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Aptel F.,University Hospital of Grenoble | Aptel F.,University Grenoble Alpes | Begle A.,EyeTechCare | Razavi A.,EyeTechCare | And 9 more authors.
Ultrasound in Medicine and Biology | Year: 2014

Several physical methods can be used to coagulate the ciliary body and decrease intra-ocular pressure in patients with glaucoma. The study described here investigated the short- and long-term effects of high-intensity focused ultrasound (HIFU) cyclocoagulation on the aqueous humor production structures and outflow pathways. Thirty-four rabbit eyes were sonicated with a ring-shaped probe containing six miniaturized HIFU transducers. Light, scanning electron and transmission electron microscopy and corrosion casts were performed. In the affected regions, the epithelium of the ciliary processes was degenerated or necrotic and sloughed off. Examinations performed several months afterward revealed involution of the ciliary processes. Vascular corrosion cast revealed focal interruption of the ciliary body microvasculature. In most animals, a sustained fluid space was seen between the sclera, the ciliary body and the choroid, likely indicating an increase in the aqueous outflow by the uveoscleral pathway. These results suggest that HIFU cyclocoagulation has a dual effect on aqueous humor dynamics. © 2014 World Federation for Ultrasound in Medicine & Biology.


PubMed | University Hospital of Grenoble, EyeTechCare, Hospices Civils de Lyon and University of Lyon
Type: Journal Article | Journal: Ultrasound in medicine & biology | Year: 2014

Several physical methods can be used to coagulate the ciliary body and decrease intra-ocular pressure in patients with glaucoma. The study described here investigated the short- and long-term effects of high-intensity focused ultrasound (HIFU) cyclocoagulation on the aqueous humor production structures and outflow pathways. Thirty-four rabbit eyes were sonicated with a ring-shaped probe containing six miniaturized HIFU transducers. Light, scanning electron and transmission electron microscopy and corrosion casts were performed. In the affected regions, the epithelium of the ciliary processes was degenerated or necrotic and sloughed off. Examinations performed several months afterward revealed involution of the ciliary processes. Vascular corrosion cast revealed focal interruption of the ciliary body microvasculature. In most animals, a sustained fluid space was seen between the sclera, the ciliary body and the choroid, likely indicating an increase in the aqueous outflow by the uveoscleral pathway. These results suggest that HIFU cyclocoagulation has a dual effect on aqueous humor dynamics.


News Article | November 30, 2016
Site: www.newsmaker.com.au

This report studies Optic Nerve Head Analyzer in Global market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with production, price, revenue and market share for each manufacturer, covering  Aeon Imaging  ArcScan  CW Optics  Eyenuk  EyeTechCare  OcuSciences  Optos  RetiVue  Vision Instruments  VisionQuest Biomedical  MEDA Market Segment by Regions, this report splits Global into several key Regions, with production, consumption, revenue, market share and growth rate of Optic Nerve Head Analyzer in these regions, from 2011 to 2021 (forecast), like  North America  Europe  China  Japan  Southeast Asia  India  Split by product type, with production, revenue, price, market share and growth rate of each type, can be divided into  Type I  Type II  Type III  Split by application, this report focuses on consumption, market share and growth rate of Optic Nerve Head Analyzer in each application, can be divided into  Application 1  Application 2  Application 3 1 Optic Nerve Head Analyzer Market Overview  1.1 Product Overview and Scope of Optic Nerve Head Analyzer  1.2 Optic Nerve Head Analyzer Segment by Type  1.2.1 Global Production Market Share of Optic Nerve Head Analyzer by Type in 2015  1.2.2 Type I  1.2.3 Type II  1.2.4 Type III  1.3 Optic Nerve Head Analyzer Segment by Application  1.3.1 Optic Nerve Head Analyzer Consumption Market Share by Application in 2015  1.3.2 Application 1  1.3.3 Application 2  1.3.4 Application 3  1.4 Optic Nerve Head Analyzer Market by Region  1.4.1 North America Status and Prospect (2011-2021)  1.4.2 Europe Status and Prospect (2011-2021)  1.4.3 China Status and Prospect (2011-2021)  1.4.4 Japan Status and Prospect (2011-2021)  1.4.5 Southeast Asia Status and Prospect (2011-2021)  1.4.6 India Status and Prospect (2011-2021)  1.5 Global Market Size (Value) of Optic Nerve Head Analyzer (2011-2021) 2 Global Optic Nerve Head Analyzer Market Competition by Manufacturers  2.1 Global Optic Nerve Head Analyzer Production and Share by Manufacturers (2015 and 2016)  2.2 Global Optic Nerve Head Analyzer Revenue and Share by Manufacturers (2015 and 2016)  2.3 Global Optic Nerve Head Analyzer Average Price by Manufacturers (2015 and 2016)  2.4 Manufacturers Optic Nerve Head Analyzer Manufacturing Base Distribution, Sales Area and Product Type  2.5 Optic Nerve Head Analyzer Market Competitive Situation and Trends  2.5.1 Optic Nerve Head Analyzer Market Concentration Rate  2.5.2 Optic Nerve Head Analyzer Market Share of Top 3 and Top 5 Manufacturers  2.5.3 Mergers & Acquisitions, Expansion 3 Global Optic Nerve Head Analyzer Production, Revenue (Value) by Region (2011-2016)  3.1 Global Optic Nerve Head Analyzer Production by Region (2011-2016)  3.2 Global Optic Nerve Head Analyzer Production Market Share by Region (2011-2016)  3.3 Global Optic Nerve Head Analyzer Revenue (Value) and Market Share by Region (2011-2016)  3.4 Global Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2011-2016)  3.5 North America Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2011-2016)  3.6 Europe Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2011-2016)  3.7 China Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2011-2016)  3.8 Japan Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2011-2016)  3.9 Southeast Asia Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2011-2016)  3.10 India Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2011-2016) 4 Global Optic Nerve Head Analyzer Supply (Production), Consumption, Export, Import by Regions (2011-2016)  4.1 Global Optic Nerve Head Analyzer Consumption by Regions (2011-2016)  4.2 North America Optic Nerve Head Analyzer Production, Consumption, Export, Import by Regions (2011-2016)  4.3 Europe Optic Nerve Head Analyzer Production, Consumption, Export, Import by Regions (2011-2016)  4.4 China Optic Nerve Head Analyzer Production, Consumption, Export, Import by Regions (2011-2016)  4.5 Japan Optic Nerve Head Analyzer Production, Consumption, Export, Import by Regions (2011-2016)  4.6 Southeast Asia Optic Nerve Head Analyzer Production, Consumption, Export, Import by Regions (2011-2016)  4.7 India Optic Nerve Head Analyzer Production, Consumption, Export, Import by Regions (2011-2016) 5 Global Optic Nerve Head Analyzer Production, Revenue (Value), Price Trend by Type  5.1 Global Optic Nerve Head Analyzer Production and Market Share by Type (2011-2016)  5.2 Global Optic Nerve Head Analyzer Revenue and Market Share by Type (2011-2016)  5.3 Global Optic Nerve Head Analyzer Price by Type (2011-2016)  5.4 Global Optic Nerve Head Analyzer Production Growth by Type (2011-2016) 6 Global Optic Nerve Head Analyzer Market Analysis by Application  6.1 Global Optic Nerve Head Analyzer Consumption and Market Share by Application (2011-2016)  6.2 Global Optic Nerve Head Analyzer Consumption Growth Rate by Application (2011-2016)  6.3 Market Drivers and Opportunities  6.3.1 Potential Applications  6.3.2 Emerging Markets/Countries 7 Global Optic Nerve Head Analyzer Manufacturers Profiles/Analysis  7.1 Aeon Imaging  7.1.1 Company Basic Information, Manufacturing Base and Its Competitors  7.1.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.1.2.1 Type I  7.1.2.2 Type II  7.1.3 Aeon Imaging Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.1.4 Main Business/Business Overview  7.2 ArcScan  7.2.1 Company Basic Information, Manufacturing Base and Its Competitors  7.2.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.2.2.1 Type I  7.2.2.2 Type II  7.2.3 ArcScan Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.2.4 Main Business/Business Overview  7.3 CW Optics  7.3.1 Company Basic Information, Manufacturing Base and Its Competitors  7.3.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.3.2.1 Type I  7.3.2.2 Type II  7.3.3 CW Optics Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.3.4 Main Business/Business Overview  7.4 Eyenuk  7.4.1 Company Basic Information, Manufacturing Base and Its Competitors  7.4.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.4.2.1 Type I  7.4.2.2 Type II  7.4.3 Eyenuk Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.4.4 Main Business/Business Overview  7.5 EyeTechCare  7.5.1 Company Basic Information, Manufacturing Base and Its Competitors  7.5.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.5.2.1 Type I  7.5.2.2 Type II  7.5.3 EyeTechCare Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.5.4 Main Business/Business Overview  7.6 OcuSciences  7.6.1 Company Basic Information, Manufacturing Base and Its Competitors  7.6.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.6.2.1 Type I  7.6.2.2 Type II  7.6.3 OcuSciences Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.6.4 Main Business/Business Overview  7.7 Optos  7.7.1 Company Basic Information, Manufacturing Base and Its Competitors  7.7.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.7.2.1 Type I  7.7.2.2 Type II  7.7.3 Optos Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.7.4 Main Business/Business Overview  7.8 RetiVue  7.8.1 Company Basic Information, Manufacturing Base and Its Competitors  7.8.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.8.2.1 Type I  7.8.2.2 Type II  7.8.3 RetiVue Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.8.4 Main Business/Business Overview  7.9 Vision Instruments  7.9.1 Company Basic Information, Manufacturing Base and Its Competitors  7.9.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.9.2.1 Type I  7.9.2.2 Type II  7.9.3 Vision Instruments Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.9.4 Main Business/Business Overview  7.10 VisionQuest Biomedical  7.10.1 Company Basic Information, Manufacturing Base and Its Competitors  7.10.2 Optic Nerve Head Analyzer Product Type, Application and Specification  7.10.2.1 Type I  7.10.2.2 Type II  7.10.3 VisionQuest Biomedical Optic Nerve Head Analyzer Production, Revenue, Price and Gross Margin (2015 and 2016)  7.10.4 Main Business/Business Overview  7.11 MEDA 8 Optic Nerve Head Analyzer Manufacturing Cost Analysis  8.1 Optic Nerve Head Analyzer Key Raw Materials Analysis  8.1.1 Key Raw Materials  8.1.2 Price Trend of Key Raw Materials  8.1.3 Key Suppliers of Raw Materials  8.1.4 Market Concentration Rate of Raw Materials  8.2 Proportion of Manufacturing Cost Structure  8.2.1 Raw Materials  8.2.2 Labor Cost  8.2.3 Manufacturing Expenses  8.3 Manufacturing Process Analysis of Optic Nerve Head Analyzer 9 Industrial Chain, Sourcing Strategy and Downstream Buyers  9.1 Optic Nerve Head Analyzer Industrial Chain Analysis  9.2 Upstream Raw Materials Sourcing  9.3 Raw Materials Sources of Optic Nerve Head Analyzer Major Manufacturers in 2015  9.4 Downstream Buyers 12 Global Optic Nerve Head Analyzer Market Forecast (2016-2021)  12.1 Global Optic Nerve Head Analyzer Production, Revenue Forecast (2016-2021)  12.2 Global Optic Nerve Head Analyzer Production, Consumption Forecast by Regions (2016-2021)  12.3 Global Optic Nerve Head Analyzer Production Forecast by Type (2016-2021)  12.4 Global Optic Nerve Head Analyzer Consumption Forecast by Application (2016-2021)  12.5 Optic Nerve Head Analyzer Price Forecast (2016-2021)


Charrel T.,University of Lyon | Charrel T.,EyeTechCare | Aptel F.,University of Lyon | Aptel F.,Edouard Herriot Hospital | And 6 more authors.
Ultrasound in Medicine and Biology | Year: 2011

This study examined the feasibility of high-intensity focused ultrasound (HIFU) for glaucoma treatment with conformal coagulation of the ciliary bodies (CB). A miniaturized high frequency (21 MHz) device was developed, based on the geometry of the eye and adapted to the anatomy of the rabbit eyeball. Six line-focus lesions were distributed along a circle and produced by six cylindrical transducers. To be conformal, the numerical model predicted an intensity of 6.9 W/cm2, with exposure duration of 3 s ON (powered per sector). In vivo experiments were conducted on two rabbits. A significant intraocular pressure reduction was noted (-45% and -31%). Histology demonstrated conformal and homogeneous coagulation of the CB without side effects. (E-mail: thomas.charrel@inserm.fr). © 2011 World Federation for Ultrasound in Medicine & Biology.


Aptel F.,Hospices Civils de Lyon | Aptel F.,University of Lyon | Charrel T.,University of Lyon | Charrel T.,EyeTechCare | And 6 more authors.
Investigative Ophthalmology and Visual Science | Year: 2011

Purpose. To evaluate the relative safety and potential efficacy of high-intensity focused ultrasound cyclocoagulation by a miniaturized annular device containing six piezoceramic transducers in patients with refractory glaucoma. Methods. This was a three-center prospective interventional pilot study. Twelve eyes of 12 patients with refractory glaucoma were insonified using a ring-shaped probe containing six miniaturized high-frequency transducers operating at 21 MHz. Ultrasound biomicroscopy (UBM) and a complete ophthalmic examination were performed before the procedure and at 1 day, 1 week, 1 month, and 3 months after the procedure. Additional visits were performed 6 and 12 months after the procedure. Results. Intraocular pressure was significantly reduced (P < 0.01) from a mean preoperative value of 37.9 ± 10.7 mm Hg to a mean postoperative value of 27.3 ± 12.4, 25.2 ± 11.3, 25.2 ± 7.7, 24.8 ± 9.8, and 26.3 ± 5.1 mm Hg at 1 day, 1 week, 1 month, 3 months, and 6 months, respectively, and to a mean value of 24.7 ± 8.5 at the last follow-up visit. No major intraoperative or postoperative complications occurred. Minor postoperative corneal complications developed in four patients with previous corneal abnormalities: superficial punctate keratitis (n = 3) and central superficial corneal ulceration (n = 1). UBM showed cystic involution of the ciliary body in 9 of the 12 eyes and a suprachoroidal fluid space in 8 of the 12 eyes. Conclusions. Ultrasonic circular cyclocoagulation using high-intensity focused ultrasound delivered by a circular miniaturized device containing six piezoceramic transducers seems to be an effective and well-tolerated method to reduce intraocular pressure in patients with refractory glaucoma. © 2011 The Association for Research in Vision and Ophthalmology, Inc.


Razavi A.,French Institute of Health and Medical Research | Razavi A.,EyeTechCare | Clement D.,EyeTechCare | Fowler R.A.,French Institute of Health and Medical Research | And 7 more authors.
Ultrasound in Medicine and Biology | Year: 2014

In ocular drug delivery, the sclera is a promising pathway for administering drugs to both the anterior and posterior segments of the eye. Due to the low permeability of the sclera, however, efficient drug delivery is challenging. In this study, pulsed ultrasound (US) was investigated as a potential method for enhancing drug delivery to the eye through the sclera. The permeability of rabbit scleral tissue to a model drug compound, sodium fluorescein, was measured after US-irradiation at 1.1 MHz using time-averaged acoustic powers of 0.5-5.4 W (6.8-12.8 MPa peak negative pressure), with a fixed duty cycle of 2.5% for two different pulse repetition frequencies of 100 and 1000 Hz. Acoustic cavitation activity was measured during exposures using a passive cavitation detector and was used to quantify the level of bubble activity. A correlation between the amount of cavitation activity and the enhancement of scleral permeability was demonstrated with a significant enhancement in permeability of US exposed samples compared to controls. Transmission electron microscopy showed no evidence of significant alteration in viability of tissue exposed to US exposures. A pulsed US protocol designed to maximum cavitation activity may therefore be a viable method for enhancing drug delivery to the eye. © 2014 World Federation for Ultrasound in Medicine & Biology.


EyeTechCare | Entity website

Mounia Chaoui is General partner at Turenne Capital in charge of venture and growth capital in Healthcare. Prior to this, Mounia has been a Life Science investor within Ventech, Inserm Transfert Initiative and Atlas Venture ...


EyeTechCare | Entity website

UNIQUE TECHNOLOGY FOR NON-INVASIVE TREATMENT EYE TECH CARE has developed the only medical procedure for uncontrolled glaucoma irrespective of previous treatment. This non-invasive therapy to reduce IOP (intraocular pressure) using proprietary focused ultrasound technology delivers good patient tolerance resulting in a predictable, trouble-free patient follow up ...


News Article | March 12, 2013
Site: www.finsmes.com

EyeTechCare SA, a Rillieux-la-Pape, near Lyon, France-based developer of non-invasive therapeutic medical devices for the ophthalmology market based on the use of ultrasound, secured a €10m third round of funding. Backers included private investor Bernard Chauvin, who has taken an equity stake in the company alongside existing investors Omnes Capital (formerly Credit Agricole Private Equity) and SHAM. In conjunction with the funding, Bernard Chauvin, Bernard Chauvin is a physician specializing in ophthalmology, will join the company’s board. Founded in 2008 and led by Fabrice Romano, CEO, EyeTechCare is developing non-invasive therapeutic medical devices for the ophthalmology market based on High-Intensity Focused Ultrasound (HIFU), a technology that allows ambulatory and rapid treatment to be performed, thereby limiting the cost and the risk to the patient. The company’s first device, EyeOP1 (R), for the treatment of glaucoma, has been undergoing clinical trials in France and Europe and was launched onto the market at the end of 2012. The device utilizes the UC3 (ultrasound circular cyclo-coagulation) procedure, which makes it possible to reduce intraocular pressure by partially and accurately destroying the ciliary bodies that produce aqueous humor. The device obtained the CE mark in May 2011. EyeTechCare now intends to use the capital to complete its EyeMUST 2 international trial, with results due to be published in 2014, and fund the initial steps required by the FDA registration process. It plans to notify the FDA before the end of 2013 of its intention to bring the device to market. Related News 05/07/2010: EyeTechCare Raises €7.5M in Second Round of Funding


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