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Saint Petersburg, Russia

Avdeyev S.N.,Federal Biomedical Agency of Russia
Terapevticheskii Arkhiv | Year: 2012

Hypoxemia can cause damage to any tissue in the human body. Tissue hypoxia is a condition in which oxygen (O2) delivery to the tissues does not meet their metabolic needs. The major goal in the treatment of patients with hypoxemic acute respiratory failure (ARF) is to ensure normal oxygenation of the body. The leading therapy option for ARF is the use of O2. The paper gives the basic principles of emergency O2 therapy: indications, treatment goals, monitoring guidelines, methods for delivery of O2, and measures to prevent its toxic effects.

Tsareva N.A.,Federal Biomedical Agency of Russia
Terapevticheskii Arkhiv | Year: 2013

The paper reviews current views of the problem of pulmonary hypertension. It shows the classification of pulmonary hypertension and considers the general issues of its pathogenesis, morphological changes, clinical picture, and main approaches to treating patients with pathology. Particular emphasis is placed on the review of clinical trials of the class of endothelin receptor antagonists.

Chuchalin A.G.,Federal Biomedical Agency of Russia
Terapevticheskii Arkhiv | Year: 2013

In current clinical practice, there are increasing numbers of patients in whom chronic obstructive disease is concurrent with three diseases: diabetes mellitus, coronary heart disease, and arterial hypertension. The concomitance of these socially significant diseases reflects a new stage of diseases of this century.

Schaefer T.V.,Federal Biomedical Agency of Russia
Bulletin of experimental biology and medicine | Year: 2012

The effect of artificial acidification of the intestinal content on neurological manifestations of acute severe cyclophosphamide intoxication was studied in rats. The animals were gavaged with 20 ml/kg sulfuric (0.05 M), hydrochloric, boric, or lactic acids (0.1 M) 3 h before intraperitoneal injections of the cytostatic in doses of 0, 200, 600, or 1000 mg/kg. The decrease in pH (by.0) and ammonia-producing activity of the cecal chyme developed within 3 h after administration of acids. Cyclophosphamide caused hyperammonemia; glutamine/ammonia and urea/ammonia ratios in the blood decreased. These changes augmented after administration of acids (boric acid produced maximum and lactic acid minimum effects). Acid treatment resulted in greatest elevation of ammonia level in the portal venous blood and a lesser elevation in the vena cava posterior blood. Acid treatment promoted manifestation of cyclophosphamide neurotoxic effect and animal death. Hence, acidification of the chyme inhibited the formation of ammonia in it, while ammonia release from the gastrointestinal tract into the blood increased; the treatment augmented hyperammonemia and aggravated the neurological manifestations of cyclophosphamide intoxication.

Marchenkov Ya.V.,Federal Biomedical Agency of Russia
Terapevticheskii Arkhiv | Year: 2013

Tracheal diverticula (TD) are a rare congenital or acquired condition. The diagnosis of TD is based on the data of multislice spiral computed tomography and fibrotracheal bronchoscopy. DTs are most frequently located in the right, may be solitary or multiple, uni- or multilocular. Uncomplicated DTs generally have no characteristic clinical features. Their symptoms can arise from the compression of adjacent organs or the addition of secondary bacterial infection and most commonly appear as cough. Differential diagnosis is mainly made with pharyngeal and laryngeal cysts and pharyngoesophageal diverticula. Asymptomatic TDs usually require no treatment. Surgical TD excision is possible in case of compression of adjacent organs and infection.

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