Federal Agency of Medical Technologies

Moscow, Russia

Federal Agency of Medical Technologies

Moscow, Russia

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Gershtein E.S.,Russian Academy of Medical Sciences | Dubova E.A.,Federal Agency of Medical Technologies | Shchegolev A.I.,Federal Agency of Medical Technologies | Kushkinskii N.E.,Russian Academy of Medical Sciences
Bulletin of Experimental Biology and Medicine | Year: 2010

Histological analysis demonstrated an increase in the number of blood vessels and expression of CD34 and vascular endothelial growth factor in hepatocellular carcinoma tissue compared to adjacent liver tissue. Increased immunohistochemical expression of vascular endothelial growth factor and the content of this factor and its type 2 receptor correlated with the degree of histological differentiation and stage of the tumor. © 2010 Springer Science+Business Media, Inc.


Bukharova T.B.,Russian Academy of Medical Sciences | Arutyunyan I.V.,Russian Academy of Medical Sciences | Shustrov S.A.,ReMeTeks Company | Alekseeva I.S.,Federal Agency of Medical Technologies | And 7 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2011

We developed a new method of creation of tissue engineering constructs for regeneration of the bone tissue based on the principle of free distribution of cells in a fi brin clot within a scaffold. The tissue engineering construct includes multipotent stromal adipose tissue cells committed in osteogenic lineage, platelet-rich plasma, and resorbed material on the basis of xenogeneic bone collagen. The culture of bone progenitor cells was characterized by the main markers of osteoblastic differon. The material meets all requirements for materials intended for tissue engineering. An innovative high-technological tissue engineering product for clinical application is prepared. © 2011 Springer Science+Business Media, Inc.


Volkov A.V.,Russian Academy of Medical Sciences | Alekseeva I.S.,Federal Agency of Medical Technologies | Kulakov A.A.,Federal Agency of Medical Technologies | Gol'Dshtein D.V.,Russian Academy of Medical Sciences | And 7 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2010

We performed a comparative study of reparative osteogenesis in rabbits with experimental critical defects of the parietal bones after implantation of commercial osteoinductive materials "Biomatrix", " Osteomatrix", "BioOss" in combination with platelet-rich plasma and transplantation of a tissue-engineering construct on the basis of autogenic multipotent stromal cells from the adipose tissue predifferentiated in osteogenic direction. It was found that experimental reparative osteogenesis is insufficiently stimulated by implantation materials and full-thickness trepanation holes were not completely closed. After transplantation of the studied tissue-engineering construct, the defect was filled with full-length bone regenerate (in the center of the regenerate and from the maternal bone) in contrast to control and reference groups, where the bone tissue was formed only on the side of the maternal bone. On day 120 after transplantation of the tissue-engineering construct, the percent of newly-formed bone tissue in the regenerate was 24% (the total percent of bone tissue in the regenerate was 39%), which attested to active incomplete regenerative process in contrast to control and reference groups. Thus, the study demonstrated effective regeneration of the critical defects of the parietal bones in rabbits 120 days after transplantation of the tissue-engineering construct in contrast to commercial osteoplastic materials for directed bone regeneration. © 2010 Springer Science+Business Media, Inc.

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