Entity

Time filter

Source Type

Grenoble, France

Giacomini G.,Fondazione Bruno Kessler | Bagolini A.,Fondazione Bruno Kessler | Boscardin M.,Fondazione Bruno Kessler | Dalla Betta G.-F.,National Institute of Nuclear Physics, Italy | And 6 more authors.
IEEE Transactions on Nuclear Science | Year: 2013

We report on the main design and technological characteristics related to the latest 3D sensor process developments at Fondazione Bruno Kessler (FBK, Trento, Italy). With respect to the previous version of this technology, which involved columnar electrodes of both doping types etched from both wafer sides and stopping at a short distance from the opposite surface, passing-through columns are now available. This feature ensures better performance, but also a higher reproducibility, which is of concern in medium volume productions. In particular, this R&D project was aimed at establishing a suitable technology for the production of 3D pixel sensors to be installed into the ATLAS Insertable B-Layer. An additional benefit is the feasibility of slim edges, which consist of a multiple ohmic column termination with an overall size as low as 100 μm. Eight batches with two different wafer layouts have been fabricated using this approach, and including several design options, among them the ATLAS 3D sensor prototypes compatible with the new read-out chip FE-I4. © 1963-2012 IEEE.


Pasquardini L.,FBK CMM | Berneschi S.,Centro Studi E Ricerche E Fermi | Berneschi S.,CNR Institute of Applied Physics Nello Carrara | Barucci A.,CNR Institute of Applied Physics Nello Carrara | And 9 more authors.
Journal of Biophotonics | Year: 2013

Whispering gallery mode resonators (WGMR), as silica microspheres, have been recently proposed as an efficient tool for the realisation of optical biosensors. In this work we present a functionalization procedure based on the DNA-aptamer sequence immobilization on WGMR, able to recognize specifically thrombin or VEGF protein, preserving a high Q factor. The protein binding was optically characterized in terms of specificity in buffer solution or in 10% diluted human serum. Simulation of the protein flow was found in good agreement with experimental data. The aptasensor was also chemically regenerated and tested again, demonstrating the reusability of our system. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Pasquardini L.,FBK CMM | Berneschi S.,Centro Studi E Ricerche E Fermi | Berneschi S.,CNR Institute of Applied Physics Nello Carrara | Barucci A.,CNR Institute of Applied Physics Nello Carrara | And 8 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2013

Whispering gallery mode resonators (WGMR), as silica microspheres, have been recently proposed as an efficient tool for the realisation of optical biosensors. In this work we present a functionalization procedure based on the DNA-aptamer sequence immobilization on WGMR, able to recognize specifically thrombin or VEGF protein, preserving a high Q factor. The protein binding was numerically modelled and optically characterized in terms of specificity in buffer solution or in 10% diluted human serum. The aptasensor was also chemically regenerated and tested again, demonstrating the reusability of our system. © 2013 Copyright SPIE.


Nunzi Conti G.,CNR Institute of Applied Physics Nello Carrara | Baldini F.,CNR Institute of Applied Physics Nello Carrara | Berneschi S.,CNR Institute of Applied Physics Nello Carrara | Berneschi S.,Centro Studi e Ricerche Enrico Fermi | And 7 more authors.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2013

We present results on the implementation of Whispering Gallery Modes (WGM) biosensors and on the demonstration of a new detection method for WGM based sensors. We first present a functionalization procedure based on the DNA-aptamer sequence immobilization on WGM resonators, able to recognize specifically thrombin protein. The protein binding was optically characterized in terms of specificity in buffer solution and in 10% diluted human serum. When performing the above measurements, we have used the typical detection scheme for WGM resonator based sensors, which relies on tracking the resonance shift - by scanning with a tunable laser - when a change of the refractive index in the region probed by the WGM takes place. In the second part of the presentation we propose a new sensing approach based instead on monitoring the position of the laser line of a fiber ring laser having a WGM microsphere in its loop. We demonstrate that the induced shift is the same for the ring laser line and for the microsphere resonance. The proposed method requires simpler and cheaper equipment and may also improve the sensor resolution because the ring laser line is narrower than the microsphere WGM resonance. © 2013 Copyright SPIE.


Morganti E.,FBK CMM | Buselli E.,SantAnna School of Advanced Studies | Collini C.,FBK CMM | Menciassi A.,SantAnna School of Advanced Studies | And 2 more authors.
Microelectronic Engineering | Year: 2011

This work focuses on the realization of three different micro-actuators that will be integrated in a lab-on-chip for bioaffinity assays. The aim is to create a microfluidic network to control the sample and reagent delivery as well as the washing cycles for a complete analysis. The three micropumps have different working principles (electromagnetic, electrolytic and peristaltic actuation methods), but they share the same fabrication process. The reason for adopting three different actuation modes is mainly related to the different functionalities that have to be managed at microfluidic level. In particular the electrolytic one-shot micropump will be used for sample and reagents delivery, while the peristaltic and the electromagnetic micropumps are both good candidates for the washing cycles. © 2011 Elsevier B.V. All rights reserved.

Discover hidden collaborations