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Savelieva E.I.,Federal Medical and Biological Agency of the Russian Federation | Gavrilova O.P.,Russian Academy of Agricultural Sciences | Gagkaeva T.Yu.,Russian Academy of Agricultural Sciences
Journal of Analytical Chemistry | Year: 2014

Published data on the methods and results of study of profiles of volatile biologically active compounds are summarized and discussed. The leading role of gas chromatography-mass spectrometry combined with headspace solid-phase microextraction as an optimum analytical method for determining the qualitative and quantitative composition of volatile organic compounds in in vivo experiments is substantiated. The results of investigation of volatile organic compounds produced by micromycetes of the genus Fusarium are reviewed. © 2014 Pleiades Publishing, Ltd. Source


Bespalov A.Y.,Federal Medical and Biological Agency of the Russian Federation | Gorchakova T.L.,Federal Medical and Biological Agency of the Russian Federation | Ivanov A.Y.,Saint Petersburg State University | Kuznetsov M.A.,Saint Petersburg State University | And 4 more authors.
Russian Journal of Organic Chemistry | Year: 2016

Regardless of the conditions, the condensation of 4-amino-2,4-dihydro-3H-1,2,4-triazole-3-thiones with aromatic aldehydes afforded the corresponding hydrazones as the only product. Both initial amines and resulting hydrazones exist as the thione rather than thiol tautomer. In no case bicyclic 5,6-dihydro[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles that are isomeric to the hydrazones were detected. DFT quantum chemical calculations at the B3LYP/6-31+g(d,p) level of theory with full geometry optimization showed that the hydrazone structure in methanol and DMF is more stable than the bicyclic isomer by 19–23 kcal/mol, which completely excluded the possibility for such cyclization. The thione tautomer of the hydrazones is more stable than the thiol structure by 11–13 kcal/mol. © 2016, Pleiades Publishing, Ltd. Source


Mikhal'chik E.V.,Federal Medical and Biological Agency of the Russian Federation | Suprun M.V.,Federal Medical and Biological Agency of the Russian Federation | Fedorkova M.V.,Federal Medical and Biological Agency of the Russian Federation | Ibragimova G.A.,Federal Medical and Biological Agency of the Russian Federation | And 3 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2014

The content of ATP in scalp hair bulbs in humans was measured in the hair roots from 15 healthy volunteers. Light and electron microscopy confirmed the presence of outer and an inner root sheaths in the root of pulled out anagen hair. Incubation of samples in buffer solution led to extraction of ATP, which was measured by the chemiluminescent method. Mechanic disintegration of hair bulbs and their freezing-defrosting did not increase ATP output. The results of microscopy indicated that ATP extraction procedure was associated with separation of the outer radical sheath from the inner one without impairing the structure of the inner sheath. The mean content of ATP was 12±2 pmol per bulb. The use of pulled out hair bulbs for ATP measurements simplified the procedure as involved no surgical removal of follicles. © 2014 Springer Science+Business Media. Source

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