Roshanzamir F.,Fasa University of Medical Sciences |
Roshanzamir F.,Isfahan University of Medical Sciences |
Safavi S.M.,Isfahan University of Medical Sciences
International Journal of Reproductive BioMedicine | Year: 2017
Background: D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions. Recently, it has been reported that D-Asp is involved in the synthesis and release of testosterone and is assumed can be used as a testosterone booster for infertile men, and by athletes to increase muscle mass and strength. Objective: The aim of this review is to summarize available evidence related to the effects of D-Asp on serum testosterone levels. Materials and Methods: We conducted a systematic review of all type studies, which evaluated the effect of the D-Asp on blood testosterone including published papers until October 2015, using PubMed, ISI Web of Science, ProQuest and Scopus database. Results: With 396 retrieved records, 23 animal studies and 4 human studies were included. In vivo and in vitro animal studies revealed the effect of D-Asp depending on species, sex and organ-specific. Our results showed that exogenous D-Asp enhances testosterone levels in male animal’s studies, whereas studies in human yielded inconsistent results. The evidence for this association in man is still sparse, mostly because of limited number and poor quality studies. Conclusion: There is an urgent need for more and well-designed human clinical trials with larger sample sizes and longer duration to investigate putative effects of D-Asp on testosterone concentrations. © 2017, Research and Clinical Center for Infertitlity. All rights reserved.
Jabbari M.,University of Yazd |
Hashempur M.H.,Fasa University of Medical Sciences |
Hashempur M.H.,Shiraz University of Medical Sciences |
Razavi S.Z.E.,Tehran University of Medical Sciences |
And 3 more authors.
Journal of Ethnopharmacology | Year: 2016
Ethnopharmacological relevance Sambucus ebulus L. (S. ebulus) has had long-standing application in Traditional Persian Medicine for joint pain and for a variety of bone and joint disorders. According to traditional use of S. ebulus and its relevant pharmacologic properties, this study was designed to evaluate the efficacy and short-term safety of topical use of S. ebulus in patients with knee osteoarthritis (OA). Methods and materials Seventy nine patients with knee OA were randomly enrolled in 2 parallel arms of a pilot randomized, double-blind, active-controlled clinical trial. The patients were treated by topical S. ebulus gel or 1% diclofenac gel, three times a day, as much as a fingertip unit for 4 weeks. Patients were assessed prior to enrollment and, then, 2 and 4 weeks subsequent to the intervention, in terms of scores of visual analogue scale (VAS) for self-grading of their knee joint pain, and according to 3 different domains of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. Any observed adverse effects were also scrutinized. Results The mean values of WOMAC pain score, total WOMAC score and VAS score for pain of the S. ebulus group were significantly lower compared with the diclofenac group (P=0.004, P=0.04, and P<0.001, respectively). In addition, no serious adverse effect was reported. Conclusion This pilot study showed that topical treatment with S. ebulus gel can be recommended for alleviating symptoms of patients with knee OA. However, longer trials involving larger samples size, are needed for achieving a comprehensive understanding about the efficacy and safety of S. ebulus in knee OA.
Shenavandeh S.,Shiraz University of Medical Sciences |
Habibi S.,Fasa University of Medical Sciences
Lupus | Year: 2017
Introduction The clinical expression of systemic lupus erythematosus (SLE) is the consequence of endothelial cell damage leading to serious multiple organ dysfunction. The aim of this study was to assess the association between nailfold capillaroscopic changes and disease activity, skin and renal involvement in patients with SLE. Methods Demographic variables, clinical manifestations and laboratory data of 108 patients with SLE were investigated. Nailfold capillaroscopy (NFC) was performed in all patients. Result Morphological changes in NFC were observed in 102 out of 108 (94.4%) SLE patients. Minor changes were found in 33 (30.6%) and major changes in 69 (63.9%) cases. The disease activity was significantly higher in the patients with major changes (p < 0.002). A higher incidence of microhaemorrhages was seen in patients with active SLE disease (p < 0.04). In SLE patients with active skin involvement, the disturbed distribution (p < 0.004) was more frequent and subtle changes (p < 0.009) were less frequently observed as compared with patients without active skin involvement. In the group of SLE patients with renal involvement, no correlation was found between the capillary abnormalities and the presence of renal involvement (p > 0.05), except for the elongated capillary loops, which were seen more often in patients with renal involvement than in patients without it (p < 0.03). Conclusion The results of the study showed that capillary changes (abnormal capillaroscopy) were very common in patients with SLE, although there were no specific patterns like the ones in scleroderma patients, and some changes may be associated with disease activity, especially in patients with active skin involvement. © 2016 SAGE Publications.
Mahjour S.B.,Stevens Institute of Technology |
Ghaffarpasand F.,Fasa University of Medical Sciences |
Wang H.,Stevens Institute of Technology
Tissue Engineering - Part B: Reviews | Year: 2012
The repair and management of full-thickness skin defects resulting from burns and chronic wounds remain a significant unmet clinical challenge. For those skin defects exceeding 50%-60% of total body surface area, it is impractical to treat with autologous skin transplants because of the shortage of donor sites. The possibility of using tissue-engineered skin grafts for full-thickness wound repair is a promising approach. The primary goal of tissue-engineered skin grafts is to restore lost barrier function, but regeneration of appendages, such as hair follicles, has to be yet achieved. The successful regeneration of hair follicles in immunodeficient mice suggests that creating human hair follicles in tissue-engineered skin grafts is feasible. However, many limitations still need to be explored, particularly enriching isolated cells with trichogenic capacity, maintaining this ability during processing, and providing the cells with proper environmental cues. Current advances in hair follicle regeneration, in vitro and in vivo, are concisely summarized in this report, and key requirements to bioengineer a hair follicle are proposed, with emphasis on a three-dimensional approach. © 2012 Mary Ann Liebert, Inc.
Ghanizadeh A.,Shiraz University of Medical Sciences |
Hedayati A.,Fasa University of Medical Sciences
Depression and Anxiety | Year: 2013
Backgrounds There are contradictory evidence about the effect of statins on depression. This 6-week-randomized placebo-controlled clinical trial assessed the efficacy and safety of lovastatin as an adjuvant agent for treating major depressive disorder (MDD). Methods The participants were 68 patients with MDD according to DSM-IV diagnostic criteria. The sample was randomly allocated into fluoxetine (up to 40 mg/day) plus lovastatin (30 mg/day) group or fluoxetine plus placebo group. Hamilton Depression Rating scale was used to measure depression score at baseline, week 2, and week 6. Results Both groups showed a significant decrease of depression score on the Hamilton Depression scale. However, the treatment group decreased depression score more than placebo group [12.8(6.3) vs. 8.2(4.0), t = 3.4, df = 60, P <.001]. Any serious adverse effect was not found. Discussion These results suggest that lovastatin as an adjuvant treatment may be effective for treating patients with MDD. © 2013 Wiley Periodicals, Inc.
Mokhtari M.,Shiraz University of Medical Sciences |
Zeraatiannejaddavani S.,Fasa University of Medical Sciences
Archives of Iranian Medicine | Year: 2012
Hydatid disease is an endemic illness in some countries. The main sites of involvement are the liver and lungs, but rarely,it can be seen in other organs as well. Herein, we report a case of primary adrenal hydatid cyst accompanied by arterial hypertension.
Jafari P.,Shiraz University of Medical Sciences |
Bagheri Z.,Shiraz University of Medical Sciences |
Bagheri Z.,Fasa University of Medical Sciences |
Safe M.,Shiraz University of Medical Sciences
Health and Quality of Life Outcomes | Year: 2012
Background: The purpose of the study was to determine whether the Persian version of the KIDSCREEN-27 has the optimal number of response category to measure health-related quality of life (HRQoL) in children and adolescents. Moreover, we aimed to determine if all the items contributed adequately to their own domain.Findings: The Persian version of the KIDSCREEN-27 was completed by 1083 school children and 1070 of their parents. The Rasch partial credit model (PCM) was used to investigate item statistics and ordering of response categories. The PCM showed that no item was misfitting. The PCM also revealed that, successive response categories for all items were located in the expected order except for category 1 in self- and proxy-reports.Conclusions: Although Rasch analysis confirms that all the items belong to their own underlying construct, response categories should be reorganized and evaluated in further studies, especially in children with chronic conditions. © 2012 Jafari et al.; licensee BioMed Central Ltd.
Hosseinzadeh Z.,University of Tübingen |
Shojaiefard M.,University of Tübingen |
Shojaiefard M.,Fasa University of Medical Sciences |
Bhavsar S.K.,University of Tübingen |
Lang F.,University of Tübingen
Biochemical and Biophysical Research Communications | Year: 2012
Janus-activated kinase-2 JAK2 is activated by hyperosmotic shock and modifies the activity of several Na + coupled transporters. Carriers up-regulated by osmotic shock include the Na + coupled osmolyte transporter BGT1 (betaine/GABA transporter 1), which accomplishes the concentrative cellular uptake of γ-amino-butyric acid (GABA). The present study thus explored whether JAK2 participates in the regulation of BGT1 activity. To this end, cRNA encoding BGT1 was injected into Xenopus oocytes with or without cRNA encoding wild type JAK2, constitutively active V617FJAK2 or inactive K882EJAK2, and electrogenic GABA transport determined by dual electrode voltage clamp. In oocytes injected with cRNA encoding BGT1 but not in oocytes injected with water or with cRNA encoding JAK2 alone, the addition of 1mM GABA to the extracellular fluid generated an inward current (I BGT). In BGT1 expressing oocytes I BGT was significantly increased by coexpression of JAK2 or V617FJAK2, but not by coexpression of K882EJAK2. According to kinetic analysis coexpression of JAK2 increased the maximal I BGT without significantly modifying the concentration required for halfmaximal I BGT (K M). In oocytes expressing BGT1 and V617FJAK2 I BGT was gradually decreased by JAK2 inhibitor AG490 (40μM). The decline of I BGT following disruption of carrier insertion with brefeldin A (5μM) was similar in the absence and presence of the JAK2 inhibitor AG490 (40μM). In conclusion, JAK2 is a novel regulator of the GABA transporter BGT1. The kinase up-regulates the carrier presumably by enhancing the insertion of carrier protein into the cell membrane. © 2012 Elsevier Inc.
Razeghinejad M.R.,Shiraz University of Medical Sciences |
Banifatemi M.,Fasa University of Medical Sciences
Journal of Ophthalmic and Vision Research | Year: 2013
Purpose: To compare ocular biometric parameters in primary angle closure suspects (PACS), primary angle closure glaucoma (PACG) and acute primary angle closure (APAC). Methods: This cross-sectional study was performed on 113 patients including 33 cases of PACS, 45 patients with PACG and 35 subjects with APAC. Central corneal thickness (CCT), axial length (AL), anterior chamber depth (ACD) and lens thickness (LT) were measured with an ultrasonic biometer. Lens-axial length factor (LAF), relative lens position, corrected ACD (CACD) and corrected lens position were calculated. The parameters were measured bilaterally but only data from the right eyes were compared. In the APAC group, biometric parameters were also compared between affected and unaffected fellow eyes. Logistic regression analysis was performed to identify risk factors. Results: No statistically significant difference was observed in biometric parameters between PACS and PACG eyes, or between affected and fellow eyes in the APAC group (P>0.05 for all comparisons). However, eyes with APAC had thicker cornea (P=0.001), thicker lens (P<0.0001), shallower ACD (P=0.009), shallower CACD (P=0.003) and larger LAF (P<0.0001). Based on ROC curve analysis, lower ACD, and larger LT, LAF and CCT values were associated with APAC. In the APAC group, LAF (P<0.0001) and CCT (P=0.001) were significant risk factors. Conclusion: This study revealed no significant difference in biometric characteristics in eyes with PACS and PACG. However, larger LAF and CCT were predictive of APAC.
Heydari M.,Shiraz University of Medical Sciences |
Homayouni K.,Shiraz University of Medical Sciences |
Hashempur M.H.,Fasa University of Medical Sciences |
Shams M.,Shiraz University of Medical Sciences
Journal of Diabetes | Year: 2016
Background: The aim of the present study was to examine the safety and efficacy of a topical formulation of Citrullus colocynthis in patients with painful diabetic polyneuropathy (PDPN). Methods: The study was designed as a two-arm double-blind randomized placebo-controlled clinical trial using a parallel design. Sixty patients with PDPN were randomly allocated to receive either a topical formulation of C. colocynthis or placebo (1:1 allocation ratio) for 3 months. Patients were evaluated before and after the intervention using the neuropathic pain scale, electrodiagnostic findings, World Health Organization Biomedical Research and Education Foundation (BREF) quality of life (WHOQOL-BREF) scores, and reported adverse events. Results: There was a significantly greater decrease in mean pain score after 3 months in the C. colocynthis (-3.89; 95% confidence interval [CI] -3.19, -4.60) than placebo (-2.28; 95% CI -1.66, -2.90) group (P<0.001). Mean changes in nerve conduction velocity of the tibial nerve, distal latency of the superficial peroneal nerve and sural nerve, and sensory amplitude of the sural nerve were significantly higher in the intervention than placebo group (P<0.001) in favour of the intervention. In the different domains of WHOQOL-BREF, there was a significant improvement only for the mean score in the physical domain. Conclusions: Application of a topical formulation of C. colocynthis fruit extract can decrease pain in patients with PDPN. It also may have some uncertain effects on nerve function and the physical domain of quality of life, which require further investigation in studies with larger sample sizes and of longer duration. © 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.