Sialvera T.E.,Agricultural University of Athens |
Pounis G.D.,Agricultural University of Athens |
Koutelidakis A.E.,Agricultural University of Athens |
Richter D.J.,Athens Euroclinic |
And 6 more authors.
Nutrition, Metabolism and Cardiovascular Diseases | Year: 2012
Background and aims: Several studies have observed a hypocholesterolemic effect of plant sterols in hypercholesterolemic patients on a balanced diet. The aim of this study was to examine the effect of phytosterol supplementation on risk factors of coronary artery disease in metabolic syndrome patients on a Westernized type diet. Methods and results: In a randomized placebo-controlled design 108 patients with metabolic syndrome were assigned to consume either 2 plant sterol-enriched yogurt mini drink which provided 4 g phytosterols per day, or a yogurt beverage without phytosterols (control). The duration of the study was 2 months and the patients in both groups followed their habitual westernized type diet and recording it on food diaries. Blood samples were drawn at baseline and after 2 months of intervention. After 2 months supplementation with phytosterols, a significant reduction in total cholesterol, LDL-cholesterol, small and dense LDL (sdLDL) levels, as well as, apoB and triglycerides concentrations were observed in the intervention group (P < 0.05) compared to the control group. In addition, phytosterol supplementation lowered serum total cholesterol by 15.9%, LDL-cholesterol by 20.3% and triglyceride levels by 19.1% (P = 0.02, P < 0.001 and P < 0.001, respectively), although the patients kept their habitual westernized type diet. No differences were observed in HDL cholesterol, apoA1, glucose, C-reactive protein, fibrinogen levels and blood pressure. Conclusions: Phytosterol supplementation improves risk factors of coronary artery disease even if the diet is a westernized type. © 2011 Elsevier B.V.
Gouveri E.T.,Evangelismos State General Hospital |
Tzavara C.,National and Kapodistrian University of Athens |
Drakopanagiotakis F.,Evangelismos State General Hospital |
Tsaoussoglou M.,Evangelismos State General Hospital |
And 3 more authors.
Nutrition in Clinical Practice | Year: 2011
Background: Previous studies demonstrated the beneficial impact of the Mediterranean diet (MedDiet) on metabolic syndrome (MetS). The aim of this study was to retrospectively investigate the association between MedDiet and MetS in a representative sample of the Athenian population in the early 1980s, when MetS had not been established as an entity yet. Methods: In a cross-sectional epidemiologic survey of cardiovascular disease (CVD), 2,074 randomly selected adults were examined: 900 men and 1,174 women (age, 46.9 ± 14.9 years). MetS was defined according to criteria of the National Cholesterol Education Program-Adult Treatment Panel III. A validated questionnaire concerning nutrition habits was administered, and MedDiet was assessed according to guidelines of the Division of Nutrition/Epidemiology, Athens University Medical School. Results: Overall, 1,023 participants (49.3%) followed MedDiet (47.3% men, 52.0% women, P =.033) with similar rates across age groups (P =.337). MetS was diagnosed in 24.0% of those following MedDiet, compared with 27.9% of those not following it (P =.041). Participants with CVD or diabetes mellitus were less likely to follow MedDiet (43% vs 50%, P =.009). Multivariate analysis revealed that MedDiet is associated with a 20% reduction in MetS (odds ratio = 0.80, 95% confidence interval = 0.65-0.98), after adjustment for age, gender, smoking, light physical activity, serum levels of low-density lipoprotein cholesterol and I-glutamyl transferase, diabetes mellitus, CVD, family history of hypertension, and/or hyperlipidemia. Conclusions: Results indicate that adherence to MedDiet may attenuate the prevalence of MetS and, consequently, the increasing burden of diabetes mellitus and CVD, especially in urban populations. © 2011 The American Society for Parenteral and Enteral Nutrition.