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Djukic-Cosic D.,Farmaceutski fakultet Univerziteta u Beogradu | Stanojevic A.,Galenika Ad | Djekic-Ivankovic M.,Institute za medicinska istrazivanja | Curcic M.,Farmaceutski fakultet Univerziteta u Beogradu | And 3 more authors.
Vojnosanitetski Pregled | Year: 2011

Background/Aim. The beneficial effects of medicinal plants are well-known from the ancient times. However, expansion of phytopharmacy and phytotherapy occured during the last decades. Medicinal plants can absorb environmental contaminants from the ground and consequently may cause harmful effects on human health. Quality control usually comprises standard methodology which includes macroscopic identification and examination of active ingredients. Additionaly, there is a permanent need to control the level of pollutants in herbs, with a particular attention to the level of toxic metals. In this study we estimated the level of contamination by determining the content of cadmium (Cd) in the herbs of Hypericum perforatum and Thymus serpyllum collected from the different localities of the mountains Rtanj and Ozren. Methods. Herbs of investigated plants were collected during July 2005 from various localities of Rtanj and Ozren mountains. After drying, homogenization and mineralization, Cd content was determined by atomic absorption spectrophotometry. Results. The obtained results show that Cd content varies significantly in Hypericum perforatum samples collected. The lowest Cd level was found in samples from the one of Rtanj localities (0.25 mg Cd/kg), while the highest was observed in Hypericum perforatum from Ozren locality (1.24 mg/kg). Levels of Cd in the three of four investigated localities were higher than proposed by WHO (0.3 mg/kg dried herb material). In all investigated samples of Thymus serpyllum herbs Cd levels were below the limit of detection of analytical method (0.2 mg Cd/kg dried materials). Conclusion. This work contributes to the issue of Cd content in Hypericum perforatum and Thymus serpyllum grown in localities of Rtanj and Ozren, and implies the importance for systemic control of Cd content in Hypericum species in order to provide safety of their preparations. Furthermore, regarding Cd toxicity, maximal permissible level of Cd in plant material should be evaluated and established concerning national legislative frame. Source


Tadic I.,Farmaceutski fakultet Univerziteta u Beogradu | Tasic L.,Farmaceutski fakultet Univerziteta u Beogradu | Djordjevic B.,Farmaceutski fakultet Univerziteta u Beogradu | Kundakovic T.,Farmaceutski fakultet Univerziteta u Beogradu | And 2 more authors.
Vojnosanitetski Pregled | Year: 2010

Background/Aim. Overweight and obesity may lead to a large number of health problems. Prevention and adequately timed treatment can lead to successful body mass regulation. The aim of the study was to analyze body mass index (BMI) of the examinees, usage of dietary supplement for weight loss (DSWL) by gender and particular products, types of information source and types of information about DSWL which provide doctors and pharmacists. Methods. The survey was conducted in the region of the town of Niš. The survey was carried out among a random sample of 505 participants, 243 men and 262 women, older than 15 years. The tool used was a questionnaire. Results. There is a positive association between aging and BMI. DSWL are used by 20.39% of the examinees. The most of the examinees that use DSWL were overweight and used it for esthetic reasons. Before the use of DSWL, women usually practice diets and men practice fluid consumption. Television is the most important source of information about DSWL. Health care professionals mostly provide information about DSWL consumption (64.08%), and only a third of them provide all the information (usage, eating regime, fluid consumption, and physical activity). Conclusion. The prevalence of obesity emphasizes the need for concentrated efforts to prevent obesity in the early age. The only way to reduce the risk of DSWLs misuse is providing all of the necessary information by the health care professionals. As pharmacists are in the direct contact with patients they have the most important role in rational and effective use of DSWL. Source

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