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Sowmya V.,Father Muller Medical CollegeKarnataka | Jayachander D.,Father Muller Medical CollegeKarnataka | Kamath V.,Father Muller Medical CollegeKarnataka | Rao M.S.K.,Father Muller Medical College | And 2 more authors.
Asian Journal of Ophthalmology

Background: The study objective was to assess the development of xerophthalmia [dry eye syndrome (DES) or keratoconjunctivitis sicca] in head and neck cancer patients undergoing radiotherapy. Methods: Twenty two head and neck cancer patients requiring more than 60 Gy of curative radiotherapy/chemoradiotherapy and ten patients requiring radiotherapy/chemoradiotherapy for treating cancers in the non head and neck regions (like breast, oesophagus, prostate, cervix and rectal cancers) were also enrolled in the study. The development of DES was studied at the beginning (day 0, before the start of radiotherapy) at day 21 (after completion of 30 Gy) and on completion of the treatment (> 60 Gy). As a comparative cohort, people with non head and neck cancer needing curative radiotherapy were also evaluated for comparison. Results: There was no difference in degree of DES between the Head and Neck cancer cohorts and non head and neck group at the beginning of treatment. However there was a statistically significant difference (p < 0.001) between the two groups at both mid and end of RT time point. Inter comparison between the various time points in the head and neck cancer group showed that the incidence of DES increased with the radiation exposure and was significant (pre to mid p < 0.001; and mid to end p < 0.005). A negative (r = -0.262) correlation was seen between DES and distance. Conclusions: The study showed that lesser the distance from the epicenter of the radiation to the orbital rim more was the severity of DES. © Asian Journal of Ophthalmology. Source

Shivashankara A.R.,Father Muller Medical College | Joy J.,Father Muller Research Center | Sunitha V.,Father Muller Research Center | Rai M.P.,Father Muller Research Center | And 5 more authors.
Journal of Clinical and Diagnostic Research

Introduction: The present study aimed to assess the levels of salivary enzymes, protein and oxidant-antioxidant system in young college-going cell phone users.Materials and Methods: The cell users (students) were categorized in to two groups – less mobile users and high mobile users, based on the duration and frequency of cell use. Unstimulated whole saliva samples of the volunteers were analysed for amylase, lactate dehydrogenase (LDH), malondialdehdye (MDA) and glutathione (GSH).Results: High mobile users had significantly higher levels of amylase (p = 0.001), LDH (p = 0.002) and MDA (p = 0.002) in saliva, when compared to less mobile users. The marginal decrease in salivary total proteins, GSH and flow rate were statistically not significant (p >0.05).Conclusion: Significant changes in salivary enzymes and MDA suggest adverse effect of high use of cell phones on cell health. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Pai Jakribettu R.,Father Muller Medical College | Boloor R.,Father Muller Medical College | Thaliath A.,Father Muller Research Center | Yesudasan George S.,Father Muller Research Center | And 5 more authors.
Journal of Tropical Medicine

Dengue is one of the arthropod-borne (arbo) viral diseases transmitted by female mosquito Aedes aegypti. Dengue fever has a wide spectrum of clinical presentation ranging from flu-like illness to severe complicated stage of dengue hemorrhagic fever leading to mortality. This was a retrospective study conducted in a tertiary care hospital in Coastal Karnataka, South India, to know the correlation between the clinical presentation and haematological parameters in the paediatric cases presented with dengue symptoms. A total of 163 paediatric cases who presented fever and dengue-like illness were included in the study. Of which, 69 were confirmed dengue patients. Critical analysis showed that there was a significant difference in the haematological parameters like total leucocyte count, percent differential leucocyte count, and platelets count, in the erythrocyte sedimentation rate (P<0.05 to 0.0001). Additionally, when compared to nondengue patients, even the liver function and renal function parameters were significantly deranged (P<0.05 to 0.0001). Stratification based on NS1, IgG, and IgM showed significant alterations in the haematological, hepatic, and renal parameters. With respect to the treatment a small percentage of patients, that is, 8% (4 patients), required platelet transfusion as their counts went below 20,000/L. Two patients succumbed to their illness while three required ICU stay. © 2015 Ramakrishna Pai Jakribettu et al. Source

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