Roshanzamir F.,Fasa University of Medical Sciences |
Roshanzamir F.,Isfahan University of Medical Sciences |
Safavi S.M.,Isfahan University of Medical Sciences
International Journal of Reproductive BioMedicine | Year: 2017
Background: D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions. Recently, it has been reported that D-Asp is involved in the synthesis and release of testosterone and is assumed can be used as a testosterone booster for infertile men, and by athletes to increase muscle mass and strength. Objective: The aim of this review is to summarize available evidence related to the effects of D-Asp on serum testosterone levels. Materials and Methods: We conducted a systematic review of all type studies, which evaluated the effect of the D-Asp on blood testosterone including published papers until October 2015, using PubMed, ISI Web of Science, ProQuest and Scopus database. Results: With 396 retrieved records, 23 animal studies and 4 human studies were included. In vivo and in vitro animal studies revealed the effect of D-Asp depending on species, sex and organ-specific. Our results showed that exogenous D-Asp enhances testosterone levels in male animal’s studies, whereas studies in human yielded inconsistent results. The evidence for this association in man is still sparse, mostly because of limited number and poor quality studies. Conclusion: There is an urgent need for more and well-designed human clinical trials with larger sample sizes and longer duration to investigate putative effects of D-Asp on testosterone concentrations. © 2017, Research and Clinical Center for Infertitlity. All rights reserved.
Mahjour S.B.,Stevens Institute of Technology |
Ghaffarpasand F.,Fasa University of Medical Sciences |
Wang H.,Stevens Institute of Technology
Tissue Engineering - Part B: Reviews | Year: 2012
The repair and management of full-thickness skin defects resulting from burns and chronic wounds remain a significant unmet clinical challenge. For those skin defects exceeding 50%-60% of total body surface area, it is impractical to treat with autologous skin transplants because of the shortage of donor sites. The possibility of using tissue-engineered skin grafts for full-thickness wound repair is a promising approach. The primary goal of tissue-engineered skin grafts is to restore lost barrier function, but regeneration of appendages, such as hair follicles, has to be yet achieved. The successful regeneration of hair follicles in immunodeficient mice suggests that creating human hair follicles in tissue-engineered skin grafts is feasible. However, many limitations still need to be explored, particularly enriching isolated cells with trichogenic capacity, maintaining this ability during processing, and providing the cells with proper environmental cues. Current advances in hair follicle regeneration, in vitro and in vivo, are concisely summarized in this report, and key requirements to bioengineer a hair follicle are proposed, with emphasis on a three-dimensional approach. © 2012 Mary Ann Liebert, Inc.
Ghanizadeh A.,Shiraz University of Medical Sciences |
Hedayati A.,Fasa University of Medical Sciences
Depression and Anxiety | Year: 2013
Backgrounds There are contradictory evidence about the effect of statins on depression. This 6-week-randomized placebo-controlled clinical trial assessed the efficacy and safety of lovastatin as an adjuvant agent for treating major depressive disorder (MDD). Methods The participants were 68 patients with MDD according to DSM-IV diagnostic criteria. The sample was randomly allocated into fluoxetine (up to 40 mg/day) plus lovastatin (30 mg/day) group or fluoxetine plus placebo group. Hamilton Depression Rating scale was used to measure depression score at baseline, week 2, and week 6. Results Both groups showed a significant decrease of depression score on the Hamilton Depression scale. However, the treatment group decreased depression score more than placebo group [12.8(6.3) vs. 8.2(4.0), t = 3.4, df = 60, P <.001]. Any serious adverse effect was not found. Discussion These results suggest that lovastatin as an adjuvant treatment may be effective for treating patients with MDD. © 2013 Wiley Periodicals, Inc.
Mokhtari M.,Shiraz University of Medical Sciences |
Zeraatiannejaddavani S.,Fasa University of Medical Sciences
Archives of Iranian Medicine | Year: 2012
Hydatid disease is an endemic illness in some countries. The main sites of involvement are the liver and lungs, but rarely,it can be seen in other organs as well. Herein, we report a case of primary adrenal hydatid cyst accompanied by arterial hypertension.
Kasraeian M.,Shiraz University of Medical Sciences |
Asadi N.,Shiraz University of Medical Sciences |
Ghaffarpasand F.,Fasa University of Medical Sciences |
Karimi A.A.,Fasa University of Medical Sciences
Climacteric | Year: 2011
Objective To investigate the value of transvaginal ultrasonography (TVU) in the evaluation of the endometrium in postmenopausal women without vaginal bleeding. Methods This was a prospective, cohort, observational study which included 259 consecutive, asymptomatic, postmenopausal women who were referred to the outpatient clinics of Shiraz University of Medical Sciences. All the participants underwent TVU by the same gynecologist at the same time as hysteroscopy and endometrial biopsy were performed. Both 3mm and 5mm were considered as cut-off values. Endometrial histopathology was considered the gold-standard diagnosis and the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of TVU were calculated on the basis of pathologic reports. Results The mean age of the patients was 54.2±7.46 years (range 36-79 years). The mean endometrial thickness was found to be 3.83±2.95mm (range 1-25mm); it was>5mm in 41 (15.8%) patients. The sensitivity, specificity, PPV and NPV were 62.2%, 93.9%, 68.3% and 92.2%, respectively. The receiver-operating characteristics curve showed an area under the curve of 0.853 (95% confidence interval 0.788-0.917), indicating a moderate accuracy. Conclusion TVU is a moderately accurate test in asymptomatic postmenopausal women. Due to its high false-positive rate, its positive results cannot be interpreted. © 2011 International Menopause Society.
Jafari P.,Shiraz University of Medical Sciences |
Bagheri Z.,Shiraz University of Medical Sciences |
Bagheri Z.,Fasa University of Medical Sciences |
Safe M.,Shiraz University of Medical Sciences
Health and Quality of Life Outcomes | Year: 2012
Background: The purpose of the study was to determine whether the Persian version of the KIDSCREEN-27 has the optimal number of response category to measure health-related quality of life (HRQoL) in children and adolescents. Moreover, we aimed to determine if all the items contributed adequately to their own domain.Findings: The Persian version of the KIDSCREEN-27 was completed by 1083 school children and 1070 of their parents. The Rasch partial credit model (PCM) was used to investigate item statistics and ordering of response categories. The PCM showed that no item was misfitting. The PCM also revealed that, successive response categories for all items were located in the expected order except for category 1 in self- and proxy-reports.Conclusions: Although Rasch analysis confirms that all the items belong to their own underlying construct, response categories should be reorganized and evaluated in further studies, especially in children with chronic conditions. © 2012 Jafari et al.; licensee BioMed Central Ltd.
Zolghadri J.,Shiraz University of Medical Sciences |
Momtahan M.,Shiraz University of Medical Sciences |
Aminian K.,Shiraz University of Medical Sciences |
Ghaffarpasand F.,Fasa University of Medical Sciences |
Tavana Z.,Shiraz University of Medical Sciences
European Journal of Obstetrics Gynecology and Reproductive Biology | Year: 2011
Objectives: We performed this study in order to investigate the role of chronic endometritis (CE) in unexplained recurrent spontaneous abortion (RSA) and to determine the correlation between hysteroscopic and histologic findings of CE in patients with unexplained RSA. We also tried to find out the relation between CE and primary vs. secondary RSA. Study design: One hundred and forty-two consecutive patients with unexplained RSA and 154 fertile women were enrolled in this study. All the patients and controls underwent hysteroscopy and, at the same time, endometrial biopsy. CE was suspected when hysteroscopy revealed signs of focal or diffuse endometrial hyperemia or endometrial endopolyps (less than 1 mm in size). Histopathologic diagnosis of CE was based on superficial stromal edema, increased stromal density, and pleomorphic stromal inflammatory infiltrate dominated by lymphocytes and plasma cells. Results were compared between cases and controls as well as those with primary (n = 61) and secondary (n = 81) RSA. Results: Patients with RSA had a significantly higher incidence of CE both hysteroscopically (67.6% vs. 27.3%; p < 0.0001) and pathologically (42.9% vs. 18.2%; p < 0.0001). The sensitivity, specificity, positive predictive value and negative predictive value of hysteroscopy in the diagnosis of CE were found to be 98.4%, 56.23%, 63.5% and 97.82% respectively. Patients with secondary RSA had a higher prevalence of CE both pathologically (83.9% vs. 45.9%; p < 0.0001) and hysteroscopically (58.1% vs. 24.6%; p < 0.0001). Conclusion: CE is associated with unexplained RSA. Hysteroscopy, with high sensitivity and acceptable specificity, is suitable for the diagnosis of CE in those with unexplained RSA. CE should be taken into consideration in those with secondary unexplained RSA. © 2010 Elsevier Ireland Ltd.
Hosseinzadeh Z.,University of Tübingen |
Shojaiefard M.,University of Tübingen |
Shojaiefard M.,Fasa University of Medical Sciences |
Bhavsar S.K.,University of Tübingen |
Lang F.,University of Tübingen
Biochemical and Biophysical Research Communications | Year: 2012
Janus-activated kinase-2 JAK2 is activated by hyperosmotic shock and modifies the activity of several Na + coupled transporters. Carriers up-regulated by osmotic shock include the Na + coupled osmolyte transporter BGT1 (betaine/GABA transporter 1), which accomplishes the concentrative cellular uptake of γ-amino-butyric acid (GABA). The present study thus explored whether JAK2 participates in the regulation of BGT1 activity. To this end, cRNA encoding BGT1 was injected into Xenopus oocytes with or without cRNA encoding wild type JAK2, constitutively active V617FJAK2 or inactive K882EJAK2, and electrogenic GABA transport determined by dual electrode voltage clamp. In oocytes injected with cRNA encoding BGT1 but not in oocytes injected with water or with cRNA encoding JAK2 alone, the addition of 1mM GABA to the extracellular fluid generated an inward current (I BGT). In BGT1 expressing oocytes I BGT was significantly increased by coexpression of JAK2 or V617FJAK2, but not by coexpression of K882EJAK2. According to kinetic analysis coexpression of JAK2 increased the maximal I BGT without significantly modifying the concentration required for halfmaximal I BGT (K M). In oocytes expressing BGT1 and V617FJAK2 I BGT was gradually decreased by JAK2 inhibitor AG490 (40μM). The decline of I BGT following disruption of carrier insertion with brefeldin A (5μM) was similar in the absence and presence of the JAK2 inhibitor AG490 (40μM). In conclusion, JAK2 is a novel regulator of the GABA transporter BGT1. The kinase up-regulates the carrier presumably by enhancing the insertion of carrier protein into the cell membrane. © 2012 Elsevier Inc.
Razeghinejad M.R.,Shiraz University of Medical Sciences |
Banifatemi M.,Fasa University of Medical Sciences
Journal of Ophthalmic and Vision Research | Year: 2013
Purpose: To compare ocular biometric parameters in primary angle closure suspects (PACS), primary angle closure glaucoma (PACG) and acute primary angle closure (APAC). Methods: This cross-sectional study was performed on 113 patients including 33 cases of PACS, 45 patients with PACG and 35 subjects with APAC. Central corneal thickness (CCT), axial length (AL), anterior chamber depth (ACD) and lens thickness (LT) were measured with an ultrasonic biometer. Lens-axial length factor (LAF), relative lens position, corrected ACD (CACD) and corrected lens position were calculated. The parameters were measured bilaterally but only data from the right eyes were compared. In the APAC group, biometric parameters were also compared between affected and unaffected fellow eyes. Logistic regression analysis was performed to identify risk factors. Results: No statistically significant difference was observed in biometric parameters between PACS and PACG eyes, or between affected and fellow eyes in the APAC group (P>0.05 for all comparisons). However, eyes with APAC had thicker cornea (P=0.001), thicker lens (P<0.0001), shallower ACD (P=0.009), shallower CACD (P=0.003) and larger LAF (P<0.0001). Based on ROC curve analysis, lower ACD, and larger LT, LAF and CCT values were associated with APAC. In the APAC group, LAF (P<0.0001) and CCT (P=0.001) were significant risk factors. Conclusion: This study revealed no significant difference in biometric characteristics in eyes with PACS and PACG. However, larger LAF and CCT were predictive of APAC.
Heydari M.,Shiraz University of Medical Sciences |
Homayouni K.,Shiraz University of Medical Sciences |
Hashempur M.H.,Fasa University of Medical Sciences |
Shams M.,Shiraz University of Medical Sciences
Journal of Diabetes | Year: 2016
Background: The aim of the present study was to examine the safety and efficacy of a topical formulation of Citrullus colocynthis in patients with painful diabetic polyneuropathy (PDPN). Methods: The study was designed as a two-arm double-blind randomized placebo-controlled clinical trial using a parallel design. Sixty patients with PDPN were randomly allocated to receive either a topical formulation of C. colocynthis or placebo (1:1 allocation ratio) for 3 months. Patients were evaluated before and after the intervention using the neuropathic pain scale, electrodiagnostic findings, World Health Organization Biomedical Research and Education Foundation (BREF) quality of life (WHOQOL-BREF) scores, and reported adverse events. Results: There was a significantly greater decrease in mean pain score after 3 months in the C. colocynthis (-3.89; 95% confidence interval [CI] -3.19, -4.60) than placebo (-2.28; 95% CI -1.66, -2.90) group (P<0.001). Mean changes in nerve conduction velocity of the tibial nerve, distal latency of the superficial peroneal nerve and sural nerve, and sensory amplitude of the sural nerve were significantly higher in the intervention than placebo group (P<0.001) in favour of the intervention. In the different domains of WHOQOL-BREF, there was a significant improvement only for the mean score in the physical domain. Conclusions: Application of a topical formulation of C. colocynthis fruit extract can decrease pain in patients with PDPN. It also may have some uncertain effects on nerve function and the physical domain of quality of life, which require further investigation in studies with larger sample sizes and of longer duration. © 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.