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Krupashankar D.S.,Manipal Hospital | Dogra S.,Jawaharlal Institute of Postgraduate Medical Education & Research | Kura M.,JJ Group of Hospitals | Saraswat A.,Indushree Skin Clinic | And 20 more authors.
Journal of the American Academy of Dermatology | Year: 2014

Background Itolizumab, a humanized monoclonal antibody to CD6, is a novel therapeutic agent evaluated in chronic plaque psoriasis. Objective We sought to assess the safety and efficacy of itolizumab in moderate to severe chronic plaque psoriasis. Methods A total of 225 patients were randomized (2:2:1) to 2 different itolizumab arms (A or B; A = 4-week loading dose of 0.4 mg/kg/wk followed by 1.6 mg/kg every 2 weeks; B = 1.6/mg every 2 weeks) or placebo. At week 12, the placebo arm was switched to 1.6 mg/kg itolizumab every 2 weeks. The primary end point was the proportion of patients with at least 75% improvement in Psoriasis Area and Severity Index score at week 12. Results At week 12, 27.0% in arm A (P =.0172 vs placebo), 36.4% in B (P =.0043 vs placebo), and 2.3% in the placebo arm had at least 75% improvement in Psoriasis Area and Severity Index score. At week 28, the proportion with at least 75% improvement in Psoriasis Area and Severity Index score was comparable: 46.1%, 45.5%, and 41.9% for A, B, and placebo, respectively. In weeks 1 to 12, the incidence of all adverse events was comparable across arms (A, 43%; B, 38%; placebo, 47%) and the incidence of infections was not greater than placebo (11.1%, 8.9%, and 18.6% for A, B, and placebo). Limitations No active comparator is a limitation. Conclusions Itolizumab is an effective and well-tolerated novel biological therapy in moderate to severe psoriasis. © 2014 by the American Academy of Dermatology, Inc.


Tauro L.F.,Father Muller Medical College and Hospital | Shetty P.,Father Muller Medical College and Hospital | Kamath A.,Father Muller Medical College and Hospital | Shetty A.,Father Muller Medical College and Hospital
Journal of Thoracic Disease | Year: 2012

Teratomas are germ cell tumours arising as the result of abnormal development of totipotential cells. They are commonly encountered in the gonads and occasionally found in mediastinum. We report a case of asymptomatic 28 years old lady with concomitant mature cystic teratoma in her mediastinum and left ovary which was diagnosed incidentally during health check up. This case is reported because of its rare and unusual coexistence. © Pioneer Bioscience Publishing Company. All rights reserved.


Malathi M.,Father Muller Medical College and Hospital | Vijay M.,Father Muller Medical College and Hospital | Shivashankara A.R.,Father Muller Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2011

Objectives: The present study was aimed to assess the oxidantantioxidant status in head and neck cancer patients before and after radiotherapy. Methods: The subjects comprised of patients who had visited the Oncology Department and were diagnosed of head and neck cancer. The plasma levels of malondialdehyde (MDA), the marker of lipid peroxidation, and the antioxidants, superoxide dismutase (SOD), vitamin A, vitamin C and ceruloplasmin, were assayed before and after radiotherapy, in comparison to the healthy controls. Results: The plasma levels of MDA were higher and the levels of SOD, vitamin A, vitamin C and ceruloplasmin were lower in the head and neck cancer patients as compared to those in the healthy controls. These parameters showed significant changes after radiotherapy, as indicated by a lower level of MDA and higher levels of SOD, vitamin A, vitamin C and ceruloplasmin in the plasma of the cancer patients after radiotherapy, as compared to the plasma levels before radiotherapy. All the results were statistically significant (P < 0.001). Conclusions: Radiotherapy caused a reduction in the lipid peroxidation and an improvement in the antioxidant status of the head and neck cancer patients.


Shetty P.,Father Muller Medical College and Hospital | Menezes L.T.,Father Muller Medical College and Hospital | Tauro L.F.,Father Muller Medical College and Hospital | Diddigi K.A.,Father Muller Medical College and Hospital
Indian Journal of Surgery | Year: 2013

Amniotic band syndrome is an uncommon congenital disorder without any genetic or hereditary disposition. It involves fetal entrapment in strands of amniotic tissue and causes an array of deletions and deformations. Primary treatment is plastic and reconstructive surgery after birth with in utero fetal surgery also coming in vogue. © 2012 Association of Surgeons of India.


Bhat R.M.,Father Muller Medical College and Hospital | Pinto H.P.,Father Muller Medical College and Hospital | Dandekeri S.,Father Muller Medical College and Hospital | Ambil S.M.,Father Muller Medical College and Hospital
Indian Journal of Dermatology | Year: 2014

Acquired bilateral nevus of Ota-like macules (ABNOM) or Hori′s nevus, a rare form of acquired dermal melanocytoses, presents as bilateral facial blue-gray macules without ocular or mucosal involvement. This condition is mostly found in women of Asian descent and usually appears in the fourth or fifth decade of life. Pathogenesis is unknown, though few theories have been proposed. Effective treatment has been found to be achieved with pigment-specific lasers. Herein, we report a case of Hori′s nevus with mucosal involvement. A 42-year-old male patient, presented to us with blue-gray discoloration on either side of his face, both eyes, and in the mouth since the age of one year. Histopathological examination showed clusters and singly dispersed pigmented melanocytes within the upper and mid-dermis regions. Special staining of melanocytes using Masson-Fontana stain was positive. Diagnosis of Hori′s nevus was made by correlating clinical and histopathological findings. Patient was informed of his treatment options, but refused treatment. A similar case of Hori′s nevus with mucosal involvement has not been reported so far.


Amin A.,Father Muller Medical College and Hospital | Umashankar T.,Father Muller Medical College and Hospital | Dsouza C.O.,Father Muller Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2015

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign vasoproliferative disease with distinct clinical and histopathological features. The most common clinical presentation is dermal and subcutaneous painless nodules in the head and neck region. The involvement of medium sized peripheral muscular artery is uncommon. It predominantly affects Caucasian adults during the third and fourth decades, but is also known to occur in Asians and it very rarely occurs in children. We here by present a case of intravascular ALHE in a 46-year-old female presenting with subcutaneous forearm nodule clinically diagnosed as ulnar artery thrombosis. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved.


Likhi M.,Father Muller Medical College and Hospital | Jidesh V.V.,Father Muller Medical College and Hospital | Kanagaraj R.,Father Muller Medical College and Hospital | George J.K.,Father Muller Medical College and Hospital
Topics in Stroke Rehabilitation | Year: 2013

Background: Attainment of functional independence is the ultimate goal of a sound stroke rehabilitation program. Good trunk stability is essential for balance and extremity use. Stroke patients may have upper extremity impairments that may affect functional activity and lower extremity impairments that may hinder mobility. Hence, quantifying the specific levels of impairment in the trunk, upper extremity, and lower extremity is helpful to determine the extent to which each might influence the ability to perform activities of daily living. Objective: To assess the impairment of the trunk and the upper and lower extremity of stroke patients and correlate it with overall function. Methods: A cross-sectional repeated correlation study. Twenty-three subjects with a first-time stroke, between 50 and 75 years of age, of both genders, admitted in hospital within 5 weeks of stroke onset were included using purposive sampling technique. On the eighth day of the stroke, trunk impairment was assessed using the Trunk Impairment Scale, upper and lower limb impairment was assessed using the Simplified Stroke Rehabilitation Assessment of Movement (upper and lower limb subscale, respectively), and overall function was measured by FIM. Results: Trunk activity showed highly significant correlation (r = 0.598, P = .003) with overall function compared with upper limb activity (r = 0.501, P = .015). Lower limb impairment showed no correlation with overall function (r = 0.208, P = .342). Conclusions: The overall functional independence in acute stroke patients is most closely correlated with the levels of impairments of trunk function, followed by upper limb impairments. © 2013 Thomas Land Publishers, Inc.


PubMed | Father Muller Medical College and Hospital
Type: Journal Article | Journal: Indian dermatology online journal | Year: 2015

Although Molluscum contagiosum (MC) is a self-limiting condition, active therapy could prevent further spread and improve cosmesis. Most of the available treatment modalities traumatize the lesions and have to be undertaken in the hospital, therefore evoking panic in children. In the quest for an alternative therapy, this study comparing 10% potassium hydroxide (KOH) solution and 5% imiquimod cream was taken up.To compare the efficacy and tolerability of 10% KOH and 5% imiquimod in the treatment of MC.This comparative study was conducted over a period of 18 months from October 2011 to March 2013, 40 patients between the age group of 1-18 years with clinically diagnosed MC were divided into two groups (lottery method), 20 patients were treated with 5% imiquimod cream (Group A) and the other 20 were treated with 10% KOH solution (Group B). Patients were followed up on the 4(th), 8(th) and 12(th) week of treatment.At the end of 12 weeks, out of 20 patients who received 10% KOH, 17 patients showed complete disappearance, whereas out of 20 patients who received 5% imiquimod, only 10 patients showed total clearance of the lesions. Adverse events were more frequent with 10% KOH, pigmentary disturbances being the most common.With only minor adverse effects, 10% KOH is an inexpensive and efficient modality for the treatment of MC in the pediatric age group. Although 5% imiquimod was effective in clearing the lesions with minimal adverse effects, the longer duration required for its efficacy may deter its wider use.


PubMed | Father Muller Medical College and Hospital
Type: Journal Article | Journal: Journal of cancer research and therapeutics | Year: 2017

Tumors of the skin may be encountered by a dermatologist either as presenting complaints or as incidental findings. Certain tumors are easily recognized clinically, while others can only be diagnosed by histopathology.To analyze the pattern of skin tumors through clinical and histopathological correlation and to assess the role of a dermatologist in the treatment of tumors.A retrospective analysis of histopathologically-diagnosed skin tumors seen in dermatology outpatient department from May 2011 to June 2013.Forty cases of skin tumors were histopathologically reported during the period under review. Out of this, nine cases were malignant, the nonmelanoma to melanoma ratio being 8:1.Dermatologists are recommended to monitor closely the changing pigmented or hyperkeratotic lesions and poorly healing ulcers to facilitate early diagnosis and effective management.


PubMed | Father Muller Medical College and Hospital and Father Muller Medical College and Hospita
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign vasoproliferative disease with distinct clinical and histopathological features. The most common clinical presentation is dermal and subcutaneous painless nodules in the head and neck region. The involvement of medium sized peripheral muscular artery is uncommon. It predominantly affects Caucasian adults during the third and fourth decades, but is also known to occur in Asians and it very rarely occurs in children. We here by present a case of intravascular ALHE in a 46-year-old female presenting with subcutaneous forearm nodule clinically diagnosed as ulnar artery thrombosis.

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