 100%) and HIV (51% and 99%). When molecular biological examination of endometrial tissue of these patients was performed with the use of a set of reagents "AmpliSens HCV/HBV/HIV-FL" produced by Federal Budgetary Institution of Science (FBUN) Central Research Institute of Epidemiology of Rospotrebnadzor of Russia, HCV was detected in 16.7% and HIV in 14.3% of cases. In 5% of patients with HCV infection and 7% with HIV, pathogens were detected in the endometrium under the non-detectable viral load in the blood plasma. Lower effectiveness of IVF in women with HIV and HCV is defined compared to the women without blood-borne infections.Conclusion: Detected HIV and HCV replications in the endometrium is the likely cause of hyperplastic and inflammatory processes of the endometrium leading to reduced efficiency of the ART programs in patients with chronic hepatitis C and HIV. © 2015 © 2015 Taylor & Francis. Source

Bashmakova N.V.,Federal State Budgetary Institution FGBU | Lisovskaya T.V.,Federal State Budgetary Institution FGBU | Putilova N.V.,Federal State Budgetary Institution FGBU | Sivov E.V.,Federal State Budgetary Institution FGBU | And 2 more authors.
Gynecological Endocrinology

The case report contains a description of multiple pregnancy in a patient with idiopathic polymyositis, which involves skin, muscles of upper and lower limbs, heart and provides expressed heart failure progressing during gestation. This report is remarkable for spontaneous multiple pregnancy in a patient of the senior reproductive age suffering from idiopathic polymyositis for several years and receiving the background glucocorticosteroid (GC) therapy and methothrexate. In the early stage of pregnancy and following the withdrawal of methothrexate, a spurt in disease was observed with aggravated clinical signs of heart failure that required increasing the course doses of GCs with further reduction thereof in the second and third trimesters. The conclusion highlights the necessity of pre-conception preparation of this category of women in order to achieve sustained inactivation of polymyositis at the onset of pregnancy. Delivery of such category of women shall take place in the III grade perinatal institution incorporating the units of child intensive care and neonatal pathology to enhance the fetal viability and to ensure efficiency of rehabilitation measures. © 2015 © 2015 Taylor & Francis. Source

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