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New York, NY, United States

The invention provides a novel method for detecting the presence or absence of one or more transfer RNAs (tRNAs) contained in microvesicles from a subject. The invention also provides a novel method for detecting the presence or absence of one or more human endogenous retrovirus elements (HERV) in microvesicles from a subject. The methods disclosed is directed to aiding diagnosis, prognosis, minotring and evaluation of a disease or other medical condition in a subject.


Patent
Exosome Diagnostics | Date: 2014-02-14

The present invention features a novel EGFR variant, EGFRvVI, and methods for detecting the novel EGFR variant. The novel EGFR variant is preferentially expressed in some cancers. Methods for detecting EGFRvVI may aid in the diagnosis, prognosis, and therapeutic assessment of a subject.


Patent
Exosome Diagnostics | Date: 2012-11-12

The present invention is directed to methods of isolating particles, such as nucleic acid-containing particles or microvesicles, from a biological sample and extracting nucleic acids therefrom, wherein the biological sample is cerebrospinal fluid. The present invention further provides methods for aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker associated with a disease or medical condition thereof.


Patent
Exosome Diagnostics | Date: 2014-01-03

The invention provides novel methods for isolating microvesicles from a biological sample and for extracting nucleic acids from the microvesicles.


A method for extracting nucleic acids from a biological sample by isolating nucleic acid-containing particles from the biological sample by one or more centrifugation procedures, performing one or more steps to mitigate adverse factors that prevent or might prevent high quality nucleic acid extraction, and extracting nucleic acids from the isolated particles. The centrifugation procedures are performed at a speed not exceeding about 200,000 g. The extracted nucleic acids contain both 18S and 28S rRNA.

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