Federal scientific center for medical and preventive health risk management technologies

Perm’, Russia

Federal scientific center for medical and preventive health risk management technologies

Perm’, Russia
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Feldblyum I.V.,Perm State University | Alyeva M.Kh.,Perm State University | Markovich N.I.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Voprosy Pitaniia | Year: 2016

Colorectal cancer (CRC) is one of the main causes of morbidity and mortality among all malignant tumors both in the world and in Russia. The purpose of the research was to study the association between diet and the probability of CRC in Perm Krai. The epidemiological analytical case-control study was performed. The questionnaire survey included 191 histologically proved colorectal cancer cases and 200 healthy individuals with excluded CRC by the results of colonoscopy. The surveyed groups were spread evenly by sex, age, ethnicity, place of residence and smoking (p>0.05). The odds to determine the following factors were higher in case group: diet including fried foods (OR=2.45,95% CI: 1.58-3.80, p<0.0001), bread more 100 g per day (OR=1.72, 95% CI: 1.72-2.60, p=0.005), over-salted food (OR=1.97, 95% CI: 1.27-3.04, p=0.001), consumption of spicy foods (OR=2.82, 95% CI: 1.59-5.13, p<0.0001) and dairy products less than 500 g per week (OR=3.94, 95% CI: 2.60-5.97, p<0.0001). The odds to determine the following factors were higher in control group: an exclusion of processed (OR=0.45, 95% CI: 0.28-0.70, p<0.0001) and red meat (OR=0.19, 95% CI: 0.05-0.51, p<0.0001). Consequently, at the present study the diet factors that have a higher rate in group of CRC patient's compared to healthy individuals have been determined. This requires to study interaction between diet, another environmental and genetic f actors.


Maksimova A.V.,Russian Academy of Sciences | Kuznetsova M.V.,Russian Academy of Sciences | Krivtsov A.V.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies | Demakov V.A.,Russian Academy of Sciences
Russian Journal of Ecology | Year: 2016

A laboratory experiment was performed to evaluate the effect of acrylonitrile (20, 200, and 2000 mg/kg soil) on the abundance and structure of soil microbial community. The results of direct inoculation showed that acrylonitrile at 200 mg/kg stimulated the development of nitrile-utilizing prokaryotes, whereas at 2000 mg/kg it inhibited all test groups of microorganisms, including nitrile- and amide-utilizing bacteria. According to real-time PCR data, representatives of α- and ß-Proteobacteria were the most labile members of the soil microbial community, while Bacteroidetes and Fungi proved to be highly resistant to the effect of the pollutant. © 2016, Pleiades Publishing, Ltd.


Kuchumov A.,Perm National Research Polytechnic Institute | Tuktamyshev V.,Perm National Research Polytechnic Institute | Kamaltdinov M.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Lekar a Technika | Year: 2017

Bile is one of 32 bio-fluids in the human body. Lithogenic bile (bile with tendency for the gallstones formation) is the pathological state of bile. Rheological properties of lithogenic bile differ from normal one. The Vateri’s papilla is the narrowest duct in the biliary system. Peristaltic motion plays important role in the bile flow in the Vateri’s papilla. In the literature, there are many papers devoted to peristaltic flow of fluids in the infinite length tubes. There are not many papers devoted to peristaltic flow of fluids in the finite length tubes. Modelling of peristaltic flow in the finite length tubes requires the imposing of boundary conditions on the ends of a tube. It leads to problem statement complication and to obtain the problem solution is getting harder. The current paper aims at developing mathematical model of the peristaltic bile transport flow through the duct at papillary stenosis as a tapered finite-length tube. It allows evaluating velocities and pressure distribution along the tube, and detecting choledochopancreatic reflux occurrence conditions. Adopting the perturbation method, the analytical solutions for velocities and pressures are obtained. Pressure distribution versus axial coordinate at different time instants are plotted for various values of Weissenberg number and amplitude ratio. It revealed that the amplitude ratio has more effect on the pressure distribution along the tube compared to the Weissenberg number. The values of the pressure gradient corresponding to reflux occurring are obtained. The comparison between developed model and numerical peristaltic model code implemented in ANSYS was made. Moreover, it is reported that the pressure drop value corresponding to average flow rate equal to zero may serve as reflux occurrence criterion. Moreover, channel shape optimization was made for subsequent stent installation to restore normal bile flow using Nelder-Mead method. © 2017, Czech Medical Association J.E. Purkyne. All rights reserved.


Trusov P.V.,Perm State University | Zaitseva N.V.,Federal scientific center for medical and preventive health risk management technologies | Kamaltdinov M.R.,Perm State University
Mathematical Biology and Bioinformatics | Year: 2015

A submodel of the digestive system is developed within the framework of multilevel model predicting the evolution of human functional disorders under environment influence. The article is dedicated to some problems associated with the submodel of food flow in the stomach. Materials in details is devoted to the reconstruction algorithm of 3D form andtroduodenal part of the digestive tract, based on ultrasonography results, and to the algorithm of the mesh node displacement caused by the antral contraction wave propagation and the pyloric sphincter motor activity. 3D form obtained and mesh configuration changing algorithm translated to program code are used for the flow calculation in antroduodenal part of the tract. Flow characteristics of one/two phased medium with opened/closed pyloric sphincter are analyzed considering functional disorders of the stomach motility; results are compared with 2D case. Further development ways of the stomach submodel and the digestive system model are noted: considering functional disorders of the pyloric sphincter, periodicity disorders of the antral contraction wave propagation in the stomach, processes of the digestive juice secretion, absorption of substances into the circulatory system. © 2015.


Romanyuk A.V.,Georgia Institute of Technology | Zvezdin V.N.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies | Samant P.,Georgia Institute of Technology | Grenader M.I.,Georgia Institute of Technology | And 2 more authors.
Analytical Chemistry | Year: 2014

Clinical medicine and public health would benefit from simplified acquisition of biological samples from patients that can be easily obtained at point of care, in the field, and by patients themselves. Microneedle patches are designed to serve this need by collecting dermal interstitial fluid containing biomarkers without the dangers, pain, or expertise needed to collect blood. This study presents novel methods to collect biomarker analytes from microneedle patches for analysis by integration into conventional analytical laboratory microtubes and microplates. Microneedle patches were made out of cross-linked hydrogel composed of poly(methyl vinyl ether-alt-maleic acid) and poly(ethylene glycol) prepared by micromolding. Microneedle patches were shown to swell with water up to 50-fold in volume, depending on degree of polymer cross-linking, and to collect interstitial fluid from the skin of rats. To collect analytes from microneedle patches, the patches were mounted within the cap of microcentrifuge tubes or formed the top of V-bottom multiwell microplates, and fluid was collected in the bottom of the tubes under gentle centrifugation. In another method, microneedle patches were attached to form the bottom of multiwell microplates, thereby enabling in situ analysis. The simplicity of biological sample acquisition using microneedle patches coupled with the simplicity of analyte collection from microneedles patches integrated into conventional analytical equipment could broaden the reach of future screening, diagnosis, and monitoring of biomarkers in healthcare and environmental/workplace settings. © 2014 American Chemical Society.


Zaytseva N.V.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies | Zemlyanova M.A.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies | Tarantin A.V.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Human Ecology | Year: 2013

The review considers the influence of the most common aromatic hydrocarbons (benzene, toluene, styrene, xylene) polluting the environment and being a risk factor for various health disorders, including metabolic changes in the protein profile of the human body.


Kokoulin A.,Perm National Research Polytechnic Institute | May I.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies | Kokoulina A.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

In this article we consider a novel fast approach based on wavelet transform for edge detection and simplified variant of active contour method - active primitives for the image processing in the research on dust emissions from industrial enterprises. The objective of the dust emissions analysis is to determine their component composition and the fine particle size distribution (PM10 and PM2.5). The scanning electronic microscope of high resolution was used to obtain the large-scale images of dust particles. We use the images of particles in different scales as the entire imagery data. © Springer International Publishing Switzerland 2015.


Zemlyanova M.A.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies | Tarantin A.V.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Human Ecology | Year: 2012

The review considers influence of exposure of the most common heavy metals (lead, chromium, cadmium, manganese, nickel, vanadium) polluting the environment and being a risk factor of various health disorders progress, including metabolic changes in the protein profile of the human body.


Trusov P.V.,Perm National Research Polytechnic Institute | Zaitseva N.V.,Federal Scientific Center for Medical and Preventive Health Risk Management Technologies | Kamaltdinov M.R.,Perm National Research Polytechnic Institute
Computational and Mathematical Methods in Medicine | Year: 2016

A group of authors has developed a multilevel mathematical model that focuses on functional disorders in a human body associated with various chemical, physical, social, and other factors. At this point, the researchers have come up with structure, basic definitions and concepts of a mathematical model at the "macrolevel" that allow describing processes in a human body as a whole. Currently we are working at the "mesolevel" of organs and systems. Due to complexity of the tasks, this paper deals with only one meso-fragment of a digestive system model. It describes some aspects related to modeling multiphase flow in the antroduodenal portion of the gastrointestinal tract. Biochemical reactions, dissolution of food particles, and motor, secretory, and absorbing functions of the tract are taken into consideration. The paper outlines some results concerning influence of secretory function disorders on food dissolution rate and tract contents acidity. The effect which food density has on inflow of food masses from a stomach to a bowel is analyzed. We assume that the future development of the model will include digestive enzymes and related reactions of lipolysis, proteolysis, and carbohydrates breakdown. © 2016 P. V. Trusov et al.


PubMed | Perm National Research Polytechnic Institute and Federal Scientific Center For Medical and Preventive Health Risk Management Technologies
Type: | Journal: Computational and mathematical methods in medicine | Year: 2016

A group of authors has developed a multilevel mathematical model that focuses on functional disorders in a human body associated with various chemical, physical, social, and other factors. At this point, the researchers have come up with structure, basic definitions and concepts of a mathematical model at the macrolevel that allow describing processes in a human body as a whole. Currently we are working at the mesolevel of organs and systems. Due to complexity of the tasks, this paper deals with only one meso-fragment of a digestive system model. It describes some aspects related to modeling multiphase flow in the antroduodenal portion of the gastrointestinal tract. Biochemical reactions, dissolution of food particles, and motor, secretory, and absorbing functions of the tract are taken into consideration. The paper outlines some results concerning influence of secretory function disorders on food dissolution rate and tract contents acidity. The effect which food density has on inflow of food masses from a stomach to a bowel is analyzed. We assume that the future development of the model will include digestive enzymes and related reactions of lipolysis, proteolysis, and carbohydrates breakdown.

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