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Taramani, India

Kumar T.V.,Evolva Biotech Private Ltd | Rao Ch.R.K.,Evolva Biotech Private Ltd | Mukkanti K.,Jawaharlal Nehru Technological University | Mainkar P.S.,Evolva Biotech Private Ltd
Asian Journal of Chemistry | Year: 2015

Polyethylene glycol (PEG-400) was found to be an effective and nontoxic reaction medium for the one-pot synthesis of substituted pyrroles under catalyst-free conditions in excellent yields. Environmental acceptability, low cost, high yields and recyclability of the polyethylene glycol are the important features of this protocol.


Chinta R.R.,Evolva Biotech Private Ltd | Harikrishna V.,Evolva Biotech Private Ltd | Tulam V.K.,Evolva Biotech Private Ltd | Mainkar P.S.,Evolva Biotech Private Ltd | Dubey P.K.,Jawaharlal Nehru Technological University
Asian Journal of Chemistry | Year: 2016

A new series of novel 8,10-dimethyl-12-aryl-12H-naphtho[1′,2,5,6]pyrano[2,3-d]pyrimidine-9,11-diones derivatives synthesized from coupling (3CC) of aldehydes, β-naphthol and 1,3-dimethylbarbituric acid derivatives with using green condition through a simple, mild and efficient procedure utilizing cellulose sulfuric acid as a catalyst. Final compounds were evaluated for antibacterial and antifungal activity. Compounds 4a, 4d, 4h display high potent antifungal activity against Candida parapsilopsis, compound 4d show more potent activity (MIC 4.6 mg/mL) better than miconazole. While compound 4d most effective on bacterial against Micrococcus luteus, Staphylococcus aureus MTCC 96 and Staphylococcus aureus MTCC 2940 with (MIC 2.3 mg/mL).


Chandra Bose. Kotte S.,Evolva Biotech Private Ltd | Dubey P.K.,Jawaharlal Nehru Technological University | Murali P.M.,Evolva Biotech Private Ltd
Analytical Methods | Year: 2014

A rapid, specific and reliable high-performance liquid chromatography combined with quadrupole time-of-flight dual electrospray ionization mass spectrometry (LC/Q-TOF-dual ESI-MS) method has been developed and validated for the identification and characterization of stressed degradation products of piperine. Piperine, an anti-hypertensive drug, was subjected to hydrolysis (acidic, alkaline and neutral), oxidation, photolysis and thermal stress, as per ICH-specified conditions. The drug showed extensive degradation under oxidation and hydrolysis (acid and base) stress conditions. However, it was more stable under thermal stress than under acidic, alkaline, neutral and photolysis stress conditions. A total of four degradation products were observed and the chromatographic separation of the drug and its degradation products was achieved on a C18column (4.6 × 50 mm, 5 μm). To characterize the degradation products, fragmentation patterns and accurate masses of the degradation products were established by subjecting them to LC-MS/Q-TOF analysis. Structure elucidation of the degradation products was achieved by comparing their fragmentation patterns with that of the drug, and confirmation was achieved through profiling a black pepper extract (Piper nigrum L.). The method identified dihydropiperine, piperylin, piperlonguminine, trans-piperine, cis-piperine, dihydropiperlonguminine, trans-piperettine and cis-piperettine. The liquid chromatography-mass spectroscopy method was validated with respect to its specificity, linearity, accuracy and precision. This journal is © the Partner Organisations 2014.


Bose K.S.C.,Evolva Biotech Private Ltd | Dubey P.K.,Jawaharlal Nehru Technological University | Murali P.M.,Evolva Biotech Private Ltd
Asian Journal of Chemistry | Year: 2013

A simple, rapid and sensitive reverse-phase LC-MS method has been developed for the simultaneous quantification of Dazmegrel, GR 32191, SQ-29548 and U-46619 in human plasma. Analytes were extracted from human plasma by liquid-liquid extraction technique using acetonitrile. Separation was achieved on a reverse phase Shodex C18, 3 μm, 4.6 × 100 mm column at ambient temperature under isocratic conditions at a flow rate of 1 mL/min, run time of 10 min with acetonitrile and 0.1 % formic acid in water (70:30 v/v). Detection was performed using dual electrospray ionization (ESI) by using a fast polarity switch mode for fragment ions and adduct as for Dazmegrel, GR32191, SQ-29548 and U-46619 in positive and negative modes. The results indicate that this proposed method is convenient and reliable for clinical studies application.


Vijaya Kumar T.,Evolva Biotech Private Ltd | Bharadwaj T.V.,Jawaharlal Nehru Technological University | Ukkanti K.,Jawaharlal Nehru Technological University | Mainkar P.S.,Evolva Biotech Private Ltd
Asian Journal of Chemistry | Year: 2015

An efficient protocol of shorter reaction times for protective opening of epoxides (POE) with pivaloyl halides under solvent-free conditions in presence of Lewis acid catalysts has been developed.

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