Tehrān, Iran
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Hamdi K.,Iran University of Medical Science | Yahyazadeh S.H.,Fayazbakhsh Hospital | Bahoor F.,Fayazbakhsh Hospital | Ziaee F.,Fayazbakhsh Hospital | And 2 more authors.
Pakistan Journal of Medical Sciences | Year: 2010

Objective: Iranian breast cancer patients are relatively younger than their Western counterparts. The objective of the present study was to investigate risk factors for breast cancer in Iranian women and compare it with other data driven from other studies. Methods: A study was conducted in April 2008 in Tehran, Iran. Demographical data and risk factor related information, including data from their mammograms were collected using a questionnaire. Results: In all, 109 participants were interviewed. The mean age of participants was 40.48 ± 0.56 years. 1.8% of women were unmarried, while 78% were married and 20.2% were divorced/widowed. The mean age for menarche was 13.34 ±1.47 years and 46.89±4.98 for the menopause, respectively. The mean parity time was 2.36±1.13 and breastfeeding in women was 23.27±14.16 months. About 5.5% of the participants used oral contraceptive as a method for contraception. 8.3% of women experienced menopause, at the mean age of 46.89±4.98. 33.3% of menopaused women, used Hormone Replace Therapy (HRT).Moreover, 8.3% of women had a positive history of breast cancer in their family. Of those women on whom mammography was done, 10.1% had breast mass in radiological findings, mostly in favour of fibrocystic change. In 20.2% of participants, further investigation was advised. Conclusion: The findings of the present study were in accordance with other studies done in Iran and in some aspects in tune with other studies about breast cancer in other countries. However, more multicentric larger scale studies should be conducted in Iran to determine a pattern for breast cancer in Iranian women.


Zendehdel N.,Iran National Institute of Genetic Engineering and Biotechnology | Biramijamal F.,Iran National Institute of Genetic Engineering and Biotechnology | Hossein-Nezhad A.,Tehran University of Medical Sciences | Zendehdel N.,Shahid Beheshti University of Medical Sciences | And 3 more authors.
Archives of Iranian Medicine | Year: 2010

Background: There are different clinical responses to omeprazole treatment in Iranian patients with gastroesophageal reflux disease. Omeprazole is metabolized in the liver by the cytochrome p450 2c19 (CYP2C19) enzyme. Two common polymorphisms of the CYP2C19 gene affect CYP2C19 enzyme activity. We investigated the effect of CYP2C19 gene polymorphisms on the clinical response to treatment with omeprazole in Iranian patients with erosive reflux esophagitis. Methods: Eighty-two Iranian patients with reflux esophagitis were enrolled in the study and underwent treatment with omeprazole at 40 mg daily for 4 weeks. A 2 mL sample of venous blood was obtained from each subject. CYP2C19 genetic polymorphisms were detected using the PCR-RFLP method. The patients were grouped into homo-extensive metabolizers and hetero-extensive metabolizers based on their CYP2C19 polymorphism. The grade of esophagitis was determined via endoscopy. The symptoms score was assessed at the beginning of treatment. Results: Our results showed that the rate of complete clinical response to treatment with omeprazole was 95% in the hetero-extensive metabolizers group, which was higher than in the homo-extensive metabolizers group (P<0.001). Conclusion: CYP2C19 polymorphism influences the therapeutic efficacy of omeprazole in the treatment of Iranian patients with erosive reflux esophagitis. The clinical response and endoscopic healing of esophagitis are both affected by CYP2C19 genotype condition.


Mohammadi S.,Tehran University of Medical Sciences | Hosseinzadeh Attar M.J.,Tehran University of Medical Sciences | Karimi M.,Tehran University of Medical Sciences | Hosseinnezhad A.,Tehran University of Medical Sciences | And 5 more authors.
Journal of Zanjan University of Medical Sciences and Health Services | Year: 2010

Background and Objective: Adiponectin is a novel adipose tissue-specific adipokine that can increase insulin sensitivity. Many studies have shown anti obesity and anti diabetic effects of green tea consumption. In this study we examined the effects of green tea extract on circulating adiponectin levels and insulin resistance status in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: In this double blind randomized clinical trial 58 type 2 diabetic patients with BMI ≥ 25 were recruited from an unselected population from the outpatient clinic of Shariati Hospital, Tehran, Iran. Patients were randomly divided into two groups; green tea extract and placebo. All the patients received the capsules for 8 weeks. Laboratory measurements including fasting serum adiponectin, insulin, HOMA-IR, FPG, OGTT, HbA1c and lipid profile and anthropometric were performed before and after the intervention. Nutrient intakes were obtained via 24- hour recall from each patient in three successive days. The data were analyzed using appropriate software. Results: We found a significant effect of green tea extract on increasing the logarithm of serum adiponectin in diabetic patients (0.15±0.10 μg/ ml, P < 0.05). A significant independent correlation between the logarithm of serum adiponectin and WHR (Waist to Hip Ratio) was found (P= 0.009, t= -2.7). The consumption of green tea extract had a significant effect in control the levels of HbA1C, weigh and also BMI in green tea group (P < 0.05). Conclusion: The results showed that consumption of green tea extract can be useful in the control of T2DM by increasing the levels of serum adiponectin and controlling the weight, BMI and HbA1C levels in patients with T2DM.


Gohari M.R.,Tehran University of Medical Sciences | Khodabakhshi R.,Fayazbakhsh Hospital | Shahidi J.,Elisabeth Bruyere Research Institute | Fard Z.M.,Tehran University of Medical Sciences | And 3 more authors.
Tumori | Year: 2012

Aims and background. Identifying the risk factors of recurrence of breast cancer is important for both the physician and patient. Analysis of the first recurrence may lead to an inaccurate evaluation of the factor's effects because it does not completely reflect the history of the disease and may result in the loss of valuable information. The present study aimed to determine the factors that influence breast cancer recurrence and to estimate disease-free survival, adjusting for multiple metastases in breast cancer patients. Methods and study design. Patients were selected from a longitudinal study carried out at Fayazabakhsh Hospital in Tehran, Iran. Women who were diagnosed with breast cancer and who underwent either modified radical mastectomy or breast-conserving surgery between January 2006 and April 2008 were recruited to take part in the study. Breast cancer recurrence was defined as the occurrence of a tumor in the contralateral breast, local-regional relapse, or distant metastasis to other organs. Using an extended Cox model, the effect of age, tumor size, estrogen receptors, HER2, progesterone receptors as well as lymph node ratio was analyzed. Results. Over a 5833 person-month follow-up, 25 of 133 patients (18.8%) had died and 108 patients (81.2%) were still alive, 9 of them with metastasis. Thirty-four patients (25.6%) experienced their first disease recurrence. A total of 11 patients had a second metastasis. The mean time to first metastasis was 19.93 months, and mean gap time between two metastases was 7.15 months. Risk of experiencing a metastasis or death in the third and fifth year after surgery was approximately 22% and 28%, respectively. Fitting multiple recurrent regression shows that high lymph node ratio, high histologic grade, large tumor size and HER2-positive tumors are prognostic factors for shorter disease-free survival. Conclusions. Our novel approach might be helpful in clinical practice to predict breast cancer recurrence after surgery and might be adapted to be used in other malignancies as well. © Il Pensiero Scientifico Editore.


Nabiuni M.,Fayazbakhsh Hospital | Sarvarian S.,Fayazbakhsh Hospital
Neurosurgery Quarterly | Year: 2014

Postoperative visual loss subsequent spine surgery is a rare but devastating complication with an estimated rate varying between 0.05% and 1.0%. However ischemic optic neuropathy, central artery thrombosis, and cortical blindness have been mentioned as recognized causes of postoperative visual loss, the exact etiologies are still unclear. The patient was a 58-year-old diabetic woman referred to our department with sudden visual loss, ophthalmoplegia, periorbital edema, and ptosis eyelid in her left eye 1 day after surgery for spinal spondylolisthesis. She mentioned the past medical history of rhinosinusitis and polyps. She did not smoke or drink alcohol. © 2013 by Lippincott Williams & Wilkins.


Salmani Nadoushan M.,University of Yazd | Nozary Heshmati B.,Tehran University of Medical Sciences | Shabanzadeh Pirsaraee A.,Tehran University of Medical Sciences | Salmani Nodoushan I.,University of Yazd | And 2 more authors.
International Journal of Organ Transplantation Medicine | Year: 2014

Background: Nowadays, organ transplantation is the treatment of choice for end-stage organ failure, which increases the importance of organ procurement. It seems that the attitude towards organ donation and transplantation affects people's satisfaction. Moreover, health care personnel, especially physicians, should be familiar with transplantation rules and standards. It seems that understanding the knowledge and attitude of this group can affect the transplantation center policies. Objective: To assess knowledge and attitude of a group of Iranian physicians towards organ and tissue donation. Methods: In a cross-sectional study, 560 Iranian physicians including nephrologists, urologists and internists were asked to fill out a validated questionnaire containing their demographics, knowledge and attitude towards organ and tissue donation and transplantation. Results: Of 560 participants, 435 (78%) agreed with organ donation after death and 285 (51%) agreed with living kidney donation. The most common reason provided by those who agreed with donation was "helping people" whereas the most common cause of disagreement was "to honor the body." Only 32 (6%) physicians had no knowledge about transplantation rules. Complete awareness about theoretical basis and financial issues of transplantation was observed in 265 (47%) and 221 (40%) participants, respectively. Conclusion: Physicians had a good attitude towards organ and tissue transplantation although less than half of them had knowledge of transplantation rules and its theoretical basis and financial issues; therefore, additional awareness and education of physicians is needed in all areas of the organ donation process in Iran.


Biglarian A.,University of Social Welfare and Rehabilitation Sciences | Bakhshi E.,University of Social Welfare and Rehabilitation Sciences | Gohari M.R.,Tehran University of Medical Sciences | Khodabakhshi R.,Fayazbakhsh Hospital
Asian Pacific Journal of Cancer Prevention | Year: 2012

Background and Objectives: Artificial neural networks (ANNs) are flexible and nonlinear models which can be used by clinical oncologists in medical research as decision making tools. This study aimed to predict distant metastasis (DM) of colorectal cancer (CRC) patients using an ANN model. Methods: The data of this study were gathered from 1219 registered CRC patients at the Research Center for Gastroenterology and Liver Disease of Shahid Beheshti University of Medical Sciences, Tehran, Iran (January 2002 and October 2007). For prediction of DM in CRC patients, neural network (NN) and logistic regression (LR) models were used. Then, the concordance index (C index) and the area under receiver operating characteristic curve (AUROC) were used for comparison of neural network and logistic regression models. Data analysis was performed with R 2.14.1 software. Results: The C indices of ANN and LR models for colon cancer data were calculated to be 0.812 and 0.779, respectively. Based on testing dataset, the AUROC for ANN and LR models were 0.82 and 0.77, respectively. This means that the accuracy of ANN prediction was better than for LR prediction. Conclusion: The ANN model is a suitable method for predicting DM and in that case is suggested as a good classifier that usefulness to treatment goals.


PubMed | Fayazbakhsh Hospital, Tehran University of Medical Sciences and Milad Hospital
Type: Journal Article | Journal: Iranian journal of cancer prevention | Year: 2014

Early stage gastric cancer diagnosis has ensued different approaches in resection strategies. In order to increase the proportion of cases which have undergone radical resection or have reduced the recurrence rate, different pre-operative treatments have introduced. Here, we have verified an active preoperative chemotherapeutic regimen in locally advanced gastric cancer patients.Forty nine patients who have found eligible to enter this phase 2 trial have treated with oxaliplatin 100 mg/m2 IV, docetaxel 50 mg/m2 IV, plus capecitabine 625 mg/m2 PO (TOX). Clinical staging has been following the first 2 cycles of induction chemotherapy. Patients that have further undergone radical surgery, have evaluated for pathological response rate.Anemia (10.2%), nausea (10.2%) and vomiting (6.1%) were the most frequent grade 3 or 4 adverse effects. Regarding the pathologic staging, 6 patients (12.2%) had complete response (95% CI 3% to 21.4%), 18 of them (36.7%) had partial response (95% CI 23.2% to 50.2%), then 3 patients (6.1%) had stable disease (95% CI 0%-12.8%). Among the patients who had surgery, 22% had pathologic complete response.Preoperative chemotherapeutic regimen of TOX seems to be an active and safe neoadjuvant therapy in non metastatic gastric cancer. It should further be considered with concurrent radiotherapy.


PubMed | Fayazbakhsh Hospital, University of Yazd and Tehran University of Medical Sciences
Type: Journal Article | Journal: International journal of organ transplantation medicine | Year: 2014

Nowadays, organ transplantation is the treatment of choice for end-stage organ failure, which increases the importance of organ procurement. It seems that the attitude towards organ donation and transplantation affects peoples satisfaction. Moreover, health care personnel, especially physicians, should be familiar with transplantation rules and standards. It seems that understanding the knowledge and attitude of this group can affect the transplantation center policies.To assess knowledge and attitude of a group of Iranian physicians towards organ and tissue donation.In a cross-sectional study, 560 Iranian physicians including nephrologists, urologists and internists were asked to fill out a validated questionnaire containing their demographics, knowledge and attitude towards organ and tissue donation and transplantation.Of 560 participants, 435 (78%) agreed with organ donation after death and 285 (51%) agreed with living kidney donation. The most common reason provided by those who agreed with donation was helping people whereas the most common cause of disagreement was to honor the body. Only 32 (6%) physicians had no knowledge about transplantation rules. Complete awareness about theoretical basis and financial issues of transplantation was observed in 265 (47%) and 221 (40%) participants, respectively.Physicians had a good attitude towards organ and tissue transplantation although less than half of them had knowledge of transplantation rules and its theoretical basis and financial issues; therefore, additional awareness and education of physicians is needed in all areas of the organ donation process in Iran.


PubMed | Fayazbakhsh Hospital
Type: Journal Article | Journal: Global spine journal | Year: 2013

Chiari malformations are a congenital heterogeneous group of disorders characterized by anatomic anomalies of the cerebellum, brain stem, and craniocervical junction associated with downward displacement of the cerebellum, alone or with lower medulla, into the cervical spine canal. The patient was a 23-year-old woman, a known case of Arnold-Chiari malformation with peripheral neuropathy and muscular atrophy, who presented with headache, drowsiness, decreased vision, and severe gait dysfunction lasting for several years. Brain magnetic resonance imaging confirmed a hypointense signal mass in the left hemisphere of the cerebellum causing mass effects on the fourth ventricle, which shifted it, accompanied with dilation of third and lateral ventricles.

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