Shin S.M.,Fatima Hospital
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi | Year: 2010
Mesothelioma is a rare aggressive tumor arising from the mesothelial cell and regarded as universally fatal disease with average survival around 1 year. The incidence rate is varied from one to forty per million in different countries and increasing by the year. The most common site of tumor origin is the pleura and only 20% to 33% of mesothelioma arise from the peritoneum. There are increasing reports of malignant mesothelioma with forty to fifty fatal cases per year in Korea. Histological studies with immunohistochemical stain is helpful for the diagnosis of peritoneal mesothelioma and imaging modality alone is not sufficient for diagnosis, so it is difficult to confirm diagnosis. A 64-year-old male patient was admitted to the hospital with a palpable mass on abdomen. The 6x6 cm sized huge mass was seen on the body of stomach adjacent to the peritoneum. We report a case of malignant peritoneal mesothelioma without evident exposure to asbestos, of which direct invasion to the gastric mucosa was confirmed by endoscopic biopsy and immunohistochemical stain.
Kim N.-H.,Seoul National University |
Kim M.,Seoul National University |
Lee S.,Fatima Hospital |
Yun N.R.,Chosun University |
And 7 more authors.
Annals of Internal Medicine | Year: 2011
Background: Blood culture contamination leads to inappropriate or unnecessary antibiotic use. However, practical guidelines are inconsistent about the routine use of sterile gloving in collection of blood for culture. Objective: To determine whether the routine use of sterile gloving before venipuncture reduces lood culture contamination rates. Design: Cluster randomized, assessor-blinded, crossover trial (ClinicalTrials.gov registration number: NCT00973063). Setting: Single-center trial involving medical wards and the intensive care unit. Participants: 64 interns in charge of collection of blood for culture were randomly assigned to routine-to-optional or optional-toroutine sterile gloving groups for 1854 adult patients who needed blood cultures. Intervention: During routine sterile gloving, the interns wore sterile gloves every time before venipuncture, but during optional sterile gloving, sterile gloves were worn only if needed. Measurements: Isolates from single positive blood cultures were classified as likely contaminant, possible contaminant, or true pathogen. Contamination rates were compared by using generalized mixed models. Result: A total of 10 520 blood cultures were analyzed: 5265 from the routine sterile gloving period and 5255 from the optional sterile gloving period. When possible contaminants were included, the contamination rate was 0.6% in routine sterile gloving and 1.1% in optional sterile gloving (adjusted odds ratio, 0.57 [95% CI, 0.37 to 0.87]; P = 0.009). When only likely contaminants were included, the contamination rate was 0.5% in routine sterile gloving and 0.9% in optional sterile gloving (adjusted odds ratio, 0.51 [CI, 0.31 to 0.83]; P = 0.007). Limitation: Blood cultures from the emergency department, surgical wards, and pediatric wards were not assessed. Conclusion: Routine sterile gloving before venipuncture may reduce blood culture contamination. © 2011 American College of Physicians.
Jung G.-H.,Kosin University |
Kim J.-D.,Kosin University |
Cho Y.,Kosin University |
Chung S.-H.,Kosin University |
And 2 more authors.
Journal of Pediatric Orthopaedics Part B | Year: 2010
Phosphaturic mesenchymal tumor is an extremely rare disease and is frequently associated with oncogenic osteomalacia showing paraneoplastic syndrome, which is characterized by phosphaturia, hypophosphatemia, normocalcemia, and decreased levels of 1,25-dihydroxyvitamin D3 associated with a tumor. A 2-year-old boy, who had a soft tissue tumor on his right thigh and previously diagnosed as myositis ossificans at 9-months-old, was presented with rachitic rosary and mildly enlarged tumor. Biochemical investigations showed hypophosphatemia, hyperphosphaturia, and an increased alkaline phosphatase level of 440 U/l (25-100 U/l), suggesting rickets, which was resistant to vitamin D dietary supplementation. We were certain of intractable rickets because of oncogenic hypophosphatemia and thus decided to excise the soft tissue mass. We observed laboratory improvement of rickets after 2 weeks. On the basis of surgical and histopathological examinations, the tumor was finally diagnosed as the phosphaturic mesenchymal tumor. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Oh C.-W.,Kyungpook National University |
Byun Y.-S.,Fatima Hospital |
Oh J.-K.,Korea University |
Kim J.-J.,University of Ulsan |
And 3 more authors.
Orthopaedics and Traumatology: Surgery and Research | Year: 2012
Purpose: This study compared clinical outcomes and complications in patients with humeral shaft fractures treated using two methods of fixation by plating. Methods: Minimally invasive plate osteosynthesis (MIPO, n= 29) was prospectively performed from around the middle of the study period, while open reduction and plate osteosynthesis (ORPO, n= 30) had been the original standard method. Locking compression plate was used in these two groups. Major characteristics of the two groups were similar in terms of fracture type, fracture location, age, associated injuries and numbers of open fractures. Results: Primary union was achieved in 28 of 29 in the MIPO and in 27 of 30 in the ORPO. Mean time to union was similar in the two groups. Mean operation time in the MIPO (110. min) was shorter than in the ORPO (169. min) (P< 0.05). Bone grafting was performed in five patients of in the ORPO, but in no patient in the MIPO (P< 0.0001). There was one case of deep infection in the ORPO. Functional outcome was satisfactory in both groups. Conclusions: Minimally invasive plate osteosynthesis may achieve comparable results with the open plate osteosynthesis method in simple as well as complex fractures of humeral shaft. Although MIPO potentially has the radiation hazard, it may reduce the perioperative complications with a shortened operation time. Level of evidence: Level III. Case-control study. © 2011 Elsevier Masson SAS.
Kwak G.Y.,Catholic University of Korea |
Kwon H.J.,Korea University |
Kim J.H.,Catholic University of Korea |
Kim H.M.,Yonsei University |
And 4 more authors.
Vaccine | Year: 2012
Since the production of various vaccine formulations by different pharmaceutical companies and interruptions in vaccine supply cannot be fully regulated, problems caused by DTaP interchangeability may occur. However, the interchangeability data on the first primary series of DTaP vaccination have not been well described. In this study we investigated immunogenicity and overall safety of diphtheria, tetanus, pertussis in children who had adventitiously received an interchangeable DTaP vaccination. A total 97 of participants were enrolled (mean age, 11 months). High immunogenicity (1.8. ±. 0.4. IU/mL, 100%) was noted against diphtheria toxoid, and similar high immunogenicity (3.2. ±. 2.1. IU/mL, 100%) was noted against tetanus toxoid. Immunogenicity against pertussis antigen was significantly greater in the interchangeable vaccinated group compared to the control group, and 57% of the interchangeable vaccinated subjects achieved high levels of protective immunity (45.2. ±. 21.5. EU/mL). No serious adverse effects were noted, and most adverse effects resolved without treatment. The immunogenicity against each antigen was high in patients who were interchangeably vaccinated for DTaP. Our results provide clinical evidence affirming the non-inferiority of interchangeable vaccination when it cannot be avoided such as in limited vaccine supply situations or different prices. © 2012 Elsevier Ltd.