Zielinsky P.,Institute of Cardiology of Rio Grande Do Sul FUC |
Piccoli Jr. A.L.,Institute of Cardiology of Rio Grande Do Sul FUC |
Manica J.L.,Institute of Cardiology of Rio Grande Do Sul FUC |
Nicoloso L.H.,Institute of Cardiology of Rio Grande Do Sul FUC |
And 10 more authors.
Journal of Perinatology | Year: 2010
Objective: To test the hypothesis that maternal consumption of polyphenol-rich foods during third trimester interferes with fetal ductal dynamics by inhibition of prostaglandin synthesis.Study Design: In a prospective analysis, Doppler ductal velocities and right-to-left ventricular dimensions ratio of 102 fetuses exposed to polyphenol-rich foods (daily estimated maternal consumption >75th percentile, or 1089 mg) were compared with 41 unexposed fetuses (flavonoid ingestion <25th percentile, or 127 mg).Result: In the exposed fetuses, ductal velocities were higher (systolic: 0.96 ± 0.23 m/s; diastolic: 0.17 ± 0.05 m/s) and right-to-left ventricular ratio was higher (1.23 ± 0.23) than in unexposed fetuses (systolic: 0.61 ± 0.18 m/s, P < 0.001; diastolic: 0.11 ± 0.04 m/s, P = 0.011; right-to-left ventricular ratio: 0.94 ± 0.14, P < 0.001).Conclusion: As maternal polyphenol-rich foods intake in late gestation may trigger alterations in fetal ductal dynamics, changes in perinatal dietary orientation are warranted. © 2010 Nature Publishing Group All rights reserved.