Fairway Medical Technologies Inc.

Houston, TX, United States

Fairway Medical Technologies Inc.

Houston, TX, United States
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Wang K.,Illinois Institute of Technology | Ermilov S.A.,Fairway Medical Technologies Inc. | Ermilov S.A.,Tomowave Laboratories, Inc. | Su R.,Fairway Medical Technologies Inc. | And 6 more authors.
IEEE Transactions on Medical Imaging | Year: 2011

Optoacoustic tomography (OAT) is a hybrid imaging modality that combines the advantages of optical and ultrasound imaging. Most existing reconstruction algorithms for OAT assume that the ultrasound transducers employed to record the measurement data are point-like. When transducers with large detecting areas and/or compact measurement geometries are utilized, this assumption can result in conspicuous image blurring and distortions in the reconstructed images. In this work, a new OAT imaging model that incorporates the spatial and temporal responses of an ultrasound transducer is introduced. A discrete form of the imaging model is implemented and its numerical properties are investigated. We demonstrate that use of the imaging model in an iterative reconstruction method can improve the spatial resolution of the optoacoustic images as compared to those reconstructed assuming point-like ultrasound transducers. © 2010 IEEE.


Yaseen M.A.,Fairway Medical Technologies Inc. | Yaseen M.A.,Biomedical Imaging Center | Ermilov S.A.,Fairway Medical Technologies Inc. | Brecht H.-P.,Fairway Medical Technologies Inc. | And 6 more authors.
Journal of Biomedical Optics | Year: 2010

Optoacoustic (OA) tomography has demonstrated utility in identifying blood-rich malignancies in breast tissue. We describe the development and characterization of a laser OA imaging system for the prostate (LOIS-P). The system consists of a fiber-coupled Q-switched laser operating at 757 nm, a commercial 128-channel ultrasonic probe, a digital signal processor, and software that, uses the filtered radial back-projection algorithm for image reconstruction. The system is used to reconstruct OA images of a blood-rich lesion in-duced in vivo in a canine prostate. OA images obtained in vivo are compared to images acquired using ultrasound, the current gold stan-dard for guiding biopsy of the prostate. Although key structural fea-tures such as the urethra could be identified with both imaging tech-niques, a bloody lesion representing a highly vascularized tumor could only be clearly identified in OA images. The advantages and limitations of both forward and backward illumination modes are also evaluated by collecting OA images of phantoms simulating blood ves-sels within tissue. System resolution is estimated to be 0.2 mm in the radial direction of the acoustic array. The minimum detectable pres-sure signal is 1.83 Pa. Our results encourage further development toward a dual-modality OA/ultrasonic system for prostate imaging and image-guided biopsy. © 2010 Society of Photo-Optical Instrumentation Engineers.


Chitnis P.V.,Riverside Research Institute | Brecht H.P.,Fairway Medical Technologies Inc. | Su R.,Fairway Medical Technologies Inc. | Oraevsky A.A.,Fairway Medical Technologies Inc.
AIP Conference Proceedings | Year: 2011

Although high-intensity focused ultrasound (HIFU) has exciting potential for noninvasively treating tumors and cardiac diseases, its clinical acceptance is hindered by the lack of a reliable and cost-effective method of noninvasively guiding and monitoring the treatment. The present study investigated the feasibility of employing optoacoustic imaging (OAI) for guiding and monitoring HIFU therapy. OAI combines molecular specificity provided by optical imaging and the resolution provided by diagnostic ultrasound. A 3-D optoacoustic imaging system was used to visualize thermal lesions produced in excised tissue specimens and in vivo mice using high intensity focused ultrasound (HIFU). A 7.5 MHz surgical, focused transducer with a radius of curvature of 35 mm and an aperture of 23 mm generated HIFU. A pulsed laser, which could operate at 755 nm and 1064 nm, illuminated the specimens. Tomographic images were obtained using a 64 element curved array while the specimens were rotated incrementally. Images were acquired before and after HIFU exposure. The images were then combined to reconstruct 3-D volume images (voxel resolution 0.5 mm). Optoacoustic images using 1064-nm illumination provided visualization of HIFU lesions. The location and the extent of the lesions were confirmed upon dissection. These preliminary results demonstrate the potential of optoacoustic imaging to assess and monitor HIFU therapy. © 2011 American Institute of Physics.


PubMed | University of Texas at Austin, University of Texas M. D. Anderson Cancer Center and Fairway Medical Technologies Inc.
Type: Journal Article | Journal: Medical physics | Year: 2016

The application of new ultrasound-based technologies in medicine has expanded in recent years. One area of rapid growth has been the combination of ultrasound with other methods of image generation and imaging modalities to produce hybrid approaches for diagnostic imaging and noninvasive therapeutic intervention. The presentations associated with this session will provide an overview of two emerging technologies that are currently being developed and implemented to enhance ultrasound-related diagnostic imaging and therapy: the utilization of optically-induced ultrasound imaging (optoacoustic / photoacoustic imaging) and the use of magnetic resonance imaging to guide the use of high-intensity focused ultrasound for therapeutic applications.1. Develop a general understanding of the underlying technologies associated with optoacoustic / photoacoustic tomography and MRguided high-intensity focused ultrasound. 2. Develop an understanding of the current methods of these new ultrasound-based technologies in preclinical research and clinical applications.


Akhtar M.W.,University of Houston | Kleis S.J.,University of Houston | Metcalfe R.W.,University of Houston | Naghavi M.,Fairway Medical Technologies Inc.
Journal of Biomechanical Engineering | Year: 2010

Both structural and functional evaluations of the endothelium exist in order to diagnose cardiovascular disease (CVD) in its asymptomatic stages. Vascular reactivity, a functional evaluation of the endothelium in response to factors such as occlusion, cold, and stress, in addition to plasma markers, is the most widely accepted test and has been found to be a better predictor of the health of the endothelium than structural assessment tools such as coronary calcium scores or carotid intima-media thickness. Among the vascular reactivity assessment techniques available, digital thermal monitoring (DTM) is a noninvasive technique that measures the recovery of fingertip temperature after 2-5 min of brachial occlusion. On release of occlusion, the finger temperature responds to the amount of blood flow rate overshoot referred to as reactive hyperemia (RH), which has been shown to correlate with vascular health. Recent clinical trials have confirmed the potential importance of DTM as an early stage predictor of CVD. Numerical simulations of a finger were carried out to establish the relationship between DTM and RH. The model finger consisted of essential components including bone, tissue, major blood vessels (macrovasculature), skin, and microvasculature. The macrovasculature was represented by a pair of arteries and veins, while the microvasculature was represented by a porous medium. The time-dependent Navier-Stokes and energy equations were numerically solved to describe the temperature distribution in and around the finger. The blood flow waveform postocclusion, an input to the numerical model, was modeled as an instantaneous overshoot in flow rate (RH) followed by an exponential decay back to baseline flow rate. Simulation results were similar to clinically measured fingertip temperature profiles in terms of basic shape, temperature variations, and time delays at time scales associated with both heat conduction and blood perfusion. The DTM parameters currently in clinical use were evaluated and their sensitivity to RH was established. Among the parameters presented, temperature rebound (TR) was shown to have the best correlation with the level of RH with good sensitivity for the range of flow rates studied. It was shown that both TR and the equilibrium start temperature (representing the baseline flow rate) are necessary to identify the amount of RH and, thus, to establish criteria for predicting the state of specific patient's cardiovascular health. Copyright © 2010 by ASME.


Lamela H.,Charles III University of Madrid | Gallego D.,Charles III University of Madrid | Oraevsky A.A.,Fairway Medical Technologies Inc.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2010

A non-metallic interferometric silica optical fiber ultrasonic wideband sensor is presented for optoacustic imaging applications. We characterized the ultrasonic sensitivity of the optical fiber sensor within the frequency range of 1 to 5 MHz. We compared detection of real world optoacoustic signals, generated from an optically absorbing object embedded in a tissue mimicking phantom, between our sensor and an array of piezoelectric transducers. Reconstructed two dimensional acoustic images of the phantom are presented and compared with images obtained with the Laser Optoacoustic Imaging System, LOIS-64B, demonstrating the feasibility of our fiber optic sensor as a wideband ultrasonic sensor. © 2010 Copyright SPIE - The International Society for Optical Engineering.


Oraevsky A.A.,Fairway Medical Technologies Inc. | Wang L.V.,Washington University in St. Louis
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2010

This PDF file contains the front matter associated with SPIE Proceedings Volume 7564, including the Title Page, Copyright information, Table of Contents, Introduction, and the Conference Committee listing. © 2010 Copyright SPIE - The International Society for Optical Engineering.


Lu W.,University of Texas M. D. Anderson Cancer Center | Huang Q.,University of Texas M. D. Anderson Cancer Center | Ku G.,Washington University in St. Louis | Wen X.,University of Texas M. D. Anderson Cancer Center | And 7 more authors.
Biomaterials | Year: 2010

Photoacoustic tomography (PAT) also referred to as optoacoustic tomography (OAT) is a hybrid imaging modality that employs nonionizing optical radiation and ultrasonic detection. Here, we describe the application of a new class of optical contrast agents based on mesoscopic hollow gold nanospheres (HAuNS) to PAT. HAuNS are ∼40 nm in diameter with a hollow interior and consist of a thin gold wall. They display strong resonance absorption tuned to the near-infrared (NIR) range, with an absorption peak at 800 nm, whose photoacoustic efficiency is significantly greater than that of blood. Following surface conjugation with thiolated poly(ethylene glycol), the pegylated HAuNS (PEG-HAuNS) had distribution and elimination half-lives of 1.38 ± 0.38 and 71.82 ± 30.46 h, respectively. Compared with PAT images based on the intrinsic optical contrast in nude mice, the PAT images acquired within 2 h after intravenous administration of PEG-HAuNS showed the brain vasculature with greater clarity and detail. The image depicted brain blood vessels as small as ∼100 μm in diameter using PEG-HAuNS as contrast agents. Preliminary results showed no acute toxicity to the liver, spleen, or kidneys in mice following a single imaging dose of PEG-HAuNS. Our results indicate that PEG-HAuNS are promising contrast agents for PAT, with high spatial resolution and enhanced sensitivity. © 2009 Elsevier Ltd. All rights reserved.


Wang K.,Illinois Institute of Technology | Anastasio M.A.,Illinois Institute of Technology | Ermilov S.A.,Fairway Medical Technologies Inc. | Brecht H.-P.,Fairway Medical Technologies Inc. | And 2 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2010

Optoacoustic Tomography (OAT) is a hybrid imaging modality that combines the advantages of both optical imaging and ultrasound imaging techniques. Most existing reconstruction algorithms for OAT assume pointlike transducers, which may result in conspicous image blurring and distortions in certain applications. In this work, a new imaging model that incorporates the transducer response is employed for image reconstruction. Computer-simulation studies demonstrate that the new reconstruction method can effectively compensate for image resolution degradation associated with the transducer response. © 2010 Copyright SPIE - The International Society for Optical Engineering.


Conjusteau A.,Fairway Medical Technologies Inc. | Ermilov S.A.,Fairway Medical Technologies Inc. | Brecht H.-P.,Fairway Medical Technologies Inc. | Oraevsky A.A.,Fairway Medical Technologies Inc.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2010

We have investigated the limitations of our laser ultrasonic plane wave δ-source. In theory, the device is capable of producing an acoustic impulse with a bandwidth exceeding 30 MHz. However, a bandwidth of 12 MHz is measured with a calibrated wideband hydrophone. A test setup was designed and built. It permits the investigation of experimental parameters that alter the generated acoustic impulse: laser pulse duration, laser spatial profile, and absorber opacity. Laser energy spatial profile is the main contributor to the narrowing of the frequency band. Our findings are presented, along with further justifications for a device with very large effective area. © 2010 Copyright SPIE - The International Society for Optical Engineering.

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