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Hacein-Bey L.,EXPO Inc | Provenzale J.M.,Duke University | Provenzale J.M.,Emory University
American Journal of Roentgenology | Year: 2011

OBJECTIVE. This article reviews current neuroimaging techniques used for screening, diagnosis, and follow-up of patients with intracranial aneurysms as well as neuroendovascular therapeutic options available to patients. CONCLUSION. The diagnosis and management of intracranial aneurysms have evolved dramatically in the past 20 years. MR angiography and CT angiography allow radiologists to reliably and noninvasively diagnose most intracranial aneurysms. Nonoperative endovascular techniques for treating intracranial aneurysms are now making treatment increasingly safer and more effective. © American Roentgen Ray Society. Source

Hacein-Bey L.,EXPO Inc | Konstas A.A.,University of California at Los Angeles | Pile-Spellman J.,Neurological Surgery | Pile-Spellman J.,Columbia University
Clinical Neurology and Neurosurgery | Year: 2014

Dural arteriovenous fistulas (DAVFs) may occur anywhere there is a dural or meningeal covering around the brain or spinal cord. Clinical manifestations are mostly related to venous hypertension, and may be protean, acute or chronic, ranging from minor to severe, from non-disabling tinnitus to focal neurological deficits, seizures, hydrocephalus, psychiatric disturbances, and developmental delay in pediatric patients. Although low-grade lesions may have a benign course and spontaneous involution may occasionally occur (i.e. cavernous sinus DAVFs), the risk of hemorrhage is considerable in high grade lesions. Angiographic features of DAVFs have been clarified since the 1970s when venous drainage pattern was clearly identified as the most significant risk predictor and as a major determinant of success or failure of treatment. The mainstay of therapy is interruption of arteriovenous shunting, which has traditionally been accomplished surgically. Currently, endovascular therapy is generally considered the first line of treatment, allowing elimination of the lesion in most patients, with surgery and stereotactic radiosurgery reserved for complex situations. This review discusses major aspects of DAVFs, including grading systems, clinical presentation, diagnostic evaluation, various issues impacting endovascular therapy, and pathophysiology. © 2014 Elsevier B.V. Source

Um H.-J.,Chungbuk National University | Kim M.,Chungbuk National University | Lee S.-H.,Chungbuk National University | Min J.,Chonbuk National University | And 3 more authors.
Talanta | Year: 2011

Using quartz crystal microbalance (QCM) as an immunosensor, this work investigates the contribution of a cyclic voltammetry (CV) on the proper immobilization of antibodies with the aim of enhancing its target recognition and binding ability. Primarily, CV in the range of -0.1 to 0.9 V was applied to form a layer of poly-(2-cyano-ethylpyrrole) (PCEPy) on gold quartz crystal electrode. Then the efficiencies of antibodies (anti-IgG, AIgG) immobilized electrochemically with CV applied in 0-0.65 V were compared to those immobilized via physical adsorption, by observing relative affinity towards AIgG-Fab and AIgG-Fc fragments. The results showed antibody-AIgG-Fab interaction could be enhanced about 4 times when CV is applied (11.2 ± 1.3 vs 41.6 ± 3.4 relative fluorescence unit). On the contrary, physisorbed antibodies showed a higher degree of affinity towards AIgG-Fc indicating inappropriate orientations of physisorbed antibodies. AIgG immobilized PCEPy-gold QC electrode was characterized further for its sensitivity towards a new target bovine albumin with both a QCM and fluorescence measurement. Such electrode exhibited a good sensitivity as well as a large linear dynamic range, from 0.4 μg/ml to 1.0 μg/ml and from 0.5 μg/ml to 10.0 μg/ml, at QCM and fluorescence measurement, respectively. © 2011 Elsevier B.V. All rights reserved. Source

Breslau J.,EXPO Inc | Lexa F.J.,University of Pennsylvania
Journal of the American College of Radiology | Year: 2011

The Patient Protection and Affordable Care Act that was signed into law in March 2010 included specific language codifying a new health care entity, the accountable care organization. The accountable care organization model is put forward as a way to increase value in health care, that is, improving outcomes as efficiently as possible. It is not known whether this concept can be applied successfully beyond the carefully selected examples where it already functions. Three general principles figure prominently in known successful models: the provision of efficient primary care, shared savings, and IT infrastructure. The authors discuss these concepts, ongoing uncertainties, and how radiologists may fit into an accountable care organization. © 2011 American College of Radiology. Source

EXPO Inc | Date: 2014-01-27

Paper, cardboard and goods made from these materials, not included in other classes; printed matter; bookbinding material; photographs; stationery; adhesives for stationery or household purposes; artists materials; paint brushes; typewriters and office requisites (except furniture); instructional and teaching material (except apparatus); plastic materials for packaging (not included in other classes); printers type; printing blocks. Meat, fish, poultry and game; meat extracts; preserved, frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs; milk and milk products; edible oils and fats. Coffee, tea, cocoa and artificial coffee; rice; tapioca and sago; flour and preparations made from cereals; bread, pastry and confectionery; ices; sugar, honey, treacle; yeast, baking-powder; salt; mustard; vinegar, sauces (condiments); spices; ice. Grains and agricultural, horticultural and forestry products not included in other classes; live animals; fresh fruits and vegetables; seeds; natural plants and flowers; foodstuffs for animals; malt. Beers; mineral and aerated waters and other non-alcoholic beverages; fruit beverages and fruit juices; syrups and other preparations for making beverages. Alcoholic beverages (except beers). Advertising; business management; business administration; office functions. Education; providing of training; entertainment; sporting and cultural activities. Services for providing food and drink; temporary accommodation.

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