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Taipei, Taiwan

Chan T.-M.,China Medical University at Taichung | Chan T.-M.,Everfront Biotech Inc | Harn H.-J.,China Medical University at Taichung | Lin H.-P.,National Health Research Institute | And 11 more authors.
Cell Transplantation | Year: 2014

Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagicinduced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, we describe the features and classification of stroke and focus on the benefits of adipose tissue-derived stem cells and their applications in stroke animal models. The results show that cell-based therapies have resulted in significant improvements in neuronal behaviors and functions through different molecular mechanisms, and no safety problems have so far arisen after transplantation. Further, we propose a clinical possibility to create a homing niche by reducing the degree of invasive intracerebroventricular transplantation and combining it with continuous intravenous administration to achieve a complete cure. © 2014 Cognizant Comm. Corp. Source


Chiu S.-C.,China Medical University at Taichung | Chung H.-Y.,China Medical University at Taichung | Chung H.-Y.,China Medical University Beigan Hospital | Cho D.-Y.,China Medical University at Taichung | And 12 more authors.
Cell Transplantation | Year: 2014

The first microRNA, let-7, and its family were discovered in Caenorhabditis elegans and are functionally conserved from worms to humans in the regulation of embryonic development and stemness. The let-7 family has been shown to have an essential role in stem cell differentiation and tumor-suppressive activity. Deregulating expression of let-7 is commonly reported in many human cancers. Emerging evidence has accumulated and suggests that reestablishment of let-7 in tumor cells is a valuable therapeutic strategy. However, findings reach beyond tumor therapeutics and may impinge on stemness and differentiation of stem cells. In this review, we discuss the role of let-7 in development and differentiation of normal adult stem/progenitor cells and offer a viewpoint of the association between deregulated let-7 expression and tumorigenesis. The regulation of let-7 expression, cancer-relevant let-7 targets, and the application of let-7 are highlighted. © 2014 Cognizant Comm. Corp. Source


Huang M.-H.,National Chung Hsing University | Lin S.-Z.,China Medical University at Taichung | Lin S.-Z.,China Medical University Beigan Hospital | Lin P.-C.,Applied Cell Technology | And 10 more authors.
Tumor Biology | Year: 2014

Developing an effective drug for treating human glioblastoma multiform (GBM) has been investigated persistently. A pure compound butylidenephthalide (BP), isolated from Angelica sinensis, has been shown the activities to arrest the growth and initiate apoptosis of GBM in our previous reports. In this study, we further demonstrated that BP treatment accelerates the cell senescence in a dose-dependent manner in vitro and in vivo. S-phase kinase-associated protein 2 (Skp2), a proto-oncogene, is generally upregulated in cancer. We found that it was downregulated in BP-treated GBM cells. The downregulation of Skp2 is parallel with increasing p16 and p21 expression which causes G0/G1 arrest and tumor cell senescence. We also found that restoring the Skp2 protein level by exogenous overexpression prevents the BP-induced cell senescence. Therefore, the linkage between cell senescence and Skp2 expression is strengthened. Promoter binding analysis further detailed that the BP-mediated SP1 reduction might involve in the Skp2 downregulation. In summary, these results emphasize that BP-triggered senescence in GBMcells is highly associated with its control on Skp2 regulation. © International Society of Oncology and BioMarkers (ISOBM) 2014. Source


Patent
Everfront Biotech Inc. | Date: 2015-04-24

A pharmaceutical composition comprising:


Ho T.-J.,China Medical University at Taichung | Ho T.-J.,China Medical University Beigang Hospital | Chan T.-M.,China Medical University at Taichung | Chan T.-M.,Everfront Biotech Inc | And 10 more authors.
Cell Transplantation | Year: 2014

This review reports on recent findings concerning the effects of acupuncture and electroacupuncture (EA) on stem cell mobilization and differentiation, in particular with regard to neurogenesis. Traditional Chinese acupuncture has a history of over 2,500 years and is becoming more popular worldwide. Evidence has demonstrated that acupuncture may be of benefit in stroke rehabilitation, parkinsonism, dementia, and depression. This article reviews recent studies concerning the effects of acupuncture/EA on stem cell mobilization and on progenitor cell proliferation in the CNS. The reviewed evidence indicates that acupuncture/EA has beneficial effects in several neurodegenerative diseases, and it may prove to be a nondrug method for mobilizing stem cells in the CNS. © 2014 Cognizant Comm. Corp. Source

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