Federal State Budgetary Institution

Moscow, Russia

Federal State Budgetary Institution

Moscow, Russia
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Shevcov V.A.,Federal State Budgetary Institution | Volgin A.R.,Federal State Budgetary Institution
Immunologiya | Year: 2015

Specific prophylaxis based on vaccination is currently the most effective preventive measure of a viral A hepatitis (HAV). Hepatitis A inactivated vaccines developed last year's successfully used in many countries. Hepatitis A inactivated vaccines licensed in Russian Federation are safe, have low reactogenicity and are highly immunogenic according to National Regulatory Authorities. However, epidemiological experience show different effectiveness of vaccines and absence of desired protection of population in some extreme conditions after vaccination. It is clearly confirmed by a single administration of HAV vaccines to individuals in epidemic outbreaks of A hepatitis. Safety parameters and immunogenic potency of Hepatitis A inactivated vaccines licensed in Russian Federation were analyzed. It is established that single-dose vaccination using the most effective vaccine can provide high prophylactic effect in early epidemic outbreaks with high individual vaccination level. Regular monitoring of the duration of protection induced by single and double doses of vaccine is permanently needed.


Barbarash O.,Federal State Budgetary Institution | Gruzdeva O.,Federal State Budgetary Institution | Uchasova E.,Federal State Budgetary Institution | Belik E.,Federal State Budgetary Institution | And 2 more authors.
Drug Design, Development and Therapy | Year: 2015

Background: Dyslipidemia is a key factor determining the development of both myocardial infarction (MI) and its subsequent complications. Dyslipidemia is associated with endothelial dysfunction, activation of inflammation, thrombogenesis, and formation of insulin resistance. Statin therapy is thought to be effective for primary and secondary prevention of complications associated with atherosclerosis. Methods: This study examined 210 patients with Segment elevated MI (ST elevated MI) who were treated with atorvastatin from the first 24hours after MI. Group 1 (n=110) were given atorvastatin 20 mg/day. Group 2 (n=100) were given atorvastatin 40mg/day. At days 1 and 12 after MI onset, insulin resistance levels determined by the homeostasis model assessment of insulin resistance index, lipid profiles, and serum glucose, insulin, adipokine, and ghrelin levels were measured. Results: Free fatty acid levels showed a sharp increase during the acute phase of MI. Treatment with atorvastatin 20mg/day, and especially with 40mg/day, resulted in a decrease in free fatty acid levels. The positive effect of low-dose atorvastatin (20mg/day) is normalization of the adipokine status. Administration of atorvastatin 20mg/day was accompanied with a statistically significant reduction in glucose levels (by 14%) and C-peptide levels (by 38%), and a decrease in the homeostasis model assessment of insulin resistance index on day 12. Conclusion: Determination of atorvastatin dose and its use during the in-hospital period and subsequent periods should take into account changes in biochemical markers of insulin resistance and adipokine status in patients with MI. © 2015 Barbarash et al.


Kuleshov A.P.,Moscow Institute of Physics and Technology | Itkin G.P.,Federal State Budgetary Institution | Dmitrieva O.Yu.,Federal State Budgetary Institution
Proceedings - 2016 International Conference on Engineering and Telecommunication, EnT 2016 | Year: 2016

In developed model of pediatric axial pump (DON-3) we search the best geometry pump straightener and impeller. Optimization included methods of computational hydrodynamics (CFD). Changing of geometric parameters lead to changing in output pump parameters. The choice of best geometry was to obtain the position with maximum effective flow-dynamic pressure characteristics under pump operating mode. The calculations were performed for the optimal pump mode 15,000 rpm. Evaluating results of the simulation for each parameter, which is satisfies the condition of maximum differential efficiency, got a new flow pressure characteristics of axial pump with new geometry. Simulations took into account output parameters such as shear stress and vorticity. The aim of this work is to increase the hydraulic efficiency of DON-3 and to reduce the risk of hemolysis and thrombosis. © 2016 IEEE.


Zaretskiy A.P.,Moscow Institute of Physics and Technology | Alimuradov A.K.,Penza State University | Kuleshov A.P.,Federal State Budgetary Institution
Proceedings - 2016 International Conference on Engineering and Telecommunication, EnT 2016 | Year: 2016

The article considers the problem of applying existing methods based on Fourier transformation for processing specific signals of biological objects. Authors developed method for the processing and recording signals from the endocardial area of the right atrium in patients with paroxysmal form of atrial fibrillation based on Fourier transform's application. The developed method is based on a comparative analysis of sampling rates and amplitude resolution of signal. The criteria's system for determination the minimum sampling rate of the signal to minimize errors during the procedure of endocardial atrial signal's interpolation in the case of paroxysmal atrial fibrillation was proposed. The developed system of criteria allows to assess the artifacts obtained from samples with small number of reference points for the subsequent spectral analysis based on Fourier transform. The practical application of the developed method allows to create a database of atrial endocardial signals in the norm, in the case of persistent and paroxysmal forms of atrial fibrillation. This database can be a training samples for using neural network algorithms. The use of neural network algorithms will allow analysis of the current atrial signal to identify sites of pathological electrophysiological excitation with minimal computational cost, thereby increasing the efficiency of radiofrequency ablation for treatment atrial fibrillation. © 2016 European Union.


Meshkov N.A.,Federal State Budgetary Institution
Radiation and Risk | Year: 2016

The article reveals findings of a study into disease incidence among workers involved in cleanup of the disaster at Chernobyl NPP (the so-called liquidators), the state of their cardiorespiratory systems and their bodies' ability to adapt. The study examined a group of 27 liquidators with an ave rage radiation dose of 205.9 mSv (95% CI: 117.8; 234.0); the reference group (RG) consisted of 17 men who had never been exposed to ionizing radiation. The groups were comparable in terms of age. When ranking diseases by incidence in the first group, research found that coronary artery disease (CAD) ranked first; cerebrovascular diseases (CVD) and essential hypertension (EH), second and third, respectively. In the RG, the top three were osteochondrosis, CAD and EH. The average age of liquidators suffering from these diseases was 8.4, 20.3 and 6.4 years lower than that of members of the RG, respectively. The group of liquidators showed high incidence of CAD (RR=2.6 and OR=19.3; p=0.001), CVD (RR=7.4 and OR=50.0; p=0.000) and EH (RR=1.5 and OR=3.2; p>0.05). 44% of liquidators were found to have hypokinetic type of central hemodynamics (RR=2.5; p<0.1); the other 56%, eukinetic [normal]. The group of liquidators had 23.8% more men with reduced reactivity of cardiovascular system (CVS) than the RG; 54.2% of them had bronchial obstruction (RR=3.1; p<0.05). The group of liquidators also had CVS dysregulation caused by sinoatrial node dysfunction: the number of men with sympathicotonia was 50% higher among liquidators than among members of the RG (p<0.05); the number of liquidators with normally functioning CVS was smaller by a factor of 2.3 (p<0.1). The group of liquidators had 1.3 times (p>0.05) more men with slower rate of aging, which indicated at higher pressure on their adaptation mechanisms.


Gruzdeva O.,Federal State Budgetary Institution | Uchasova E.,Federal State Budgetary Institution | Dyleva Y.,Federal State Budgetary Institution | Belik E.,Federal State Budgetary Institution | And 2 more authors.
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | Year: 2013

Background: The most common cause of myocardial infarction (MI) is stenotic atherosclerotic lesions in subepicardial coronary arteries. Artery disease progression induces clinical signs and symptoms, among which MI is the leader in mortality and morbidity. Recent studies have been trying to find new biochemical markers that could predict the evolution of clinical complications; among those markers, free fatty acids (FFA) and oxidative modification of low-density lipoproteins (oxidized LDL) have a special place. Materials and methods: Seventy-nine ST-elevation MI patients were enrolled. The first group included MI patients without the signs of acute heart failure (Killip class I) while MI patients with Killip classes II-IV made up the second group. Thirty-three individuals with no cardiovascular disease were the controls. The lipid profile, serum oxidized LDL, and their antibodies, C-peptide and insulin were measured at days 1 and 12. The level of insulin resistance was assessed with the quantitative insulin sensitivity check index (QUICKI). Results: MI patients had atherogenic dyslipidemia; however, the Killip II-IV group had the most pronounced and prolonged increase in FFA, oxidized LDL, and their antibodies. Additionally, positive correlations between FFA levels and creatine kinase activity (12 days, R = 0.301; P = 0.001) and negative correlations between the QUICKI index and FFA levels (R = -0.46; P = 0.0013 and R = -0.5; P = 0.01) were observed in the both groups. Conclusion: The development of MI complications is accompanied by a significant increase in FFA levels, which not only demonstrate myocardial injury, but also take part in development of insulin resistance. Measuring FFA levels can have a great prognostic potential for risk stratification of both acute and recurrent coronary events and choice of treatment strategy. © 2013 Gruzdeva et al, publisher and licensee Dove Medical Press Ltd.


Sakhno N.G.,Federal State Budgetary Institution | Gunar O.V.,Federal State Budgetary Institution
Russian Journal of Biopharmaceuticals | Year: 2016

The article described the typed of cellular products, featured of its production and quality control. The data on microbial contaminants species, potential sources of contamination and ways to eliminate it are given. Particular attention is paid to rapid microbiological methods of sterility testing. The prospects of its development and implementation to cellular products sterility control are discussed. © 2016, Folium Ltd. All rights reserved.


Ershov F.I.,Federal State Budgetary Institution | Narovlyansky A.N.,Federal State Budgetary Institution
Voprosy Virusologii | Year: 2015

Domestic researchers succeeded to create a group of original Interferon inducers (II) with a high chemotherapeutic index and suitable for the prevention and treatment of viral infections and a number of other diseases. Clinical application of II concerns, first of all, a wide range of viral infections: influenza and other acute respiratory viral infections, herpes, hepatitis, encephalitis, rabies, slow and mixed infections, etc. The accumulated experience is generalized and the conclusion is made about the main advantages of II, which induce a balanced synthesis of endogenous interferon without antigenicity of its own. It is emphasized that a single injection of II "includes" synthesis of IFN in certain populations of ceils and organs and provides a relatively long circulation of IFN at a therapeutic level and creation of long-term anti-virus resistance. It Is concluded that, in general, interferon inducers with pronounced antiviral and immunomodulatory properties are currently used as effective tools for the prevention and treatment of a variety of diseases. The fact that II different in their chemical nature act at different stages of reproduction of viruses and affect various links of the innate and adaptive immunity explains the increased scope of the application of this group of drugs in medical practice.


Mediouni M.,2500 Boul Of Luniversite | Volosnikov A.,Federal State Budgetary Institution
Journal of Orthopaedics | Year: 2015

Generally, in some universities of medicine, orthopaedic training procedures represent a difficult task due to the inadequacies of the systems, the resources, and the use of technologies. This article explains the challenges and the needs for more research in the issue of orthopaedic simulation around the world. © 2015 Prof. P K Surendran Memorial Education Foundation.


Patent
Federal State Budgetary Institution and Moscow State Technical University | Date: 2010-12-24

The invention pertains to the field of nuclear physics and can be used in system for identifying nuclear explosions based on the measured activities in the atmosphere of naturally-occurring radioactive gases (NORG). The technical result is an increase in the determination efficiency and in the reliability of punctual estimations of deposits from various types of fission in the global activity for each krypton and xenon isotope.

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