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Garazd Y.L.,Eximed | Garazd M.M.,Eximed | Lesyk R.B.,Danila Galitskii Lviv National Medical University
Chemistry of Natural Compounds | Year: 2016

The synthesis of 6-[5-aryl-4,5-dihydropyrazol-3-yl]-5-hydroxy-7-methylcoumarins is reported. The anticancer activities of the synthesized compounds are studied. © 2016 Springer Science+Business Media New York


Galayev O.,Eximed | Garazd Y.,Eximed | Garazd M.,Eximed | Lesyk R.,Lviv National Medical University
European Journal of Medicinal Chemistry | Year: 2015

A series of novel 7-hydroxy-8-methyl-coumarins with indole, pyrimidine, pyrazole, pyran, tetrazolo[1,5-α]pyrimidine, pyrimido[1,2-α]benzimidazol, 2-oxo-1,2-dihydropyridine and dihydropyrazolo[3,4-b]pyridine moieties at C6 position of heterocyclic core have been synthesized. Anticancer activity screening on NCI60 cell lines allowed identification of 6-(6-fluoro-1H-indol-2-yl)-7-hydroxy-4,8-dimethyl-2H-chromen-2-one (23) with the highest level of antimitotic activity with mean GI50/TGI values of 3.28/13.24 μM and certain sensitivity profile towards the Non-Small Cell Lung Cancer cell line HOP-92 (GI50/TGI/LC50 values 0.95/4.17/29.9 μM). © 2015 Elsevier Masson SAS.


PubMed | Eximed and Lviv National Medical University
Type: | Journal: European journal of medicinal chemistry | Year: 2015

A series of novel 7-hydroxy-8-methyl-coumarins with indole, pyrimidine, pyrazole, pyran, tetrazolo[1,5-a]pyrimidine, pyrimido[1,2-a]benzimidazol, 2-oxo-1,2-dihydropyridine and dihydropyrazolo[3,4-b]pyridine moieties at C6 position of heterocyclic core have been synthesized. Anticancer activity screening on NCI60cell lines allowed identification of 6-(6-fluoro-1H-indol-2-yl)-7-hydroxy-4,8-dimethyl-2H-chromen-2-one (23) with the highest level of antimitotic activity with mean GI50/TGI values of 3.28/13.24M and certain sensitivity profile towards the Non-Small Cell Lung Cancer cell line -92 (GI50/TGI/LC50 values 0.95/4.17/29.9M).


Yazlovitskii A.V.,Eximed | Garazd M.M.,Eximed | Kartsev V.G.,InterBioScreen
Chemistry of Natural Compounds | Year: 2016

N-acylamino-acid derivatives of cytisine were prepared by reacting cytisine with methyl esters of aminoacid isocyanates. © 2016 Springer Science+Business Media New York


Garazd Y.L.,Eximed | Garazd M.M.,Eximed
Chemistry of Natural Compounds | Year: 2016

The syntheses of linear and angular dihydropyranocoumarincarboxylic acids, modified structural derivatives of dihydroxanthyletin and dihydroseselin, were described. © 2016 Springer Science+Business Media New York


Nikitina Y.A.,Eximed | Galaev A.I.,Eximed | Garazd Y.L.,Eximed | Garazd M.M.,Eximed | Kartsev V.G.,InterBioScreen
Chemistry of Natural Compounds | Year: 2016

New coumarin derivatives containing a lupinine moiety were prepared via amidation of coumarinyloxyacetic, coumarinylacetic, and coumarinylpropionic acids by lupinamine. © 2016 Springer Science+Business Media New York


Garazd Y.L.,Eximed | Garazd M.M.,Eximed
Chemistry of Natural Compounds | Year: 2016

Natural dibenzo[b,d]pyran-6-ones are common and structurally diverse secondary metabolites that occur frequently in plants, fungi, lichens, and animal waste and possess broad spectra of biological activities such as cytotoxic, antioxidant, antifungal, and antimicrobial. The literature on the isolation, structural diversity, and biological activity of natural dibenzo[b,d]pyran-6-ones from 1949 to December 2014 was reviewed. © 2016 Springer Science+Business Media New York


Garazd Y.L.,Eximed | Garazd M.M.,Eximed | Kartsev V.G.,InterBioScreen
Chemistry of Natural Compounds | Year: 2015

Colchicine derivatives modified on C-10 by natural and synthetic amino acids were synthesized. © 2015 Springer Science+Business Media New York.


Nikitina Y.A.,Eximed | Galaev A.I.,Eximed | Garazd Y.L.,Eximed | Garazd M.M.,Eximed | Kartsev V.G.,InterBioScreen
Chemistry of Natural Compounds | Year: 2015

New coumarin derivatives containing a lupinine moiety were synthesized via amidation of furocoumarinylacetic, furocoumarinylpropionic, and dihydropyranocoumarinyloxyacetic acids with lupinylamine. © 2015 Springer Science+Business Media New York.

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