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Charrel T.,University of Lyon | Charrel T.,EyeTechCare | Aptel F.,University of Lyon | Birer A.,University of Lyon | And 5 more authors.
Ultrasound in Medicine and Biology | Year: 2011

This study examined the feasibility of high-intensity focused ultrasound (HIFU) for glaucoma treatment with conformal coagulation of the ciliary bodies (CB). A miniaturized high frequency (21 MHz) device was developed, based on the geometry of the eye and adapted to the anatomy of the rabbit eyeball. Six line-focus lesions were distributed along a circle and produced by six cylindrical transducers. To be conformal, the numerical model predicted an intensity of 6.9 W/cm2, with exposure duration of 3 s ON (powered per sector). In vivo experiments were conducted on two rabbits. A significant intraocular pressure reduction was noted (-45% and -31%). Histology demonstrated conformal and homogeneous coagulation of the CB without side effects. (E-mail: thomas.charrel@inserm.fr). © 2011 World Federation for Ultrasound in Medicine & Biology. Source

Aptel F.,University Hospital of Grenoble | Aptel F.,University Grenoble alpes | Begle A.,EyeTechCare | Razavi A.,EyeTechCare | And 9 more authors.
Ultrasound in Medicine and Biology | Year: 2014

Several physical methods can be used to coagulate the ciliary body and decrease intra-ocular pressure in patients with glaucoma. The study described here investigated the short- and long-term effects of high-intensity focused ultrasound (HIFU) cyclocoagulation on the aqueous humor production structures and outflow pathways. Thirty-four rabbit eyes were sonicated with a ring-shaped probe containing six miniaturized HIFU transducers. Light, scanning electron and transmission electron microscopy and corrosion casts were performed. In the affected regions, the epithelium of the ciliary processes was degenerated or necrotic and sloughed off. Examinations performed several months afterward revealed involution of the ciliary processes. Vascular corrosion cast revealed focal interruption of the ciliary body microvasculature. In most animals, a sustained fluid space was seen between the sclera, the ciliary body and the choroid, likely indicating an increase in the aqueous outflow by the uveoscleral pathway. These results suggest that HIFU cyclocoagulation has a dual effect on aqueous humor dynamics. © 2014 World Federation for Ultrasound in Medicine & Biology. Source

EyeTechCare | Entity website

Mounia Chaoui is General partner at Turenne Capital in charge of venture and growth capital in Healthcare. Prior to this, Mounia has been a Life Science investor within Ventech, Inserm Transfert Initiative and Atlas Venture ...

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EyeTechCare | Entity website

UNIQUE TECHNOLOGY FOR NON-INVASIVE TREATMENT EYE TECH CARE has developed the only medical procedure for uncontrolled glaucoma irrespective of previous treatment. This non-invasive therapy to reduce IOP (intraocular pressure) using proprietary focused ultrasound technology delivers good patient tolerance resulting in a predictable, trouble-free patient follow up ...

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