Fatima Hospital

Daegu, South Korea

Fatima Hospital

Daegu, South Korea
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Pyeon J.S.,Catholic University of Korea | Moon K.P.,Catholic University of Korea | Kang J.H.,Catholic University of Korea | Ma S.H.,Fatima Hospital | Bae S.M.,Korea National Institute of Health
Pediatric Infection and Vaccine | Year: 2016

Purpose: The purpose of this study was to investigate the etiology of acute pharygotonsillitis in pediatric patients. Methods: Pharyngeal swabs from patients with acute pharyngotonsillitis were evaluated for viruses and bacterial organisms from March 2010 through March 2011. Results: Of 615 patients, potentially pathogenic bacteria were isolated in 40 (6.5%), viruses were isolated in 310 (50.4%), and no pathogens were isolated in 267 patients (43.4%). Both viral and bacterial pathogens were found in 2 (0.3%). Of 40 patients with bacterial pathogens, group A streptococci were found in 31 (77.5%). Among 310 patients with virus infection, adenovirus was the most frequently recovered (203 patients; 65.5%), followed by rhinovirus (65 patients; 21.0%), enterovirus (43 patients; 13.9%) and coronavirus (18 patients; 5.8%). There were 25 patients who had been coinfected with 2 viruses. In viral pharyngotonsillitis, cough, rhinorrhea, conjunctivitis and diarrhea were prominent. On the other hand, pharyngeal injection and pharyngeal petechiae were prominent in bacterial pharyngotonsillitis. Conclusions: Virus infection was a big part of acute pharyngotonsillitis and there were differences in clinical manifestations among viral and bacterial infections. Therefore, we need to distinguish between virus infection and bacterial infection using clinical signs for preventing the abuse of antibiotics. © 2016, The Korean Society of Pediatric Infectious Diseases, All rights reserved.

Kwak S.,Kyungpook National University | Ku S.-K.,Daegu Haany University | Han M.-S.,Fatima Hospital | Bae J.-S.,Kyungpook National University
Toxicology and Applied Pharmacology | Year: 2014

Inhibition of high mobility group box 1 (HMGB1) protein and restoration of endothelial integrity is emerging as an attractive therapeutic strategy in the management of sepsis. Here, three structurally related polyphenols found in the Chinese herb Huang Qui, baicalin (BCL), baicalein (BCN), and wogonin (WGN), were examined for their effects on lipopolysaccharide (LPS)- or cecal ligation and puncture (CLP)-mediated release of HMGB1 and on modulation of HMGB1-mediated inflammatory responses. According to our data, BCL, BCN, and WGN inhibited the release of HMGB1 and down-regulated HMGB1-dependent inflammatory responses in human endothelial cells. BCL, BCN, and WGN also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in mice. In addition, treatment with BCL, BCN, and WGN reduced CLP-induced release of HMGB1 and sepsis-related mortality and pulmonary injury in mice. These results indicate that BCL, BCN, and WGN could be candidate therapeutic agents for various severe vascular inflammatory diseases owing to their inhibition of the HMGB1 signaling pathway. © 2014 Elsevier Inc.

Lee E.K.,Catholic University of Korea | Kang J.H.,Catholic University of Korea | Ma S.H.,Fatima Hospital
Pediatric Infection and Vaccine | Year: 2015

Posterior reversible leukoencephalopathy syndrome is a clinical radiographic syndrome of many causative factors. Sudden onset headache, vomiting, altered mental status, blurred vision and seizures are main symptoms shown in posterior reversible leukoencephalopathy syndrome. In addition, it typically shows radiological findings of edema in the white matter of posterior cerebrum, being in commonly bilateral but asymmetric. We report a case of poststreptococcal glomerulonephritis (PSGN) presenting as posterior reversible leukoencephalopathy syndrome. Immediate control of hypertension resulted in rapid and complete neurological recovery. © 2015, The Korean Society of Pediatric Infectious Diseases, All rights reserved.

Jung S.,Catholic University of Korea | Kang S.,Catholic University of Korea | Kang J.H.,Catholic University of Korea | Ma S.H.,Fatima Hospital
Pediatric Infection and Vaccine | Year: 2015

Virus-associated immune thrombocytopenic purpura (ITP) can occur following common viruses, but cases of ITP associated with influenza infection has seldom been reported. In this report we describe a previously healthy 5-year-old boy who admitted with fever, flu-like symptoms and a few bruises on both legs. Severe thrombocytopenia were found. Bone marrow aspirates and biopsy showed no abnormalities and results of coagulation tests were all in normal limit. Real-time polymerase chain reaction was positive for influenza B infection. The patient fully recovered with intravenous immunoglobulins and steroid therapy. © 2015, The Korean Society of Pediatric Infectious Diseases, All rights reserved.

Oh C.-W.,Kyungpook National University | Byun Y.-S.,Fatima Hospital | Oh J.-K.,Korea University | Kim J.-J.,University of Ulsan | And 3 more authors.
Orthopaedics and Traumatology: Surgery and Research | Year: 2012

Purpose: This study compared clinical outcomes and complications in patients with humeral shaft fractures treated using two methods of fixation by plating. Methods: Minimally invasive plate osteosynthesis (MIPO, n= 29) was prospectively performed from around the middle of the study period, while open reduction and plate osteosynthesis (ORPO, n= 30) had been the original standard method. Locking compression plate was used in these two groups. Major characteristics of the two groups were similar in terms of fracture type, fracture location, age, associated injuries and numbers of open fractures. Results: Primary union was achieved in 28 of 29 in the MIPO and in 27 of 30 in the ORPO. Mean time to union was similar in the two groups. Mean operation time in the MIPO (110. min) was shorter than in the ORPO (169. min) (P< 0.05). Bone grafting was performed in five patients of in the ORPO, but in no patient in the MIPO (P< 0.0001). There was one case of deep infection in the ORPO. Functional outcome was satisfactory in both groups. Conclusions: Minimally invasive plate osteosynthesis may achieve comparable results with the open plate osteosynthesis method in simple as well as complex fractures of humeral shaft. Although MIPO potentially has the radiation hazard, it may reduce the perioperative complications with a shortened operation time. Level of evidence: Level III. Case-control study. © 2011 Elsevier Masson SAS.

Lee S.-W.,Kyungpook National University | Lee H.J.,Kyungpook National University | Kim H.J.,Kyungpook National University | Lee J.,Kyungpook National University | And 3 more authors.
Radiology | Year: 2013

Purpose: To investigate the usefulness of the combined categorical reporting system of ultrasonography (US) and cytology results for thyroid nodules to suggest indications of repeat US-guided fine needle aspiration cytology (FNAC). Materials and Methods: Institutional review board approval was obtained, and the requirement for informed consent was waived for this retrospective study. From June 2001 to December 2009, 1084 patients (978 women, 106 men) who underwent repeat US-guided FNAC of thyroid nodules were included. FNAC results were reported by using the Bethesda system for reporting thyroid cytopathologic findings and five thyroid US categories (category US 1, benign; US 2, probably benign; US 3, indeterminate; US 4, probably malignant; US 5, malignant). The relative risk ratios were evaluated in each separate FNAC and combined initial category by means of Cox proportional risk model. Results: Eighty-one of 1084 (7.5%) patients had malignancy over a mean follow-up time of 20.8 months (range, 3-98 months). Initial FNAC category of atypia of undetermined significance (relative risk ratio, 9.677) and US categories of US 3 (28.76), US 4 (142.0), and US 5 (411.6) had high relative risk ratios for malignancy (P < .05). Combined categories of benign cytology findings with US 3-5, nondiagnostic cytology findings with US 3-5, and atypia of undermined significance with any US categorization had high relative risk ratios of 104.80 (95% confidence interval: 53.328, 205.966). Conclusion: The combination of the categorical reporting systems between cytology and US results could be useful to suggest indications of repeat US-guided FNAC. © RSNA, 2012.

Park K.-C.,Hanyang University | Oh C.-W.,Kyungpook National University | Byun Y.-S.,Fatima Hospital | Oh J.-K.,Korea University | And 4 more authors.
Injury | Year: 2012

Background: Femoral fractures in adolescents usually need operative treatment, but the optimal method is unclear. The purpose of this study is to compare intramedullary nailing (IN) and submuscular plating (SP) in adolescent femoral fractures. Materials and methods: We performed the prospective, comparison study of IN and SP in adolescent femoral shaft fractures at a mean age of 13.9 years (11-17.4). Twenty-two cases of IN and 23 cases of SP were followed for a minimum of 1 year. We compared radiological and clinical results, surgical parameters, and complications of two techniques. Results: Bony union was achieved in all cases except one case of IN. Time to union was similar in both groups. None showed mal-union over 10° or limb length discrepancy over 1 cm. None of SP group and 2 in IN group experienced re-operation; one patient had deep infection with nonunion. The other patient sustained mal-rotation. Both patients healed after revision procedure. All patients showed excellent or satisfactory results of Flynn's criteria. The time to full-weight bearing was shorter in IN (IN: 57.3 days, SP: 89.2 days, p < 0.05). In surgical parameters, operative time seemed shorter in IN (IN: 94.7 min, SP: 104 min, p = 0.095), and fluoroscopy time was shorter in IN (IN: 58 s, SP: 109 s, p < 0.05) than SP group. Conclusion: Although both IN and SP yield good results and minimal complication in adolescent femoral fractures, IN may be advantageous in less need of fluoroscopy, technical easiness in reduction and early weight bearing. © 2011 Elsevier Ltd. All rights reserved.

Hantsoo L.,University of Pennsylvania | Czarkowski K.A.,University of Pennsylvania | Child J.,Fatima Hospital | Howes C.,Yale University | Epperson C.N.,University of Pennsylvania
Journal of Women's Health | Year: 2014

Background: Among women worldwide, major depression (MDD) and heart disease rank first and second, respectively, in burden of disease. Although selective serotonin reuptake inhibitors (SSRIs) are frequently prescribed, possible inhibition of nitric oxide (NO) function has caused concerns about their effects on protective vascular mechanisms. Our study aimed to determine the effect of SSRIs on flow-mediated vascular dilatation (FMD), platelet aggregation, and platelet NO production among women. Methods: Women (n=28) without known cardiovascular disease were recruited prior to undergoing SSRI treatment for MDD, postpartum depression (PPD), or premenstrual dysphoric disorder (PMDD). Symptoms were quantified using the Hamilton Depression/Anxiety and Beck Depression scales. FMD, platelet aggregation, and platelet NO production were measured before and after 1 month of SSRI (sertraline, fluoxetine, or paroxetine) therapy. Results: Depression and anxiety symptoms decreased significantly with SSRI treatment (ps <0.01). FMD and platelet aggregation did not differ between pre-and posttreatment, although FMD rose to the normal range (≥8%) in two of three women with abnormal FMD prior to SSRI treatment. We observed a 21% decrease (p=0.024) in platelet NO production. Conclusions: SSRI treatment had little effect on FMD or platelet aggregation. The health impact of decreased NO production is unclear, particularly in this relatively young group of women without cardiovascular disease, but should be considered in future studies focusing on SSRI safety in patients with cardiovascular disease. © 2014, Mary Ann Liebert, Inc.

Kim N.-H.,Seoul National University | Kim M.,Seoul National University | Lee S.,Fatima Hospital | Yun N.R.,Chosun University | And 7 more authors.
Annals of Internal Medicine | Year: 2011

Background: Blood culture contamination leads to inappropriate or unnecessary antibiotic use. However, practical guidelines are inconsistent about the routine use of sterile gloving in collection of blood for culture. Objective: To determine whether the routine use of sterile gloving before venipuncture reduces lood culture contamination rates. Design: Cluster randomized, assessor-blinded, crossover trial (ClinicalTrials.gov registration number: NCT00973063). Setting: Single-center trial involving medical wards and the intensive care unit. Participants: 64 interns in charge of collection of blood for culture were randomly assigned to routine-to-optional or optional-toroutine sterile gloving groups for 1854 adult patients who needed blood cultures. Intervention: During routine sterile gloving, the interns wore sterile gloves every time before venipuncture, but during optional sterile gloving, sterile gloves were worn only if needed. Measurements: Isolates from single positive blood cultures were classified as likely contaminant, possible contaminant, or true pathogen. Contamination rates were compared by using generalized mixed models. Result: A total of 10 520 blood cultures were analyzed: 5265 from the routine sterile gloving period and 5255 from the optional sterile gloving period. When possible contaminants were included, the contamination rate was 0.6% in routine sterile gloving and 1.1% in optional sterile gloving (adjusted odds ratio, 0.57 [95% CI, 0.37 to 0.87]; P = 0.009). When only likely contaminants were included, the contamination rate was 0.5% in routine sterile gloving and 0.9% in optional sterile gloving (adjusted odds ratio, 0.51 [CI, 0.31 to 0.83]; P = 0.007). Limitation: Blood cultures from the emergency department, surgical wards, and pediatric wards were not assessed. Conclusion: Routine sterile gloving before venipuncture may reduce blood culture contamination. © 2011 American College of Physicians.

Shin S.M.,Fatima Hospital
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi | Year: 2010

Mesothelioma is a rare aggressive tumor arising from the mesothelial cell and regarded as universally fatal disease with average survival around 1 year. The incidence rate is varied from one to forty per million in different countries and increasing by the year. The most common site of tumor origin is the pleura and only 20% to 33% of mesothelioma arise from the peritoneum. There are increasing reports of malignant mesothelioma with forty to fifty fatal cases per year in Korea. Histological studies with immunohistochemical stain is helpful for the diagnosis of peritoneal mesothelioma and imaging modality alone is not sufficient for diagnosis, so it is difficult to confirm diagnosis. A 64-year-old male patient was admitted to the hospital with a palpable mass on abdomen. The 6x6 cm sized huge mass was seen on the body of stomach adjacent to the peritoneum. We report a case of malignant peritoneal mesothelioma without evident exposure to asbestos, of which direct invasion to the gastric mucosa was confirmed by endoscopic biopsy and immunohistochemical stain.

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