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Mar del Plata, Argentina

Diehl C.,National University of Cordoba | Ferrari A.,FASTA University
Journal of Drugs in Dermatology | Year: 2013

Background: Seborrheic dermatitis (SD) is a chronic mild skin disorder with high prevalence. Various treatment options are available, including topical antifungals and anti-inflammatories. Antifungal and anti-inflammatory properties of Quassia amara have been reported. Aim: To check the efficacy and safety of a topical gel with 4% Quassia amara extract and compare it with topical 2% ketoconazole and 1% topical ciclopiroxolamine in the treatment of facial SD. Methods: A group of 60 patients displaying facial SD were randomly distributed in 3 groups and given either a topical gel with 4% Quassia amara extract, a topical gel with 2% ketoconazole, or a topical gel with 1% ciclopirox olamine for 4 weeks. Disease severity was assessed at the start and weekly along treatment, as well as 4 weeks after the end of treatment. In each selected area, severity of erythema, scaling, pruritus, and papules were scored from 0 to 3, the sum of these values representing the score of SD on the face. This evaluation was conducted at each visit. The decrease in SD score with all 3 products was compared at each visit. At each stage, overall improvement, safety, and tolerability were also assessed. Results: Of the 60 patients, 54 (90%) completed the study. The 3 therapeutic options resulted to be very effective, with a significant advantage in efficacy for 4% Quassia extract. For the other 2 drugs, the results were in line with those previously published in the literature. Conclusion: Topical gel with 4% Quassia extract represents a new, safe, and effective treatment for facial SD.

de Villalobos A.E.,National University of the South | Trilla G.G.,Institute Investigaciones e Ingenieria Ambiental 3iA | Botte S.E.,National University of the South | Marcovecchio J.E.,National University of Costa Rica | Marcovecchio J.E.,FASTA University
Chemistry and Ecology | Year: 2012

In order to examine the role of position in the tidal range on biomass production and nutrient pools in Spartina alterniflora in an Argentinian estuary, we estimated productivity, the concentration of C, N and P in tissues and pools (concentration×biomass) of these elements in low (LM) and high (HM) zones. Aboveground biomass of S. alterniflora was higher in HM than in LM. Aboveground primary productivity was 106 and 439 g dry wt m-2 year-1 in LM and HM, respectively. Belowground biomass was similar in LM and HM. Belowground primary productivity was 526 and 744 g dry wt m-2 year-1 for LM and HM, respectively. Nutrient pools were higher in HM than in LM. Biomass and productivity values were low, which makes nutrient pools low. The lower values of the parameters analysed in LM than in HM indicate that position in the tidal range is an important factor in this system, possibly due to the effect of flooding. Moreover, this pattern is opposite to the general one observed in the northern hemisphere, meaning that studying marshes from different environments is worth doing. Because pools were higher in HM, this zone would be more important for nutrient input to the estuary. © 2012 Copyright Taylor and Francis Group, LLC.

Arias A.H.,CONICET | Arias A.H.,National University of the South | Pereyra M.T.,National University of the South | Marcovecchio J.E.,CONICET | And 2 more authors.
Environmental Monitoring and Assessment | Year: 2011

Forty-nine superficial sediment samples used in this study were collected from eight sites in the Bahia Blanca Estuary, located in the Buenos Aires Province southwest, Argentina, in a period between April 2005 and March 2009, to assess the concentration levels, spatial and seasonal distribution, and putative input sources of 18 selected organochlorine pesticides (OCs), following UNEP-IAEA procedures. Average concentration levels in sediments ranged between 3.54 and 63.79 ng g∈-∈1, d.w. (mean = 15.99 ng g ∈-∈1, d.w.), for ΣOCs, and from nondetectable to 8.03 ng g∈-∈1, d.w. (mean = 2.16 ng g∈-∈1, d.w.), and from nondetectable to 3.20 ng g∈-∈1 (mean = 0.97 ng g∈-∈1, d.w.) for hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethanes (DDTs), respectively. Principal component analysis allowed the classification of sampling sites according to the main OCs inputs over the estuary. In comparison to other worldwide locations and to the world coastal sediment concentrations range, sediment DDTs and HCHs levels were in the low range; on the opposite, ΣOCs average was in the medium range. OCs seasonal distribution was found to be highly correlated with the precipitations seasonality and sowing seasons in the adjacent agriculture fields. In addition, an ecotoxicological risk assessment pointed industrial and agriculture catchment zones with intermediate probability of adverse effects to biota, while the city sewage outfall was classified with none indication of an immediate threat. Data indicated that the estuary sediments were functioning as a sink for persistent OC pesticides (either in use or banned), however, it was found a declining trend on their environmental burden. © 2010 Springer Science+Business Media B.V.

Corral P.,FASTA University
Revista de la Federacion Argentina de Cardiologia | Year: 2015

Corneal arcus refers to cholesterol ester deposition in the corneal stroma subsequently forming a peripheral arc. Different studies have tried to determine its correlation with atherosclerotic disease and circulating lipid levels. The distinguishing characteristics of corneal, avascular tissue, without the ability of macrophage migration, make the deposit of such lipids to have a distinctive pattern, adopting the classic arch image at its inception, to conclude in a true corneal ring. The finding of this clinical sign in patients younger than 45-50 years should alert physicians about a severe disorder of the lipid metabolism, implementing all the elements at their disposal to make a correct diagnosis and then give an possible management. In familial hypercholesterolemia-a severe and frequent disorder of the lipoprotein metabolic activity-the finding of this sign is a classic sign, specific and sensitive for its clinical diagnosis. © 2015, Federacion Argentina de Cardiologia. All rights reserved.

Simonetti P.,CONICET | Botte S.E.,CONICET | Botte S.E.,National University of the South | Fiori S.M.,CONICET | And 4 more authors.
Archives of Environmental Contamination and Toxicology | Year: 2012

Copper (Cu), cadmium (Cd), and chromium (Cr) in soft tissues of male and female burrowing crab Neohelice granulate, as well as their eggs, were measured in two different locations in the Bahía Blanca estuary, a moderately polluted ecosystem, from October 2008 to August 2009. Differences between sexes, sites, and seasonality were assessed. Furthermore, metal levels in eggs were compared with metal levels in female crabs. The results showed no significant differences for Cu and Cd between sexes (Student t test p > 0.25 for both sites) and sites (two-way analysis of variance: Cu p = 0.82 and Cd p = 0.29). Nevertheless, seasonality was found, with winter having significantly lower concentrations for both metals. The range of Cu concentrations was between 96.92 and 152.18 μg g -1 dry weight (dw), and the range of Cd concentrations was between 6.09 and 10.41 μg g -1 dw. Cr concentrations could not be assessed because most of the values were lower than the detection limit. Although heavy metals in sediments were not measured in this study, a bioaccumulation process may be occurring for Cd because levels found during the entire sampling period were greater than levels in sediment from previous years. For Cu, a regulation process may be occurring considering that this is an essential metal and levels of Cu in N. granulata found in this study were between 1 and 2 orders of magnitude greater than levels in sediments. Finally, Cu and Cd levels in eggs were detectable, but they were lower than levels in female crabs. The importance of these findings is linked to the fact that metal accumulation seems to be occurring before hatch. The presence of heavy metals in soft tissues as well as in eggs of N. granulata is of great importance considering that this is a key species within the Bahía Blanca estuary; therefore, it plays a major role in the transference of pollutants to greater trophic levels. © 2011 Springer Science+Business Media, LLC.

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