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Denisov A.A.,Federal Medico Biological Agency | Sclyarov O.D.,Federal State Institution | Salmakov K.M.,Federal State Institution | Shumilov K.V.,Federal State Institution
OIE Revue Scientifique et Technique | Year: 2013

Russia has extensive experience in controlling brucellosis in large and small animals, based on systematic animal health and disease control measures, combined with the use of specific prophylaxis. Widespread application of the live brucellosis vaccine Brucella abortus strain 82 has led to a dramatic reduction in the prevalence of brucellosis. Among the distinctive properties of this vaccine are weak agglutinogenicity and high anti-epizootic efficacy, which allow differentiation between infected animals and vaccinated animals, combined with protection against brucellosis infection. In this paper, the authors review brucellosis epidemiology, diagnostics, the application of vaccines and management procedures that allow the Russian Federation to reduce the overall prevalence of brucellosis.

Medvedeva N.G.,Russian Academy of Sciences | Polyak Y.M.,Russian Academy of Sciences | Zaytseva T.B.,Russian Academy of Sciences | Zharikov G.A.,Federal Medico Biological Agency
Biology Bulletin | Year: 2012

Destruction of mustard gas hydrolysis products by bacterial cultures isolated from soils and bottom waters at the sites of chemical weapons disposal has been studied. Among the tested microorganisms, the soil bacteria Pseudomonas putida Y-21 and Rhodococcus erythropolis 8D and the marine bacteria Achromobacter sp. 75-1, Arthrobacter sp. 23-3, and Pseudomonas sp. 93-2 show the highest activity. Thiodiglycol is utilized by two pathways; one of them, with formation of [(2-hydroxyethyl)thio]acetic and thiodiglycolic and thioglycolic acids, is a common pathway for all bacteria under study. The results demonstrate both the possibility of self-purification of natural objects by natural communities of microorganisms and the prospects for application of microorganisms-destructors in bioremediation of polluted territories. © 2012 Pleiades Publishing, Ltd.

Vyatchanina E.S.,Federal Medico Biological Agency
Journal of Trace Elements in Medicine and Biology | Year: 2011

It is known that alcohol possesses embryotoxic, teratogenic, neurotoxic and other effects. Alteration of the trace element and mineral metabolism can be one of the triggering mechanisms of metabolic changes during an alcoholic intoxication. The aim of the recent study was to compare the profiles of elements in brain structures of matured offspring which were born by female rats exposed and non-exposed to alcohol before conception. A decreasing tendency in the levels of all detected macro and trace elements in four brain structures was observed. The most prominent changes were found in the brain cortex. Experimental data show that short term consumption of alcohol by female rats before pregnancy alters the distribution of macro and trace elements in the offspring's brain structures. © 2010 Elsevier GmbH.

Ivanenko N.B.,Saint Petersburg State University | Solovyev N.D.,Saint Petersburg State University | Ivanenko A.A.,Federal Medico Biological Agency | Navolotskii D.V.,Federal Medico Biological Agency
Journal of Analytical Atomic Spectrometry | Year: 2014

A digestion-free blood arsenic assessment method based upon in situ trapping of arsenic hydride in coated graphite furnace was developed. Double layer coating of the furnace with Na2WO4-H2PtCl6was used. Arsenic limit of detection (3σ) for whole blood samples was 0.1 μg L-1. Dynamic range was 60-1000 pg As. Relative standard deviation for blood samples (n = 3) was 7-13%. Blood arsenic biomonitoring in infants residing in an industrially polluted area was performed using the designed method. Whole blood arsenic determination was performed in 92 subjects of case group and 56 subjects of age-matched control group. For both groups observed, blood arsenic distribution was found to be close to lognormal. Lognormalized mean blood arsenic for the case group was 5.89 ± 1.31 μg L-1, whereas for controls it was 1.50 ± 2.26 μg L-1. Significant blood arsenic elevation was observed in the case group of the infants under study as compared to the controls and previously published data. © 2014 the Partner Organisations.

Lazarev V.N.,Federal Medico Biological Agency | Govorun V.M.,Federal Medico Biological Agency
Applied Biochemistry and Microbiology | Year: 2010

The review presents the current classification of antimicrobial peptides (AMP), which are the main component of innate immunity. The mechanism of their action and the molecular basis of the formation of resistance towards these peptides are described. Data on the use of AMP for the treatment of various infectious diseases, as well as the state of the art in genetic therapy using AMP, are given. © 2010 Pleiades Publishing, Ltd.

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