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Castro Alves, Brazil

The aim of this study was to evaluate the allelopathic effects of extracts from Coleus barbatus on germination and seedling growth of lettuce. The experiments were conducted in the laboratory using different concentrations (0, 7.5, 15, 22.5, 30%) of aqueous extracts from "falso-boldo" leaves harvested in all four seasons; extracts were obtained by grinding, maceration, infusion and decoction. Seeds were distributed on Petri dishes moistened with 10 mL solution. Results showed that the leaf extracts affected the germination of lettuce seeds only at the concentration of 30% extract prepared by decoction of leaves harvested in the winter. Germination speed index showed significant reduction for ground extracts prepared in the fall and winter, as well as for macerated leaves harvested in the summer and fall and for extracts prepared through decoction in the winter. The extracts stimulated the growth of shoots of lettuce seedlings, whereas root length was affected by the extracts, which either stimulated or inhibited its growth. Extracts of "falso-boldo" leaves harvested in all four seasons had allelopathic effect on germination and development of lettuce, and the latter varied depending on the harvest season, the form of preparing the extracts and the tested concentrations.

Romero F.R.,Hospital Policlinica Cascavel | Romero F.R.,Instituto Curitiba Of Saude | Romero F.R.,Federal University of Parana | Romero A.W.,Hospital Policlinica Cascavel | And 3 more authors.
International Braz J Urol | Year: 2013

Purpose: To report the prevalence and risk factors of penile lesions/anomalies in a Metropolitan Brazilian city. Materials and Methods: All participants undergoing prostate cancer screening in the city of Curitiba were systematically examined to identify penile lesions including cutaneous mycosis, sexually transmitted diseases, penile cancer, meatalstenosis, hypospadias, and Peyronie's disease. Outcomes of interest included the prevalence and the relative risk and 95% confidence intervals of the lesions/anomalies accordingto age, school level, race, personal history of diabetes, arterial hypertension, nonspecific urethritis, and vasectomy. Results: Balanoposthitis occurred in 11.8% of all participants, with an increased risk in those with diabetes (RR = 1.73), or past history of nonspecific urethritis (RR = 1.58); tinea of the penis was present in 0.2%; condyloma acuminatain 0.5%; herpes virus infection in 0.4%; urethral discharge in 0.2%; genital vitiligo in 0.7%, with an increased prevalence in non-white men (RR = 4.43), and in subjects with lower school level (RR = 7.24); phimosis in 0.5%, with a nearly 7-fold increased risk in diabetics; lichen sclerosus in 0.3%; stenosis of the external urethral meatus in 0.7%, with a higher prevalence in subjects with lichen sclerosus (RR = 214.9), and in those older than 60 years of age (RR = 3.57); hypospadia in 0.6%; fibrosis suggestive of Peyronie's disease in 0.9%, especially in men older than 60 years (RR = 4.59) and with diabetes (RR = 3.91); and penile cancer in 0.06%.Conclusion: We estimated the prevalence and risk factors of commonly seen penile diseases in an adult cohort of Brazilian men.

Romero F.R.,Federal University of Parana | Romero A.W.,Cascavel and Hospital Policlinica Cascavel | de Almeida R.M.S.,Faculdade Assis Gurgacz FAG | Filho R.T.,Federal University of Parana
International Braz J Urol | Year: 2012

Background: Black men have a higher incidence of prostate cancer compared with White men in several countries. In Brazil, most studies reported a similar prevalence of prostate cancer between Blacks and Whites as a result of the high race mixture of the population. Objective: To perform a systematic review with meta-analysis of the prevalence of prostate cancer in Black versus White, Brown versusWhite, and Black versus Brown Brazilian men. Design, Setting, and Participants: This systematic review included cohort, cross sectional and case-control studies comparing the prevalence of prostate cancer between races in Brazil. It was performed using an electronic search of references in bibliographic databases, and dissertations and theses databases from several Brazilian hospitals, universities, and schools of medicine. Meta-analysis was conducted using the RevMan software from the Cochrane Collaboration. To control for potential confounding variables, sensitivity analyses excluding case-controland cross sectional studies were performed. Measurements: The outcomes of interest included the number of participants, prevalence of prostate cancer, and odds ratio of cancer between Black and White men, Brown and White men, and Black and Brown men. Results and Limitations: : Twelve studies approaching the prevalence of prostate cancer in Black or Brown vs. White men in Brazil were identifi ed, totalizing 41388 participants. The prevalence of prostate cancer was 9.6% in Black vs. 5.6% in White men (OR 1.58), 10.1% in Black vs. 6.7% in Brown men (OR 1.43), and 6.7% in Brown vs. 6.6% in White men (OR1.14). Limitations of this review refl ect the complexity and ambiguity in the defi nition of who is Black and who is not in such an heterogeneous population like the Brazilian people. Conclusions: Thissystematic review with meta-analysis demonstrates a higher prevalence of prostate cancer in Black mencompared to White or Brown Brazilian men. The prevalence of prostate cancer is similar in Brown versus White men.

Romero F.R.,Hospital Policlinica Cascavel | Romero F.R.,Instituto Curitiba Of Saude | Romero F.R.,Federal University of Parana | Xavier L.R.T.P.,Faculdade Assis Gurgacz FAG | And 4 more authors.
International Braz J Urol | Year: 2015

Objectives: To evaluate if the different results of prostate cancer risk between black and white Brazilian men may be associated with the varying methodology used to define participants as either Blacks or Whites. Patients and Methods: We evaluated median PSA values, rate of PSA level ≥4.0 ng/mL, indications for prostate biopsy, prostate cancer detection rate, biopsy/cancer rate, cancer/biopsy rate, and the relative risk of cancer between blacks versus whites, blacks versus non-blacks (browns and whites), non-whites (browns and blacks) versus whites, African versus non-African descendants, and African descendants or blacks versus non-African descendants and non-blacks. Results: From 1544 participants, there were 51.4% whites, 37.2% browns, 11.4% blacks, and 5.4% African descendants. Median PSA level was 0.9 ng/mL in whites, browns, and non-African descendants, compared to 1.2 ng/mL in blacks, and African descendants or blacks, and 1.3 ng/mL in African descendants. Indications for prostate biopsy were present in 16.9% for African descendants, 15.9% of black, 12.3% of white, 11.4% for non-African descendants, and 9.9% of brown participants. Prostate cancer was diagnosed in 30.3% of performed biopsies: 6.2% of African descendants, 5.1% of blacks, 3.3% of whites, 3.0% of non-African descendants, and 2.6% of browns. Conclusions: Median PSA values were higher for Blacks versus Whites in all classification systems, except for non-white versus white men. The rate of prostate biopsy, prostate cancer detection rate, and relative risk for cancer was increased in African descendants, and African descendants or blacks, compared to non-African descendants, and non-African descendants and non-blacks, respectively.

da Silva M.C.L.,Faculdade Assis Gurgacz FAG | Lima D.M.D.R.,Faculdade Assis Gurgacz FAG | Lima D.M.D.R.,Federal University of Ceara | Sagae U.E.,Federal University of Ceara | And 2 more authors.
Journal of Coloproctology | Year: 2016

Objective: This study aims to correlate the findings of the three-dimensional anorectal ultrasonography (3D-AUS) with pathological findings in patients with deep pelvic infiltrating endometriosis. Methods: Prospective study of a series of 40 patients with deep pelvic infiltrating endometriosis diagnosed by three-dimensional anorectal ultrasonography and who were submitted to a laparoscopy. The specimens were examined histologically and compared with the results of the three-dimensional anorectal ultrasonography. The research was conducted between March 2008 and March 2011. Results: The results of the examinations were: 72.5% of patients (n = 29) with endometriosis, 12.5% (n = 5) with nonspecific chronic inflammatory reaction, 5% (n = 2) with nonspecific fibrous tissue, 2.5% (n = 1) with adenomyoma, 2.5% (n = 1) with colonic mucosa with foci of recent hemorrhage, edema of lamina propria and superficial erosions, 2.5% (n = 1) with hyperplasia of lymphoid follicles, and the remaining 2.5% (n = 1) with peritoneal tissue within normal limits. Conclusion: We conclude that the use of three-dimensional anorectal ultrasonography in patients with deep pelvic infiltrating endometriosis aid in the diagnosis of rectal lesions, when compared with the pathological findings of surgical specimens. © 2016 Sociedade Brasileira de Coloproctologia. Published by Elsevier Editora Ltda.

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