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Ghanizadeh A.,Shiraz University of Medical Sciences | Hedayati A.,Fasa University of Medical Sciences
Depression and Anxiety | Year: 2013

Backgrounds There are contradictory evidence about the effect of statins on depression. This 6-week-randomized placebo-controlled clinical trial assessed the efficacy and safety of lovastatin as an adjuvant agent for treating major depressive disorder (MDD). Methods The participants were 68 patients with MDD according to DSM-IV diagnostic criteria. The sample was randomly allocated into fluoxetine (up to 40 mg/day) plus lovastatin (30 mg/day) group or fluoxetine plus placebo group. Hamilton Depression Rating scale was used to measure depression score at baseline, week 2, and week 6. Results Both groups showed a significant decrease of depression score on the Hamilton Depression scale. However, the treatment group decreased depression score more than placebo group [12.8(6.3) vs. 8.2(4.0), t = 3.4, df = 60, P <.001]. Any serious adverse effect was not found. Discussion These results suggest that lovastatin as an adjuvant treatment may be effective for treating patients with MDD. © 2013 Wiley Periodicals, Inc.

Mokhtari M.,Shiraz University of Medical Sciences | Zeraatiannejaddavani S.,Fasa University of Medical Sciences
Archives of Iranian Medicine | Year: 2012

Hydatid disease is an endemic illness in some countries. The main sites of involvement are the liver and lungs, but rarely,it can be seen in other organs as well. Herein, we report a case of primary adrenal hydatid cyst accompanied by arterial hypertension.

Razeghinejad M.R.,Shiraz University of Medical Sciences | Banifatemi M.,Fasa University of Medical Sciences
Journal of Ophthalmic and Vision Research | Year: 2013

Purpose: To compare ocular biometric parameters in primary angle closure suspects (PACS), primary angle closure glaucoma (PACG) and acute primary angle closure (APAC). Methods: This cross-sectional study was performed on 113 patients including 33 cases of PACS, 45 patients with PACG and 35 subjects with APAC. Central corneal thickness (CCT), axial length (AL), anterior chamber depth (ACD) and lens thickness (LT) were measured with an ultrasonic biometer. Lens-axial length factor (LAF), relative lens position, corrected ACD (CACD) and corrected lens position were calculated. The parameters were measured bilaterally but only data from the right eyes were compared. In the APAC group, biometric parameters were also compared between affected and unaffected fellow eyes. Logistic regression analysis was performed to identify risk factors. Results: No statistically significant difference was observed in biometric parameters between PACS and PACG eyes, or between affected and fellow eyes in the APAC group (P>0.05 for all comparisons). However, eyes with APAC had thicker cornea (P=0.001), thicker lens (P<0.0001), shallower ACD (P=0.009), shallower CACD (P=0.003) and larger LAF (P<0.0001). Based on ROC curve analysis, lower ACD, and larger LT, LAF and CCT values were associated with APAC. In the APAC group, LAF (P<0.0001) and CCT (P=0.001) were significant risk factors. Conclusion: This study revealed no significant difference in biometric characteristics in eyes with PACS and PACG. However, larger LAF and CCT were predictive of APAC.

Hosseinzadeh Z.,University of Tubingen | Shojaiefard M.,University of Tubingen | Shojaiefard M.,Fasa University of Medical Sciences | Bhavsar S.K.,University of Tubingen | Lang F.,University of Tubingen
Biochemical and Biophysical Research Communications | Year: 2012

Janus-activated kinase-2 JAK2 is activated by hyperosmotic shock and modifies the activity of several Na + coupled transporters. Carriers up-regulated by osmotic shock include the Na + coupled osmolyte transporter BGT1 (betaine/GABA transporter 1), which accomplishes the concentrative cellular uptake of γ-amino-butyric acid (GABA). The present study thus explored whether JAK2 participates in the regulation of BGT1 activity. To this end, cRNA encoding BGT1 was injected into Xenopus oocytes with or without cRNA encoding wild type JAK2, constitutively active V617FJAK2 or inactive K882EJAK2, and electrogenic GABA transport determined by dual electrode voltage clamp. In oocytes injected with cRNA encoding BGT1 but not in oocytes injected with water or with cRNA encoding JAK2 alone, the addition of 1mM GABA to the extracellular fluid generated an inward current (I BGT). In BGT1 expressing oocytes I BGT was significantly increased by coexpression of JAK2 or V617FJAK2, but not by coexpression of K882EJAK2. According to kinetic analysis coexpression of JAK2 increased the maximal I BGT without significantly modifying the concentration required for halfmaximal I BGT (K M). In oocytes expressing BGT1 and V617FJAK2 I BGT was gradually decreased by JAK2 inhibitor AG490 (40μM). The decline of I BGT following disruption of carrier insertion with brefeldin A (5μM) was similar in the absence and presence of the JAK2 inhibitor AG490 (40μM). In conclusion, JAK2 is a novel regulator of the GABA transporter BGT1. The kinase up-regulates the carrier presumably by enhancing the insertion of carrier protein into the cell membrane. © 2012 Elsevier Inc.

Jafari P.,Shiraz University of Medical Sciences | Bagheri Z.,Shiraz University of Medical Sciences | Bagheri Z.,Fasa University of Medical Sciences | Safe M.,Shiraz University of Medical Sciences
Health and Quality of Life Outcomes | Year: 2012

Background: The purpose of the study was to determine whether the Persian version of the KIDSCREEN-27 has the optimal number of response category to measure health-related quality of life (HRQoL) in children and adolescents. Moreover, we aimed to determine if all the items contributed adequately to their own domain.Findings: The Persian version of the KIDSCREEN-27 was completed by 1083 school children and 1070 of their parents. The Rasch partial credit model (PCM) was used to investigate item statistics and ordering of response categories. The PCM showed that no item was misfitting. The PCM also revealed that, successive response categories for all items were located in the expected order except for category 1 in self- and proxy-reports.Conclusions: Although Rasch analysis confirms that all the items belong to their own underlying construct, response categories should be reorganized and evaluated in further studies, especially in children with chronic conditions. © 2012 Jafari et al.; licensee BioMed Central Ltd.

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