Colorectal cancer prevalence linked to human papillomavirus: A systematic review with meta-analysis [Prevalência de câncer colorretal associado ao papilomavírus humano: Uma revisão sistemática com metanálise]
Pelizzer T.,Faculdade da Serra Gaucha |
Dias C.P.,Federal University of Rio Grande do Sul |
Poeta J.,Faculdade da Serra Gaucha |
Poeta J.,Federal University of Rio Grande do Sul |
And 4 more authors.
Revista Brasileira de Epidemiologia | Year: 2016
Introduction: Colorectal cancer is one of the most prevalent types of tumors worldwide. Deaths caused by these malignant tumors remain high and have stayed practically at the same level for the last few decades. Among the established risk factors for the development of cancer are infections due to pathogens or viruses. Among the viruses, the human papillomavirus (HPV) is the most prevalent, with over 180 strains, 40 of which are directly related to anogenital infections. Objective: Systematically assess the main studies which link HPV to colorectal cancer with meta-analysis. Methods: The search strategy adopted was the logic based on specific descriptors (English language), in combination with the Boolean operators (AND/OR). The search was conducted in the following databases: PubMed, ScienceDirect, and Scientific Electronic Library Online (SciELO), between April and May 2015. Results: 1,549 samples were assessed, with 956 (61.7%) being males. Six hundred thirty out of 1,358 cases of colorectal cancer due to HPV were diagnosed (51.9%). From these, 408 of 767 (51.9%) were male and 404 of 598 (67.5%) were linked to HPV 16 and 18, with tumor prevalence in the area of the cervix (253 of 411; 61.3%). From the total of 598 samples for the prevalence estimate of HPV 16 and 18, the number of cases with similar numbers was 204 (31.7%) and 200 (35.8%), respectively. Relatively significant numbers were found in the area of the cervix, 253 (61.3%), and the area of the rectum, 158 (38.7%). Conclusion: After conducting the present study, the link between HPV and colorectal cancer was made evident, without a distinction between the sexes, with similar values between HPV 16 and HPV 18. © 2016, Assocaicao Brasileira de Pos, Gradacao em Saude Coletiva. All rights reserved.
Michelon F.,University of Caxias do Sul |
Branco C.S.,University of Caxias do Sul |
Calloni C.,University of Caxias do Sul |
Giazzon I.,University of Caxias do Sul |
And 3 more authors.
Current Nutrition and Food Science | Year: 2012
The Araucaria angustifolia (Bertolini, Otto Kuntze) tree belongs to the family Araucariaceae and is known as Brazilian pine. The female strobilus consists of seeds (the edible part of A. angustifolia) and bracts (non-developed seeds). These bracts, which represent approximately 80% of the female strobilus, have no use. It has previously been suggested that the dietary intake of antioxidants could be a useful strategy to reduce the incidence of diseases associated with oxidative stress, such as cancer, atherosclerosis and neurodegenerative disorders. This study aimed to evaluate the phenolic profile and the possible antioxidant, mutagenic and antimutagenic activities of the aqueous extract from bracts of A. angustifolia. The results showed that the extract of A. angustifolia presents important in vitro and in vivo antioxidant activity. Additionally, lower concentrations of the extract were non-mutagenic and avoided DNA damage induced by hydrogen peroxide in yeast cells. Catechin, epicatechin and rutin were the main phenolic compounds found in the extract. These results may provide new perspectives for the development of strategies with natural compounds in the nutraceutical field. In addition, the use of this waste will help maintain the environmental balance. © 2012 Bentham Science Publishers.
Garcez M.E.,University of Caxias do Sul |
Branco C.S.,University of Caxias do Sul |
Lara L.V.,University of Caxias do Sul |
Spada P.D.S.,Faculdade da Serra Gaucha |
And 2 more authors.
Jornal Brasileiro de Reproducao Assistida | Year: 2011
The aim of this study was to analyze potential beneficial effects of adding ascorbic acid to cryopreservation media of semen of infertile men. Semen from 20 infertile and 10 fertile (control group) men was cryopreserved with and without 10 mM ascorbic acid. Addition of ascorbic acid to the cryopreservation media was able to reduce the lipid oxidative damage induced by the cryopreservation process and increase the antioxidant enzyme superoxide dismutase activity in infertile men. However, this antioxidant was not able to avoid the loss of motility observed in post-thaw spermatozoa of both infertile and fertile men.
PubMed | Faculdade da Serra Gaucha and University of Sao Paulo
Type: | Journal: Brazilian oral research | Year: 2015
The aim of this study was to evaluate the effect of industrialised foods and drinks on primary tooth enamel previously eroded with hydrochloric acid (HCl). The crowns of one hundred two specimens were subjected to an erosive challenge with HCl and randomly divided into six groups (n = 17): Chocolate Milk (Toddynho - Pepsico) - negative control; Petit Suisse Yogurt (Danoninho - Danone); Strawberry Yogurt (Vigor); Apple puree (Nestl); Fermented Milk (Yakult - Yakult); and Home Squeezed Style Orange Juice (del Valle) - positive control. The 28-day immersion cycles for the test products were performed twice daily and were interspersed with exposure of the test substrate to artificial saliva. Measurements of enamel surface microhardness (SMH) were performed initially, after immersion in HCl and at 7, 14, 21 and 28 days of experimentation. A two-way ANOVA, according to a split-plot design, followed by the sum of squares decomposition and Tukeys test, revealed a significant effect for the interaction between Foods and Drinks and Length of Exposure (p < 0.00001). Orange juice resulted in greater mineral loss of enamel after 28 days. None of the test products was associated with recovery of tooth enamel microhardness.
Tiggemann C.L.,Faculdade da Serra Gaucha |
Dias C.P.,Faculdade da Serra Gaucha |
Noll M.,Federal University of Rio Grande do Sul |
Schoenell M.C.W.,Federal University of Rio Grande do Sul |
Kruel L.F.M.,Federal University of Rio Grande do Sul
Revista da Educacao Fisica | Year: 2013
The proportion of elderly in the population is growing in different countries, which makes essential to examine this part of the population in different perspectives. In this way, the objective of this review is to understand how aging affects the neuromuscular system, especially muscle strength, and how this decline works on functional aspects, i.e. on everyday tasks. In addition, it is investigated how strength training, specifically aimed at improving muscle strength, can be a safe and effective strategy in combating the adverse effects of aging on neuromuscular system.
Borba E.,Centro Universitario Metodista do |
Philipi A.,Centro Universitario Metodista do |
Nascimento F.,Centro Universitario Metodista do |
Guimaraes A.,Centro Universitario Metodista do |
And 4 more authors.
Scientia Medica | Year: 2012
Aims: To evaluate the lipid profile and its relationship with obesity in men from Flores da Cunha, Rio Grande do Sul. Methods: A population-based cross-sectional study included men living in the county of Flores da Cunha, located in northeastern Rio Grande do Sul, the southernmost state in Brazil. Sociodemographic data were obtained through a questionnaire. Blood samples were taken at a health center and the biochemical analyzes were performed in the laboratory of Toxicology of the Centro Universitário Metodista do IPA. Results: We studied 368 men whose ages ranged from 25 to 83 years, mean 49.3 years. Biochemical analysis showed the following average values: total cholesterol 211.3 mg/dL, triglycerides 178.3 mg/dL, HDL (high density lipoprotein) cholesterol 46.4 mg/dL, and LDL (low-density lipoprotein) cholesterol 132.4 mg/dL. There were significant differences when comparing results of triglycerides in body mass index (BMI) normal and obese subjects (p<0.001) and among overweight and obese groups (p=0.001). HDL cholesterol differed between groups with normal BMI and overweight (p<0.001) and between obese and normal BMI (p<0.001). The normal individuals had the lowest values of triglycerides and higher HDL cholesterol. Conclusions: The data of approximately 80% of the sample presenting overweight and a relevant percentage presenting elevated plasma levels of lipids are cause for concern, considering the morbidity and mortality to which these factors are linked.
Timm A.U.,Faculdade da Serra Gaucha |
Roberti D.R.,Federal University of Santa Maria |
Streck N.A.,Federal University of Santa Maria |
de Goncalves L.G.G.,National Institute for Space Research |
And 6 more authors.
Journal of Hydrometeorology | Year: 2014
During approximately 80% of its growing season, lowland flooded irrigated rice ecosystems in southern Brazil are kept within a 5-10-cm water layer. These anaerobic conditions have an influence on the partitioning of the energy and water balance components. Furthermore, this cropping system differs substantially from any other upland nonirrigated or irrigated crop ecosystems. In this study, daily, seasonal, and annual dynamics of the energy and water balance components were analyzed over a paddy rice farm in a subtropical location in southern Brazil using eddy covariance measurements. In this region, rice is grown once a year in low wetlands while the ground is kept fallow during the remaining of the year. Results show that the energy budget residual corresponded to up to 20% of the net radiation during the rice-growing season and around 10% for the remainder of the year (fallow). The energy and water balance analysis also showed that because of the high water table in the region, soil was near saturation most of the time, and latent heat flux dominated over sensible heat flux by up to one order of magnitude in some cases. The estimate of evapotranspiration ET using the crop coefficient multiplied by the reference evapotranspiration KcETo and the Penman-Monteith equation ETPM, describing the canopy resistance through leaf area index (LAI) obtained by remote sensing, represent well the measured evapotranspiration, mainly in the fallow periods. Therefore, using a specific crop parameter like LAI and crop height can be an easy and interesting alternative to estimate ET in vegetated lowland areas. © 2014 American Meteorological Society.
Bruno F.B.,Faculdade da Serra Gaucha |
Silva T.L.K.,Federal University of Rio Grande do Sul |
Silva R.P.,Federal University of Rio Grande do Sul |
Teixeira F.G.,Federal University of Rio Grande do Sul
Campus-Wide Information Systems | Year: 2012
Purpose: The purpose of this paper is to propose a web-based tool that enables the development and provision of learning designs and its reuse and re-contextualization as generative learning objects, aimed at developing educational materials. Design/methodology/approach: The use of learning objects can facilitate the process of production and delivering of educational material and their reuse and re-contextualization in different scenarios - such process is due to the current development stage of information and communication technologies (ICTs), which allow easy access to products and services related to them. ICTs combined with instructional design theories, lead to the emergence of new generations of distance learning, which add educational content to web-based services. From this combination rises a hybrid mode of education, which combines tools for face-to-face and distance learning (blended learning). Findings: The use of the web as a platform for production and management of learning objects comes as a solution for storage and sharing. The utilization of objects is justified when its reusability is facilitated. This gives rise to possibilities in a client-server environment, where information is centralized and available anywhere in the network. Research limitations/implications: The combination of ICT and instructional design theories has potential and could result in hybrids which are yet to be fully understood and explored. This can enhance blended learning provision. Originality/value: The paper presents a tool in which the learning designs work as structures built on XML, based on concept maps, which act as an interaction layer between the learning objects, organizing the content to be available. © Emerald Group Publishing Limited.