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Missaoui N.,Research Unit 03 UR 08 13 | Missaoui N.,Farhet Hached University Hospital | Missaoui N.,University of Sousse | Jaidene L.,Farhet Hached University Hospital | And 8 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2011

Introduction: The aim of this study was to survey for the first time the burden and characteristics of corpus uteri cancers in Central Tunisia. Design: Characteristics of all cancer cases diagnosed during a 15-year period were analyzed based on the data of the Cancer Registry of the Center of Tunisia. Five-year age-specific rates, crude incidence rates, world age-standardized rates (ASR), and annual percent change (APC) were calculated using annual data on population size and its estimated age structure. Results: A total of 218 new cases of corpus uteri cancer were recorded. The ASR was 3.1 per 100,000 with a significant increase over time (APC: +7.1%; 95% CI: 3.1%, 11.1%). The median age at diagnosis was 60 years and only 20.6% of patients were less than 50 years old. The tumor size was higher than 2 cm in 83.5% of cases. Stage I was the most frequent (59.9%) followed by advanced stages (23.2%). Endometrial adenocarcinoma was the most frequent histological type (62.8%) with grade II accounting for 48.5% of cases. Conclusion: Corpus uteri cancer is an important female cancer with increasing trend over time. These findings justify the need to plan and develop effective programs aiming at the control of the spread of cancer in Tunisia. Source


Missaoui N.,Cancer Epidemiology and Cytopathology in Tunisian Center | Missaoui N.,Farhet Hached University Hospital | Abdelkader A.B.,Farhet Hached University Hospital | Beizig N.,Farhet Hached University Hospital | And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2010

Introduction: Colorectal cancer is the third most commonly diagnosed cancer worldwide. Design: In order to review the clinical and pathological features of colorectal cancer in Tunisia, a retrospective study was carried out on 1,443 cancer cases diagnosed in the Pathology Department, Farhet Hached University Hospital of Sousse, for a 15-year period (1993-2007). Results: The median age was 61 years. Adenocarcinoma was the most frequent (90.9%) with moderately differentiated tumors accounting for 76.7% of cases. Only eighty patients were identified as being in early stages (0 and A) and 85.8% in advanced stages (B-D). Over time, we observed a significant decrease of stage B (p=0.02) and a significant increase of stage D (p=0.002). The tumor size was larger than 5 cm in 67.5% of cases. Conclusion: The large proportion of patients presented at advanced stages, compared to only 5.5% of patients at early stages, emphasizes the need to plan and develop a screening program for the early detection of this cancer and its precursor lesions in Tunisia. Source


Missaoui N.,Research Unit 03 UR 08 13 | Missaoui N.,Farhet Hached University Hospital | Abdelkrim S.B.,Farhet Hached University Hospital | Abdelkader A.B.,Farhet Hached University Hospital | And 5 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2011

Introduction: The aim of this study was to survey the clinical and pathological features of breast cancer in the Center of Tunisia. Design: Characteristics of all breast cancer cases diagnosed in the Pathology Department, Farhet Hached Hospital, Sousse, Tunisia during a 15-year period (1993-2007) were analyzed. Results: A total of 2,404 new cases of breast cancer were recorded, only 48 being diagnosed in men. The age-standardized incidence rate was 0.7 and 29.2 per 100,000 in men and women, respectively, with median ages of 48.0 and 64.5 years. Invasive ductal carcinoma was the most common (2,012 cases). Stage II was the most frequent (47.7%) followed by advanced stages (Stage III and IV, 41%). Conclusion: Cancer of the breast remains the most common cancer in the absence of specific screening measures among Tunisian women. Our study justifies the need to plan and develop effective programs aiming at the control and prevention of the spread of breast cancer in Tunisia. Source

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