Evolva Biotech Private Ltd

Taramani, India

Evolva Biotech Private Ltd

Taramani, India
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Thulam V.K.,Evolva Biotech Private Ltd | Kotte S.C.B.,Evolva Biotech Private Ltd | Sanjay Kumar H.,Evolva Biotech Private Ltd | Murali P.M.,Evolva Biotech Private Ltd | And 2 more authors.
Journal of Pharmacy Research | Year: 2013

Background: The N-acylation of sulfonamides and carbamates with acid anhydrides in the presence of Lewis catalysis has been described. The N-acylation of various sulfonamides and carbamates with carboxylic acid anhydrides were effectively promoted by catalytic amount of CeCl3 under solvent-free conditions to produce the corresponding N-acyl products in good to excellent yields. The synthesized compounds were tested for their antifungal activity. Methods: To a mixture of sulfonamide and anhydride, and anhydrous CeCl3 was added and the reaction was stirred for the given time. After completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with water and brine solution. The combined organic layers were dried over Na2SO4 and evaporated in vacuum. The crude compound was purified by column chromatography to afford the corresponding N-acylated product. Results: Synthesized compounds were screened for their antifungal activity against two virulent organisms Malassezia furfur and Malassezia pachydermatis. The compounds were tested in different concentrations ranging from 200 uM to 1 uM and taking their growth observations at OD 600 nm at different time intervals. The growth in the treated wells was compared with the growth in the untreated wells. Ketoconazole was used as control, among the compounds screened 2a, 2i and 4a showed activity than the standard antifungal drug i.e. Ketoconazole. Conclusion: Synthesized compounds were evaluated for their antifungal activity and three compounds 2a, 2i, and 4a showed very good activity against both the organisms, for the first time N-acyl sulfonamides and carbamates classes were evaluated as potential anti- Malassezia agents. © 2013, JPR Solutions.


Subhash Chandra Bose K.,Evolva Biotech Private Ltd | Vijaya Kumar T.,Evolva Biotech Private Ltd | Dubey P.K.,Jawaharlal Nehru University | Murali P.M.,Evolva Biotech Private Ltd
Journal of Pharmacy Research | Year: 2013

A simple, rapid, fast, precise and accurate reverse-phase HPLC method was developed and validated for the simultaneous determination of Dexamethasone, Testosterone and Estrone (E1) in pre-mixture by using RP-HPLC having photon diode array detector, Evaporative Light Scattering Detector (ELSD) and coupled with dual electrospray ionization mass spectrometry Quadrupole time-of-flight (LCMS). The method has shown adequate separation for Dexamethasone, Testosterone and Estrone (E1). Separation was achieved on reverse phase Shodex C18, 3 μm, 4.6 × 100 mm, using isocratic elution mode with a mobile phase Acetonitrile and 0.1% formic acid in water. The flow rate was 1 mL/min and effluents were monitored at 240 and 280 nm, using photodiode array (PDA) detector, ELSD and Ion detection was performed by dual electrospray ionization source (dual ESI) in positive mode. The recovery of steroids was found to be in the range of 98-102%. The described method was linear. The precision, ruggedness and robustness values were also within the prescribed limits. © 2012, JPR Solutions.


Kumar T.V.,Evolva Biotech Private Ltd | Rao Ch.R.K.,Evolva Biotech Private Ltd | Mukkanti K.,Jawaharlal Nehru Technological University | Mainkar P.S.,Evolva Biotech Private Ltd
Asian Journal of Chemistry | Year: 2015

Polyethylene glycol (PEG-400) was found to be an effective and nontoxic reaction medium for the one-pot synthesis of substituted pyrroles under catalyst-free conditions in excellent yields. Environmental acceptability, low cost, high yields and recyclability of the polyethylene glycol are the important features of this protocol.


Vijaya Kumar T.,Evolva Biotech Private Ltd | Bharadwaj T.V.,Jawaharlal Nehru Technological University | Ukkanti K.,Jawaharlal Nehru Technological University | Mainkar P.S.,Evolva Biotech Private Ltd
Asian Journal of Chemistry | Year: 2015

An efficient protocol of shorter reaction times for protective opening of epoxides (POE) with pivaloyl halides under solvent-free conditions in presence of Lewis acid catalysts has been developed.


Chandra Bose. Kotte S.,Evolva Biotech Private Ltd | Dubey P.K.,Jawaharlal Nehru Technological University | Murali P.M.,Evolva Biotech Private Ltd
Analytical Methods | Year: 2014

A rapid, specific and reliable high-performance liquid chromatography combined with quadrupole time-of-flight dual electrospray ionization mass spectrometry (LC/Q-TOF-dual ESI-MS) method has been developed and validated for the identification and characterization of stressed degradation products of piperine. Piperine, an anti-hypertensive drug, was subjected to hydrolysis (acidic, alkaline and neutral), oxidation, photolysis and thermal stress, as per ICH-specified conditions. The drug showed extensive degradation under oxidation and hydrolysis (acid and base) stress conditions. However, it was more stable under thermal stress than under acidic, alkaline, neutral and photolysis stress conditions. A total of four degradation products were observed and the chromatographic separation of the drug and its degradation products was achieved on a C18column (4.6 × 50 mm, 5 μm). To characterize the degradation products, fragmentation patterns and accurate masses of the degradation products were established by subjecting them to LC-MS/Q-TOF analysis. Structure elucidation of the degradation products was achieved by comparing their fragmentation patterns with that of the drug, and confirmation was achieved through profiling a black pepper extract (Piper nigrum L.). The method identified dihydropiperine, piperylin, piperlonguminine, trans-piperine, cis-piperine, dihydropiperlonguminine, trans-piperettine and cis-piperettine. The liquid chromatography-mass spectroscopy method was validated with respect to its specificity, linearity, accuracy and precision. This journal is © the Partner Organisations 2014.


Chinta R.R.,Evolva Biotech Private Ltd | Harikrishna V.,Evolva Biotech Private Ltd | Tulam V.K.,Evolva Biotech Private Ltd | Mainkar P.S.,Evolva Biotech Private Ltd | Dubey P.K.,Jawaharlal Nehru Technological University
Asian Journal of Chemistry | Year: 2016

A new series of novel 8,10-dimethyl-12-aryl-12H-naphtho[1′,2,5,6]pyrano[2,3-d]pyrimidine-9,11-diones derivatives synthesized from coupling (3CC) of aldehydes, β-naphthol and 1,3-dimethylbarbituric acid derivatives with using green condition through a simple, mild and efficient procedure utilizing cellulose sulfuric acid as a catalyst. Final compounds were evaluated for antibacterial and antifungal activity. Compounds 4a, 4d, 4h display high potent antifungal activity against Candida parapsilopsis, compound 4d show more potent activity (MIC 4.6 mg/mL) better than miconazole. While compound 4d most effective on bacterial against Micrococcus luteus, Staphylococcus aureus MTCC 96 and Staphylococcus aureus MTCC 2940 with (MIC 2.3 mg/mL).


Chinta R.R.,Evolva Biotech Private Ltd | Harikrishna V.,Jawaharlal Nehru Technological University | Tulam V.K.,Evolva Biotech Private Ltd | Bejjanki N.K.,Evolva Biotech Private Ltd | And 2 more authors.
Asian Journal of Chemistry | Year: 2016

A synthesis of (-)-curcuphenol, (-)-curcuquinone and (-)-curcuhydroquinone from o-valerolactone is described. The key steps include an Evans asymmetric methylation of 5-(benzyloxy)pentanoic acid (5), an oxidative aromatization of enone (11) and a regioselective oxidation of the phenol to o-quinone derivative with bis(trifluoro acetate)iodobenzene.


Kumar A.S.S.,Dalmia Center for Research and Development | Bose K.S.C.,Evolva Biotech Private Ltd | Kumar K.V.T.S.P.,Dalmia Center for Research and Development | Raghavan S.,Dalmia Center for Research and Development | And 2 more authors.
Asian Journal of Chemistry | Year: 2014

Plant derived bio products have become integral part of world health care system which not only include botanical drugs but also agro chemicals, cosmetics, nutraceuticals, flavors and fragrances and so on. The World Bank estimates that global trade in plant derived products will grow at average 10-12 % per year and will reach whooping USD 123 billion by 2020. Inevitably this brought attention to our sthala vriksha or sacred tree neem (Azadirachta indica) considered as store house of high value products with vast array of biological activities like insecticidal, spermicidal, anticancer, hypoglycemic, antiulcer, antiinflammatory, and many more. However due to inherent complexities in scalability which includes consistent supply chain and difficulty in synthesizing bioactive metabolites using established chemical routes and seasonal variation in bio-efficacy with change in plant chemistry, place, age etc. makes large scale production of most of them is impossible. Hence there is need for a paradigm shift in combining traditional approaches with more sophisticated biotechnological methods to produce these products in heterologous system, thereby enabling a consistent scale-up at a commercial level. This article reviews the terpenoids reported in neem so far, their proposed biosynthetic pathways and potential avenues for expressing them in microbial cell factories.


Bose K.S.C.,Evolva Biotech Private Ltd | Dubey P.K.,Jawaharlal Nehru Technological University | Murali P.M.,Evolva Biotech Private Ltd
Asian Journal of Chemistry | Year: 2013

A simple, rapid and sensitive reverse-phase LC-MS method has been developed for the simultaneous quantification of Dazmegrel, GR 32191, SQ-29548 and U-46619 in human plasma. Analytes were extracted from human plasma by liquid-liquid extraction technique using acetonitrile. Separation was achieved on a reverse phase Shodex C18, 3 μm, 4.6 × 100 mm column at ambient temperature under isocratic conditions at a flow rate of 1 mL/min, run time of 10 min with acetonitrile and 0.1 % formic acid in water (70:30 v/v). Detection was performed using dual electrospray ionization (ESI) by using a fast polarity switch mode for fragment ions and adduct as for Dazmegrel, GR32191, SQ-29548 and U-46619 in positive and negative modes. The results indicate that this proposed method is convenient and reliable for clinical studies application.

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