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Krupashankar D.S.,Manipal Hospital | Dogra S.,Jawaharlal Institute of Postgraduate Medical Education & Research | Kura M.,JJ Group of Hospitals | Saraswat A.,Indushree Skin Clinic | And 20 more authors.
Journal of the American Academy of Dermatology | Year: 2014

Background Itolizumab, a humanized monoclonal antibody to CD6, is a novel therapeutic agent evaluated in chronic plaque psoriasis. Objective We sought to assess the safety and efficacy of itolizumab in moderate to severe chronic plaque psoriasis. Methods A total of 225 patients were randomized (2:2:1) to 2 different itolizumab arms (A or B; A = 4-week loading dose of 0.4 mg/kg/wk followed by 1.6 mg/kg every 2 weeks; B = 1.6/mg every 2 weeks) or placebo. At week 12, the placebo arm was switched to 1.6 mg/kg itolizumab every 2 weeks. The primary end point was the proportion of patients with at least 75% improvement in Psoriasis Area and Severity Index score at week 12. Results At week 12, 27.0% in arm A (P =.0172 vs placebo), 36.4% in B (P =.0043 vs placebo), and 2.3% in the placebo arm had at least 75% improvement in Psoriasis Area and Severity Index score. At week 28, the proportion with at least 75% improvement in Psoriasis Area and Severity Index score was comparable: 46.1%, 45.5%, and 41.9% for A, B, and placebo, respectively. In weeks 1 to 12, the incidence of all adverse events was comparable across arms (A, 43%; B, 38%; placebo, 47%) and the incidence of infections was not greater than placebo (11.1%, 8.9%, and 18.6% for A, B, and placebo). Limitations No active comparator is a limitation. Conclusions Itolizumab is an effective and well-tolerated novel biological therapy in moderate to severe psoriasis. © 2014 by the American Academy of Dermatology, Inc. Source


Menezes R.G.,University of Dammam | Kharoshah M.A.,Forensic Medicine Center | Madadin M.,University of Dammam | Marakala V.,Management and Science University | And 2 more authors.
Science and Engineering Ethics | Year: 2015

This article seeks to address and dispel some of the popular myths and misconceptions surrounding authorship of a scientific publication as this is often misconstrued by beginners in academia especially those in the developing world. While ethical issues in publishing related to authorship have been increasingly discussed, not much has been written about the myths and misconceptions of who might be an author. Dispelling these myths and misconceptions would go a long way in shaping the thoughts and plans of students, junior faculty and researchers in academia especially in the developing world. © 2015 Springer Science+Business Media Dordrecht Source


Emelia Lobo M.,Father Muller Medical College and Hospital | Kanagaraj R.,Father Muller Medical College and Hospital | Kanagaraj R.,King Khalid University | Jidesh V.,Father Muller Medical College and Hospital
International Journal of Therapy and Rehabilitation | Year: 2013

Background/aims: This study aims to assess adolescents' level of knowledge and attitudes towards low back pain (LBP) as this is required for effective prevention. As knowledge and attitude can influence occurrence, this study correlates adolescents' level of knowledge and attitude towards LBP with its occurrence in Mangalore, India. Methods: A cross-sectional survey with a self-administered questionnaire was conducted among 605 students from four pre-university colleges to evaluate their knowledge of, attitude to, and the occurrence of LBP. Results: This study revealed a moderate level of knowledge (45.39%) and a good attitude (61.95%) towards LBP. The lifetime prevalence of LBP among adolescents is 30.5%. No correlation was found between knowledge and the occurrence (Χ2=5.03, P=0.17) but a correlation exists between adolescents' attitudes and the occurrence of LBP (Χ2=14.64, P=0.002). Conclusion: Even with a moderate knowledge and a good attitude, the number of adolescents with LBP is considerable in this region and, therefore, prevention strategies need to be initiated. Source


Amin A.,Father Muller Medical College and Hospital | Umashankar T.,Father Muller Medical College and Hospital | Dsouza C.O.,Father Muller Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2015

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign vasoproliferative disease with distinct clinical and histopathological features. The most common clinical presentation is dermal and subcutaneous painless nodules in the head and neck region. The involvement of medium sized peripheral muscular artery is uncommon. It predominantly affects Caucasian adults during the third and fourth decades, but is also known to occur in Asians and it very rarely occurs in children. We here by present a case of intravascular ALHE in a 46-year-old female presenting with subcutaneous forearm nodule clinically diagnosed as ulnar artery thrombosis. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved. Source


Furtado S.,Father Muller Medical College and Hospital | Bhat R.M.,Father Muller Medical College and Hospital | Sukumar D.,Father Muller Medical College and Hospital | Nandakishore B.,Father Muller Medical College and Hospital
Singapore Medical Journal | Year: 2011

Metastatic cancer of unknown primary (CUP) may unexpectedly manifest on the skin and subcutaneous tissue, prompting the patient to first visit a dermatologist. We describe an interesting case of cutaneous metastases from poorly differentiated adenocarcinoma of an unknown primary site in a 57-year-old man. The CUP had an unusually long period of indolence between presentation as a solitary axillary lymph node metastasis and rapid cutaneous dissemination. The possible causes of such a presentation are reviewed, and the management is briefly discussed. Diagnosis of unusual cutaneous manifestations of occult systemic malignancies could pose a diagnostic challenge to dermatologists. Source

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