Faculdade Integrado de Campo Mourao

Campo Mourão, Brazil

Faculdade Integrado de Campo Mourao

Campo Mourão, Brazil
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Silva D.M.,Faculdade Integrado de Campo Mourao | Musial D.C.,Faculdade Integrado de Campo Mourao | Altmeyer C.,Faculdade Integrado de Campo Mourao | Valentini S.A.,Faculdade Integrado de Campo Mourao
Revista de Ciencias Farmaceuticas Basica e Aplicada | Year: 2011

The development of new vehicles combining sustainability and quality is a challenge facing pharmaceutical research. Thus, the search for novel raw material sources seems to occupy a great portion of the studies and investments of the pharmaceutical sector. One example of such a raw material with wide applicability in the pharmaceutical and cosmetics industries is cellulose. There are several angiosperm species with potential as suppliers of cellulose, such as coconut, bamboo and sugarcane, to name a few found in Brazil. Bagasse, the fibrous residue from crushed sugarcane, has a significant cellulose content from which new compounds can be derived. Brazil currently occupies first place in the production of ethanol and sugar from sugarcane. The aim of the present study was to assess a dispersion obtained from a derivative of the cellulose extracted from sugarcane pulp.

Moreira W.H.,State University of Maringá | Betioli Jr. E.,State University of Maringá | Petean L.P.,Faculdade Integrado de Campo Mourao | Tormena C.A.,UEM | And 3 more authors.
Revista Brasileira de Ciencia do Solo | Year: 2012

The trampling of grazing animals can compact the surface layers and affect the physical quality of soils in crop-livestock systems (ICL). The hypothesis of this study is that increased trampling from animal grazing of oats and ryegrass reduces the soil physical quality of an Oxisol under no-tillage with ICL. The purpose of this study was to quantify bulk density (Bd), air-filled porosity (εa), soil air permeability (Ka), soil resistance to penetration (SR) and estimate an index of pore continuity from the linear relationships between εa and Ka. In the experimental area in Campo Mourao - PR, with ICL under no-tillage, soybean or corn was grown as cash crops and oat plus ryegrass as forage for grazing. The treatments were four grazing heights (7, 14, 21, and 28 cm) and an ungrazed control. From each treatment, 20 undisturbed samples were collected from the layers 0-7.5 and 7.5-15 cm. There were no significant differences in Bd, εa and Ka between the control and the grazed treatments. In the 0-7.5 cm layer, the mean Ka values were similar between treatments. After eight years of ICL, the BD, εa and Ka did not confirm the hypothesis that intensification of grazing reduces the soil physical quality. However, SR showed differences between the control and grazed treatments, with restrictive SR values down to a depth of 15 cm, suggesting that increasing the grazing intensity reduces the soil physical quality.

Ecco M.,State University of Mato Grosso do Sul | Santiago E.F.,State University of Mato Grosso do Sul | Lima P.R.,Faculdade Integrado de Campo Mourao
Comunicata Scientiae | Year: 2014

In the sugarcane crop the initial phenological stages are critical to the development of plants due to the influence of many stress factors. In this work are discussed the effects of hydric stress and aluminum toxicity, for the initial development of two varieties (RB855536 e RB867515). In this way, billets containing two gems (± 25 cm) were planted in polyethylene vases with soil. The levels of water in the soil were defined as: control (70 to 90 % of the field capacity (FC)) and hydric stress (20 to 40 % of FC). Different doses of aluminum were applied: 0, 0.2 and 0.4 mmol L-1 in the form of Al2(SO4)3.H2O18. With exception of number of number of tillers, the fresh mass of billet for the variety RB855536 and dry mass of billet for variety RB867515, were verified significant differences among all t..he evaluated variables of growing for the used treatments. The significant reduction of dry mass from billet in the variety RB855536 suggests higher energy consumption under stress conditions, while in variety RB867515 this effect was not observed, what can indicate higher tolerance to hydric stress and by aluminum.

Silva V.S.,Faculdade Integrado de Campo Mourao | De Almeida Garcia C.,Faculdade Integrado de Campo Mourao | Da Silva C.M.,Faculdade Integrado de Campo Mourao
Revista em Agronegocio e Meio Ambiente | Year: 2010

This research aims at studying what the destination of the sugar cane pomace is, produced by the sugar- alcohol agricultural industry in Paraná, in order that the alcohol sector of Paraná has a great potential through the pomace and it is the second largest producer of sugar cane in the country. For the realization of this goal it was searched information about the pomace use on the energy co-generation, identifying the use of sugarcane pomace in agribusiness in Paraná and analyzing the uptake of industries in relation to co-generation power . For this, we conducted a survey of quantitative character with charts and graphs generated with data obtained in the literature bibliographic research with several authors who discuss the issue and collect data through questionnaires applied to sugarcane agro-industries of Paraná, which were sent to the industries and in response it was obtained six questionnaires back. It was found that the sugar cane pomace has several uses, being the co-generation the most used, where the industries in Paraná still show great potential to be explored in electricity relation applications and pomace co-generation as a way to add value to their production.

De Souza Silva F.M.,Faculdade Integrado de Campo Mourao | Rocha Alves Da Silva M.H.,State University of Maringa | Bracht A.,State University of Maringa | Eller G.J.,State University of Maringa | And 2 more authors.
Molecular and Cellular Biochemistry | Year: 2010

Although metformin has been used to treat type 2 diabetes for several decades, the mechanism of its action on glucose metabolism remains controversial. To further assess the effect of metformin on glucose metabolism this work was undertaken to investigate the acute actions of metformin on glycogenolysis, glycolysis, gluconeogenesis, and ureogenesis in perfused rat livers. Metformin (5 mM) inhibited oxygen consumption and increased glycolysis and glycogenolysis in livers from fed rats. In perfused livers of fasted rats, the drug (concentrations higher than 1.0 mM) inhibited oxygen consumption and glucose production from lactate and pyruvate. Gluconeogenesis and ureogenesis from alanine were also inhibited. The cellular levels of ATP were decreased by metformin whereas the AMP levels of livers from fasted rats were increased. Taken together our results indicate that the energy status of the cell is probably compromised by metformin. The antihyperglycemic effect of metformin seems to be the result of a reduced oxidative phosphorylation without direct inhibition of key enzymatic activities of the gluconeogenic pathway. The AMP-activated protein kinase cascade could also be a probable target for metformin, which switches on catabolic pathways such as glycogenolysis and glycolysis, while switches off ATP consuming processes. © 2010 Springer Science+Business Media, LLC.

Ribas-Silva R.C.,Faculdade Integrado de Campo Mourao | Eid A.A.,Faculdade Integrado de Campo Mourao
Revista Brasileira de Hematologia e Hemoterapia | Year: 2012

Background: Dengue is an urban arbovirus whose etiologic agent is a virus of the genus Flavorius with four distinct antigen serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) that is transmitted to humans through the bite of the mosquito Aedes aegypti. The Campo Mourão region in Brazil is endemic for dengue fever. Obtective: The aim of this study was to evaluate the presence of IgG and IgM antibodies specific to the four serotypes of dengue in donors of the blood donor service in the city of Campo Mourão. Methods: Epidemiological records were evaluated and 4 mL of peripheral blood from 213 blood donors were collected in tubes without anticoagulant. Serum was then obtained and immunochromatographic tests were undertaken (Imuno-Rápido Dengue IgM/IgG™). Individuals involved in the study answered a social and epidemiological questionnaire on data which included age, gender and diagnosis of dengue. Results: Only three (1.4%) of the 213 blood tests were positive for IgG anti-dengue antibodies. No donors with IgM antibody, which identifies acute infection, were identified. Conclusions: The results of the current analysis show that the introduction of quantitative or molecular serological methods to determine the presence of anti-dengue antibodies or the detection of the dengue virus in blood donors in endemic regions should be established so that the quality of blood transfusions is guaranteed.

Maggioni D.,Faculdade Integrado de Campo Mourao | Do Prado I.N.,State University of Maringá | Zawadzki F.,State University of Maringa | Valero M.V.,State University of Maringa | And 4 more authors.
Semina:Ciencias Agrarias | Year: 2012

This study was carried out to evaluate the effect of genetic groups and carcass fat thickness levels on unfreeze losses (UFL), cooking losses (COL), pH, shear force (SF), frequency and diameters of slow-twitch-oxidative and red color (SO), fast-twitch-glicolytic and intermediate color and fast-twitch-glycolitic and white color (FG) on Longissimus muscle of bulls finished in feedlot. It were evaluated NEL - Nellore; LIN - 1/2 Limousin + 1/2 Nellore and RAN - 1/2 Angus + 1/2 Nellore genetic groups slaughtered with fat thickness levels of 3 or 5 mm. There was an interaction between genetic group RAN and fat thickness levels to the characteristics of UFL, COL, pH, SF and redness. The NEL produced meat darker than the crossbred, and had higher ultimate pH. However, the meat of these animals had lower UFL, COL and SF when compared to crossbred. Bulls RAN had the highest frequency of fast oxidative glicolytic fiber and lowest in slow-twitch oxidative fibers, and larger diameters for these fibers. Difference in meat quality among genetic groups are found in the smallest fat thickness levels of the carcass, while these differences cease to exist when the slaughter occurs with higher fat thickness levels. Fat thickness levels did not affect on meat quality of bulls finished in feedlot.

Dos Santos Bitencourt J.,Faculdade Integrado de Campo Mourao | Felgueira Pavanelli M.,State University of Maringá
Jornal Brasileiro de Patologia e Medicina Laboratorial | Year: 2014

Introduction: Cases of bacterial resistance in urinary tract infections (UTIs) have increased significantly, mainly due to indiscriminate use of antimicrobials. Objective: To evaluate the prevalence and antimicrobial susceptibility of microorganisms isolated in urine cultures of patients of Consórcio Intermunicipal de Saúde da Comunidade dos Municípios da Região de Campo Mourão (CISCOMCAM) clinical laboratory. Method: We performed a retrospective study of data from urine culture and sensitivity done between January 2012 and December 2013. Results: The most prevalent bacteria were Escherichia coli; women were the most affected gender and people 16-45 years, the most affected age group. The sensitivity profile showed that the antimicrobial combination trimethoprim/ sulfamethoxazole was not associated with the highest rate of bacterial resistance (59.7%) and the combination of amoxicillin/clavulanic acid showed the lowest resistance rate (15.3%). For most antimicrobials, including ciprofloxacin and norfloxacin, the rates of bacterial resistance have increased from 2012 to 2013 with statistical significance (p < 0.05) in some cases. Discussion: The prevalence of Gram-negative bacilli in urinary infections is due to the fact that intestinal flora is rich in enterobacteria, and women are most affected by anatomical factors. The development of bacterial resistance to antimicrobials probably arises from their indiscriminate use. Conclusion: The rate of microbial resistance has risen, showing the need for a more effective control of antimicrobial use.

PubMed | Faculdade Integrado de Campo Mourao and State University of Maringá
Type: Journal Article | Journal: Revista da Sociedade Brasileira de Medicina Tropical | Year: 2015

Serological screening in blood banks does not include all transmittable diseases. American cutaneous leishmaniasis (ACL) has a high detection rate in the municipalities of the State of Paran.This study analyzed the presence of anti- Leishmania braziliensisantibodies in 176 blood donors who live in these endemic areas. The variables were analyzed with the 2 test and Stata 9.1 software.Twenty (11.4%) samples were positive for the presence of anti- L. braziliensisantibodies.The high percentage of donors with anti- Leishmania spp. antibodies indicates the need to study the risk of ACL transmission through blood donors.

PubMed | Rochester College, Faculdade Integrado de Campo Mourao, State University of Maringá and Federal University of Mato Grosso do Sul
Type: Journal Article | Journal: Acta histochemica | Year: 2016

Enteric neuropathy associated with Diabetes Mellitus causes dysfunction in the digestive system, such as: nausea, diarrhea, constipation, vomiting, among others. The aim of this study was to compare the effects of supplementation with 2% l-glutamine and 1% l-glutathione on neurons and enteric glial cells of ileum of diabetic rats.Thirty male Wistar rats have been used according to these group distributions: Normoglycemic (N), Normoglycemic supplemented with l-glutamine (NG), Normoglycemic supplemented with l-glutathione (NGO), Diabetic (D), Diabetic supplemented with l-glutamine (DG) and Diabetic supplemented with l-glutathione (DGO). After 120days, the ileum was processed for immunohistochemistry of HuC/D and S100. Quantitative and morphometric analysis have been performed.Diabetic rats presented a decrease in the number of neurons when compared to normoglycemic animals. However, diabetes was not associated with a change in glial density. l-Glutathione prevented the neuronal death in diabetic rats. l-Glutathione increased a glial proliferation in diabetic rats. The neuronal area in diabetic rats increased in relation to the normoglycemics. The diabetic rats supplemented with l-glutamine and l-glutathione showed a smaller neuronal area in comparison to diabetic group. The glial cell area was a decreased in the diabetics. The diabetic rats supplemented with l-glutamine and l-glutathione did not have significant difference in the glial cell body area when compared to diabetic rats.It is concluded that the usage of l-glutamine and l-glutathione as supplements presents both desired and side effects that are different for the same substance in considering normoglycemic or diabetic animals.

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