Federal Institute of Piaui

Parnaíba, Brazil

Federal Institute of Piaui

Parnaíba, Brazil

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Dos S.c.l. Da Silva A.P.,Federal University of Piauí | Lopes J.S.L.,Federal University of Piauí | De S. Vieira P.,Federal University of Piauí | E.a. Pinheiro E.,Federal Institute of Piaui | And 5 more authors.
Pharmacology Biochemistry and Behavior | Year: 2014

Garcinielliptone FC (GFC) isolated from hexanic fraction seed extract of species Platonia insignis Mart. It is widely used in folk medicine to treat skin diseases in both humans and animals as well as the seed decoction has been used to treat diarrheas and inflammatory diseases. However, there is no research on GFC effects in the central nervous system of rodents. The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (γ-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures. GFC produced an increased latency to first seizure, at doses 25 mg/kg (20.12 ± 2.20 min), 50 mg/kg (20.95 ± 2.21 min) or 75 mg/kg (23.43 ± 1.99 min) when compared with seized mice. In addition, GABA content of mice hippocampus treated with GFC75 plus P400 showed an increase of 46.90% when compared with seized mice. In aspartate, glutamine and glutamate levels detected a decrease of 5.21%, 13.55% and 21.80%, respectively in mice hippocampus treated with GFC75 plus P400 when compared with seized mice. Hippocampus mice treated with GFC75 plus P400 showed an increase in AChE activity (63.30%) when compared with seized mice. The results indicate that GFC can exert anticonvulsant activity and reduce the frequency of installation of pilocarpine-induced status epilepticus, as demonstrated by increase in latency to first seizure and decrease in mortality rate of animals. In conclusion, our data suggest that GFC may influence in epileptogenesis and promote anticonvulsant actions in pilocarpine model by modulating the GABA and glutamate contents and of AChE activity in seized mice hippocampus. This compound may be useful to produce neuronal protection and it can be considered as an anticonvulsant agent. © 2014 Elsevier Inc.


Fonteles C.A.L.,Federal University of Piauí | Brito G.F.,UFS | Reis Sobrinho J.F.,Federal Institute of Piaui | Alves T.S.,Federal University of Piauí | Barbosa R.,Federal University of Piauí
Materials Science Forum | Year: 2016

This set of mechanical properties of plant fibers allows its use as a reinforcement element in polymeric matrices and composites can be used in various sectors, and thus expanding the scope of use and the aggregate value of plant fibers. In this work, the choice by the use of alkali process to make the treatment of epicarp babassu fibers was decided in view of that it provides an effective, simple and low cost implementation process and also for being the most widely used method for modifying the surface of the fiber forming polymer composites. By SEM, it was observed the removal of wax layers, the impurities on the fiber surface and tyloses. With alkali treatment, it was also possible to notice the narrowing and closing of craters due to the packaging of denser material. © 2016 Trans Tech Publications, Switzerland.


Costa Junior J.S.,Lutheran University of Brazil | Costa Junior J.S.,Federal Institute of Piaui | Ferraz A.B.F.,Lutheran University of Brazil | Filho B.A.B.,Federal Institute of Piaui | And 4 more authors.
Journal of Medicinal Plants Research | Year: 2011

The antioxidant effects of garcinielliptone FC (GFC) isolated from the seeds of Platonia insignis were assessed in vitro tests (thiobarbituric acid reactive species (TBARS) assay, hydroxyl radicalscavenging activity, and scavenging activity of nitric oxide (NO)). GFC was identified by analysis of spectroscopic data. GFC prevented oxidative damage to lipids induced by a free radical source in vitro (AAPH) and showed antioxidant potential against two different reactive species in vitro. GFC in high dose demonstrated to exert a significant scavenging effect against NO and hydroxyl radicals generated in vitro. In conclusions, our results support that GFC compound exhibits an antioxidant action. © 2011 Academic Journals.


dos Santos E.P.,University of Brasilia | dos Santos E.P.,Federal Institute of Piaui | Gadelha A.B.,University of Brasilia | Safons M.P.,University of Brasilia | And 3 more authors.
Archives of Gerontology and Geriatrics | Year: 2014

The purpose of this study was to examine the association between sarcopenia and sarcopenic obesity (SO) with cardiometabolic risk factors in postmenopausal women. 149 volunteers (67.17±6.12 years) underwent body composition assessment using dual energy X-ray absorptiometry (DXA) and had analyzed blood samples collected for lipid profile, glucose metabolism and C-reactive protein (CRP). Sarcopenia was defined as an appendicular fat-free mass (AFFM) divided by height squared ≤5.45kg/m2 while SO was classified based on the residuals of a regression. Waist circumference (WC) and arterial blood pressure were also measured. Student's t-tests and correlations were used for analyses. Prevalence of sarcopenia and SO were respectively 16.8 and 21.5%. WC was significantly correlated with all the examined risk factors. AFFM relative to height squared was positively correlated with systolic blood pressure (SBP) and diastolic blood pressure (DBP), CRP, insulinaemia, HOMA score, and those classified as sarcopenic presented lower HOMA score when compared to nonsarcopenic. Regarding SO, although volunteers classified presented significantly higher fat mass (FM) and lower AFFM, it was not observed association with the examined risk factors. These findings support the association between WC and cardiometabolic risk factors in older women. In contrast, the approaches used to define sarcopenia and SO are not associated with cardiometabolic impairments. © 2014 Elsevier Ireland Ltd.


Da Ponte D.F.,Federal Institute of Piaui | Da Rocha C.A.F.,Federal University of Santa Catarina | Hizume D.C.,Santa Catarina State University | Moraes R.,Federal University of Santa Catarina
IEEE Transactions on Instrumentation and Measurement | Year: 2014

Lung sounds recorded on the chest are attenuated by the thorax and thorax-microphone interface. In order to recover waveforms similar to the ones generated within the lungs, this paper equalizes crackle sounds recorded on the chest. From an experiment in which eight subjects (seven men) took part, an estimation of the channel (thorax and thorax-microphone interface) attenuation was obtained to design the equalizer. For that, multiple tones between 100 and 1200 Hz were applied to each subjects' mouth where they were acquired by an electret microphone. These tones were also recorded on the chest using another electret microphone housed into an acoustic coupler. The attenuation of each tone was calculated by the power ratio between the one measured on the chest and that measured at the mouth. After obtaining the average attenuation curve from the volunteers, a discrete-time equalizer was designed and applied to crackles acquired from 30 patients with fibrosis, congestive heart failure, and pneumonia. The maximum frequency and two cycle duration indices measured from these crackles were modified by the equalization. The obtained results show that the equalizer improves the extraction of features from the crackles sounds. Equalization of crackles may contribute to better characterize the different diseases. © 2014 IEEE.


da Costa Jr. J.S.,Lutheran University of Brazil | da Costa Jr. J.S.,Federal Institute of Piaui | Feitosa C.M.,Federal University of Piauí | das Gracas Lopes Cito A.M.,Federal Institute of Piaui | And 3 more authors.
Journal of Biological Sciences | Year: 2010

The objective of the present study was to evaluate the Central Nervous System (CNS) antioxidant and anticonvulsant activities of Ethanolic Extract (EE) from P. insignis in animal models. The EE from P. insignis (10 mg kg -1) was tested by intraperitoneal (i.p.) to evaluate effects on lipid peroxidation level, nitrite formation, as well as on locomotor activity by the open-field test and anticonvulsant activity against acute pilocarpine-induced seizures. Wistar rats were treated with, 0.9% saline (i.p., control group), EE (10 mg kg -1, i.p., EE group), pilocarpine (400 mg kg -1, i.p., P400 group), or the combination of EE (10 mg kg -1, i.p.) and pilocarpine (400 mg kg -1, i.p.). After the treatments all groups were observed for 24 h. The lipid peroxidation and nitrite concentrations were measured using spectrophotometric methods. In P400 group rats there was a significant decrease in the motor activity when compared with control group. In EE and pilocarpine co-administered rats was observed a significant increase in motor activity when compared with P400 group, up to 24 h after the administration. In P400 group rats there was a significant increase in lipid peroxidation and nitrite levels. In EE and pilocarpine co-administered rats, antioxidant treatment significantly reduced the lipid peroxidation level and nitrite content after seizures. Present findings strongly support the hypothesis that oxidative stress occurs in striatum during pilocarpine-induced seizures, indicate that brain damage induced by the oxidative process plays a crucial role in seizures pathogenic consequences, and imply that strong protective effect on SNC could be achieved using EE from P. insignis. © 2010 Asian Network for Scientific Information.


Da Costa J.S.,Lutheran University of Brazil | De Almeida A.A.C.,Federal Institute of Piaui | Tome A.D.R.,State University of Ceará | Cito A.M.D.G.L.,Federal Institute of Piaui | And 2 more authors.
Epilepsy and Behavior | Year: 2011

The aim of present study was to examine the effects of the ethyl acetate fraction (EAF) from Platonia insignis on lipid peroxidation level, nitrite formation, and superoxide dismutase and catalase activities in rat striatum prior to pilocarpine-induced seizures as well as to explore its anticonvulsant activity in adult rats prior to pentylenetetrazole (PTZ)- and picrotoxin (PIC)-induced seizures. Wistar rats were treated with vehicle, atropine (25. mg/kg), EAF (0.1, 1, and 10. mg/kg), pilocarpine (400. mg/kg, P400 group), PTZ (60. mg/kg, PTZ group), PIC (8. mg/kg, PIC group), atropine. +. P400, EAF. +. P400, EAF. +. PTZ, or EAF. +. PIC. Significant decreases in number of crossings and rearings were observed in the P400 group. The EAF 10. +. P400 group also had significant increases in these parameters. In addition, in rats treated with P400, there were significant increases in lipid peroxidation and nitrite levels; however, there were no alterations in SOD and catalase activities. In the EAF 10. +. P400 group, lipid peroxidation and nitrite levels significantly decreased and SOD and catalase activities significantly increased after pilocarpine-induced seizures. Additionally, effects of the EAF were evaluated in PTZ and PIC models. EAF did not increase the latency to development of convulsions induced with PTZ and PIC at the doses tested. Our findings strongly support the hypothesis that EAF does not have anticonvulsant activity in the different models of epilepsy studied. Our results indicate that in the in vivo model of pilocarpine-induced seizures, EAF has antioxidant activity, but not anticonvulsant properties at the doses tested. © 2011.


Bezerra R.D.S.,Federal Institute of Piaui | Silva M.M.F.,Interdisciplinary Laboratory for Advanced Materials LIMAV | Morais A.I.S.,Interdisciplinary Laboratory for Advanced Materials LIMAV | Santos M.R.M.C.,Interdisciplinary Laboratory for Advanced Materials LIMAV | And 2 more authors.
Journal of Environmental Chemical Engineering | Year: 2014

The natural biopolymer cellulose has been successfully used as sorbent due to its biocompatibility, degradability and chemical variability. For this application the pristine biomaterial was characterized through X-ray diffraction, infrared spectroscopy, scanning electron microscopy and carbon nuclear magnetic resonance. These results confirmed the biopolymer crystallinity. Its ability for ranitidine drug removal from aqueous solution was evaluated, investigating the effect of time, concentration, pH and temperature, to give favorable results in alkaline conditions. From the kinetic point of view, the sorptive process followed the pseudo-second-order model. The maximum sorption capacity gave 28.1; 32.1 and 32.9 mg g-1 at 298 ± 1; 308 ± 1 and 318 ± 1 K, respectively, after adjusting the data to the Freundlich model. The experimental data are in agreement that natural cellulose is a promising biopolymer to remove this drug from the environment. © 2013 Elsevier Ltd.


Ponte D.F.,Federal Institute of Piaui | Ponte D.F.,Federal University of Santa Catarina | Moraes R.,Federal University of Santa Catarina | Hizume D.C.,Santa Catarina State University | Alencar A.M.,University of Sao Paulo
Medical Engineering and Physics | Year: 2013

The spectral analysis of crackles sounds has been carried out based on the assumption that they are stationary signals, and the majority of the work on the crackles was accomplished before the publication of the Computerized Respiratory Sound Analysis (CORSA) guidelines. This works characterizes crackles acquired from patients with fibrosis, heart failure, and pneumonia, breathing at a constant rate, with a system developed according to the CORSA guidelines. Their maximum frequency was obtained by applying discrete pseudo Wigner-Ville distribution, suitable for non-stationary signals, and an objective method to estimate the maximum frequency, the modified geometric method. The effects of the breathing rate and the tidal volume on the spectra of the crackles were also investigated. The role of the high-pass filter cutoff frequency of the acquisition system on the characteristics of the acquired crackles was also assessed in this present study. Higher high-pass filter cutoff frequency allows for higher amplification which modifies the maximum frequency and the 2CD index. It is shown that the crackles acquired according to the CORSA guidelines have higher frequencies and shorter 2CD indexes than those previously reported, highlighting the need for the standardization and detailed report of the acquisition setup when quantifying lung sounds. The results pointed out that the maximum frequency and the 2CD indexes may allow crackles generated by fibrosis to be distinguished from the ones generated by the heart failure and pneumonia. It is not possible, however, by means of these two indexes, to differentiate between pneumonia and heart failure crackles. © 2012 IPEM.


PubMed | Federal University of Piauí, Federal University of Bahia, North Union of Parana and Federal Institute of Piaui
Type: | Journal: Pharmacology, biochemistry, and behavior | Year: 2014

Garcinielliptone FC (GFC) isolated from hexanic fraction seed extract of species Platonia insignis Mart. It is widely used in folk medicine to treat skin diseases in both humans and animals as well as the seed decoction has been used to treat diarrheas and inflammatory diseases. However, there is no research on GFC effects in the central nervous system of rodents. The present study aimed to evaluate the GFC effects at doses of 25, 50 or 75 mg/kg on seizure parameters to determine their anticonvulsant activity and its effects on amino acid (-aminobutyric acid (GABA), glutamine, aspartate and glutathione) levels as well as on acetylcholinesterase (AChE) activity in mice hippocampus after seizures. GFC produced an increased latency to first seizure, at doses 25mg/kg (20.12 2.20 min), 50mg/kg (20.95 2.21 min) or 75 mg/kg (23.43 1.99 min) when compared with seized mice. In addition, GABA content of mice hippocampus treated with GFC75 plus P400 showed an increase of 46.90% when compared with seized mice. In aspartate, glutamine and glutamate levels detected a decrease of 5.21%, 13.55% and 21.80%, respectively in mice hippocampus treated with GFC75 plus P400 when compared with seized mice. Hippocampus mice treated with GFC75 plus P400 showed an increase in AChE activity (63.30%) when compared with seized mice. The results indicate that GFC can exert anticonvulsant activity and reduce the frequency of installation of pilocarpine-induced status epilepticus, as demonstrated by increase in latency to first seizure and decrease in mortality rate of animals. In conclusion, our data suggest that GFC may influence in epileptogenesis and promote anticonvulsant actions in pilocarpine model by modulating the GABA and glutamate contents and of AChE activity in seized mice hippocampus. This compound may be useful to produce neuronal protection and it can be considered as an anticonvulsant agent.

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