FBK CMM

Grenoble, France
Grenoble, France

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Finlayson N.,University of Edinburgh | Parmesan L.,FBK CMM | Dutton N.A.W.,United Microelectronics | Calder N.J.,University of Edinburgh | Henderson R.K.,University of Edinburgh
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2016

Single-photon avalanche diodes (SPADs) in the form of high-resolution imaging pixel arrays are used in 3D cameras, motion-tracking, biomedical and time-correlated single photon counting (TCSPC) applications. Rapid spatial and temporal zoom onto objects of interest is an attractive feature. We present here novel high-speed time-zoom functionality achieved with the digital readout mode of the TACImager, a 256 x 256 TCSPC image sensor array based on sample and hold Time to Amplitude Converter (TAC) pixels. A column-parallel flash Analogue to Digital Converter (ADC) is implemented in the TACImager to support fast digital readout, allowing per-pixel, 3-bin TCSPC histogramming at frame rates of 4 kfps. New results related to this high-speed mode of operation are presented. The TACImager utilises a global ramp voltage as a timing reference, allowing time-zoom to be achieved through dynamic adjustment of comparator voltages, ramp offset voltages and ramp waveforms. We demonstrate the influence of fixed pattern noise in the pixels and column parallel ADCs on the results. © 2016 SPIE.


Morganti E.,FBK CMM | Buselli E.,Sant'Anna School of Advanced Studies | Collini C.,FBK CMM | Menciassi A.,Sant'Anna School of Advanced Studies | And 2 more authors.
Microelectronic Engineering | Year: 2011

This work focuses on the realization of three different micro-actuators that will be integrated in a lab-on-chip for bioaffinity assays. The aim is to create a microfluidic network to control the sample and reagent delivery as well as the washing cycles for a complete analysis. The three micropumps have different working principles (electromagnetic, electrolytic and peristaltic actuation methods), but they share the same fabrication process. The reason for adopting three different actuation modes is mainly related to the different functionalities that have to be managed at microfluidic level. In particular the electrolytic one-shot micropump will be used for sample and reagents delivery, while the peristaltic and the electromagnetic micropumps are both good candidates for the washing cycles. © 2011 Elsevier B.V. All rights reserved.


Lukowiak A.,Institute of Low Temperature And Structure Research | Marciniak L.,Institute of Low Temperature And Structure Research | Vasilchenko I.,CNR Institute for Photonics and Nanotechnologies | Vasilchenko I.,University of Trento | And 7 more authors.
International Conference on Transparent Optical Networks | Year: 2016

A group of nanocrystalline polyphosphates is presented showing the advantages arising from their spectroscopic properties. Their unique optical features are related, among others, with their structural properties. For example, reduced cross relaxation processes between doped lanthanide ions are observed in tetraphosphate matrices due to the relatively large active ions distance. For selected praseodymium doped polyphosphates, such as LiPr(PO3)4, a cascade emission transitions can be observed due to the two-step 4f2 transitions that take place under UV excitation into 4f5d levels. Such property could be used for scintillation devices. Other interesting behavior is the efficient anti-Stokes white broadband emission induced by NIR laser diode in LiYb(PO3)4 nanocrystals. Additionally, the properties of planar waveguides based on SiO2-HfO2 system and doped with P2O5 or tetraphosphate nanocrystals are presented. © 2016 IEEE.


Pasquardini L.,FBK CMM | Berneschi S.,Centro Studi E Ricerche E Fermi | Berneschi S.,CNR Institute of Applied Physics Nello Carrara | Barucci A.,CNR Institute of Applied Physics Nello Carrara | And 9 more authors.
Journal of Biophotonics | Year: 2013

Whispering gallery mode resonators (WGMR), as silica microspheres, have been recently proposed as an efficient tool for the realisation of optical biosensors. In this work we present a functionalization procedure based on the DNA-aptamer sequence immobilization on WGMR, able to recognize specifically thrombin or VEGF protein, preserving a high Q factor. The protein binding was optically characterized in terms of specificity in buffer solution or in 10% diluted human serum. Simulation of the protein flow was found in good agreement with experimental data. The aptasensor was also chemically regenerated and tested again, demonstrating the reusability of our system. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Giacomini G.,Fondazione Bruno Kessler | Bagolini A.,Fondazione Bruno Kessler | Boscardin M.,Fondazione Bruno Kessler | Dalla Betta G.-F.,National Institute of Nuclear Physics, Italy | And 6 more authors.
IEEE Transactions on Nuclear Science | Year: 2013

We report on the main design and technological characteristics related to the latest 3D sensor process developments at Fondazione Bruno Kessler (FBK, Trento, Italy). With respect to the previous version of this technology, which involved columnar electrodes of both doping types etched from both wafer sides and stopping at a short distance from the opposite surface, passing-through columns are now available. This feature ensures better performance, but also a higher reproducibility, which is of concern in medium volume productions. In particular, this R&D project was aimed at establishing a suitable technology for the production of 3D pixel sensors to be installed into the ATLAS Insertable B-Layer. An additional benefit is the feasibility of slim edges, which consist of a multiple ohmic column termination with an overall size as low as 100 μm. Eight batches with two different wafer layouts have been fabricated using this approach, and including several design options, among them the ATLAS 3D sensor prototypes compatible with the new read-out chip FE-I4. © 1963-2012 IEEE.


Nunzi Conti G.,CNR Institute of Applied Physics Nello Carrara | Baldini F.,CNR Institute of Applied Physics Nello Carrara | Berneschi S.,CNR Institute of Applied Physics Nello Carrara | Berneschi S.,Centro Studi e Ricerche Enrico Fermi | And 7 more authors.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2013

We present results on the implementation of Whispering Gallery Modes (WGM) biosensors and on the demonstration of a new detection method for WGM based sensors. We first present a functionalization procedure based on the DNA-aptamer sequence immobilization on WGM resonators, able to recognize specifically thrombin protein. The protein binding was optically characterized in terms of specificity in buffer solution and in 10% diluted human serum. When performing the above measurements, we have used the typical detection scheme for WGM resonator based sensors, which relies on tracking the resonance shift - by scanning with a tunable laser - when a change of the refractive index in the region probed by the WGM takes place. In the second part of the presentation we propose a new sensing approach based instead on monitoring the position of the laser line of a fiber ring laser having a WGM microsphere in its loop. We demonstrate that the induced shift is the same for the ring laser line and for the microsphere resonance. The proposed method requires simpler and cheaper equipment and may also improve the sensor resolution because the ring laser line is narrower than the microsphere WGM resonance. © 2013 Copyright SPIE.


Pasquardini L.,FBK CMM | Berneschi S.,Centro Studi E Ricerche E Fermi | Berneschi S.,CNR Institute of Applied Physics Nello Carrara | Barucci A.,CNR Institute of Applied Physics Nello Carrara | And 8 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2013

Whispering gallery mode resonators (WGMR), as silica microspheres, have been recently proposed as an efficient tool for the realisation of optical biosensors. In this work we present a functionalization procedure based on the DNA-aptamer sequence immobilization on WGMR, able to recognize specifically thrombin or VEGF protein, preserving a high Q factor. The protein binding was numerically modelled and optically characterized in terms of specificity in buffer solution or in 10% diluted human serum. The aptasensor was also chemically regenerated and tested again, demonstrating the reusability of our system. © 2013 Copyright SPIE.

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