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PubMed | Florida Hospital, University of Lausanne, Federal State Budgetary Institution, Princess Margaret Cancer and 9 more.
Type: | Journal: Annals of oncology : official journal of the European Society for Medical Oncology | Year: 2016

Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate with limited treatment options. Gemcitabine provides a marginal survival benefit for patients with advanced PDAC. Dasatinib is a competitive inhibitor of Src kinase, which is overexpressed in PDAC tumors. Dasatinib and gemcitabine were combined in a phase 1 clinical trial where stable disease was achieved in 2 of 8 patients with gemcitabine-refractory PDAC.This placebo-controlled, randomized, double-blind, phase II study compared the combination of gemcitabine plus dasatinib to gemcitabine plus placebo in patients with locally advanced, non-metastatic PDAC. Patients received gemcitabine 1,000 mg/m2 (30- minute IV infusion) on days 1, 8, 15 of a 28-day cycle combined with either 100 mg oral dasatinib or placebo tablets daily. The primary objective was overall survival (OS), with safety and progression-free survival (PFS) as secondary objectives. Exploratory endpoints included overall response rate, freedom from distant metastasis, pain and fatigue progression and response rate, and CA19-9 response rate.There was no statistically significant difference in OS between the 2 treatment groups (HR = 1.16; 95% confidence interval [CI]: 0.81-1.65; p=0.5656). Secondary and exploratory endpoint analyses also showed no statistically significant differences. The burden of toxicity was higher on the dasatinib arm.Dasatinib failed to show increased OS or PFS in patients with locally advanced PDAC. Alternative combinations or trial designs may show a role for src inhibition in PDAC treatment.


Gruzdeva O.,Federal State Budgetary Institution | Uchasova E.,Federal State Budgetary Institution | Dyleva Y.,Federal State Budgetary Institution | Belik E.,Federal State Budgetary Institution | And 2 more authors.
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | Year: 2013

Background: The most common cause of myocardial infarction (MI) is stenotic atherosclerotic lesions in subepicardial coronary arteries. Artery disease progression induces clinical signs and symptoms, among which MI is the leader in mortality and morbidity. Recent studies have been trying to find new biochemical markers that could predict the evolution of clinical complications; among those markers, free fatty acids (FFA) and oxidative modification of low-density lipoproteins (oxidized LDL) have a special place. Materials and methods: Seventy-nine ST-elevation MI patients were enrolled. The first group included MI patients without the signs of acute heart failure (Killip class I) while MI patients with Killip classes II-IV made up the second group. Thirty-three individuals with no cardiovascular disease were the controls. The lipid profile, serum oxidized LDL, and their antibodies, C-peptide and insulin were measured at days 1 and 12. The level of insulin resistance was assessed with the quantitative insulin sensitivity check index (QUICKI). Results: MI patients had atherogenic dyslipidemia; however, the Killip II-IV group had the most pronounced and prolonged increase in FFA, oxidized LDL, and their antibodies. Additionally, positive correlations between FFA levels and creatine kinase activity (12 days, R = 0.301; P = 0.001) and negative correlations between the QUICKI index and FFA levels (R = -0.46; P = 0.0013 and R = -0.5; P = 0.01) were observed in the both groups. Conclusion: The development of MI complications is accompanied by a significant increase in FFA levels, which not only demonstrate myocardial injury, but also take part in development of insulin resistance. Measuring FFA levels can have a great prognostic potential for risk stratification of both acute and recurrent coronary events and choice of treatment strategy. © 2013 Gruzdeva et al, publisher and licensee Dove Medical Press Ltd.


Sakhno N.G.,Federal State Budgetary Institution | Gunar O.V.,Federal State Budgetary Institution
Russian Journal of Biopharmaceuticals | Year: 2016

The article described the typed of cellular products, featured of its production and quality control. The data on microbial contaminants species, potential sources of contamination and ways to eliminate it are given. Particular attention is paid to rapid microbiological methods of sterility testing. The prospects of its development and implementation to cellular products sterility control are discussed. © 2016, Folium Ltd. All rights reserved.


Ershov F.I.,Federal State Budgetary Institution | Narovlyansky A.N.,Federal State Budgetary Institution
Voprosy Virusologii | Year: 2015

Domestic researchers succeeded to create a group of original Interferon inducers (II) with a high chemotherapeutic index and suitable for the prevention and treatment of viral infections and a number of other diseases. Clinical application of II concerns, first of all, a wide range of viral infections: influenza and other acute respiratory viral infections, herpes, hepatitis, encephalitis, rabies, slow and mixed infections, etc. The accumulated experience is generalized and the conclusion is made about the main advantages of II, which induce a balanced synthesis of endogenous interferon without antigenicity of its own. It is emphasized that a single injection of II "includes" synthesis of IFN in certain populations of ceils and organs and provides a relatively long circulation of IFN at a therapeutic level and creation of long-term anti-virus resistance. It Is concluded that, in general, interferon inducers with pronounced antiviral and immunomodulatory properties are currently used as effective tools for the prevention and treatment of a variety of diseases. The fact that II different in their chemical nature act at different stages of reproduction of viruses and affect various links of the innate and adaptive immunity explains the increased scope of the application of this group of drugs in medical practice.


Boytsov S.A.,Federal State Budgetary Institution | Samorodskaya I.V.,Federal State Budgetary Institution
Kardiologiya | Year: 2014

Objective: to study the dynamics of CVD mortality in men and women in the Russian Federation (RF) for the period from 2002 to 2011. Methods: The study was performed on the basis of official statistics "Rosstat". Results. In 2011 the average death rate from CVD for the regions of the Russian Federation among men and women was significantly lower than in 2002 (p< 0.0001). Average mortality from CVD among women was lower than among men (p < 0.0001). Factors of time and gender were statistically significant (p < 0.0001 ) for changes CVD mortality in the subjects of the Russian Federation. The mean absolute decrease in CVD mortality among men in Russia amounted to -39.7; among women 24.9. In regions with 2002 CVD mortality in men above 1000 the mean absolute decrease was -41.1 ± 15.1 while in regions with 2002 CVD mortality below 1000 mean absolute decrease was -22.1 ± 11.8 (p=0.001 ). At the same time, in 39 subjects the downward trend in performance was unstable, between-year differences were substantial, especially among male population. Conclusion: During the period 2002-2011 decline of CVD mortality of men and women was recorded in all regions of Russia. At the same time, given the significant variation of figures and high probability of inadequate coding of causes of death additional research is needed in one-year age groups using the RF subjects uniform criteria of causes of death.


Mediouni M.,2500 Boul Of Luniversite | Volosnikov A.,Federal State Budgetary Institution
Journal of Orthopaedics | Year: 2015

Generally, in some universities of medicine, orthopaedic training procedures represent a difficult task due to the inadequacies of the systems, the resources, and the use of technologies. This article explains the challenges and the needs for more research in the issue of orthopaedic simulation around the world. © 2015 Prof. P K Surendran Memorial Education Foundation.


PubMed | Russian Academy of Sciences, RAS Engelhardt Institute of Molecular Biology and Federal State Budgetary Institution
Type: Journal Article | Journal: Genome announcements | Year: 2016

The draft genome sequence of Geobacillus subterraneus strain K, a thermophilic aerobic oil-oxidizing bacterium isolated from production water of the Uzen high-temperature oil field in Kazakhstan, is presented here. The genome is annotated for elucidation of the genomic and phenotypic diversity of thermophilic alkane-oxidizing bacteria.


PubMed | Federal State Budgetary Institution and Siberian State Medical University
Type: Journal Article | Journal: Annals of laboratory medicine | Year: 2016

Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications.We included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups: the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA.On day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004).The level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP.


Patent
Federal State Budgetary Institution and Moscow State Technical University | Date: 2010-12-24

The invention pertains to the field of nuclear physics and can be used in system for identifying nuclear explosions based on the measured activities in the atmosphere of naturally-occurring radioactive gases (NORG). The technical result is an increase in the determination efficiency and in the reliability of punctual estimations of deposits from various types of fission in the global activity for each krypton and xenon isotope.


PubMed | Federal State Budgetary Institution
Type: | Journal: The Journal of pediatrics | Year: 2016

We present a historical and analytical overview of the Russian child health care system describing strengths and challenges of the system. Main indicators of social environment and childrens health, general demographics, and socioeconomic factors of Russia are described. The Russian health care system has preserved positive elements of the former Soviet model of pediatric care. However, beginning in 1991, it has been altered greatly in its funding and management. The child health care system is composed of a special network of outpatient and inpatient facilities. The key element of pediatric community care is the pediatric polyclinic, staffed by district pediatricians and nurses. Undergraduate pediatric training is separate from adult medical training. From day one onward, future pediatricians are trained at separate pediatric faculties of universities. Thus, they qualify as general pediatricians after only 2years of postgraduate training. It should be emphasized that the gap between the health status of children in developed countries and the Russian Federation is largely due to the influence of socioeconomic determinants, such as traffic accidents, poverty, pollution, and hazardous life styles, including binge drinking. Further improvements of childrens health require protective measures by the state to address the underlying socioeconomic determinants.

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