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Hradec Králové, Czech Republic

Fever is part of the normal inflammatory response and most frequently occurs in response to infection. It is also often seen after vaccination, particularly in children following immunisation with diphtheria-tetanus- pertussis (DTP), measles and pneumococcal conjugate vaccines. Prophylactic paracetamol administered during the first 24 hours significantly reduced febrile reactions reported within 4 days of vaccination but had no effect on the occurrence of fever >39.5°C. However at same time GMCs and GMTs for a number of the vaccine antigens were reduced in the group receiving prophylactic paracetamol compared to those not receiving paracetamol. Due to a lack of clinical benefit and potential reduction in response to vaccination, prophylactic administration of antipyretics should not be routinely recommended unless medically justified.

Feuermannova A.,Fakultni Nemocnice Hradec Kralove
Interni Medicina pro Praxi | Year: 2012

Ocular allergy is inflammatory response of anterior segment of the eye. Allergic disease includes seasonal allergic conjunctivitis (SAC), perennial allergic conjunctivitis (PAC), gigant papillary conjunctivitis (GPC) vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC) and contact allergy (CA). There is a summary of various diagnosis and possibilities of the treatment in this article.

Rusinova K.,Klinika Anesteziologie | Pokorna E.,Institute Klinicke a Experimentalni Mediciny | Vavra V.,Klinika Anesteziologie | Kusova D.,Klinika Anesteziologie | And 10 more authors.
Anesteziologie a Intenzivni Medicina | Year: 2014

This case study reports the initial management, prognosis assessment and withdrawal of life support followed by retrieval of vital organs for transplantation in a patient admitted after out-of-hospital cardiac arrest. This is the first description of a case of controlled donation after circulatory death in the Czech Republic. We discuss in detail the practical aspects of organ retrieval management, the role of echocardiography in circulatory arrest, indication of palliative treatment including terminal weaning and determining death due to circulatory arrest. We also emphasize communication with family members. The protocol used to determine death after circulatory arrest is presented along with the basic ethical and legal considerations in this sub-group of organ donors.

Kraliakova P.,Fakultni Nemocnice Hradec Kralove | Krejsek J.,Fakultni Nemocnice Hradec Kralove | Krcmova I.,Fakultni Nemocnice Hradec Kralove
Prakticky Lekar | Year: 2011

The incidence of cancer increased substantially during the 20th century. Cancer is the second leading cause of mortality in developed countries. Partially effective therapeutic approaches and medicamentous treatments: - irradiation, - chemotherapy, and - later biological therapy were developed in the second half of the last century to help combat this cancer epidemic. We review the efficacy of biological therapy based on cell-mediated immunity (BCG vaccination, cancer vaccination, adoptive immunotherapy). The aim of biological therapy is to optimally target the tumorigenesis process and to reverse it with minimal side effects.

Dostalova V.,Fakultni Nemocnice Hradec Kralove | Dostal P.,Fakultni Nemocnice Hradec Kralove | Schreiberova J.,Fakultni Nemocnice Hradec Kralove | Cerny V.,Fakultni Nemocnice Hradec Kralove
Anesteziologie a Intenzivni Medicina | Year: 2010

Hyperosmolar solutions of mannitol and hypertonic saline (HS) have been both used to treat elevated intracranial pressure in critically ill patients and during neurosurgery interventions. The hyperosmolarity of mannitol and HS, combined with the impermeability of the blood - brain barrier to mannitol and sodium, provides favourable conditions for moving water from the brain to the intravascular compartment. However, a number of prospective clinical trials comparing the effects of mannitol and HS on intracranial pressure have suggested that HS is at least as effective as, if not better than, mannitol in the treatment of intracranial hypertension and perifocal oedema.

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