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Belo Horizonte, Brazil

Lima K.S.,Federal University of Minas Gerais | Albuquerque W.,Federal University of Minas Gerais | Arantes V.N.,Federal University of Minas Gerais | Drummond-Lage A.P.,FCMMG | Coelho L.G.V.,Federal University of Minas Gerais
Arquivos de Gastroenterologia | Year: 2014

Context - Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is clearly associated with Helicobacter pylori gastritis and can be cured with anti- H pylori therapy alone. The presence of t(11;18)(q21;q21) translocation is thought to predict a lower response rate to anti- H pylori treatment. Objective - To study the presence of t(11;18)(q21;q21) genetic translocation and its clinical impact in low-grade gastric MALT lymphoma Brazilian patients. Methods - A consecutive series of eight patients with gastric MALT lymphoma were submitted to gastroscopy, endoscopic ultrasound, histopathological examination, H pylori search and RT-PCR-based methodology. All patients received anti-H pylori treatment. Eradicated patients were followed-up every 3-6 months for 2 years. Results - Eight patients were studied. All patients had tumor involvement restricted to the mucosa or submucosa and seven patients had low-grade gastric MALT lymphoma. All infected patients achieved H pylori eradication. Histological tumor regression was observed in 5/7 (71%) of the low-grade gastric MALT lymphoma patients. The presence of t(11;18)(q21;q21) translocation was found in 4 (57%) of these patients; among them only two had histological tumor regression following H pylori eradication. Conclusion - RT-PCR is a feasible and efficient method to detect t(11;18)(q21;q21) translocation, being carried out in routine molecular biology laboratories. The early detection of such translocation can be very helpful for better targeting the therapy to be applied to gastric MALT lymphoma patients. Source


Objective:This study explores the use of psychoactive drugs among pupils between 17 and 21 years old in university entrance courses, according to their selected academic fi elds. Methods: Forms were distributed to random classes at two leading university entrance schools, for voluntary completion by these pupils, preserving their anonymity. Results: The total sample consisted of 886 pupils, completing the forms in the presence of the researcher, who collected each form as it was completed. it was ascertained that 182 pupils take some type of psychoactive drug, separated into pharmacological groups, with anti-depressants being the most widely used. The highest rate was among the 21 year-olds, with no signifi cant statistical difference among their selected academic fi elds and psychoactive drug use. The chi-square test for independence indicates that taking psychoactive drugs and selected academic fi elds are not related (p-value: 0.117). Conclusion: This leads to the conclusion that psychoactive drug use is high among university entrance course pupils, refl ecting diffi culties in coping with increasingly keener competition, social and family pressures, doubts about choice of profession and other anxieties that might be age-related or could be linked to other factors. A serious problem of self-medication with psychoactive drugs was noted, despite restricted sales and retained prescriptions, which can have severe and unexpected consequences. Some questions were raised about the use of these drugs and the factors triggering their use. Source


Aramayo A.L.G.,University of Sao Paulo | Lopes Filho G.J.,University of Sao Paulo | Barbosa C.A.,University of Medical science of Minas Gerais | Amaral V.F.,Federal University of Minas Gerais | Costa L.A.,FCMMG
Acta Cirurgica Brasileira | Year: 2013

PURPOSE: To investigate abdominal wound healing using specific biomaterials in incisional hernias. METHODS: Incisional hernias were produced in 40 rabbits, after that they were reoperated with or without the use of meshes: PREMILENE® (PPL), ULTRAPRO® (UP), PROCEED® (PCD) or repairing without mesh (TRANSPALB). After 30 days a macroscopic and microscopic study of the part withdrawn from the abdominal wall was performed. RESULTS: Macroscopic: adhesion Area: PPL> UP and PCD (p = 0.031). Vascularization: PPL> UP and PCD (p = 0.001). PPL groups (p = 0.032) and PCD (p <0.001) showed greater meshes shrinkages when compared to UP. Microscopic: neutrophils: PCD> PPL, UP and TRANSPALB (p = 0.010); eosinophils: PPL> UP, and TRANSPALB PCD (p = 0.010); granulation tissue: PPL and PCD> UP and TRANSPALB (p <0.001); macrophages: PPL, UP and PCD> TRANSPALB (p <0.001); lymphocytes: PPL and PCD> UP (p = 0.009) and TRANSPALB (p <0.001); giant cells: PPL, UP and PCD> TRANSPALB (p <0.001); viscera adhered: PPL and UP> PCD and TRANSPALB (p <0.001). CONCLUSION: All types of meshes caused the formation of adhesions. The UP and PCD groups showed lower area and vascularization of the adhesions. The PPL and PCD groups showed higher meshes shrinkage and there was a predominance of acute inflammatory process in the PCD group. Source


Rodrigues D.S.,FCMMG | Leao F.A.A.,FCMMG | Siqueira S.L.,FCMMG | Siqueira S.L.,Federal University of Minas Gerais | And 5 more authors.
Journal of Morphological Sciences | Year: 2015

The thoracic duct is a lymph vessel extending from the abdomen to the base of the neck where it drains to one of the large veins in the region. Many cases are described in the scientific literature, regarding anatomical variations of the thoracic duct, from its origin, path, until its end, and the vast majority intended to relate variations in the last part of the duct. The reports related to variations of its path are very scarce. In a male cadaver dissection in the anatomy laboratory of the Faculdade de Ciências Médicas of Minas Gerais (FCMMG), an anatomical variation of the position of the thoracic duct was found. The thoracic duct was presented to the left of the aorta and spine, from its entry in the aortic hiatus of the diaphragm and chest throughout its length. There were also anatomical variations of interest in the venous circulatory system, such as the absence of the veins: hemiazygos and accessory hemiazygos, and the different location of the azygos vein, which was located to the left of the aorta. These variations have no relation to each other. The study of this variation is important because the knowledge of variations in the thoracic duct path allows lower rates of trauma and iatrogenic lesions in thoracic surgery, with possible serious complications, such as a chylothorax. © 2015, Brazilian Society of Anatomy. All rights reserved. Source


Silva A.T.,FCMMG | Gama H.V.P.,FCMMG | Siqueira S.L.,Federal University of Minas Gerais | Siqueira S.L.,Federal University of Ouro Preto | And 3 more authors.
Journal of Morphological Sciences | Year: 2014

Introduction: In most of cases, the emergency of the nervous roots of the brachial plexus in the posterior cervical triangle occur between the anterior and middle scalene muscles. However, anatomic variations in the brachial plexus are not rare. Methods: In the laboratory of Human Anatomy of the "Faculdade de Ciências Médicas de Minas Gerais" 106 cadavers were dissected. There were dissected the cervical region of all of the cadavers bilaterally. Results: In routinely dissection in the laboratory of human anatomy of the "Faculdade de Ciências Médicas de Minas Gerais" we've found in the left cervical region of a male cadaver the ventral branch of the seventh cervical nerve (C7) perforating the substance of the middle scalene muscle. Conclusion: Professionals that work with this region on the practice must pay attention to this and other variations in the constitution of the brachial plexus in the clinic and surgical procedures to avoid complications. Source

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