Swende T.Z.,Benue State University |
Swende L.T.,Federal Medical Center Makurdi
International Journal of Women's Health | Year: 2012
Background: The purpose of this study was to determine the prevalence and risk factors for cervical squamous intraepithelial lesions (SIL) among women infected with human immunodeficiency virus type 1 (HIV-1) receiving care at the Federal Medical Center Makurdi, Nigeria. Methods: Between March and December 2009, a total of 253 women infected with HIV-1 had cervical smears taken for cytology. HIV-1 RNA viral load and CD4 counts were also measured. Results: Of the 253 women, cervical SIL were present in 45 (17.8%). However, abnormal cervical cytology was noted in 146 (57.7%). Of those with abnormal cervical cytology, 101 (39.9%) women had atypical squamous cells of undetermined significance, 16 (6.3%) had low-grade SIL, and 29 (11.5%) women had high-grade SIL. The median CD4 lymphocyte count was lower in participants with cervical SIL compared with those without (132 versus 184 cells/mm 3; P = 0.03). The median HIV-1 RNA viral load was higher in women with cervical SIL (102,705 versus 64,391 copies/mL; P = 0.02). A CD4 lymphocyte count of <200 cells/mm 3 and an HIV-1 RNA viral load of <10,000 copies/mL were found to be significantly associated with cervical SIL. Conclusion: A high prevalence of cervical SIL was found among HIV-1-infected women in Makurdi, Nigeria. Increased immune suppression and HIV-1 viremia are significantly associated with cervical SIL. © 2012 Swende et al, publisher and licensee Dove Medical Press Ltd.
Odinka P.C.,University of Nigeria |
Oche M.,Federal Medical Center Makurdi |
Ndukuba A.C.,University of Nigeria |
Muomah R.C.,University of Nigeria |
And 4 more authors.
Journal of Health Care for the Poor and Underserved | Year: 2014
A large proportion of psychiatric patients in Nigeria seek help from other sources which ultimately lead to treatment delay. Treatment delay could have deleterious effects on treatment outcome especially for people with schizophrenia. The study aimed to determine the socio-demographic characteristics associated with treatment delay in people with schizophrenia. This was a cross-sectional study of 367 patients with schizophrenia presenting for the first time at a psychiatric hospital. About 76% of them had visited traditional/faith healers as a first treatment option. Long distance and use of traditional healers as first treatment option were associated with treatment delay. There is need for effective community psychiatry service delivery with emphasis on those strategies that can educate, influence, and mobilize communities concerning the aetiology, prevention, early detection, and treatment of mental illness. © Meharry Medical College.
Onyemaechi N.O.,Federal Medical Center Makurdi
Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria | Year: 2012
Acute osteomyelitis in neonates is uncommon and compartment syndrome complicating this condition is rare. The evaluation of a 4-week old female neonate who presented with compartment syndrome of the right forearm following an acute osteomyelitis of the right radius is presented. The patient had a full recovery with emergency fasciotomy and antibiotics therapy. A high index of suscipion is needed to recognize this limb and life-threatening complication, specially in neonates and infants. Prompt surgical intervention is necessary for the best clinical outcome.
Onyemaechi N.O.C.,University of Nigeria |
Popoola S.O.,Ekiti State University, Ado Ekiti |
Schuh A.,Musculoskeletal Center |
Iorbo A.T.,Federal Medical Center Makurdi |
And 2 more authors.
Indian Journal of Surgery | Year: 2015
There is paucity of reports describing the pattern of surgical mortality in Nigeria. The aim of this study was to determine the incidence and pattern of mortality associated with surgical care in our hospital and to identify areas of improvement. The records of all patients who died after admission for surgical care at the Federal Medical Centre Makurdi between January 2009 and December 2011 were studied retrospectively. Data extracted were patients’ demographics, surgical diagnosis, co-morbidity, surgical procedures performed, duration of hospital admission and outcome of treatment. Data were analyzed with SPSS version 17. There were 2,273 admissions into the surgical wards within the study period. During this period, there were 151 deaths with a crude mortality rate of 6.6 %. Ninety-four (62.3 %) patients were males and 57 (37.7 %) were females (M:F = 1.6:1). The age of the patients ranged from 8 days to 95 years with a mean age of 36.1 ± 20.1 years. Acute abdomen (37, 24.5 %), traumatic brain injury (32, 21.2 %) and malignancy (28, 18.5 %) were the commonest surgical diagnosis. Trauma-related deaths accounted for 48 (31.8 %) of all the deaths. Road traffic crash (89.6 %) was the commonest cause of injury. Surgical operations were performed in 75 (49.7 %) of the patients who died, while 76 (50.3 %) did not have any operative intervention. Mortality in patients admitted into the surgical ward was 6.6 %. Trauma-related death was the commonest. Traumatic brain injury, typhoid perforation of the bowel and malignancy were the leading causes of surgical death in our centre. © 2014, Association of Surgeons of India.
PubMed | Osun State University, Alfaisal University, University of Munster, Saarland University and Federal Medical Center Makurdi
Type: | Journal: Frontiers in microbiology | Year: 2015
Staphylococcus aureus is an important human pathogen causing nosocomial and community-acquired infections worldwide. In the characterization of this opportunistic pathogen, DNA microarray hybridization technique is used as an alternative to sequence based genotyping to obtain a comprehensive assessment on the virulence, resistance determinants, and population structure. The objective of this study was to characterize a defined collection of S. aureus isolates from Nigeria using the microarray technique, and to assess the extent that it correlates with sequence-based genotyping methods. The clonal diversity and genomic content of 52 methicillin-susceptible Staphylococcus aureus (MSSA) were investigated by spa typing, MLST and DNA microarray hybridization. More than half (55.8%) of these isolates were associated with clonal complexes (CCs) typically associated with methicillin-resistant S. aureus (MRSA) clones i.e., CC1, CC5, CC8, CC30, and CC45. Certain genes linked with virulence (hlgA and clfA) and adherence (ebpS, fnbA, sspA, sspB, and sspP) were detected in all isolates. A number of genes or gene clusters were associated with distinct clonal types. The enterotoxin gene cluster (egc) was linked with CC5, CC25, CC30, CC45, and CC121, enterotoxin H gene (seh) with CC1, exfoliative toxin D gene (etd) with CC25 and CC80, and the epidermal cell differentiation inhibitor B gene (edinB) with CC25, CC80, and CC152. The excellent agreement between data from DNA microarray and MLST in the delineation of Nigerian MSSA isolates indicates that the microarray technique is a useful tool to provide information on antibiotic resistance, clonal diversity and virulence factors associated with infection and disease.
PubMed | Federal Medical Center Makurdi
Type: Case Reports | Journal: Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria | Year: 2010
Worldwide, Intra Uterine Devices (IUDs) are among the most commonly used reversible methods of contraception. This is particularly true in developing countries. Insertion of IUD may be interval or postpartum. The concept of early postpartum IUD insertion has been investigated since the 1960s and has become accepted worldwide, even though IUDs inserted in the immediate postpartum appear to have a higher expulsion rate. Several complications associated with IUD use have been documented, for instance, the association between IUD use and pelvic inflammatory disease or salpingitis has been demonstrated in several studies. Contamination at the time of insertion has been suggested to be responsible for this risk of infection. We report here an unusual case of early postpartum IUD insertion without the patients knowledge or adequate counselling sixteen years prior to presentation with secondary infertility.