Buenos Aires, Argentina
Buenos Aires, Argentina

The Favaloro University is a private university in the city of Buenos Aires in Argentina. It was founded by surgeon René Favaloro in 1998; it obtained its definitive authorization on October 23, 2003 by decree 963/03 of president Néstor Kirchner. Favaloro did not see his project completely realised, for he committed suicide a few years before completion. Wikipedia.

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Bipolar Disorders are among the ten leading causes of morbity and lithium is considered first-line treatment and the most cost-effective. Nevertheless, its use takes a back seat to other treatment options less effective, safe and more expensive; and the reasons for this remains unclear. The present study investigates clinical concepts related to its underutilization. An anonymous questionnaire concerning different aspects of lithium clinical use (compared efficacy, adverse effects, practical aspects regarding its use, use in special populations) was administered during the XXV Congress of the Argentinean Psychiatrist Association. 164 questionnaires were analyzed. Less than one-third of the sample referred lithium as their most frequent treatment option, although almost 60% qualified it as effective. Almost two-thirds considered its utilization as more complex and ill-ascribed adverse effects to it. One third referred not to use it in youth and senior populations. Contrary to current recommendations, lithium is under utilized. This is the first report on the possible causes leading to such phenomena, which can be related to ill concepts regarding its safety, clinical use and adverse effects; although not to its effectiveness.

Allen P.G.,Comision Nacional de la Energia Atomica | Scoccola N.N.,Comision Nacional de la Energia Atomica | Scoccola N.N.,CONICET | Scoccola N.N.,Favaloro University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

The phase structure of magnetized cold quark matter is analyzed in the framework of the two-flavor Nambu-Jona-Lasinio models paying special attention to its dependence on the model parameters as different values within the phenomenological allowed range are considered. We first discuss the simpler chiral limit case, and then the more realistic situation of finite current masses. We show that in spite of the difference in the nature of some transitions, both cases are alike and exhibit a rather rich phase structure for a significant range of acceptable parameters. A simplification of the phase structure is obtained as parameters leading to larger values of the dressed quark mass in the vacuum are considered. Finally, we consider the so-called "inverse catalysis effect" showing that in some phases it implies an actual decrease of the order parameter as the magnetic field increases. © 2013 American Physical Society.

Forastiero R.,Favaloro University
Hematology | Year: 2012

Antiphospholipid syndrome (APS) is an autoimmune disease characterized clinically by the occurrence of venous or arterial thrombosis, and/or pregnancy morbidity. The detection of persistently elevated levels of antiphospholipid antibodies (aPL) is a requisite laboratory feature for the diagnosis of APS. The positivity for at least one aPL test: lupus anticoagulant and/or IgG/IgM anticardiolipin and/ or IgG/IgM antiβ2glycoprotein I antibodies must be detected. Sometimes aPL coagulopathy may start with a hemorrhagic syndrome when a severe thrombocytopenia, or an acquired thrombocytopathy, or an acquired fator VIII inhibitor, or an acquired prothrombin deficiency is present. aPL-associated thrombocytopenia is usually moderate without clinical manifestations. Except in the occasional situations in which thrombocytopenia is associated with thrombotic microangiopathy, such as catastrophic APS, bleeding is uncommon in APS patients. When platelet counts are less than 30×109/L and there are symptoms of bleeding, the treatments used are the same for idiopathic thrombocytopenic purpura. In rare occasions a hemorrhagic diathesis due to the occurrence of non-neutralizing anti-prothrombin antibodies causing severe hypoprothrombinemia (HPT) can be observed. Levels of prothrombin in plasma are less than 10-20% in cases with HPT-related bleeding requiring transfusion and/or corticosteroid treatment. The APS mainly causes thrombosis, and pregnancy losses. However, other clinical manifestations are also associated with the presence of persistent autoimmune aPL. Bleeding is uncommon but can be the first clinical manifestation in patients having severe thrombocytopenia or prothrombin deficiency. © W. S. Maney & Son Ltd 2012.

Melloni M.,Favaloro University | Melloni M.,CONICET | Lopez V.,University of Santiago de Chile | Ibanez A.,Favaloro University | And 2 more authors.
Cognitive, Affective and Behavioral Neuroscience | Year: 2014

Empathy is a highly flexible and adaptive process that allows for the interplay of prosocial behavior in many different social contexts. Empathy appears to be a very situated cognitive process, embedded with specific contextual cues that trigger different automatic and controlled responses. In this review, we summarize relevant evidence regarding social context modulation of empathy for pain. Several contextual factors, such as stimulus reality and personal experience, affectively link with other factors, emotional cues, threat information, group membership, and attitudes toward others to influence the affective, sensorimotor, and cognitive processing of empathy. Thus, we propose that the frontoinsular-temporal network, the so-called social context network model (SCNM), is recruited during the contextual processing of empathy. This network would (1) update the contextual cues and use them to construct fast predictions (frontal regions), (2) coordinate the internal (body) and external milieus (insula), and (3) consolidate the context-target associative learning of empathic processes (temporal sites). Furthermore, we propose these context-dependent effects of empathy in the framework of the frontoinsular-temporal network and examine the behavioral and neural evidence of three neuropsychiatric conditions (Asperger syndrome, schizophrenia, and the behavioral variant of frontotemporal dementia), which simultaneously present with empathy and contextual integration impairments. We suggest potential advantages of a situated approach to empathy in the assessment of these neuropsychiatric disorders, as well as their relationship with the SCNM. © 2013 Psychonomic Society, Inc.

Scoccola N.N.,Comision Nacional de la Energia Atomica | Scoccola N.N.,CONICET | Scoccola N.N.,Favaloro University | Riska D.O.,Finnish Society of Science and Letters | Rho M.,CEA Saclay Nuclear Research Center
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

Using the bound state version of the topological soliton model for the baryons we show that the existence of a bound (or quasibound) D¯-soliton state leads to the possibility of having hidden charm pentaquarks with quantum numbers and masses, which are compatible with those of the candidates recently reported by the LHCb experiment. The implications of heavy quark symmetry are elaborated. © 2015 American Physical Society. © 2015 American Physical Society.

The Barratt Impulsiveness Scale was designed to assess the impulsivity construct in three dimensions: attentional, motor and unplanned. The scale has been applied to patients with different diagnoses in which the impulsivity symptoms are characteristic. In Argentina there aren't studies that evaluate the psychometrics properties of the scale in clinical population. The objective of the research was to evaluate the psychometrics properties in a sample of the city of Buenos Aires. 150 adult subjects were selected: 67 didn't have relevant psychiatric diagnoses, 56 met criteria for bipolar disorder and 27 had Attention Deficit Disorder. The internal consistency, the construct validity, discriminative validity and the factorial structure were assessed. The Cronbach alpha was 0.84 for the total scale. Also the instrument has demonstrated acceptable indicators of construct and discriminative validity. Significant differences were found when the results of the present study and the original factorial structure were compared. The results support the usefulness of the scale in the psychiatric, scientific and clinical context to evaluate the impulsivity construct. The total score of the scale obtained the strongest indicators of reliability and validity.

Samame C.,Favaloro University | Martino D.J.,Favaloro University | Strejilevich S.A.,Favaloro University
Acta Psychiatrica Scandinavica | Year: 2012

Objective: Deficits in social cognition have been reported in euthymic subjects with bipolar disorder (BD). However, some studies have failed to find differences favoring controls. As most investigations have been conducted with small samples, they have not had sufficient power to detect statistically significant differences. Furthermore, studies communicating positive results have scarcely attempted to estimate effect sizes for patient-control differences. The aim of this study was to summarize the findings of reports on social cognition in patients with euthymic BD and to combine their data to identify possible deficits and quantify their magnitude. Method: Systematic literature review and meta-analysis. Results: Impairments of moderate magnitude (0.5

Strejilevich S.A.,Favaloro University | Strejilevich S.A.,Cognitive Neurology Institute INECO | Martino D.J.,Favaloro University
Journal of Affective Disorders | Year: 2013

Objective: Neurocognitive dysfunction is considered as the main predictor of overall outcome of BD. The issue of whether neurocognitive dysfunction in BD is progressive-or not-has become critical in the effort to define staging models for these disorders. Data about cognitive dysfunction evolution are scarce and contradictory. While some studies showed a progressive pattern others have found a stable form of evolution. Methods: Twenty four patients with BD aged 60 years or older (E-BD), 24 patients with BD aged 40 years or younger (Y-BD) and 20 healthy controls matched by the E-BD group were evaluated with traditional clinical instruments and an extensive neuropsychological battery was completed. We used ANOVA and Chi-squared for comparisons. Raw score of neurocognitive tasks was transformed to standardized Z-score from the normative data of each test to avoid the effect of age. In order to decrease the risk of type I errors, one-way multivariate analysis of variance was conducted. Results: Despite having an illness duration that was 4 times longer, E-BD did not differ in terms of key cognitive domains compared to Y-BD. These data do not support the hypothesis of a progression of cognitive dysfunction due to illness chronicity. © 2013 Elsevier B.V. All rights reserved.

Craiem D.,Favaloro University | Magin R.L.,University of Illinois at Chicago
Physical Biology | Year: 2010

New lumped-element models of red blood cell mechanics can be constructed using fractional order generalizations of springs and dashpots. Such 'spring-pots' exhibit a fractional order viscoelastic behavior that captures a wide spectrum of experimental results through power-law expressions in both the time and frequency domains. The system dynamics is fully described by linear fractional order differential equations derived from first order stress-strain relationships using the tools of fractional calculus. Changes in the composition or structure of the membrane are conveniently expressed in the fractional order of the model system. This approach provides a concise way to describe and quantify the biomechanical behavior of membranes, cells and tissues. © 2010 IOP Publishing Ltd.

Binaghi D.,Favaloro University
Magnetic Resonance Imaging Clinics of North America | Year: 2015

Almost all movements of the upper extremities during routine daily life and many athletic activities require a painless and stable elbow joint. Studying the elbow is a diagnostic challenge because of its complex anatomy. MR imaging is an extremely important tool in the evaluation of common elbow disorders, the spectrum of which ranges from obvious acute lesions to chronic overuse injuries whose imaging manifestations can be subtle. © 2015 Elsevier Inc.

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