Žilina, Slovakia
Žilina, Slovakia

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Vladimir B.,Faculty Hospital in Zilina | Kullova M.,Faculty Hospital in Zilina
Journal of Pakistan Association of Dermatologists | Year: 2016

Objective To analyze a topographic distribution of cutaneous basal cell carcinoma (BCC) and clinicopathological differences of disease with regards to the extent of sunlight exposure. Methods A total of 1,065 BCC cases from 815 patients were investigated. The topographic regions of the body affected were merged into the sun-protected, intermittently sun-exposed, and permanently sun-exposed sites. Results BCCs occurred most commonly in the permanently sun-exposed sites (63.8%), followed by intermittently sun-exposed sites (30.8%), and sun-protected sites (5.4%). There was higher proportion of the men in the parts of the body intermittently exposed to sunlight and vice versa, higher percentage of the women in the sun-protected, as well as, in the permanently sun-exposed parts. There was a statistically significant trend towards an increased age with rising extent of sunlight exposure. Superficial BCC correlated positively with the intermittently sun-exposed sites and negatively with the permanently sun-exposed sites. Nodular BCC was related to the permanently sun-exposed sites and negatively with the intermittently sun-exposed sites. Infiltrative BCC was linked to permanently sun-exposed sites, while it was completely absent in the body regions, the skin of which was usually protected from UVR. A proportion of BCCs with aggressive growth phenotype positively correlated with rising extent of sunlight exposure. Conclusion Considerable clinicopathological variations in BCCs depending on locations and corresponding solar exposure levels were confirmed. With respect to the body sites, from which the lesions arise, this neoplasia may have distinct etiopathogenesis and biology. Probably, different patterns of sun exposure are independent risk factors for certain histological BCC subtypes and hence prognosis of this malignancy.


Novakova E.,Comenius University | Kincekova J.,Slovak Academy of Sciences | Adamicova K.,Comenius University | Kompanikova J.,Comenius University | And 5 more authors.
Helminthologia | Year: 2011

Dirofilariosis is a vector-borne disease that is spreading in Europe from the southern endemic regions to the northern countries, including Slovakia. The dog parasites Dirofilaria immitis and D. repens are zoonotic agents, responsible for the development of human pulmonary and subcutaneous dirofilariosis, respectively. The present paper reports the third case of human dirofilariosis in Slovakia caused by D. repens. The pacient, a 41-year-old woman, was referred with tumour process in the subcutaneous area of the right forearm. Within 14 days the USG confirmed the rapid increase of the nodule from 20 × 10 mm to 30 × 25 mm. The surgical extirpation of the tumour was indicated. Histological examination revealed the formation with eosinofilic rime and the presence of a worm in the centre, detected as D. repens. © 2011 Versita Warsaw and Springer-Verlag Wien.


Bartos V.,Faculty Hospital in Zilina | Adamicova K.,Faculty Hospital in Zilina | Adamicova K.,Institute of Pathological Anatomy | Kullova M.,Faculty Hospital in Zilina | Pec M.,Institute of Medical Biology
Biologia | Year: 2012

Evaluation of tumor cell proliferation status belongs to the basic prognostic indicators in a routine biopsy report. In cutaneous basal cell carcinoma (BCC), however, there are discrepancies about a true prognostic significance of this histopathological parameter. The aim of this study was to assess a proliferative activity (Ki-67 index) in BCCs of the skin. Biopsy specimens from 80 cutaneous BCCs (63 primary, 17 recurrent) of different histological types from 75 subjects (34 men, 41 women) were enrolled into this study. All samples were immunohistochemically stained by antibody against Ki-67 antigen (DAKO, clone MIB-1, dilution 1:100). For the statistical analysis, χ 2 test was employed. We found a striking percentage variability of nuclear Ki-67 expression in individual tumors (range 2-70%). Mean value of Ki-67 index was 27.4% (in primary tumors 28.1 %, in recurrent lesions 25.6%). The highest Ki-67 expression occurred in infiltrative BCCs (average 38.1%), morpheaform BCCs (average 37.0%), and superficial BCCs (average 35.7%), the lowest expression was recorded in nodular BCCs (average 21.7%) and BCCs with adnexal (trichoepithelial) differentiation (18.6%). There were not persuasive and statistically significant quantitative differences in proliferation activity of tumor cells between the individual histological BCC types, as well as between primary and recurrent lesions. A distribution of Ki-67 positive cells in tumor nests was mostly irregular and areas with a high number of Ki-67 labeled cells often occurred adjacent to areas with a lower number of cells expressing this marker. Because of a marked Ki-67 staining variability, we can conclude that the simple quantification of BCC proliferation activity alone may not be sufficient for the prediction of further biological behavior, evolution and clinical outcome of this malignancy. © 2012 Versita Warsaw and Springer-Verlag Wien.


Bartos V.,Faculty Hospital in Zilina | Adamicova K.,Institute of Pathological Anatomy | Kullova M.,Faculty Hospital in Zilina | Pec M.,Institute of Medical Biology
Klinicka Onkologie | Year: 2012

Background: Basal cell carcinoma (BCC) recurrences are relatively frequent event in a routine dermatologic practice. One of the most important factor which impacts risk of their development is a histomorphological appearance of tumor. Design: The purpose of our study was to compare histological types of primary and corresponding relapsing BCCs of the skin. Material and methods: The study included 36 cases of BCC recurrences from 34 patients, 17 women and 17 men. The patients ranged in age from 32 to 97 years, with a mean age of 67.1 years at the time of (the first) recurrence. Results: Both tumor groups generally exhibited the same proportion of indolent and aggressive histological phenotype. In 21 cases (58.4%), we found an identical histological BCC type in primary and subsequent relapsing lesion. In 3 cases (8.3%), primary lesion showed indolent histological features without aggressive-growth component, while recurrent tumor already manifested it. Conversely, in next 3 cases (8.3%) primary tumor exhibited focal infiltrative-growth features and corresponding relapsing lesion did not. Of the remainig 9 cases (25%), histomorpological phenotype was not identical, but it showed the same prognostic histological tumor variant. Conclusion: Based on the results of our study it can be assumed that a BCC recurrence is a dynamic histogenetic process, during which the phenotypic transformation and the changes in histomorphological picture of lesions occur, probably as a result of the interactions between cancer cells and re-modulated surrounding stroma.

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