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Khabarovsk Vtoroy, Russia

Ryzhavskii B.Y.,Far Eastern State Medical University
Bulletin of experimental biology and medicine | Year: 2012

Morphometric characteristics and free radical oxidation in neurons of the neocortex and hippocampus of male and female rats were studied 1 month after administration of Sustanon-250 in a dose of 8 mg/kg during the pubertal period of ontogeny. The weight of the brain was shown to decrease in males. In both female and male rats, the width of the anterior parietal lobe and the numerical density of neocortical and hippocampal neurons decreased. Sex differences were found in free radical oxidation in the cerebral cortex. The intensity of this process increased significantly in females, but decreased in males. Source

Mediannikov O.,Aix - Marseille University | Socolovschi C.,Aix - Marseille University | Bassene H.,Aix - Marseille University | Diatta G.,Aix - Marseille University | And 5 more authors.
Emerging Infectious Diseases | Year: 2014

As malaria cases in Africa decline, other causes of acute febrile illness are being explored. To determine incidence of Borrelia crocidurae infection during June 2010- October 2011, we collected 1,566 blood specimens from febrile patients in Senegal. Incidence was high (7.3%). New treatment strategies, possibly doxycycline, might be indicated for febrile patients. Source

Ukrainets I.V.,National University of Pharmacy | Petrushova L.A.,National University of Pharmacy | Dzyubenko S.P.,Vinnitsya National Pirogov Memorial Medical University | Sim G.,Far Eastern State Medical University
Chemistry of Heterocyclic Compounds | Year: 2014

We have developed an effective synthetic method and prepared several 4-hydroxy-1-methyl-2,2-dioxo-N-(1,3-thiazol-2-yl)-1H-2λ6,1- benzothiazine-3-carboxamides and a few structurally related heterocyclic arylamides. The structural features of one of the substituted thiazolyl-2-amides obtained have been investigated. Compounds with a high analgesic activity have been identified within this group by pharmacological screening. © 2014 Springer Science+Business Media New York. Source

Ukrainets I.V.,National University of Pharmacy | Petrushova L.A.,National University of Pharmacy | Shishkina S.V.,Ukrainian Academy of Sciences | Sim G.,Far Eastern State Medical University
Chemistry of Heterocyclic Compounds | Year: 2015

The alkylation of methyl 4-hydroxy-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate in DMSO or acetone with ethyl iodide at 25°C gave a mixture of 3-ethyl- and 4-ethoxy-substituted derivatives, in complete agreement with quantum-chemical calculations. The ratio of C- and O-alkylation products changed depending on the alkali metal carbonate used as a base. The reaction practically did not proceed in anhydrous THF or water due to the low nucleophilicity of the anion. © 2015 Springer Science+Business Media New York. Source

Keita A.K.,French National Center for Scientific Research | Bassene H.,IRD Montpellier | Tall A.,Institute Pasteur Of Dakar | Sokhna C.,IRD Montpellier | And 7 more authors.
PLoS Neglected Tropical Diseases | Year: 2011

Background: Tropheryma whipplei is known as the cause of Whipple's disease, but it is also an emerging pathogen, detected in stool, that causes various chronic localized infections without histological digestive involvement and is associated with acute infections, including gastroenteritis and bacteremia. Methods/Principal Findings: We conducted a study in 2008 and 2009 using 497 non-diarrheic and diarrheic stool samples, 370 saliva samples, 454 sera samples and 105 samples obtained from water samples in two rural Sine-Saloum villages (Dielmo and Ndiop) in Senegal. The presence of T. whipplei was investigated by using specific quantitative PCR. Genotyping was performed on positive samples. A serological analysis by western blotting was performed to determine the seroprevalence and to detect seroconversion. Overall, T. whipplei was identified in 31.2% of the stool samples (139/446) and 3.5% of the saliva samples (13/370) obtained from healthy subjects. The carriage in the stool specimens was significantly (p&10 -3) higher in children who were between 0 and 4 years old (60/80, 75%) compared to samples obtained from individuals who were between 5 to 10 years old (36/119, 30.2%) or between 11 and 99 years old (43/247, 17.4%). The carriage in the stool was also significantly more common (p = 0.015) in subjects with diarrhea (25/51, 49%). We identified 22 genotypes, 16 of which were new. Only one genotype (#53) was common to both villages. Among the specific genotypes, one (#52) was epidemic in Dielmo (15/28, 53.4%, p&10 -3) and another (#49) in Ndiop (27.6%, p = 0.002). The overall seroprevalence was estimated at 72.8% (291/400). Seroconversion was detected in 66.7% (18/27) of children for whom PCR became positive in stools between 2008 and 2009. Conclusions/Significance: T. whipplei is a common bacterium in the Sine-Saloum area of rural Senegal that is contracted early in childhood. Epidemic genotypes suggest a human transmission of the bacterium. © 2011 Keita et al. Source

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